메뉴 건너뛰기




Volumn 8, Issue 1, 2008, Pages 33-43

Overview of thrombopoietic agents in the treatment of thrombocytopenia

Author keywords

AKR 501; AMG 531; Eltrombopag; Interleukin 11; Megakaryocytes

Indexed keywords

AKR 501; CARBOPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DIMETHOATE; DOXORUBICIN; ELTROMBOPAG; ETOPOSIDE; FLUOROURACIL; IDARUBICIN; INTERFERON; INTERLEUKIN 11; LGD 4665; MITOXANTRONE; NEUTRALIZING ANTIBODY; NIP 004; PACLITAXEL; RECOMBINANT MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; RECOMBINANT THROMBOPOIETIN; REMIPLISTIM; SB 559448; UNCLASSIFIED DRUG;

EID: 41349111682     PISSN: 15579190     EISSN: None     Source Type: Journal    
DOI: 10.3816/CLM.2008.n.002     Document Type: Review
Times cited : (6)

References (90)
  • 2
    • 0036214534 scopus 로고    scopus 로고
    • Classical management of refractory adult immune (idiopathic) thrombocytopenic purpura
    • McMillan R. Classical management of refractory adult immune (idiopathic) thrombocytopenic purpura. Blood Rev 2002; 16:51-5.
    • (2002) Blood Rev , vol.16 , pp. 51-55
    • McMillan, R.1
  • 3
    • 0842328846 scopus 로고    scopus 로고
    • Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP
    • McMillan R, Wang L, Tomer A, et al. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood 2004; 103:1364-9.
    • (2004) Blood , vol.103 , pp. 1364-1369
    • McMillan, R.1    Wang, L.2    Tomer, A.3
  • 4
    • 0043245959 scopus 로고    scopus 로고
    • Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro
    • Chang M, Nakagawa PA, Williams SA, et al. Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood 2003; 102:887-95.
    • (2003) Blood , vol.102 , pp. 887-895
    • Chang, M.1    Nakagawa, P.A.2    Williams, S.A.3
  • 6
    • 0023798680 scopus 로고
    • Preclinical studies and clinical correlation of the effect of alkylating dose
    • Frei E III, Teicher BA, Holden SA, et al. Preclinical studies and clinical correlation of the effect of alkylating dose. Cancer Res 1988; 48:6417-23.
    • (1988) Cancer Res , vol.48 , pp. 6417-6423
    • Frei III, E.1    Teicher, B.A.2    Holden, S.A.3
  • 7
    • 0142058029 scopus 로고    scopus 로고
    • Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults
    • Kolb EA, Kushner BH, Gorlick R, et al. Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults. J Clin Oncol 2003; 21:3423-30.
    • (2003) J Clin Oncol , vol.21 , pp. 3423-3430
    • Kolb, E.A.1    Kushner, B.H.2    Gorlick, R.3
  • 8
    • 0031865087 scopus 로고    scopus 로고
    • Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas
    • Patel SR, Vadhan-Raj S, Burgess MA, et al. Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas. Am J Clin Oncol 1998; 21:317-21.
    • (1998) Am J Clin Oncol , vol.21 , pp. 317-321
    • Patel, S.R.1    Vadhan-Raj, S.2    Burgess, M.A.3
  • 9
    • 33751037747 scopus 로고    scopus 로고
    • Treatment of advanced soft-tissue sarcomas using a combined strategy of high-dose ifosfamide, high-dose doxorubicin and salvage therapies
    • Leyvraz S, Herrmann R, Guillou L, et al. Treatment of advanced soft-tissue sarcomas using a combined strategy of high-dose ifosfamide, high-dose doxorubicin and salvage therapies. Br J Cancer 2006; 95:1342-7.
    • (2006) Br J Cancer , vol.95 , pp. 1342-1347
    • Leyvraz, S.1    Herrmann, R.2    Guillou, L.3
  • 10
    • 0035147188 scopus 로고    scopus 로고
    • Prospective randomized trial between two doses of granulocyte colony-stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent or refractory solid tumors: A Children's Cancer Group report
    • Cairo MS, Shen V, Krailo MD, et al. Prospective randomized trial between two doses of granulocyte colony-stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent or refractory solid tumors: a Children's Cancer Group report. J Pediatr Hematol Oncol 2001; 23:30-8.
    • (2001) J Pediatr Hematol Oncol , vol.23 , pp. 30-38
    • Cairo, M.S.1    Shen, V.2    Krailo, M.D.3
  • 11
    • 33750477330 scopus 로고    scopus 로고
    • Multicentre phase II study of the baseline BEACOPP regimen for patients with advanced-stage Hodgkin's lymphoma
    • Niitsu N, Okamoto M, Tomita N, et al. Multicentre phase II study of the baseline BEACOPP regimen for patients with advanced-stage Hodgkin's lymphoma. Leuk Lymphoma 2006; 47:1908-14.
    • (2006) Leuk Lymphoma , vol.47 , pp. 1908-1914
    • Niitsu, N.1    Okamoto, M.2    Tomita, N.3
  • 12
    • 0031917065 scopus 로고    scopus 로고
    • Effects of granulocyte-macrophage colony-stimulating factor and dose intensification of V-ICE chemotherapy in small-cell lung cancer: A prospective randomized study of 300 patients
    • Steward WP, von Pawel J, Gatzemeier U, et al. Effects of granulocyte-macrophage colony-stimulating factor and dose intensification of V-ICE chemotherapy in small-cell lung cancer: a prospective randomized study of 300 patients. J Clin Oncol 1998; 16:642-50.
    • (1998) J Clin Oncol , vol.16 , pp. 642-650
    • Steward, W.P.1    von Pawel, J.2    Gatzemeier, U.3
  • 13
    • 0033977253 scopus 로고    scopus 로고
    • Granulocyte colony stimulating factor permits dose intensification by interval compression in the treatment of Ewing's sarcomas and soft tissue sarcomas in children
    • Womer RB, Daller RT, Fenton JG, et al. Granulocyte colony stimulating factor permits dose intensification by interval compression in the treatment of Ewing's sarcomas and soft tissue sarcomas in children. Eur J Cancer 2000; 36:87-94.
    • (2000) Eur J Cancer , vol.36 , pp. 87-94
    • Womer, R.B.1    Daller, R.T.2    Fenton, J.G.3
  • 14
    • 4344638243 scopus 로고    scopus 로고
    • Prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor decrease febrile neutropenia after chemotherapy in children with cancer: A meta-analysis of randomized controlled trials
    • Sung L, Nathan PC, Lange B, et al. Prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor decrease febrile neutropenia after chemotherapy in children with cancer: a meta-analysis of randomized controlled trials. J Clin Oncol 2004; 22:3350-6
    • (2004) J Clin Oncol , vol.22 , pp. 3350-3356
    • Sung, L.1    Nathan, P.C.2    Lange, B.3
  • 15
    • 33846668768 scopus 로고    scopus 로고
    • Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer treated with fluorouracil-based chemotherapy
    • Rosen LS, Abdi E, Davis ID, et al. Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer treated with fluorouracil-based chemotherapy. J Clin Oncol 2006; 24:5194-200.
    • (2006) J Clin Oncol , vol.24 , pp. 5194-5200
    • Rosen, L.S.1    Abdi, E.2    Davis, I.D.3
  • 16
    • 10344242939 scopus 로고    scopus 로고
    • Palifermin for oral mucositis after intensive therapy for hematologic cancers
    • Spielberger R, Stiff P, Bensinger W, et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 2004; 351:2590-8.
    • (2004) N Engl J Med , vol.351 , pp. 2590-2598
    • Spielberger, R.1    Stiff, P.2    Bensinger, W.3
  • 17
    • 0032005594 scopus 로고    scopus 로고
    • Recombinant human erythropoietin in the prevention of chemotherapy-induced anaemia in children with malignant solid tumours
    • Csáki C, Ferencz T, Schuler D, et al. Recombinant human erythropoietin in the prevention of chemotherapy-induced anaemia in children with malignant solid tumours. Eur J Cancer 1998; 34:364-7.
    • (1998) Eur J Cancer , vol.34 , pp. 364-367
    • Csáki, C.1    Ferencz, T.2    Schuler, D.3
  • 18
    • 28244469788 scopus 로고    scopus 로고
    • High efficacy of gemcitabine and cisplatin plus trastuzumab in patients with HER2-overexpressing metastatic breast cancer: A phase II study
    • Stemmler HJ, Kahlert S, Brudler O, et al. High efficacy of gemcitabine and cisplatin plus trastuzumab in patients with HER2-overexpressing metastatic breast cancer: a phase II study. Clin Oncol (R Coll Radiol) 2005; 17:630-5.
    • (2005) Clin Oncol (R Coll Radiol) , vol.17 , pp. 630-635
    • Stemmler, H.J.1    Kahlert, S.2    Brudler, O.3
  • 19
    • 0028799917 scopus 로고
    • Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in children and young adults
    • Kushner BH, Meyers PA, Gerald WL, et al. Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in children and young adults. J Clin Oncol 1995; 13:2796-804.
    • (1995) J Clin Oncol , vol.13 , pp. 2796-2804
    • Kushner, B.H.1    Meyers, P.A.2    Gerald, W.L.3
  • 20
    • 33750607556 scopus 로고    scopus 로고
    • Platelet autoantibodies are common in hepatitis C infection, irrespective of the presence of thrombocytopenia
    • Panzer S, Seel E, Brunner M, et al. Platelet autoantibodies are common in hepatitis C infection, irrespective of the presence of thrombocytopenia. Eur J Haematol 2006; 77:513-7.
    • (2006) Eur J Haematol , vol.77 , pp. 513-517
    • Panzer, S.1    Seel, E.2    Brunner, M.3
  • 21
    • 11144252779 scopus 로고    scopus 로고
    • The use of growth factors to manage the hematologic side effects of PEG-interferon alfa and ribavirin
    • Collantes RS, Younossi ZM. The use of growth factors to manage the hematologic side effects of PEG-interferon alfa and ribavirin. J Clin Gastroenterol 2005; 39(1 suppl):S9-13.
    • (2005) J Clin Gastroenterol , vol.39 , Issue.1 SUPPL.
    • Collantes, R.S.1    Younossi, Z.M.2
  • 22
    • 11144316875 scopus 로고    scopus 로고
    • Hematologic side effects of interferon and ribavirin therapy
    • Kowdley KV. Hematologic side effects of interferon and ribavirin therapy. J Clin Gastroenterol 2005; 39(1 suppl):S3-8.
    • (2005) J Clin Gastroenterol , vol.39 , Issue.1 SUPPL.
    • Kowdley, K.V.1
  • 23
    • 0002184519 scopus 로고    scopus 로고
    • Thrombopoietin: Biology and clinical applications
    • Kuter DJ. Thrombopoietin: biology and clinical applications. Oncologist 1996; 1:98-106.
    • (1996) Oncologist , vol.1 , pp. 98-106
    • Kuter, D.J.1
  • 24
    • 0037111558 scopus 로고    scopus 로고
    • Recombinant human thrombopoietin: Basic biology and evaluation of clinical studies
    • Kuter DJ, Begley CG. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 2002; 100:3457-69.
    • (2002) Blood , vol.100 , pp. 3457-3469
    • Kuter, D.J.1    Begley, C.G.2
  • 25
    • 0032832532 scopus 로고    scopus 로고
    • Thrombopoietin: Its role from early hematopoiesis to platelet production
    • Wendling F. Thrombopoietin: its role from early hematopoiesis to platelet production. Haematologica 1999; 84:158-66.
    • (1999) Haematologica , vol.84 , pp. 158-166
    • Wendling, F.1
  • 26
    • 33746508365 scopus 로고    scopus 로고
    • Megakaryocyte development and platelet production
    • Deutsch VR, Tomer A. Megakaryocyte development and platelet production. Br J Haematol 2006; 134:453-66.
    • (2006) Br J Haematol , vol.134 , pp. 453-466
    • Deutsch, V.R.1    Tomer, A.2
  • 27
    • 33746366769 scopus 로고    scopus 로고
    • The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells
    • Ninos JM, Jefferies LC, Cogle CR, et al. The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells. J Transl Med 2006; 4:9.
    • (2006) J Transl Med , vol.4 , pp. 9
    • Ninos, J.M.1    Jefferies, L.C.2    Cogle, C.R.3
  • 28
    • 31044439372 scopus 로고    scopus 로고
    • The molecular mechanisms that control thrombopoiesis
    • Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest 2005; 115:3339-47.
    • (2005) J Clin Invest , vol.115 , pp. 3339-3347
    • Kaushansky, K.1
  • 29
    • 0029865443 scopus 로고    scopus 로고
    • Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets
    • Fielder PJ, Gurney AL, Stefanich E, et al. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 1996; 87:2154-61.
    • (1996) Blood , vol.87 , pp. 2154-2161
    • Fielder, P.J.1    Gurney, A.L.2    Stefanich, E.3
  • 31
    • 0037071389 scopus 로고    scopus 로고
    • The molecular and cellular biology of thrombopoietin: The primary regulator of platelet production
    • Kaushansky K, Drachman JG. The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene 2002; 21:3359-67.
    • (2002) Oncogene , vol.21 , pp. 3359-3367
    • Kaushansky, K.1    Drachman, J.G.2
  • 32
    • 33646490285 scopus 로고    scopus 로고
    • Lineage-specific hematopoietic growth factors
    • Kaushansky K. Lineage-specific hematopoietic growth factors. N Engl J Med 2006; 354:2034-45.
    • (2006) N Engl J Med , vol.354 , pp. 2034-2045
    • Kaushansky, K.1
  • 33
    • 17944389931 scopus 로고    scopus 로고
    • Basser RL, Rasko JE, Clarke K, et al. Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer [published correction appears in Blood 1997; 90:2513]. Blood 1997; 89:3118-28.
    • Basser RL, Rasko JE, Clarke K, et al. Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer [published correction appears in Blood 1997; 90:2513]. Blood 1997; 89:3118-28.
  • 34
    • 0033485568 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia
    • Archimbaud E, Ottmann OG, Yin JA, et al. A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia. Blood 1999; 94:3694-701.
    • (1999) Blood , vol.94 , pp. 3694-3701
    • Archimbaud, E.1    Ottmann, O.G.2    Yin, J.A.3
  • 35
    • 0033861984 scopus 로고    scopus 로고
    • Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer
    • Basser RL, Underhill C, Davis I, et al. Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer. J Clin Oncol 2000; 18:2852-61.
    • (2000) J Clin Oncol , vol.18 , pp. 2852-2861
    • Basser, R.L.1    Underhill, C.2    Davis, I.3
  • 36
    • 0034655649 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia
    • Schiffer CA, Miller K, Larson RA, et al. A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia. Blood 2000; 95:2530-5.
    • (2000) Blood , vol.95 , pp. 2530-2535
    • Schiffer, C.A.1    Miller, K.2    Larson, R.A.3
  • 37
    • 0345688614 scopus 로고    scopus 로고
    • Prior and concurrent administration of recombinant human megakaryocyte growth and development factor in patients receiving consolidation chemotherapy for de novo acute myeloid leukemia - a randomized, placebo-controlled, double-blind safety and efficacy study
    • Geissler K, Yin JA, Ganser A, et al. Prior and concurrent administration of recombinant human megakaryocyte growth and development factor in patients receiving consolidation chemotherapy for de novo acute myeloid leukemia - a randomized, placebo-controlled, double-blind safety and efficacy study. Ann Hematol 2003; 82:677-83.
    • (2003) Ann Hematol , vol.82 , pp. 677-683
    • Geissler, K.1    Yin, J.A.2    Ganser, A.3
  • 38
    • 4243780751 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, blinded, dose scheduling trial of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) with filgrastim support in non-small cell lung cancer (NSCLC) patients treated with paclitaxel and carboplatin during multiple cycles of chemotherapy
    • Abstract 285
    • Crawford J, Glaspy J, Belani C, et al. A randomized, placebo-controlled, blinded, dose scheduling trial of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) with filgrastim support in non-small cell lung cancer (NSCLC) patients treated with paclitaxel and carboplatin during multiple cycles of chemotherapy. Proc Am Soc Clin Oncol 1998; 17:73a (Abstract 285).
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Crawford, J.1    Glaspy, J.2    Belani, C.3
  • 39
    • 85031374901 scopus 로고    scopus 로고
    • Cripe L, Neuber D, Tallman M, et al. A pilot study of recombinant human thrombopoietin (rh-TPO) and GM-CSF following induction therapy in patients older than 55 years with acute myeloid leukemia (AML). Blood 1998; 92:(Absttact 2359).
    • Cripe L, Neuber D, Tallman M, et al. A pilot study of recombinant human thrombopoietin (rh-TPO) and GM-CSF following induction therapy in patients older than 55 years with acute myeloid leukemia (AML). Blood 1998; 92:(Absttact 2359).
  • 40
    • 0034050651 scopus 로고    scopus 로고
    • Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer
    • Vadhan-Raj S, Verschraegen CF, Bueso-Ramos C, et al. Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer. Ann Intern Med 2000; 132:364-8.
    • (2000) Ann Intern Med , vol.132 , pp. 364-368
    • Vadhan-Raj, S.1    Verschraegen, C.F.2    Bueso-Ramos, C.3
  • 41
    • 20244376150 scopus 로고    scopus 로고
    • A phase I clinical, pharmacologic, and biologic study of thrombopoietin and granulocyte colony-stimulating factor in children receiving ifosfamide, carboplatin, and etoposide chemotherapy for recurrent or refractory solid tumors: A Children's Oncology Group experience
    • Angiolillo AL, Davenport V, Bonilla MA, et al. A phase I clinical, pharmacologic, and biologic study of thrombopoietin and granulocyte colony-stimulating factor in children receiving ifosfamide, carboplatin, and etoposide chemotherapy for recurrent or refractory solid tumors: a Children's Oncology Group experience. Clin Cancer Res 2005; 11:2644-50.
    • (2005) Clin Cancer Res , vol.11 , pp. 2644-2650
    • Angiolillo, A.L.1    Davenport, V.2    Bonilla, M.A.3
  • 42
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethylene glycolconjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • Fanucchi M, Glaspy J, Crawford J, et al. Effects of polyethylene glycolconjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 1997; 336:404-9.
    • (1997) N Engl J Med , vol.336 , pp. 404-409
    • Fanucchi, M.1    Glaspy, J.2    Crawford, J.3
  • 43
    • 0041411416 scopus 로고    scopus 로고
    • Importance of predosing of recombinant human thrombopoietin to reduce chemotherapy-induced early thromobocytopenia
    • Vadhan-Raj S, Patel S, Bueso-Ramos C, et al. Importance of predosing of recombinant human thrombopoietin to reduce chemotherapy-induced early thromobocytopenia. J Clin Oncol 2003; 21:3158-67.
    • (2003) J Clin Oncol , vol.21 , pp. 3158-3167
    • Vadhan-Raj, S.1    Patel, S.2    Bueso-Ramos, C.3
  • 44
    • 33748910858 scopus 로고    scopus 로고
    • Clinical approaches involving thrombopoietin to shorten the period of thrombocytopenia after high-dose chemotherapy
    • Tijssen MR, van der Schoot CE, Voermans C, et al. Clinical approaches involving thrombopoietin to shorten the period of thrombocytopenia after high-dose chemotherapy. Transfus Med Rev 2006; 20:283-93.
    • (2006) Transfus Med Rev , vol.20 , pp. 283-293
    • Tijssen, M.R.1    van der Schoot, C.E.2    Voermans, C.3
  • 45
    • 0036517818 scopus 로고    scopus 로고
    • Whatever happened to thrombopoietin?
    • Kuter DJ. Whatever happened to thrombopoietin? Transfusion 2002; 42:279-83.
    • (2002) Transfusion , vol.42 , pp. 279-283
    • Kuter, D.J.1
  • 46
    • 11144356721 scopus 로고    scopus 로고
    • Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
    • Avecilla ST, Hattori K, Heissig B, et al. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 2004; 10:64-71.
    • (2004) Nat Med , vol.10 , pp. 64-71
    • Avecilla, S.T.1    Hattori, K.2    Heissig, B.3
  • 47
    • 0037100423 scopus 로고    scopus 로고
    • Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura
    • Nomura S, Dan K, Hotta T, et al. Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura. Blood 2002; 100:728-30.
    • (2002) Blood , vol.100 , pp. 728-730
    • Nomura, S.1    Dan, K.2    Hotta, T.3
  • 48
    • 0034781155 scopus 로고    scopus 로고
    • Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy
    • Rice L, Nichol JL, McMillan R, et al. Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy. Am J Hematol 2001; 68:210-4.
    • (2001) Am J Hematol , vol.68 , pp. 210-214
    • Rice, L.1    Nichol, J.L.2    McMillan, R.3
  • 49
    • 18944407713 scopus 로고    scopus 로고
    • Multiple cycles of recombinant human thrombopoietin therapy in a patient with chronic refractory idiopathic thrombocytopenic purpura
    • Hua B, Zou N, Wang S, et al. Multiple cycles of recombinant human thrombopoietin therapy in a patient with chronic refractory idiopathic thrombocytopenic purpura. Blood Coagul Fibrinolysis 2005; 16:291-5.
    • (2005) Blood Coagul Fibrinolysis , vol.16 , pp. 291-295
    • Hua, B.1    Zou, N.2    Wang, S.3
  • 50
    • 0035760892 scopus 로고    scopus 로고
    • Thrombocytopenia caused by the development of antibodies to thrombopoietin
    • Li J, Yang C, Xia Y, et al. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 2001; 98:3241-8.
    • (2001) Blood , vol.98 , pp. 3241-3248
    • Li, J.1    Yang, C.2    Xia, Y.3
  • 51
    • 0036530040 scopus 로고    scopus 로고
    • Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor
    • Basser RL, O'Flaherty E, Green M, et al. Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood 2002; 99:2599-602.
    • (2002) Blood , vol.99 , pp. 2599-2602
    • Basser, R.L.1    O'Flaherty, E.2    Green, M.3
  • 52
    • 0035085969 scopus 로고    scopus 로고
    • Haemopoietic growth factors in paediatric oncology: A review of the literature
    • Wagner LM, Furman WL. Haemopoietic growth factors in paediatric oncology: a review of the literature. Paediatr Drugs 2001; 3:195-217.
    • (2001) Paediatr Drugs , vol.3 , pp. 195-217
    • Wagner, L.M.1    Furman, W.L.2
  • 53
    • 33748674848 scopus 로고    scopus 로고
    • Drug evaluation: AMG-531 for the treatment of thrombocytopenias
    • Rice L. Drug evaluation: AMG-531 for the treatment of thrombocytopenias. Curr Opin Investig Drugs 2006; 7:834-41.
    • (2006) Curr Opin Investig Drugs , vol.7 , pp. 834-841
    • Rice, L.1
  • 54
    • 33748517860 scopus 로고    scopus 로고
    • AMG 531: An investigational thrombopoiesis-stimulating peptibody
    • Nichol JL. AMG 531: an investigational thrombopoiesis-stimulating peptibody. Pediatr Blood Cancer 2006; 47(5 suppl):723-5.
    • (2006) Pediatr Blood Cancer , vol.47 , Issue.5 SUPPL. , pp. 723-725
    • Nichol, J.L.1
  • 55
    • 10044296968 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
    • Wang B, Nichol JL, Sullivan JT. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther 2004; 76:628-38.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 628-638
    • Wang, B.1    Nichol, J.L.2    Sullivan, J.T.3
  • 56
    • 33750051618 scopus 로고    scopus 로고
    • An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura
    • Newland A, Caulier MT, Kappers-Klunne M, et al. An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura. Br J Haematol 2006; 135:547-53.
    • (2006) Br J Haematol , vol.135 , pp. 547-553
    • Newland, A.1    Caulier, M.T.2    Kappers-Klunne, M.3
  • 57
    • 33750035507 scopus 로고    scopus 로고
    • Bussel JB, Kuter DJ, George JN, et al. AMG 531, a thrombopoiesis- stimulating protein, for chronic ITP [published correction appears in N Engl J Med 2006; 355:2054]. N Engl J Med 2006; 355:1672-81.
    • Bussel JB, Kuter DJ, George JN, et al. AMG 531, a thrombopoiesis- stimulating protein, for chronic ITP [published correction appears in N Engl J Med 2006; 355:2054]. N Engl J Med 2006; 355:1672-81.
  • 58
    • 33646481176 scopus 로고    scopus 로고
    • Long-term dosing of AMG 531 is effective and well tolerated in thrombocytopenic patients with immune thrombocytopenic purpura
    • Abstract 220
    • Bussel JB, Kuter DJ, George JN, et al. Long-term dosing of AMG 531 is effective and well tolerated in thrombocytopenic patients with immune thrombocytopenic purpura. Blood 2005; 106:68a (Abstract 220).
    • (2005) Blood , vol.106
    • Bussel, J.B.1    Kuter, D.J.2    George, J.N.3
  • 59
    • 33947096577 scopus 로고    scopus 로고
    • Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 48-week update
    • Abstract 476
    • Kuter D, Bussel JB, George J, et al. Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 48-week update. Blood 2006; 108:144a (Abstract 476).
    • (2006) Blood , vol.108
    • Kuter, D.1    Bussel, J.B.2    George, J.3
  • 60
    • 0036263664 scopus 로고    scopus 로고
    • Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders
    • Douglas VK, Tallman MS, Cripe LD, et al. Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders. Am J Clin Pathol 2002; 117:844-50.
    • (2002) Am J Clin Pathol , vol.117 , pp. 844-850
    • Douglas, V.K.1    Tallman, M.S.2    Cripe, L.D.3
  • 61
    • 64049100729 scopus 로고    scopus 로고
    • Bone marrow reticulin in patients with immune thrombocytopenic purpura
    • Abstract 3982
    • Mufti G, Bagg A, Hasserjian R, et al. Bone marrow reticulin in patients with immune thrombocytopenic purpura. Blood 2006; 108:73a (Abstract 3982).
    • (2006) Blood , vol.108
    • Mufti, G.1    Bagg, A.2    Hasserjian, R.3
  • 62
    • 33746612565 scopus 로고    scopus 로고
    • Safety profile of AMG 531 in healthy volunteers and in thrombocytopenic patients with immune thromobocytopenic purpura
    • Abstract 1240
    • Stepan DE, Sergis-Deavenport E, Kelly R, et al. Safety profile of AMG 531 in healthy volunteers and in thrombocytopenic patients with immune thromobocytopenic purpura. Blood 2005; 106:361a (Abstract 1240).
    • (2005) Blood , vol.106
    • Stepan, D.E.1    Sergis-Deavenport, E.2    Kelly, R.3
  • 63
    • 84864946954 scopus 로고    scopus 로고
    • Available at:, Accessed: February 28, 2008
    • ClinicalTrials.gov Web site. Available at: http://clinicaltrials.gov. Accessed: February 28, 2008.
    • ClinicalTrials.gov Web site
  • 64
    • 33746604143 scopus 로고    scopus 로고
    • Discovery of SB-497115, a small-molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia
    • Abstract 2910
    • Luengo JI, Duffy KJ, Shaw AN, et al. Discovery of SB-497115, a small-molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia. Blood 2004; 104:795a (Abstract 2910).
    • (2004) Blood , vol.104
    • Luengo, J.I.1    Duffy, K.J.2    Shaw, A.N.3
  • 65
    • 34249719511 scopus 로고    scopus 로고
    • Phase I clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
    • Jenkins JM, Williams D, Deng Y, et al. Phase I clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007; 109:4739-41.
    • (2007) Blood , vol.109 , pp. 4739-4741
    • Jenkins, J.M.1    Williams, D.2    Deng, Y.3
  • 66
    • 36549001698 scopus 로고    scopus 로고
    • Eltrombopag for treatment of chronic idiopathic thrombocytopenic purpura
    • Bussel JB, Cheng G, Saleh M, et al. Eltrombopag for treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 2007; 357:2237-47.
    • (2007) N Engl J Med , vol.357 , pp. 2237-2247
    • Bussel, J.B.1    Cheng, G.2    Saleh, M.3
  • 67
    • 85031388786 scopus 로고    scopus 로고
    • The safety profile of eltrombopag, a novel, oral platelet growth factor
    • thrombocytopenic patients and healthy subjects, 18 suppl):695s Abstract 18596
    • Provan D, Saleh D, Goodison S, et al. The safety profile of eltrombopag, a novel, oral platelet growth factor, in thrombocytopenic patients and healthy subjects. J Clin Oncol 2006; 24(18 suppl):695s (Abstract 18596).
    • (2006) J Clin Oncol , pp. 24
    • Provan, D.1    Saleh, D.2    Goodison, S.3
  • 68
    • 37249063116 scopus 로고    scopus 로고
    • Eltrombopag raises platelet count and reduces bleeding compared with placebo during short-term treatment in chronic idiopathic thrombocytopenic purpura: A phase III study
    • Abstract 0390
    • Bussel JB, Provan A, Shamsi T, et al. Eltrombopag raises platelet count and reduces bleeding compared with placebo during short-term treatment in chronic idiopathic thrombocytopenic purpura: a phase III study. Haematologica 2007; 92(suppl 2):143 (Abstract 0390).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 2 , pp. 143
    • Bussel, J.B.1    Provan, A.2    Shamsi, T.3
  • 69
    • 36549047972 scopus 로고    scopus 로고
    • Eltrombopag for thrombocytopenia in patients with cirrhoisis associated with hepatitis C
    • McHutchison JG, Dusheiko G, Shiffman ML, et al. Eltrombopag for thrombocytopenia in patients with cirrhoisis associated with hepatitis C. N Engl J Med 2007; 357:2227-36.
    • (2007) N Engl J Med , vol.357 , pp. 2227-2236
    • McHutchison, J.G.1    Dusheiko, G.2    Shiffman, M.L.3
  • 70
    • 41349094489 scopus 로고    scopus 로고
    • A phase I study to investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of an oral platelet growth factor (SB-559448) in healthy subjects
    • Abstract 1072
    • Su S-F, Peng B, Williams D, et al. A phase I study to investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of an oral platelet growth factor (SB-559448) in healthy subjects. Blood 2006; 108:319a (Abstract 1072).
    • (2006) Blood , vol.108
    • Su, S.-F.1    Peng, B.2    Williams, D.3
  • 71
    • 33746558969 scopus 로고    scopus 로고
    • YM477, a novel orally-active thrombopoietin receptor agonist
    • Abstract 2298
    • Suzuki K, Abe M, Fukushima-Shintani M, et al. YM477, a novel orally-active thrombopoietin receptor agonist. Blood 2005; 106:647a (Abstract 2298).
    • (2005) Blood , vol.106
    • Suzuki, K.1    Abe, M.2    Fukushima-Shintani, M.3
  • 72
    • 34648847269 scopus 로고    scopus 로고
    • Single and multiple oral doses of AKR-501 (YM477) increase the platelet count in healthy volunteers
    • Abstract 477
    • Desjardins RE, Tempel DL, Lucek R, et al. Single and multiple oral doses of AKR-501 (YM477) increase the platelet count in healthy volunteers. Blood 2006; 108:145a (Abstract 477).
    • (2006) Blood , vol.108
    • Desjardins, R.E.1    Tempel, D.L.2    Lucek, R.3
  • 74
    • 40849150244 scopus 로고    scopus 로고
    • Single and multiple oral doses of LGD-4665, a small molecule thrombopoietin receptor agonist, increase platelet counts in healthy male subjects
    • Abstract 1298
    • Dziewanowska ZE, Matsumoto RM, Zhang JK, et al. Single and multiple oral doses of LGD-4665, a small molecule thrombopoietin receptor agonist, increase platelet counts in healthy male subjects. Blood 2007; 110:390a (Abstract 1298).
    • (2007) Blood , vol.110
    • Dziewanowska, Z.E.1    Matsumoto, R.M.2    Zhang, J.K.3
  • 75
    • 33744456732 scopus 로고    scopus 로고
    • A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis
    • Nakamura T, Miyakawa Y, Miyamura A, et al. A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood 2006; 107:4300-7.
    • (2006) Blood , vol.107 , pp. 4300-4307
    • Nakamura, T.1    Miyakawa, Y.2    Miyamura, A.3
  • 76
    • 34447106299 scopus 로고    scopus 로고
    • Prevention of human interferon-alpha-induced thrombocytopenia by a non-peptidyl human thrombopoietin receptor activator, NIP-004
    • Abstract 1145
    • Yamane A, Nakamura,T, Ito M, et al. Prevention of human interferon-alpha-induced thrombocytopenia by a non-peptidyl human thrombopoietin receptor activator, NIP-004. Blood 2006; 108:339a (Abstract 1145).
    • (2006) Blood , vol.108
    • Yamane, A.1    Nakamura, T.2    Ito, M.3
  • 77
    • 0030917254 scopus 로고    scopus 로고
    • Interleukin-11: Review of molecular, cell biology, and clinical use
    • Du X, Williams DA. Interleukin-11: review of molecular, cell biology, and clinical use. Blood 1997; 89:3897-908.
    • (1997) Blood , vol.89 , pp. 3897-3908
    • Du, X.1    Williams, D.A.2
  • 78
    • 84862776276 scopus 로고    scopus 로고
    • FDA oncology tools product label details in conventional order for oprelvekin, Available at:, Accessed: February 28, 2008
    • FDA oncology tools product label details in conventional order for oprelvekin. Food and Drug Administration Web site. Available at: http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=Oprelvekin. Accessed: February 28, 2008.
    • Food and Drug Administration Web site
  • 79
    • 0030666621 scopus 로고    scopus 로고
    • Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin
    • Isaacs C, Robert NJ, Bailey FA, et al. Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin. J Clin Oncol 1997; 15:3368-77.
    • (1997) J Clin Oncol , vol.15 , pp. 3368-3377
    • Isaacs, C.1    Robert, N.J.2    Bailey, F.A.3
  • 80
    • 9244234420 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy
    • Tepler I, Elias L, Smith JW II, et al. A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy. Blood 1996; 87:3607-14.
    • (1996) Blood , vol.87 , pp. 3607-3614
    • Tepler, I.1    Elias, L.2    Smith II, J.W.3
  • 81
    • 33750453783 scopus 로고    scopus 로고
    • Phase II study of low-dose interleukin-11 in patients with myelodysplastic syndrome
    • Montero AJ, Estrov Z, Freireich EJ, et al. Phase II study of low-dose interleukin-11 in patients with myelodysplastic syndrome. Leuk Lymphoma 2006; 47:2049-54.
    • (2006) Leuk Lymphoma , vol.47 , pp. 2049-2054
    • Montero, A.J.1    Estrov, Z.2    Freireich, E.J.3
  • 82
    • 0038036517 scopus 로고    scopus 로고
    • Recombinant human interleukin-11 improves thrombocytopenia in patients with cirrhosis
    • Ghalib R, Levine C, Hassan M, et al. Recombinant human interleukin-11 improves thrombocytopenia in patients with cirrhosis. Hepatology 2003; 37:1165-71.
    • (2003) Hepatology , vol.37 , pp. 1165-1171
    • Ghalib, R.1    Levine, C.2    Hassan, M.3
  • 83
    • 0035116327 scopus 로고    scopus 로고
    • A pilot study of rhuIL-11 treatment of refractory ITP
    • Bussel JB, Mukherjee R, Stone AJ. A pilot study of rhuIL-11 treatment of refractory ITP. Am J Hematol 2001; 66:172-7.
    • (2001) Am J Hematol , vol.66 , pp. 172-177
    • Bussel, J.B.1    Mukherjee, R.2    Stone, A.J.3
  • 84
    • 33644786946 scopus 로고    scopus 로고
    • Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia
    • Corazza F, Hermans C, D'Hondt S, et al. Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia. Blood 2006; 107:2525-30.
    • (2006) Blood , vol.107 , pp. 2525-2530
    • Corazza, F.1    Hermans, C.2    D'Hondt, S.3
  • 85
    • 33644797198 scopus 로고    scopus 로고
    • Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells
    • Romanelli RG, Petrai I, Robino G, et al. Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells. Am J Physiol Gastrointest Liver Physiol 2006; 290:G120-8.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Romanelli, R.G.1    Petrai, I.2    Robino, G.3
  • 86
    • 0031593742 scopus 로고    scopus 로고
    • Thrombopoietin in patients with hepatoblastoma
    • Komura E, Matsumura T, Kato T, et al. Thrombopoietin in patients with hepatoblastoma. Stem Cells 1998; 16:329-33.
    • (1998) Stem Cells , vol.16 , pp. 329-333
    • Komura, E.1    Matsumura, T.2    Kato, T.3
  • 87
    • 33750547396 scopus 로고    scopus 로고
    • Haematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: Report from the Research on Adverse Drug Events and Reports (RADAR) project
    • Bennett CL, Evens AM, Andritsos LA, et al. Haematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: report from the Research on Adverse Drug Events and Reports (RADAR) project. Br J Haematol 2006; 135:642-50.
    • (2006) Br J Haematol , vol.135 , pp. 642-650
    • Bennett, C.L.1    Evens, A.M.2    Andritsos, L.A.3
  • 88
    • 0142186283 scopus 로고    scopus 로고
    • Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial
    • Henke M, Laszig R, Rübe C, et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet 2003; 362:1255-60.
    • (2003) Lancet , vol.362 , pp. 1255-1260
    • Henke, M.1    Laszig, R.2    Rübe, C.3
  • 89
    • 24944454286 scopus 로고    scopus 로고
    • Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: A survival study
    • Leyland-Jones B, Semiglazov V, Pawlicki M, et al. Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study. J Clin Oncol 2005; 23:5960-72.
    • (2005) J Clin Oncol , vol.23 , pp. 5960-5972
    • Leyland-Jones, B.1    Semiglazov, V.2    Pawlicki, M.3
  • 90
    • 85031385294 scopus 로고    scopus 로고
    • FDA public health advisory: erythropoiesis-stimulating agents (ESAs). Food and Drug Administration Web site. Available at: http://www.fda.gov/cder/ drug/advisory/RHE2007.htm. Accessed: February 28, 2008.
    • FDA public health advisory: erythropoiesis-stimulating agents (ESAs). Food and Drug Administration Web site. Available at: http://www.fda.gov/cder/ drug/advisory/RHE2007.htm. Accessed: February 28, 2008.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.