A pilot study of rhuIL-11 treatment of refractory ITP

American Journal of Hematology

Volumn 66, Issue 3, 2001, Pages 172-177

  Bussel, James B ^a   Mukherjee, Robin ^a   Stone, Anne J ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b PFIZER INC   (United States)

Author keywords

Bleeding; Cytokine; Interleukin 11; ITP; Platelets; RhuIL 11; Thrombocytopenia

Indexed keywords

AMINOCAPROIC ACID; AZATHIOPRINE; CORTICOSTEROID; DEXAMETHASONE; IMMUNOGLOBULIN; INTERLEUKIN 11; MEDROXYPROGESTERONE ACETATE; METHYLPREDNISOLONE SODIUM SUCCINATE; RECOMBINANT INTERLEUKIN 11; VINBLASTINE; VINCA ALKALOID;

ADOLESCENT; ADULT; ARTHRALGIA; ARTICLE; AUTOIMMUNE DISEASE; BREATHING DISORDER; CLINICAL ARTICLE; DRUG EFFECT; DRUG EFFICACY; HEADACHE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MEGAKARYOPOIESIS; NAUSEA; NEUROPATHY; PRIORITY JOURNAL; SPLENECTOMY; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS; TREATMENT FAILURE; VOMITING;

ADOLESCENT; ADULT; HEMATOPOIESIS; HEMOGLOBINS; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INTERLEUKIN-11; MEGAKARYOCYTES; MIDDLE AGED; PILOT PROJECTS; PLATELET COUNT; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECOMBINANT PROTEINS; TREATMENT OUTCOME;

EID: 0035116327     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-8652(200103)66:3<172::AID-AJH1041>3.0.CO;2-Q     Document Type: Article

References (23)

1. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura
2. Immune thrombocytopenic purpura, neonatal alloimmune thrombocytopenia and posttransfusion purpura
3. Chronic idiopathic thrombocytopenic purpura
4. Platelet survival and platelet production in idiopathic thrombocytopenic purpura
5. Thrombokinetics in idiopathic thrombocytopenic purpura
6. Mathematical modeling of platelet survival with implications for optimal transfusion practice in the chronically platelet transfusion-dependent patient
7. Mechanisms of response to treatment in autoimmune thrombocytopenic purpura
8. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura: Evidence of both impaired platelet production and increased platelet clearance
9. Serum thrombopoietin level in various hematological diseases
10. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction
11. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
12. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
13. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
14. Characterization of an anti-thrombopoietin antibody that developed in a cancer patient following the injection of PEG-rHuMGDF
15. The appearance of anti-thrombopoietin antibody and circulating thromhopoietin-IgG complexes in a patient developing thrombocytopenia after the injection of PEG-rHuMGDF
16. Intefieukin-11 enhances human megakaryocytopoiesis in vitro
17. Effects of recombinant interleukin 11 on human megakaryocyte progenitor cells
18. Recombinant human interleukin-11 (rhuIL-11) stimulates megakaryocyte maturation and increase in peripheral platelet number in vivo
19. Constant subcutaneous infusion of recombinant human interleukin-11 induces stem cell mobilization and causes prolonged elevation of peripheral platelets
20. In vivo effects of recombinant interleukin-11 on myelopoiesis in mice
21. Effects of recombinant human interleuikin-11 on hematopoietic reconstitution in transplant mice: Acceleration of recovery of peripheral blood neutrophils and platelets
22. Idiopathic thrombocytopenic purpura: A practice guideline developed by explicit methods for the American Society of Hematology
23. Combination chemotherapy in refractory immune thrombocytopenic purpura