Neurofilament subunits can undergo axonal transport without incorporation into triton-insoluble structures

Cell Motility and the Cytoskeleton

Volumn 40, Issue 1, 1998, Pages 44-58

  Jung, Cheolwha ^a   Yabe, Jason ^a   Wang, Feng Song ^a,b   Shea, Thomas B ^a  

^a UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Axon; Axonal transport; Cytoskeleton; Microinjection; Neurofilaments; Neuronal differentiation

Indexed keywords

NEUROFILAMENT PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MOLECULAR DYNAMICS; MOUSE; NERVE CELL DIFFERENTIATION; NERVE FIBER TRANSECTION; NEUROBLASTOMA CELL; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALS; AXONAL TRANSPORT; CELLS, CULTURED; CHICK EMBRYO; INTERMEDIATE FILAMENTS; MICE; MICROINJECTIONS; NEURITES; NEUROFILAMENT PROTEINS; NEURONS; OCTOXYNOL; RETINA; SOLUBILITY; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0031968643     PISSN: 08861544     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0169(1998)40:1<44::AID-CM5>3.0.CO;2-F     Document Type: Article

References (52)

1. Anderton, B.H., Breinburg, D., Downes, M.J., Gree, P.J., Tomilson, B.E., Ulrich, J., Wood, J.N., and Kahn, J. (1982): Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants. Nature 298:84-86.
2. Angelides, K.J., Smith, K.E., and Takeda, M. (1989): Assembly and exchange of intermediate filament proteins of neurons: NFs are dynamic structures. J. Cell Biol. 108:1495-1506.
3. Baas, P.W., Ahmad, F.J., Pienlowski, T.P., Brown, A., and Black, M.M. (1993): Sites of microtubule stabilization for the axon. J. Neurosci. 13:2177-2185.
4. Brady, S.T. (1993): Motor neurons and neurofilaments in sickness and health. Cell 73:1-3.
5. Bray, J.J., and Mills, R.G. (1991): Transport complexes associated with slow axonal flow. Neurochem. Res. 16:645-649.
6. Burrell, K.A., Enayate, Z.E., Powell, J.F., Leigh, P.N., and Gallo, J.-M. (1996): Overexpression of wildtype and mutant Cu/Zn superoxide dismutase in a differentiated mouse neuroblastoma cell line. Mol. Biol. Cell. 7:220a.
7. Carter, J.E., Gallo, J.-M., Anderson, V.E.R., Anderton, B.H., and Robertson, J. (1996): Aggregation of neurofilaments in NF-L-transfected neuronal cells: Regeneration of the filamentous network by a protein kinase C inhibitor. J. Neurochem. 67:1997-2004.
8. Celis, J.E., Larsen, P.M., Fey, S.J., and Cells, A. (1983): Phosphorylation of keratin and vimentin polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns. J. Neurosci. 7:3489-3504.
9. Chiu, F.-C., and Norton, W.T. (1982): Bulk preparations of mammalian CNS cytoskeletons. J. Neurochem. 39:1252-1260.
10. Cohlberg, J.A., Hajarian, H., Tran, T., Alipourjeddi, A., and Noveen, A. (1995): Neurofilament protein heterotetramers as assembly intermediates. J. Biol .Chem. 270:9334-9339.
11. Cressman, C.M., and Shea, T.B. (1995): Hyperphosphorylation of tau and filopodial retraction following microinjection of protein kinase C catalytic subunits. J. Neurosci. Res. 42:648-656.
12. Evans, R.M., and Fink, L.M. (1988): An alteration in the phosphorylation of vimentin-type intermediate filaments is associated with mitosis in cultured mammalian cells. Cell 29:43-52.
13. Fischer, I., Beermann, M.L., Nixon, R.A., Edwards, M.A., and Shea, T.B. (1993): Dynamics of phosphorylation and assembly of the high molecular weight NF protein in mouse CNS. Soc. Neurosci. Abstr. 19:1083.
14. Glass, J.D., and Griffin, J.W. (1994): Retrograde transport of radiolabeled cytoskeletal proteins in transected nerves. J.Neurosci. 14:3915-3921.
15. Hisanaga, S., and Hirowawa, N. (1988): Structure of the peripheral domains of neurofilaments revealed by low angle rotary shadowing. J. Mol. Biol. 202:297-305.
16. Hirokawa, N. (1993): Axonal transport and the cytoskeleton. Curr. Opin. Neurobiol. 3:724-731.
17. Huffman, P.N., and Lasek, R.J. (1975): The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian axons. J. Cell Biol. 66:351-366.
18. Inagaki, M., Nishi, Y., Nishizawa, K., Matsuyama, M., and Sato, C. (1989): Site-specific phosphorylation induces disassembly of vimentin filaments in vitro. Nature 328:649-652.
19. Inagaki, M., Gonda, Y., Nishizawa, K., Kitamura, S., Sato, C., Ando, S., Tanabe, K., Kikuchi, K., Tsuiki, S., and Nishi, Y. (1990): Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-a-helical head domain. J. Biol. Chem. 265:4722-4729.
20. Issacs, W.B., Cook, R.K., Van Atta, J.C., Redmond, C.M., and Fulton, A.B. (1989): Assembly of vimentin in cultured cells varies with cell type. J. Biol. Chem. 264:17953-17960.
21. Kitamura, S., Ando, S., Shibata, M., Tanabe, K., Sato, C., and Inagaki, M. (1989): Protein kinase C phosphorylation of desmin at four serine residues within the non-α-helical head domain. J. Biol. Chem. 264:5674-5678.
22. Lasek, R.J., Paggi, P., and Katz, M.J. (1992): Slow axonal transport mechanisms move neurofilaments relentlessly in mouse optic axons. J. Cell Biol. 117:607-616.
23. Lasek, R.J., Paggi, P., and Katz, M.J. (1993): The maximum rate of neurofilament transport in axons: A view of molecular transport mechanisms continuously engaged. Brain Res. 616:58-64.
24. Matus, A. (1987): Putting together the neuronal cytoskeleton. Trends Neurosci. 10:186-188.
25. Miller KE and Joshi HC (1996) Tubulin transport in neurons. J Cell Biol 133:1355-1366.
26. Nixon, R.A. (1993): The regulation of neurofilament protein dynamics by phosphorylation: Clues to neurofibrillary pathology? Brain Pathol. 3:29-38.
27. Nixon, R.A., and Lewis, S.E. (1986): Differential turnover of phosphate groups on neurofilament subunits in mammalian neurons in vivo. J. Biol. Chem. 261:16298-16301.
28. Nixon, R.A., and Lewis, S.E. (1987): Phosphorylation and dephosphorylation of ne neurofilament proteins in retinal ganglion cell neurons in vivo. In: Ehrlich, Y.H., Lenox, R.H., Kornecki, E., and Berry, W.O. (eds.): "Molec Mech Neuronal Responsiveness." New York: Plenum Press, pp. 167-186.
29. Nixon, R.A., Lewis, S.E., Dahl, D., Marotta, A.C., and Drager, U.C. (1989): Early posttranslational modification of neurofilament proteins by phosphate during axoplasmic transport in retinal ganglion cell neurons. Mol. Brain Res. 5:93-108.
30. Nixon RA, and Logvinenko KB (1986) Multiple fates of newly synthesized neurofilament proteins: evidence for a stationary neurofilament network distributed non-uniformly along axons of retinal ganglion cell neurons. J Cell Biol 102:647-659.
31. Ochs, S., Jersild, J.K., and Li, J.-M. (1989): Slow transport of freely movable cytoskeletal components shown by beading partition of nerve fibers in the cat. Neruoscience 33:421-430.
32. Okabe S and Hirokawa N (1992) Dynamics of neuronal intermediate filaments. Molec Biol Cell 3:355 (abstr).
33. Okabe S, Miyasaka H and Hirokawa N (1993) Dynamics of the neuronal intermediate filaments. J Cell Biol 121:375-386.
34. Shea, T.B. (1995a): Differential synthesis and cytoskeletal deposition of neurofilament subunits before and during axonal outgrowth in NB2a/d1 cells: Evidence that segregation of phosphorylated suhunits within the axonal cytoskeleton involves selective deposition. J. Neurosci. Res. 40:225-232.
35. Shea, T.B. (I995b): Leupeptin enhances phosphorylated neurofilament immunoreactivity in Triton-insoluble cytoskeletons of mouse NB2a/d1 cells. Neurosci. Res. Commun. 15:143-148.
36. Shea, T.B., and Beermann. M.L. (1994): Sequential requirements for NFs, MTs, and the MT-associated proteins MAP1B and tau in axonal neurite initiation, elongation and stabilization. Mol. Cell. Biol. 5:863-875.
37. Shea, T.B., Sihag, R.K., and Nixon, R.A. (1990): Dynamics of phosphorylation and assembly of the high molecular weight NF subunit in NB2a/d1 neuroblastoma. J. Neurochem. 55:1784-1792.
38. Shea, T.B., Fischer, I., Paskevich, P.A., Beermann, M.L., Lewis, S.A., and Nixon, R.A. (1993a): Triton-soluble, extensively phosphorylated 200kDa NF-H in mouse CNS. Trans. Am. Soc. Neurochem. 24:195.
39. Shea, T.B., Fischer, I., Paskevich, P.A., and Beermann, M.L. (I993b): The protein phosphatase inhibitor okadaic acid increases axonal NFs and neurite caliber, and decreases axonal MTs in NB2a/d1 cells. J. Neurosci. Res. 35:507-521.
40. Shea, T.B., Sihag, R.K., and Nixon, R.A. (1988): Neurofilament triplet proteins of NB2a/d1 neuroblastoma: Posttranslational modification and incorporation into the cytoskeleton during differentiation. Dev. Brain Res. 43:97-109.
41. Shea, TB., Beermann, M.L., and Nixon, R.A. (1995a): Aluminum treatment of intact neuroblastoma cells alters neurofilament subunit phosphorylation. solubility and proteolysis. Mol. Chem. Neuropathol. 26:1-11
42. Shea, T.B., Wheeler, E., and Wang, F.-S. (1995b): Neurofilament translocation into axonal neurites is distinct from incorporation into the cytoskeleton. Mol. Biol. Cell 6:375a.
43. Shea, T.B., Dahl, D., Nixon, R.A., and Fischer, I. (1997): Triton-soluble phosphovariants of the heavy neurofilament subunit in developing and mature mouse central nervous system. J. Neurosci. Res. 48:515-523.
44. Steinert, P.M., and Liem, R.K.H. (1990): Intermediate filament dynamics. Cell 60:521-523.
45. Straube-West K, Loomis PA, Opal P and Goldman RD (1996) Alterations in neural intermediate filament organization: functional implications and the induction of pathological changes related to motor neuron disease. J Cell Sci 109:2319-2329.
46. Takeda, S., Okabe, S., Funakoshi, T., and Hirokawa, N. (1994): Differential dynamics of neurofilament-H protein and neurofilament-L protein in neurons. J. Cell Biol. 127:173-185.
47. Terada, S., Nakata, T., Peterson, A.C., and Hirokawa, N. (1996): Visualization of slow axonal transport in vivo. Science 273:784-788.
48. Tsuda, M., Tashiro, T., and Komiya, Y. (1997): Increased solubility of high-molecular-mass neurofilament subunit by suppression of dephosphorylation: its relation to axonal transport. J. Neurochem. 68:2558-2565.
49. Vikstrom, K.L., Borisy, G.G., and Goldman, R.D. (1989): Dynamic aspects of intermediate filament networks in BHK-12 cells. Proc. Natl. Acad. Sci. U.S.A. 86:549-553.
50. Wang, F.-S., and Shea, T.B. (1994): Transport and incorporation into the axonal cytoskeleton of NB2a/d1 cells of biotinylated NF-H. Mol. Biol. Cell 5:50a.
51. Watson, D.W., Glass, J.D., and Griffin, J.W. (1993): Redistribution of cytoskeletal proteins in mammalian axons disconnected from their cell bodies. J. Neurosci. 13:4354-4360.
52. Weisenberg RC, Flynn J, Gao BC, Awodi S, Skee F, Goodman SR, and ReidererBM (1987) Microtubule gelation-contraction: essential components and relation to slow axonal transport. Science 238:1119-1122.