Polychlorinated biphenyls-modulated tumorigenesis in sprague-dawley rats: Correlation with mixed function oxidase activities and superoxide (O2•-) formation potentials and implied mode of action

Toxicological Sciences

Volumn 98, Issue 2, 2007, Pages 375-394

  Brown Jr , John F ^a,b   Mayes, Brian A ^a   Silkworth, Jay B ^a   Hamilton, Stephen B ^a  

^a GENERAL ELECTRIC COMPANY   (United States)

^b Global Research Center ^*  (United States)

Author keywords

Cancer; PCB; PH50; Quinone; Rat; RO3; Superoxide; Tumorigenesis

Indexed keywords

CATECHOL DERIVATIVE; CYCLINE; DIOXIN; ESTROGEN; OXIDOREDUCTASE; POLYCHLORINATED BIPHENYL DERIVATIVE; QUINONE DERIVATIVE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CANCER GROWTH; CATALYSIS; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATIONAL STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; FOLLOW UP; HISTOPATHOLOGY; LIVER ADENOMA; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CYTOSOL; LIVER METABOLISM; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; RAT; SIGNAL TRANSDUCTION; TOXICOKINETICS;

ADENOMA; ADIPOSE TISSUE; ALANINE TRANSAMINASE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BRAIN; CARCINOGENS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; FEMALE; GLUTATHIONE PEROXIDASE; LIVER; LIVER NEOPLASMS; MALE; MICROSOMES, LIVER; POLYCHLORINATED BIPHENYLS; RATS; RATS, SPRAGUE-DAWLEY; STEROID HYDROXYLASES; SUPEROXIDES;

RATTUS;

EID: 34547914857     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm122     Document Type: Article

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