Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants

Journal of Medicinal Chemistry

Volumn 43, Issue 6, 2000, Pages 1062-1070

  Singh, Suresh B ^a,c   Malamas, Michael S ^a   Hohman, Thomas C ^a   Nilakantan, Ramaswamy ^a   Carper, Deborah A ^b   Kitchen, Douglas ^a,d  

^a PFIZER INC   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d ALBANY MOLECULAR RESEARCH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; IMIRESTAT; PONALRESTAT; TOLRESTAT; ZENARESTAT; ZOPOLRESTAT;

ARTICLE; BINDING SITE; CATALYSIS; CATARACTOGENESIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME INHIBITOR COMPLEX; MOLECULAR MODEL; NONHUMAN; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ALDEHYDE REDUCTASE; BENZOTHIAZOLES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHTHALAZINES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0034704811     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990168z     Document Type: Article

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