-
1
-
-
0033959520
-
Cancer statistics, 2000
-
Greenlee RT, Murray T, Bolden S, Wingo PA (2000) Cancer statistics, 2000. CA Cancer J Clin 50:7-33
-
(2000)
CA Cancer J Clin
, vol.50
, pp. 7-33
-
-
Greenlee, R.T.1
Murray, T.2
Bolden, S.3
Wingo, P.A.4
-
2
-
-
25144525540
-
CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis
-
Mailand N, Diffley JF (2005) CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell 122:915-926
-
(2005)
Cell
, vol.122
, pp. 915-926
-
-
Mailand, N.1
Diffley, J.F.2
-
3
-
-
29544435484
-
Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase
-
Randell JC, Bowers JL, Rodriguez HK, Bell SP (2006) Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase. Mol Cell 21:29-39
-
(2006)
Mol Cell
, vol.21
, pp. 29-39
-
-
Randell, J.C.1
Bowers, J.L.2
Rodriguez, H.K.3
Bell, S.P.4
-
4
-
-
28444493713
-
Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells
-
Takeda DY, Shibata Y, Shibata Y, Parvin JD, Dutta A (2005) Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells. Genes Dev 19:2827-2836
-
(2005)
Genes Dev
, vol.19
, pp. 2827-2836
-
-
Takeda, D.Y.1
Shibata, Y.2
Shibata, Y.3
Parvin, J.D.4
Dutta, A.5
-
5
-
-
0034665628
-
Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1
-
Petersen BO, Wagener C, Marinoni F, Kramer ER, Melixetian M, Denchi EL, Gieffers C, Matteucci C, Peters JM, Helin K (2000) Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Genes Dev 14:2330-2343
-
(2000)
Genes Dev
, vol.14
, pp. 2330-2343
-
-
Petersen, B.O.1
Wagener, C.2
Marinoni, F.3
Kramer, E.R.4
Melixetian, M.5
Denchi, E.L.6
Gieffers, C.7
Matteucci, C.8
Peters, J.M.9
Helin, K.10
-
6
-
-
0032994432
-
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
-
Jiang W, Wells NJ, Hunter T (1999) Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Proc Natl Acad Sci USA 96:6193-6198
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6193-6198
-
-
Jiang, W.1
Wells, N.J.2
Hunter, T.3
-
7
-
-
0037415724
-
Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1
-
Clay-Farrace L, Pelizon C, Santamaria D, Pines J, Laskey RA (2003) Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1. EMBO J 22:704-712
-
(2003)
EMBO J
, vol.22
, pp. 704-712
-
-
Clay-Farrace, L.1
Pelizon, C.2
Santamaria, D.3
Pines, J.4
Laskey, R.A.5
-
8
-
-
33645460360
-
Oncogenic activity of Cdc6 through repression of the INK4/ARF locus
-
Gonzalez S, Klatt P, Delgado S, Conde E, Lopez-Rios F, Sanchez-Cespedes M, Mendez J, Antequera F, Serrano M (2006) Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature 440:702-706
-
(2006)
Nature
, vol.440
, pp. 702-706
-
-
Gonzalez, S.1
Klatt, P.2
Delgado, S.3
Conde, E.4
Lopez-Rios, F.5
Sanchez-Cespedes, M.6
Mendez, J.7
Antequera, F.8
Serrano, M.9
-
9
-
-
0037623356
-
A p53-dependent checkpoint pathway prevents rereplication
-
Vaziri C, Saxena S, Jeon Y, Lee C, Murata K, Machida Y, Wagle N, Hwang DS, Dutta A (2003) A p53-dependent checkpoint pathway prevents rereplication. Mol Cell 11:997-1008
-
(2003)
Mol Cell
, vol.11
, pp. 997-1008
-
-
Vaziri, C.1
Saxena, S.2
Jeon, Y.3
Lee, C.4
Murata, K.5
Machida, Y.6
Wagle, N.7
Hwang, D.S.8
Dutta, A.9
-
10
-
-
23344451688
-
p53-dependent regulation of Cdc6 protein stability controls cellular proliferation
-
Duursma A, Agami R (2005) p53-dependent regulation of Cdc6 protein stability controls cellular proliferation. Mol Cell Biol 25:6937-6947
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6937-6947
-
-
Duursma, A.1
Agami, R.2
-
11
-
-
0037169358
-
Apoptosis: A link between cancer genetics and chemotherapy
-
Johnstone RW, Ruefli AA, Lowe SW (2002) Apoptosis: A link between cancer genetics and chemotherapy. Cell 108:153-164
-
(2002)
Cell
, vol.108
, pp. 153-164
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Lowe, S.W.3
-
12
-
-
0842278331
-
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303:1010-1014
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
Droin, N.M.4
Newmeyer, D.D.5
Schuler, M.6
Green, D.R.7
-
13
-
-
24644436766
-
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
-
Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR (2005) PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309:1732-1735
-
(2005)
Science
, vol.309
, pp. 1732-1735
-
-
Chipuk, J.E.1
Bouchier-Hayes, L.2
Kuwana, T.3
Newmeyer, D.D.4
Green, D.R.5
-
14
-
-
0037349289
-
p53 has a direct apoptogenic role at the mitochondria
-
Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM (2003) p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11:577-590
-
(2003)
Mol Cell
, vol.11
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
Petrenko, O.4
Chittenden, T.5
Pancoska, P.6
Moll, U.M.7
-
15
-
-
0032575688
-
The Bcl-2 protein family: Arbiters of cell survival
-
Adams JM, Cory S (1998) The Bcl-2 protein family: Arbiters of cell survival. Science 281:1322-1326
-
(1998)
Science
, vol.281
, pp. 1322-1326
-
-
Adams, J.M.1
Cory, S.2
-
16
-
-
0033635733
-
BH3-only proteins-essential initiators of apoptotic cell death
-
Huang DC, Strasser A (2000) BH3-only proteins-essential initiators of apoptotic cell death. Cell 103:839-842
-
(2000)
Cell
, vol.103
, pp. 839-842
-
-
Huang, D.C.1
Strasser, A.2
-
17
-
-
9744244990
-
The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA
-
Cartron PF, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P, Meflah K, Vallette FM, Juin P (2004) The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. Mol Cell 16:807-818
-
(2004)
Mol Cell
, vol.16
, pp. 807-818
-
-
Cartron, P.F.1
Gallenne, T.2
Bougras, G.3
Gautier, F.4
Manero, F.5
Vusio, P.6
Meflah, K.7
Vallette, F.M.8
Juin, P.9
-
18
-
-
7444243152
-
Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity
-
Harada H, Quearry B, Ruiz-Vela A, Korsmeyer SJ (2004) Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc Natl Acad Sci USA 101:15313-15317
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 15313-15317
-
-
Harada, H.1
Quearry, B.2
Ruiz-Vela, A.3
Korsmeyer, S.J.4
-
20
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Orntoft T, Lukas J, Bartek J (2001) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434:864-870
-
(2001)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
Kramer, A.4
Tort, F.5
Zieger, K.6
Guldberg, P.7
Sehested, M.8
Nesland, J.M.9
Lukas, C.10
Orntoft, T.11
Lukas, J.12
Bartek, J.13
-
21
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA Jr, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434:907-913
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
Zacharatos, P.4
Kotsinas, A.5
Liloglou, T.6
Venere, M.7
Ditullio Jr., R.A.8
Kastrinakis, N.G.9
Levy, B.10
Kletsas, D.11
Yoneta, A.12
Herlyn, M.13
Kittas, C.14
Halazonetis, T.D.15
-
22
-
-
0035881581
-
Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines
-
Keshelava N, Zuo JJ, Chen P, Waidyaratne SN, Luna MC, Gomer CJ, Triche TJ, Reynolds CP (2001) Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines. Cancer Res 61:6185-6193
-
(2001)
Cancer Res
, vol.61
, pp. 6185-6193
-
-
Keshelava, N.1
Zuo, J.J.2
Chen, P.3
Waidyaratne, S.N.4
Luna, M.C.5
Gomer, C.J.6
Triche, T.J.7
Reynolds, C.P.8
-
23
-
-
33749073162
-
Downregulation of human Cdc6 protein using a lentivirus RNA interference expression vector
-
Feng L, Yee JK, Huang SH, Wu LT, Jong AY (2006) Downregulation of human Cdc6 protein using a lentivirus RNA interference expression vector. Methods Mol Biol 342:287-293
-
(2006)
Methods Mol Biol
, vol.342
, pp. 287-293
-
-
Feng, L.1
Yee, J.K.2
Huang, S.H.3
Wu, L.T.4
Jong, A.Y.5
-
24
-
-
0025917804
-
p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells
-
Millar JB, Blevitt J, Gerace L, Sadhu K, Featherstone C, Russell P (1991) p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells. Proc Natl Acad Sci USA 88:10500-10504
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 10500-10504
-
-
Millar, J.B.1
Blevitt, J.2
Gerace, L.3
Sadhu, K.4
Featherstone, C.5
Russell, P.6
-
25
-
-
0025324692
-
Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2
-
Sadhu K, Reed SI, Richardson H, Russell P (1990) Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Proc Natl Acad Sci USA 87:5139-5143
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 5139-5143
-
-
Sadhu, K.1
Reed, S.I.2
Richardson, H.3
Russell, P.4
-
26
-
-
0033564697
-
CDK inhibitors: Positive and negative regulators of G1-phase progression
-
Sherr CJ, Roberts JM (1999) CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 13:1501-1512
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
27
-
-
0025773123
-
Cyclins and cancer
-
Hunter T, Pines J (1991) Cyclins and cancer. Cell 66:1071-1074
-
(1991)
Cell
, vol.66
, pp. 1071-1074
-
-
Hunter, T.1
Pines, J.2
-
28
-
-
0031307157
-
The role of cyclin E in cell proliferation, development and cancer
-
Keyomarsi K, Herliczek TW (1997) The role of cyclin E in cell proliferation, development and cancer. Prog Cell Cycle Res 3:171-191
-
(1997)
Prog Cell Cycle Res
, vol.3
, pp. 171-191
-
-
Keyomarsi, K.1
Herliczek, T.W.2
-
29
-
-
0031048716
-
Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
-
Porter PL, Malone KE, Heagerty PJ, Alexander GM, Gatti LA, Firpo EJ, Daling JR, Roberts JM (1997) Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat Med 3:222-225
-
(1997)
Nat Med
, vol.3
, pp. 222-225
-
-
Porter, P.L.1
Malone, K.E.2
Heagerty, P.J.3
Alexander, G.M.4
Gatti, L.A.5
Firpo, E.J.6
Daling, J.R.7
Roberts, J.M.8
-
30
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323-330
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
31
-
-
4944252223
-
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant
-
Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L (2004) An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell 16:47-58
-
(2004)
Mol Cell
, vol.16
, pp. 47-58
-
-
Ji, P.1
Jiang, H.2
Rekhtman, K.3
Bloom, J.4
Ichetovkin, M.5
Pagano, M.6
Zhu, L.7
-
32
-
-
19444386666
-
RNA silencing of S-phase kinase-interacting protein 2 inhibits proliferation and centrosome amplification in lung cancer cells
-
Jiang F, Caraway NP, Li R, Katz RL (2005) RNA silencing of S-phase kinase-interacting protein 2 inhibits proliferation and centrosome amplification in lung cancer cells. Oncogene 24:3409-3418
-
(2005)
Oncogene
, vol.24
, pp. 3409-3418
-
-
Jiang, F.1
Caraway, N.P.2
Li, R.3
Katz, R.L.4
-
33
-
-
26444489119
-
Connected to death: The (unexpurgated) mitochondrial pathway of apoptosis
-
Spierings D, McStay G, Saleh M, Bender C, Chipuk J, Maurer U, Green DR (2005) Connected to death: The (unexpurgated) mitochondrial pathway of apoptosis. Science 310:66-67
-
(2005)
Science
, vol.310
, pp. 66-67
-
-
Spierings, D.1
McStay, G.2
Saleh, M.3
Bender, C.4
Chipuk, J.5
Maurer, U.6
Green, D.R.7
|