-
2
-
-
0036214534
-
Classical management of refractory adult immune (idiopathic) thrombocytopenic purpura
-
McMillan R. Classical management of refractory adult immune (idiopathic) thrombocytopenic purpura. Blood Rev 2002; 16:51-5.
-
(2002)
Blood Rev
, vol.16
, pp. 51-55
-
-
McMillan, R.1
-
3
-
-
0842328846
-
Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP
-
McMillan R, Wang L, Tomer A, et al. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood 2004; 103:1364-9.
-
(2004)
Blood
, vol.103
, pp. 1364-1369
-
-
McMillan, R.1
Wang, L.2
Tomer, A.3
-
4
-
-
0043245959
-
Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro
-
Chang M, Nakagawa PA, Williams SA, et al. Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood 2003; 102:887-95.
-
(2003)
Blood
, vol.102
, pp. 887-895
-
-
Chang, M.1
Nakagawa, P.A.2
Williams, S.A.3
-
6
-
-
0023798680
-
Preclinical studies and clinical correlation of the effect of alkylating dose
-
Frei E III, Teicher BA, Holden SA, et al. Preclinical studies and clinical correlation of the effect of alkylating dose. Cancer Res 1988; 48:6417-23.
-
(1988)
Cancer Res
, vol.48
, pp. 6417-6423
-
-
Frei III, E.1
Teicher, B.A.2
Holden, S.A.3
-
7
-
-
0142058029
-
Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults
-
Kolb EA, Kushner BH, Gorlick R, et al. Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults. J Clin Oncol 2003; 21:3423-30.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3423-3430
-
-
Kolb, E.A.1
Kushner, B.H.2
Gorlick, R.3
-
8
-
-
0031865087
-
Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas
-
Patel SR, Vadhan-Raj S, Burgess MA, et al. Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas. Am J Clin Oncol 1998; 21:317-21.
-
(1998)
Am J Clin Oncol
, vol.21
, pp. 317-321
-
-
Patel, S.R.1
Vadhan-Raj, S.2
Burgess, M.A.3
-
9
-
-
33751037747
-
Treatment of advanced soft-tissue sarcomas using a combined strategy of high-dose ifosfamide, high-dose doxorubicin and salvage therapies
-
Leyvraz S, Herrmann R, Guillou L, et al. Treatment of advanced soft-tissue sarcomas using a combined strategy of high-dose ifosfamide, high-dose doxorubicin and salvage therapies. Br J Cancer 2006; 95:1342-7.
-
(2006)
Br J Cancer
, vol.95
, pp. 1342-1347
-
-
Leyvraz, S.1
Herrmann, R.2
Guillou, L.3
-
10
-
-
0035147188
-
Prospective randomized trial between two doses of granulocyte colony-stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent or refractory solid tumors: A Children's Cancer Group report
-
Cairo MS, Shen V, Krailo MD, et al. Prospective randomized trial between two doses of granulocyte colony-stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent or refractory solid tumors: a Children's Cancer Group report. J Pediatr Hematol Oncol 2001; 23:30-8.
-
(2001)
J Pediatr Hematol Oncol
, vol.23
, pp. 30-38
-
-
Cairo, M.S.1
Shen, V.2
Krailo, M.D.3
-
11
-
-
33750477330
-
Multicentre phase II study of the baseline BEACOPP regimen for patients with advanced-stage Hodgkin's lymphoma
-
Niitsu N, Okamoto M, Tomita N, et al. Multicentre phase II study of the baseline BEACOPP regimen for patients with advanced-stage Hodgkin's lymphoma. Leuk Lymphoma 2006; 47:1908-14.
-
(2006)
Leuk Lymphoma
, vol.47
, pp. 1908-1914
-
-
Niitsu, N.1
Okamoto, M.2
Tomita, N.3
-
12
-
-
0031917065
-
Effects of granulocyte-macrophage colony-stimulating factor and dose intensification of V-ICE chemotherapy in small-cell lung cancer: A prospective randomized study of 300 patients
-
Steward WP, von Pawel J, Gatzemeier U, et al. Effects of granulocyte-macrophage colony-stimulating factor and dose intensification of V-ICE chemotherapy in small-cell lung cancer: a prospective randomized study of 300 patients. J Clin Oncol 1998; 16:642-50.
-
(1998)
J Clin Oncol
, vol.16
, pp. 642-650
-
-
Steward, W.P.1
von Pawel, J.2
Gatzemeier, U.3
-
13
-
-
0033977253
-
Granulocyte colony stimulating factor permits dose intensification by interval compression in the treatment of Ewing's sarcomas and soft tissue sarcomas in children
-
Womer RB, Daller RT, Fenton JG, et al. Granulocyte colony stimulating factor permits dose intensification by interval compression in the treatment of Ewing's sarcomas and soft tissue sarcomas in children. Eur J Cancer 2000; 36:87-94.
-
(2000)
Eur J Cancer
, vol.36
, pp. 87-94
-
-
Womer, R.B.1
Daller, R.T.2
Fenton, J.G.3
-
14
-
-
4344638243
-
Prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor decrease febrile neutropenia after chemotherapy in children with cancer: A meta-analysis of randomized controlled trials
-
Sung L, Nathan PC, Lange B, et al. Prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor decrease febrile neutropenia after chemotherapy in children with cancer: a meta-analysis of randomized controlled trials. J Clin Oncol 2004; 22:3350-6
-
(2004)
J Clin Oncol
, vol.22
, pp. 3350-3356
-
-
Sung, L.1
Nathan, P.C.2
Lange, B.3
-
15
-
-
33846668768
-
Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer treated with fluorouracil-based chemotherapy
-
Rosen LS, Abdi E, Davis ID, et al. Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer treated with fluorouracil-based chemotherapy. J Clin Oncol 2006; 24:5194-200.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5194-5200
-
-
Rosen, L.S.1
Abdi, E.2
Davis, I.D.3
-
16
-
-
10344242939
-
Palifermin for oral mucositis after intensive therapy for hematologic cancers
-
Spielberger R, Stiff P, Bensinger W, et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 2004; 351:2590-8.
-
(2004)
N Engl J Med
, vol.351
, pp. 2590-2598
-
-
Spielberger, R.1
Stiff, P.2
Bensinger, W.3
-
17
-
-
0032005594
-
Recombinant human erythropoietin in the prevention of chemotherapy-induced anaemia in children with malignant solid tumours
-
Csáki C, Ferencz T, Schuler D, et al. Recombinant human erythropoietin in the prevention of chemotherapy-induced anaemia in children with malignant solid tumours. Eur J Cancer 1998; 34:364-7.
-
(1998)
Eur J Cancer
, vol.34
, pp. 364-367
-
-
Csáki, C.1
Ferencz, T.2
Schuler, D.3
-
18
-
-
28244469788
-
High efficacy of gemcitabine and cisplatin plus trastuzumab in patients with HER2-overexpressing metastatic breast cancer: A phase II study
-
Stemmler HJ, Kahlert S, Brudler O, et al. High efficacy of gemcitabine and cisplatin plus trastuzumab in patients with HER2-overexpressing metastatic breast cancer: a phase II study. Clin Oncol (R Coll Radiol) 2005; 17:630-5.
-
(2005)
Clin Oncol (R Coll Radiol)
, vol.17
, pp. 630-635
-
-
Stemmler, H.J.1
Kahlert, S.2
Brudler, O.3
-
19
-
-
0028799917
-
Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in children and young adults
-
Kushner BH, Meyers PA, Gerald WL, et al. Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in children and young adults. J Clin Oncol 1995; 13:2796-804.
-
(1995)
J Clin Oncol
, vol.13
, pp. 2796-2804
-
-
Kushner, B.H.1
Meyers, P.A.2
Gerald, W.L.3
-
20
-
-
33750607556
-
Platelet autoantibodies are common in hepatitis C infection, irrespective of the presence of thrombocytopenia
-
Panzer S, Seel E, Brunner M, et al. Platelet autoantibodies are common in hepatitis C infection, irrespective of the presence of thrombocytopenia. Eur J Haematol 2006; 77:513-7.
-
(2006)
Eur J Haematol
, vol.77
, pp. 513-517
-
-
Panzer, S.1
Seel, E.2
Brunner, M.3
-
21
-
-
11144252779
-
The use of growth factors to manage the hematologic side effects of PEG-interferon alfa and ribavirin
-
Collantes RS, Younossi ZM. The use of growth factors to manage the hematologic side effects of PEG-interferon alfa and ribavirin. J Clin Gastroenterol 2005; 39(1 suppl):S9-13.
-
(2005)
J Clin Gastroenterol
, vol.39
, Issue.1 SUPPL.
-
-
Collantes, R.S.1
Younossi, Z.M.2
-
22
-
-
11144316875
-
Hematologic side effects of interferon and ribavirin therapy
-
Kowdley KV. Hematologic side effects of interferon and ribavirin therapy. J Clin Gastroenterol 2005; 39(1 suppl):S3-8.
-
(2005)
J Clin Gastroenterol
, vol.39
, Issue.1 SUPPL.
-
-
Kowdley, K.V.1
-
23
-
-
0002184519
-
Thrombopoietin: Biology and clinical applications
-
Kuter DJ. Thrombopoietin: biology and clinical applications. Oncologist 1996; 1:98-106.
-
(1996)
Oncologist
, vol.1
, pp. 98-106
-
-
Kuter, D.J.1
-
24
-
-
0037111558
-
Recombinant human thrombopoietin: Basic biology and evaluation of clinical studies
-
Kuter DJ, Begley CG. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 2002; 100:3457-69.
-
(2002)
Blood
, vol.100
, pp. 3457-3469
-
-
Kuter, D.J.1
Begley, C.G.2
-
25
-
-
0032832532
-
Thrombopoietin: Its role from early hematopoiesis to platelet production
-
Wendling F. Thrombopoietin: its role from early hematopoiesis to platelet production. Haematologica 1999; 84:158-66.
-
(1999)
Haematologica
, vol.84
, pp. 158-166
-
-
Wendling, F.1
-
26
-
-
33746508365
-
Megakaryocyte development and platelet production
-
Deutsch VR, Tomer A. Megakaryocyte development and platelet production. Br J Haematol 2006; 134:453-66.
-
(2006)
Br J Haematol
, vol.134
, pp. 453-466
-
-
Deutsch, V.R.1
Tomer, A.2
-
27
-
-
33746366769
-
The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells
-
Ninos JM, Jefferies LC, Cogle CR, et al. The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells. J Transl Med 2006; 4:9.
-
(2006)
J Transl Med
, vol.4
, pp. 9
-
-
Ninos, J.M.1
Jefferies, L.C.2
Cogle, C.R.3
-
28
-
-
31044439372
-
The molecular mechanisms that control thrombopoiesis
-
Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest 2005; 115:3339-47.
-
(2005)
J Clin Invest
, vol.115
, pp. 3339-3347
-
-
Kaushansky, K.1
-
29
-
-
0029865443
-
Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets
-
Fielder PJ, Gurney AL, Stefanich E, et al. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 1996; 87:2154-61.
-
(1996)
Blood
, vol.87
, pp. 2154-2161
-
-
Fielder, P.J.1
Gurney, A.L.2
Stefanich, E.3
-
31
-
-
0037071389
-
The molecular and cellular biology of thrombopoietin: The primary regulator of platelet production
-
Kaushansky K, Drachman JG. The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene 2002; 21:3359-67.
-
(2002)
Oncogene
, vol.21
, pp. 3359-3367
-
-
Kaushansky, K.1
Drachman, J.G.2
-
32
-
-
33646490285
-
Lineage-specific hematopoietic growth factors
-
Kaushansky K. Lineage-specific hematopoietic growth factors. N Engl J Med 2006; 354:2034-45.
-
(2006)
N Engl J Med
, vol.354
, pp. 2034-2045
-
-
Kaushansky, K.1
-
33
-
-
17944389931
-
-
Basser RL, Rasko JE, Clarke K, et al. Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer [published correction appears in Blood 1997; 90:2513]. Blood 1997; 89:3118-28.
-
Basser RL, Rasko JE, Clarke K, et al. Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer [published correction appears in Blood 1997; 90:2513]. Blood 1997; 89:3118-28.
-
-
-
-
34
-
-
0033485568
-
A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia
-
Archimbaud E, Ottmann OG, Yin JA, et al. A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia. Blood 1999; 94:3694-701.
-
(1999)
Blood
, vol.94
, pp. 3694-3701
-
-
Archimbaud, E.1
Ottmann, O.G.2
Yin, J.A.3
-
35
-
-
0033861984
-
Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer
-
Basser RL, Underhill C, Davis I, et al. Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer. J Clin Oncol 2000; 18:2852-61.
-
(2000)
J Clin Oncol
, vol.18
, pp. 2852-2861
-
-
Basser, R.L.1
Underhill, C.2
Davis, I.3
-
36
-
-
0034655649
-
A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia
-
Schiffer CA, Miller K, Larson RA, et al. A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia. Blood 2000; 95:2530-5.
-
(2000)
Blood
, vol.95
, pp. 2530-2535
-
-
Schiffer, C.A.1
Miller, K.2
Larson, R.A.3
-
37
-
-
0345688614
-
Prior and concurrent administration of recombinant human megakaryocyte growth and development factor in patients receiving consolidation chemotherapy for de novo acute myeloid leukemia - a randomized, placebo-controlled, double-blind safety and efficacy study
-
Geissler K, Yin JA, Ganser A, et al. Prior and concurrent administration of recombinant human megakaryocyte growth and development factor in patients receiving consolidation chemotherapy for de novo acute myeloid leukemia - a randomized, placebo-controlled, double-blind safety and efficacy study. Ann Hematol 2003; 82:677-83.
-
(2003)
Ann Hematol
, vol.82
, pp. 677-683
-
-
Geissler, K.1
Yin, J.A.2
Ganser, A.3
-
38
-
-
4243780751
-
A randomized, placebo-controlled, blinded, dose scheduling trial of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) with filgrastim support in non-small cell lung cancer (NSCLC) patients treated with paclitaxel and carboplatin during multiple cycles of chemotherapy
-
Abstract 285
-
Crawford J, Glaspy J, Belani C, et al. A randomized, placebo-controlled, blinded, dose scheduling trial of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) with filgrastim support in non-small cell lung cancer (NSCLC) patients treated with paclitaxel and carboplatin during multiple cycles of chemotherapy. Proc Am Soc Clin Oncol 1998; 17:73a (Abstract 285).
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Crawford, J.1
Glaspy, J.2
Belani, C.3
-
39
-
-
85031374901
-
-
Cripe L, Neuber D, Tallman M, et al. A pilot study of recombinant human thrombopoietin (rh-TPO) and GM-CSF following induction therapy in patients older than 55 years with acute myeloid leukemia (AML). Blood 1998; 92:(Absttact 2359).
-
Cripe L, Neuber D, Tallman M, et al. A pilot study of recombinant human thrombopoietin (rh-TPO) and GM-CSF following induction therapy in patients older than 55 years with acute myeloid leukemia (AML). Blood 1998; 92:(Absttact 2359).
-
-
-
-
40
-
-
0034050651
-
Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer
-
Vadhan-Raj S, Verschraegen CF, Bueso-Ramos C, et al. Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer. Ann Intern Med 2000; 132:364-8.
-
(2000)
Ann Intern Med
, vol.132
, pp. 364-368
-
-
Vadhan-Raj, S.1
Verschraegen, C.F.2
Bueso-Ramos, C.3
-
41
-
-
20244376150
-
A phase I clinical, pharmacologic, and biologic study of thrombopoietin and granulocyte colony-stimulating factor in children receiving ifosfamide, carboplatin, and etoposide chemotherapy for recurrent or refractory solid tumors: A Children's Oncology Group experience
-
Angiolillo AL, Davenport V, Bonilla MA, et al. A phase I clinical, pharmacologic, and biologic study of thrombopoietin and granulocyte colony-stimulating factor in children receiving ifosfamide, carboplatin, and etoposide chemotherapy for recurrent or refractory solid tumors: a Children's Oncology Group experience. Clin Cancer Res 2005; 11:2644-50.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2644-2650
-
-
Angiolillo, A.L.1
Davenport, V.2
Bonilla, M.A.3
-
42
-
-
0031049879
-
Effects of polyethylene glycolconjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
-
Fanucchi M, Glaspy J, Crawford J, et al. Effects of polyethylene glycolconjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 1997; 336:404-9.
-
(1997)
N Engl J Med
, vol.336
, pp. 404-409
-
-
Fanucchi, M.1
Glaspy, J.2
Crawford, J.3
-
43
-
-
0041411416
-
Importance of predosing of recombinant human thrombopoietin to reduce chemotherapy-induced early thromobocytopenia
-
Vadhan-Raj S, Patel S, Bueso-Ramos C, et al. Importance of predosing of recombinant human thrombopoietin to reduce chemotherapy-induced early thromobocytopenia. J Clin Oncol 2003; 21:3158-67.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3158-3167
-
-
Vadhan-Raj, S.1
Patel, S.2
Bueso-Ramos, C.3
-
44
-
-
33748910858
-
Clinical approaches involving thrombopoietin to shorten the period of thrombocytopenia after high-dose chemotherapy
-
Tijssen MR, van der Schoot CE, Voermans C, et al. Clinical approaches involving thrombopoietin to shorten the period of thrombocytopenia after high-dose chemotherapy. Transfus Med Rev 2006; 20:283-93.
-
(2006)
Transfus Med Rev
, vol.20
, pp. 283-293
-
-
Tijssen, M.R.1
van der Schoot, C.E.2
Voermans, C.3
-
45
-
-
0036517818
-
Whatever happened to thrombopoietin?
-
Kuter DJ. Whatever happened to thrombopoietin? Transfusion 2002; 42:279-83.
-
(2002)
Transfusion
, vol.42
, pp. 279-283
-
-
Kuter, D.J.1
-
46
-
-
11144356721
-
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
-
Avecilla ST, Hattori K, Heissig B, et al. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 2004; 10:64-71.
-
(2004)
Nat Med
, vol.10
, pp. 64-71
-
-
Avecilla, S.T.1
Hattori, K.2
Heissig, B.3
-
47
-
-
0037100423
-
Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura
-
Nomura S, Dan K, Hotta T, et al. Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura. Blood 2002; 100:728-30.
-
(2002)
Blood
, vol.100
, pp. 728-730
-
-
Nomura, S.1
Dan, K.2
Hotta, T.3
-
48
-
-
0034781155
-
Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy
-
Rice L, Nichol JL, McMillan R, et al. Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy. Am J Hematol 2001; 68:210-4.
-
(2001)
Am J Hematol
, vol.68
, pp. 210-214
-
-
Rice, L.1
Nichol, J.L.2
McMillan, R.3
-
49
-
-
18944407713
-
Multiple cycles of recombinant human thrombopoietin therapy in a patient with chronic refractory idiopathic thrombocytopenic purpura
-
Hua B, Zou N, Wang S, et al. Multiple cycles of recombinant human thrombopoietin therapy in a patient with chronic refractory idiopathic thrombocytopenic purpura. Blood Coagul Fibrinolysis 2005; 16:291-5.
-
(2005)
Blood Coagul Fibrinolysis
, vol.16
, pp. 291-295
-
-
Hua, B.1
Zou, N.2
Wang, S.3
-
50
-
-
0035760892
-
Thrombocytopenia caused by the development of antibodies to thrombopoietin
-
Li J, Yang C, Xia Y, et al. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 2001; 98:3241-8.
-
(2001)
Blood
, vol.98
, pp. 3241-3248
-
-
Li, J.1
Yang, C.2
Xia, Y.3
-
51
-
-
0036530040
-
Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor
-
Basser RL, O'Flaherty E, Green M, et al. Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood 2002; 99:2599-602.
-
(2002)
Blood
, vol.99
, pp. 2599-2602
-
-
Basser, R.L.1
O'Flaherty, E.2
Green, M.3
-
52
-
-
0035085969
-
Haemopoietic growth factors in paediatric oncology: A review of the literature
-
Wagner LM, Furman WL. Haemopoietic growth factors in paediatric oncology: a review of the literature. Paediatr Drugs 2001; 3:195-217.
-
(2001)
Paediatr Drugs
, vol.3
, pp. 195-217
-
-
Wagner, L.M.1
Furman, W.L.2
-
53
-
-
33748674848
-
Drug evaluation: AMG-531 for the treatment of thrombocytopenias
-
Rice L. Drug evaluation: AMG-531 for the treatment of thrombocytopenias. Curr Opin Investig Drugs 2006; 7:834-41.
-
(2006)
Curr Opin Investig Drugs
, vol.7
, pp. 834-841
-
-
Rice, L.1
-
54
-
-
33748517860
-
AMG 531: An investigational thrombopoiesis-stimulating peptibody
-
Nichol JL. AMG 531: an investigational thrombopoiesis-stimulating peptibody. Pediatr Blood Cancer 2006; 47(5 suppl):723-5.
-
(2006)
Pediatr Blood Cancer
, vol.47
, Issue.5 SUPPL.
, pp. 723-725
-
-
Nichol, J.L.1
-
55
-
-
10044296968
-
Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
-
Wang B, Nichol JL, Sullivan JT. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther 2004; 76:628-38.
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 628-638
-
-
Wang, B.1
Nichol, J.L.2
Sullivan, J.T.3
-
56
-
-
33750051618
-
An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura
-
Newland A, Caulier MT, Kappers-Klunne M, et al. An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura. Br J Haematol 2006; 135:547-53.
-
(2006)
Br J Haematol
, vol.135
, pp. 547-553
-
-
Newland, A.1
Caulier, M.T.2
Kappers-Klunne, M.3
-
57
-
-
33750035507
-
-
Bussel JB, Kuter DJ, George JN, et al. AMG 531, a thrombopoiesis- stimulating protein, for chronic ITP [published correction appears in N Engl J Med 2006; 355:2054]. N Engl J Med 2006; 355:1672-81.
-
Bussel JB, Kuter DJ, George JN, et al. AMG 531, a thrombopoiesis- stimulating protein, for chronic ITP [published correction appears in N Engl J Med 2006; 355:2054]. N Engl J Med 2006; 355:1672-81.
-
-
-
-
58
-
-
33646481176
-
Long-term dosing of AMG 531 is effective and well tolerated in thrombocytopenic patients with immune thrombocytopenic purpura
-
Abstract 220
-
Bussel JB, Kuter DJ, George JN, et al. Long-term dosing of AMG 531 is effective and well tolerated in thrombocytopenic patients with immune thrombocytopenic purpura. Blood 2005; 106:68a (Abstract 220).
-
(2005)
Blood
, vol.106
-
-
Bussel, J.B.1
Kuter, D.J.2
George, J.N.3
-
59
-
-
33947096577
-
Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 48-week update
-
Abstract 476
-
Kuter D, Bussel JB, George J, et al. Long-term dosing of AMG 531 in thrombocytopenic patients with immune thrombocytopenic purpura: 48-week update. Blood 2006; 108:144a (Abstract 476).
-
(2006)
Blood
, vol.108
-
-
Kuter, D.1
Bussel, J.B.2
George, J.3
-
60
-
-
0036263664
-
Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders
-
Douglas VK, Tallman MS, Cripe LD, et al. Thrombopoietin administered during induction chemotherapy to patients with acute myeloid leukemia induces transient morphologic changes that may resemble chronic myeloproliferative disorders. Am J Clin Pathol 2002; 117:844-50.
-
(2002)
Am J Clin Pathol
, vol.117
, pp. 844-850
-
-
Douglas, V.K.1
Tallman, M.S.2
Cripe, L.D.3
-
61
-
-
64049100729
-
Bone marrow reticulin in patients with immune thrombocytopenic purpura
-
Abstract 3982
-
Mufti G, Bagg A, Hasserjian R, et al. Bone marrow reticulin in patients with immune thrombocytopenic purpura. Blood 2006; 108:73a (Abstract 3982).
-
(2006)
Blood
, vol.108
-
-
Mufti, G.1
Bagg, A.2
Hasserjian, R.3
-
62
-
-
33746612565
-
Safety profile of AMG 531 in healthy volunteers and in thrombocytopenic patients with immune thromobocytopenic purpura
-
Abstract 1240
-
Stepan DE, Sergis-Deavenport E, Kelly R, et al. Safety profile of AMG 531 in healthy volunteers and in thrombocytopenic patients with immune thromobocytopenic purpura. Blood 2005; 106:361a (Abstract 1240).
-
(2005)
Blood
, vol.106
-
-
Stepan, D.E.1
Sergis-Deavenport, E.2
Kelly, R.3
-
63
-
-
84864946954
-
-
Available at:, Accessed: February 28, 2008
-
ClinicalTrials.gov Web site. Available at: http://clinicaltrials.gov. Accessed: February 28, 2008.
-
ClinicalTrials.gov Web site
-
-
-
64
-
-
33746604143
-
Discovery of SB-497115, a small-molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia
-
Abstract 2910
-
Luengo JI, Duffy KJ, Shaw AN, et al. Discovery of SB-497115, a small-molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia. Blood 2004; 104:795a (Abstract 2910).
-
(2004)
Blood
, vol.104
-
-
Luengo, J.I.1
Duffy, K.J.2
Shaw, A.N.3
-
65
-
-
34249719511
-
Phase I clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
-
Jenkins JM, Williams D, Deng Y, et al. Phase I clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007; 109:4739-41.
-
(2007)
Blood
, vol.109
, pp. 4739-4741
-
-
Jenkins, J.M.1
Williams, D.2
Deng, Y.3
-
66
-
-
36549001698
-
Eltrombopag for treatment of chronic idiopathic thrombocytopenic purpura
-
Bussel JB, Cheng G, Saleh M, et al. Eltrombopag for treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 2007; 357:2237-47.
-
(2007)
N Engl J Med
, vol.357
, pp. 2237-2247
-
-
Bussel, J.B.1
Cheng, G.2
Saleh, M.3
-
67
-
-
85031388786
-
The safety profile of eltrombopag, a novel, oral platelet growth factor
-
thrombocytopenic patients and healthy subjects, 18 suppl):695s Abstract 18596
-
Provan D, Saleh D, Goodison S, et al. The safety profile of eltrombopag, a novel, oral platelet growth factor, in thrombocytopenic patients and healthy subjects. J Clin Oncol 2006; 24(18 suppl):695s (Abstract 18596).
-
(2006)
J Clin Oncol
, pp. 24
-
-
Provan, D.1
Saleh, D.2
Goodison, S.3
-
68
-
-
37249063116
-
Eltrombopag raises platelet count and reduces bleeding compared with placebo during short-term treatment in chronic idiopathic thrombocytopenic purpura: A phase III study
-
Abstract 0390
-
Bussel JB, Provan A, Shamsi T, et al. Eltrombopag raises platelet count and reduces bleeding compared with placebo during short-term treatment in chronic idiopathic thrombocytopenic purpura: a phase III study. Haematologica 2007; 92(suppl 2):143 (Abstract 0390).
-
(2007)
Haematologica
, vol.92
, Issue.SUPPL. 2
, pp. 143
-
-
Bussel, J.B.1
Provan, A.2
Shamsi, T.3
-
69
-
-
36549047972
-
Eltrombopag for thrombocytopenia in patients with cirrhoisis associated with hepatitis C
-
McHutchison JG, Dusheiko G, Shiffman ML, et al. Eltrombopag for thrombocytopenia in patients with cirrhoisis associated with hepatitis C. N Engl J Med 2007; 357:2227-36.
-
(2007)
N Engl J Med
, vol.357
, pp. 2227-2236
-
-
McHutchison, J.G.1
Dusheiko, G.2
Shiffman, M.L.3
-
70
-
-
41349094489
-
A phase I study to investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of an oral platelet growth factor (SB-559448) in healthy subjects
-
Abstract 1072
-
Su S-F, Peng B, Williams D, et al. A phase I study to investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of an oral platelet growth factor (SB-559448) in healthy subjects. Blood 2006; 108:319a (Abstract 1072).
-
(2006)
Blood
, vol.108
-
-
Su, S.-F.1
Peng, B.2
Williams, D.3
-
71
-
-
33746558969
-
YM477, a novel orally-active thrombopoietin receptor agonist
-
Abstract 2298
-
Suzuki K, Abe M, Fukushima-Shintani M, et al. YM477, a novel orally-active thrombopoietin receptor agonist. Blood 2005; 106:647a (Abstract 2298).
-
(2005)
Blood
, vol.106
-
-
Suzuki, K.1
Abe, M.2
Fukushima-Shintani, M.3
-
72
-
-
34648847269
-
Single and multiple oral doses of AKR-501 (YM477) increase the platelet count in healthy volunteers
-
Abstract 477
-
Desjardins RE, Tempel DL, Lucek R, et al. Single and multiple oral doses of AKR-501 (YM477) increase the platelet count in healthy volunteers. Blood 2006; 108:145a (Abstract 477).
-
(2006)
Blood
, vol.108
-
-
Desjardins, R.E.1
Tempel, D.L.2
Lucek, R.3
-
74
-
-
40849150244
-
Single and multiple oral doses of LGD-4665, a small molecule thrombopoietin receptor agonist, increase platelet counts in healthy male subjects
-
Abstract 1298
-
Dziewanowska ZE, Matsumoto RM, Zhang JK, et al. Single and multiple oral doses of LGD-4665, a small molecule thrombopoietin receptor agonist, increase platelet counts in healthy male subjects. Blood 2007; 110:390a (Abstract 1298).
-
(2007)
Blood
, vol.110
-
-
Dziewanowska, Z.E.1
Matsumoto, R.M.2
Zhang, J.K.3
-
75
-
-
33744456732
-
A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis
-
Nakamura T, Miyakawa Y, Miyamura A, et al. A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood 2006; 107:4300-7.
-
(2006)
Blood
, vol.107
, pp. 4300-4307
-
-
Nakamura, T.1
Miyakawa, Y.2
Miyamura, A.3
-
76
-
-
34447106299
-
Prevention of human interferon-alpha-induced thrombocytopenia by a non-peptidyl human thrombopoietin receptor activator, NIP-004
-
Abstract 1145
-
Yamane A, Nakamura,T, Ito M, et al. Prevention of human interferon-alpha-induced thrombocytopenia by a non-peptidyl human thrombopoietin receptor activator, NIP-004. Blood 2006; 108:339a (Abstract 1145).
-
(2006)
Blood
, vol.108
-
-
Yamane, A.1
Nakamura, T.2
Ito, M.3
-
77
-
-
0030917254
-
Interleukin-11: Review of molecular, cell biology, and clinical use
-
Du X, Williams DA. Interleukin-11: review of molecular, cell biology, and clinical use. Blood 1997; 89:3897-908.
-
(1997)
Blood
, vol.89
, pp. 3897-3908
-
-
Du, X.1
Williams, D.A.2
-
78
-
-
84862776276
-
-
FDA oncology tools product label details in conventional order for oprelvekin, Available at:, Accessed: February 28, 2008
-
FDA oncology tools product label details in conventional order for oprelvekin. Food and Drug Administration Web site. Available at: http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=Oprelvekin. Accessed: February 28, 2008.
-
Food and Drug Administration Web site
-
-
-
79
-
-
0030666621
-
Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin
-
Isaacs C, Robert NJ, Bailey FA, et al. Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin. J Clin Oncol 1997; 15:3368-77.
-
(1997)
J Clin Oncol
, vol.15
, pp. 3368-3377
-
-
Isaacs, C.1
Robert, N.J.2
Bailey, F.A.3
-
80
-
-
9244234420
-
A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy
-
Tepler I, Elias L, Smith JW II, et al. A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy. Blood 1996; 87:3607-14.
-
(1996)
Blood
, vol.87
, pp. 3607-3614
-
-
Tepler, I.1
Elias, L.2
Smith II, J.W.3
-
81
-
-
33750453783
-
Phase II study of low-dose interleukin-11 in patients with myelodysplastic syndrome
-
Montero AJ, Estrov Z, Freireich EJ, et al. Phase II study of low-dose interleukin-11 in patients with myelodysplastic syndrome. Leuk Lymphoma 2006; 47:2049-54.
-
(2006)
Leuk Lymphoma
, vol.47
, pp. 2049-2054
-
-
Montero, A.J.1
Estrov, Z.2
Freireich, E.J.3
-
82
-
-
0038036517
-
Recombinant human interleukin-11 improves thrombocytopenia in patients with cirrhosis
-
Ghalib R, Levine C, Hassan M, et al. Recombinant human interleukin-11 improves thrombocytopenia in patients with cirrhosis. Hepatology 2003; 37:1165-71.
-
(2003)
Hepatology
, vol.37
, pp. 1165-1171
-
-
Ghalib, R.1
Levine, C.2
Hassan, M.3
-
83
-
-
0035116327
-
A pilot study of rhuIL-11 treatment of refractory ITP
-
Bussel JB, Mukherjee R, Stone AJ. A pilot study of rhuIL-11 treatment of refractory ITP. Am J Hematol 2001; 66:172-7.
-
(2001)
Am J Hematol
, vol.66
, pp. 172-177
-
-
Bussel, J.B.1
Mukherjee, R.2
Stone, A.J.3
-
84
-
-
33644786946
-
Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia
-
Corazza F, Hermans C, D'Hondt S, et al. Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia. Blood 2006; 107:2525-30.
-
(2006)
Blood
, vol.107
, pp. 2525-2530
-
-
Corazza, F.1
Hermans, C.2
D'Hondt, S.3
-
85
-
-
33644797198
-
Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells
-
Romanelli RG, Petrai I, Robino G, et al. Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells. Am J Physiol Gastrointest Liver Physiol 2006; 290:G120-8.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Romanelli, R.G.1
Petrai, I.2
Robino, G.3
-
86
-
-
0031593742
-
Thrombopoietin in patients with hepatoblastoma
-
Komura E, Matsumura T, Kato T, et al. Thrombopoietin in patients with hepatoblastoma. Stem Cells 1998; 16:329-33.
-
(1998)
Stem Cells
, vol.16
, pp. 329-333
-
-
Komura, E.1
Matsumura, T.2
Kato, T.3
-
87
-
-
33750547396
-
Haematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: Report from the Research on Adverse Drug Events and Reports (RADAR) project
-
Bennett CL, Evens AM, Andritsos LA, et al. Haematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: report from the Research on Adverse Drug Events and Reports (RADAR) project. Br J Haematol 2006; 135:642-50.
-
(2006)
Br J Haematol
, vol.135
, pp. 642-650
-
-
Bennett, C.L.1
Evens, A.M.2
Andritsos, L.A.3
-
88
-
-
0142186283
-
Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial
-
Henke M, Laszig R, Rübe C, et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet 2003; 362:1255-60.
-
(2003)
Lancet
, vol.362
, pp. 1255-1260
-
-
Henke, M.1
Laszig, R.2
Rübe, C.3
-
89
-
-
24944454286
-
Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: A survival study
-
Leyland-Jones B, Semiglazov V, Pawlicki M, et al. Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study. J Clin Oncol 2005; 23:5960-72.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5960-5972
-
-
Leyland-Jones, B.1
Semiglazov, V.2
Pawlicki, M.3
-
90
-
-
85031385294
-
-
FDA public health advisory: erythropoiesis-stimulating agents (ESAs). Food and Drug Administration Web site. Available at: http://www.fda.gov/cder/ drug/advisory/RHE2007.htm. Accessed: February 28, 2008.
-
FDA public health advisory: erythropoiesis-stimulating agents (ESAs). Food and Drug Administration Web site. Available at: http://www.fda.gov/cder/ drug/advisory/RHE2007.htm. Accessed: February 28, 2008.
-
-
-
|