Inhibition of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 3245-3254

  Dhagat, Urmi ^a   Endo, Satoshi ^b   Hara, Akira ^b   El Kabbani, Ossama ^a  

^a MONASH UNIVERSITY   (Australia)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Aldo keto reductases; Aldose reductase; Drug design; Enzyme inhibition; Hydroxysteroid dehydrogenases; Molecular modeling

Indexed keywords

3(17)ALPHA HYDROXYSTEROID DEHYDROGENASE; ALDOSE REDUCTASE INHIBITOR; CHRYSIN; FIDARESTAT; HYDROXYSTEROID DEHYDROGENASE; MINALRESTAT; MYRICETIN; PHENYLALANINE; QUERCETIN; QUERCITRIN; SORBINIL; TOLRESTAT; TYROSINE; UNCLASSIFIED DRUG; ZOPOLRESTAT;

ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; IC 50; MOLECULAR MODEL; MOLECULAR RECOGNITION; PROTEIN FAMILY;

3-HYDROXYSTEROID DEHYDROGENASES; ALDEHYDE REDUCTASE; ANIMALS; BINDING SITES; ENZYME INHIBITORS; MICE; MODELS, MOLECULAR; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 40949101330     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.12.016     Document Type: Article

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