Mitochondrial DNA damage and impaired base excision repair during epileptogenesis

Neurobiology of Disease

Volumn 30, Issue 1, 2008, Pages 130-138

  Jarrett, Stuart G ^a   Liang, Li Ping ^a   Hellier, Jennifer L ^a   Staley, Kevin J ^b   Patel, Manisha ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Base excision repair; Epileptogenesis; Mitochondrial dysfunction; mtDNA damage; Oxidative stress; Status epilepticus

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DNA DIRECTED DNA POLYMERASE GAMMA; HYDROGEN PEROXIDE; KAINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; EPILEPTOGENESIS; EXCISION REPAIR; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; IMMUNOBLOTTING; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPORAL LOBE EPILEPSY;

ACONITUM; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGLUCOSE; DEOXYGUANOSINE; DISEASE MODELS, ANIMAL; DNA GLYCOSYLASES; DNA REPAIR; DNA, MITOCHONDRIAL; EPILEPSY, TEMPORAL LOBE; FUMARATE HYDRATASE; GENE EXPRESSION REGULATION; HYDROGEN PEROXIDE; KAINIC ACID; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 40849151857     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2007.12.009     Document Type: Article

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