Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit

Journal of Neuroscience

Volumn 17, Issue 24, 1997, Pages 9466-9472

  Giasson, Benoit I ^a   Mushynski, Walter E ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Cyclin dependent kinase 5; Heavy neurofilament subunit; p38 kinases; Phosphorylation; Stress activated kinases

Indexed keywords

CYCLIN DEPENDENT KINASE; PROLINE; PROTEIN KINASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; INTERMEDIATE FILAMENT; MOUSE; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; SCHWANN CELL; SPINAL GANGLION;

EID: 0031452245     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-24-09466.1997     Document Type: Article

References (15)

1. Archer DR, Watson DF, Griffin JW (1994) Phosphorylation-depcndent immunoreactivity of neurofilaments and the rate of slow axonal transport in the central and peripheral axons of the rat dorsal root ganglion. J Neurochem 62:1119-1125.
2. Athlan ES, Sacher MG, Mushynski WE (1997) Associations between intermediate filament proteins expressed in cultured dorsal root ganglion neurons. J Neurosci Res 47:300-310.
3. Beaudette KN, Lew J, Wang JH (1993) Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain. J Biol Chem 268:20825-208730.
4. Brewis ND, Street AJ, Prescott PR, Cohen TW (1993) PPX, a novel protein serine/threonine phosphatase localized to centrosomes. EMBO J 12:987-996.
5. Cano E, Mahadevan LC (1995) Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20:117-122.
6. Carden MJ, Schlaepfer WW, Lee VM-Y (1985) The structure, biochemical properties, and immunogenicity of neurofilament peripheral regions arc determined by phosphorylation state. J Biol Chem 260:9805-9817.
7. Carpenter S (1968) Proximal axonal enlargement in motor neuron disease. Neurology 18:841-851.
8. Chou S-M, Hartman H (1965) Electron microscopy of focal neuroaxonal lesions produced by β-β′-iminodipropionitrile (IDPN) in rats. Acta Neuropathol 4:590-603.
9. Cole JS, Messing A, Trojanowski JQ, Lee VM-Y (1994) Modulation of axonal diameter and neurofilaments by hypomyelinating Schwann cells in transgenic mice. J Neurosci 14:6956-6966.
10. Collard J-F, Côté F, Julien J-P (1995) Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature 375:61-64.
11. Cork LC, Sternberger NH, Sternberger LA, Casanova MF, Struble RG, Price DL (1986) Phosphorylated neurofilament antigens in neurofibrillary tangles in Alzheimer's disease. J Neuropathol Exp Neurol 45:56-64.
12. Côté F, Collard J-F, Julien J-P (1993) Progressive neuropathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell 73:35-46.
13. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, Lee JC (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364:229-233.
14. Miyasaka H, Okabe S, Ishigura K, Uchida T, Hirokawa N (1993) Interaction of the tail domain of high molecular weight subunits of neurofilament with the COOH-terminal region of tubulin and its regulation by tau protein kinase II. J Biol Chem 268:22695-22702.
15. Munoz DO, Greene C, Perl DP, Selkoe DJ (1988) Accumulation of phosphorylated neurofilaments in anterior horn motorneurons of amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 47:9-18.