메뉴 건너뛰기




Volumn 107, Issue 3-5, 2007, Pages 156-162

Selective conversion by microglia of dehydroepiandrosterone to 5-androstenediol-A steroid with inherent estrogenic properties

Author keywords

5 androstenediol; DHEA; Estrogen; Microglia

Indexed keywords

4 ANDROSTENEDIOL; ANDROSTENEDIOL; ESTRONE; PRASTERONE; TESTOSTERONE;

EID: 34548497901     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2007.04.004     Document Type: Article
Times cited : (36)

References (40)
  • 1
    • 0028309503 scopus 로고
    • (DHEA)-the multifunctional steroid. Effects on the CNS, cell proliferation, metabolic and vascular, clinical and other effects. Mechanism of action?
    • Regelson W., Kalimi M., and Dehydroepiandrosterone. (DHEA)-the multifunctional steroid. Effects on the CNS, cell proliferation, metabolic and vascular, clinical and other effects. Mechanism of action?. Ann. NY Acad. Sci. 719 (1994) 564-575
    • (1994) Ann. NY Acad. Sci. , vol.719 , pp. 564-575
    • Regelson, W.1    Kalimi, M.2    Dehydroepiandrosterone3
  • 2
    • 0003074589 scopus 로고
    • Neurosteroids: a function of the brain
    • Costa E., and Paul S.M. (Eds), Thieme, New York
    • Baulieu E.E. Neurosteroids: a function of the brain. In: Costa E., and Paul S.M. (Eds). Neurosteroids and Brain Function (1991), Thieme, New York 63-73
    • (1991) Neurosteroids and Brain Function , pp. 63-73
    • Baulieu, E.E.1
  • 3
    • 0029552972 scopus 로고
    • Neuronal actions of dehydroepiandrosterone: possible roles in the brain development, aging, memory and affect
    • Majewska M.D. Neuronal actions of dehydroepiandrosterone: possible roles in the brain development, aging, memory and affect. Ann. NY Acad. Sci. 774 (1995) 111-120
    • (1995) Ann. NY Acad. Sci. , vol.774 , pp. 111-120
    • Majewska, M.D.1
  • 4
    • 0002845980 scopus 로고    scopus 로고
    • Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages
    • Schmidt M., Kruetz M., Loffler G., Scholmerich J., and Straub R.H. Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages. J. Endocrinol. 164 (2000) 161-169
    • (2000) J. Endocrinol. , vol.164 , pp. 161-169
    • Schmidt, M.1    Kruetz, M.2    Loffler, G.3    Scholmerich, J.4    Straub, R.H.5
  • 5
    • 0027408686 scopus 로고
    • Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone, regulation by cell density
    • Akwa Y., Sananes N., Gouezou M., Robel P., Baulieu E.E., and Goascogne C. Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone, regulation by cell density. J. Cell Biol. 121 (1993) 135-143
    • (1993) J. Cell Biol. , vol.121 , pp. 135-143
    • Akwa, Y.1    Sananes, N.2    Gouezou, M.3    Robel, P.4    Baulieu, E.E.5    Goascogne, C.6
  • 6
    • 0032910967 scopus 로고    scopus 로고
    • Dehydroepiandrosterone: biosynthesis and metabolism in the brain
    • Zwain I.H., and Yen S.S.C. Dehydroepiandrosterone: biosynthesis and metabolism in the brain. Endocrinology 140 (1999) 880-887
    • (1999) Endocrinology , vol.140 , pp. 880-887
    • Zwain, I.H.1    Yen, S.S.C.2
  • 7
    • 0029924284 scopus 로고    scopus 로고
    • Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid β-peptide toxicity in hippocampal neurons
    • Goodman Y., Bruce A.J., Cheng B., and Mattson M.P. Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid β-peptide toxicity in hippocampal neurons. J. Neurochem. 66 (1996) 1836-1844
    • (1996) J. Neurochem. , vol.66 , pp. 1836-1844
    • Goodman, Y.1    Bruce, A.J.2    Cheng, B.3    Mattson, M.P.4
  • 9
    • 0035089767 scopus 로고    scopus 로고
    • Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action
    • Wise P.M., Dubal D.B., Wilson M.E., Rau S.W., and Bottner M. Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action. Endocrinology 142 (2001) 969-973
    • (2001) Endocrinology , vol.142 , pp. 969-973
    • Wise, P.M.1    Dubal, D.B.2    Wilson, M.E.3    Rau, S.W.4    Bottner, M.5
  • 10
    • 0031432937 scopus 로고    scopus 로고
    • Steroid hormone modulation of hippocampal dependent spatial memory
    • Luine V.N. Steroid hormone modulation of hippocampal dependent spatial memory. Stress 2 (1997) 21-36
    • (1997) Stress , vol.2 , pp. 21-36
    • Luine, V.N.1
  • 11
    • 0032192065 scopus 로고    scopus 로고
    • Estradiol enhances learning and memory in spatial memory task and affects levels of monoaminergic neurotransmitters
    • Luine V.N., Richards S.T., Wu V.Y., and Beck K.D. Estradiol enhances learning and memory in spatial memory task and affects levels of monoaminergic neurotransmitters. Horm. Behav. 34 (1998) 149-162
    • (1998) Horm. Behav. , vol.34 , pp. 149-162
    • Luine, V.N.1    Richards, S.T.2    Wu, V.Y.3    Beck, K.D.4
  • 12
    • 0033970185 scopus 로고    scopus 로고
    • Estrogen is more than just a "sex hormone": novel sites for estrogen action in the hippocampus and cerebral cortex
    • Shughrue P.G., and Merchenthaler I. Estrogen is more than just a "sex hormone": novel sites for estrogen action in the hippocampus and cerebral cortex. Front. Neuroendocrinol. 21 (2000) 95-101
    • (2000) Front. Neuroendocrinol. , vol.21 , pp. 95-101
    • Shughrue, P.G.1    Merchenthaler, I.2
  • 13
    • 0035162296 scopus 로고    scopus 로고
    • Metabolism of dehydroepiandrosterone by rat hippocampal cells in culture: possible role of aromatization and 7-hydroxylation in neuroprotection
    • Jellinck P.H., Lee S.J., and McEwen B.S. Metabolism of dehydroepiandrosterone by rat hippocampal cells in culture: possible role of aromatization and 7-hydroxylation in neuroprotection. J. Steroid Biochem. Mol. Biol. 78 (2001) 313-317
    • (2001) J. Steroid Biochem. Mol. Biol. , vol.78 , pp. 313-317
    • Jellinck, P.H.1    Lee, S.J.2    McEwen, B.S.3
  • 15
    • 0032814562 scopus 로고    scopus 로고
    • Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function
    • Raivich G., Bohatschek M., Kloss C.U.A., Werner A.L., Jones L., and Kruetzberg G.W. Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res. Rev. 30 (1999) 77-105
    • (1999) Brain Res. Rev. , vol.30 , pp. 77-105
    • Raivich, G.1    Bohatschek, M.2    Kloss, C.U.A.3    Werner, A.L.4    Jones, L.5    Kruetzberg, G.W.6
  • 16
  • 17
    • 0033565292 scopus 로고    scopus 로고
    • Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat
    • Tanapat P., Hastings N.B., Reeves A.J., and Gould E. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat. J. Neurosci. 19 (1999) 5792-5801
    • (1999) J. Neurosci. , vol.19 , pp. 5792-5801
    • Tanapat, P.1    Hastings, N.B.2    Reeves, A.J.3    Gould, E.4
  • 18
    • 11144328239 scopus 로고    scopus 로고
    • Ovarian steroids influence cell proliferation in the dentate gyrus of the adult female rat in a dose- and time-dependent manner
    • Tanapat P., Hastings N.B., and Gould E. Ovarian steroids influence cell proliferation in the dentate gyrus of the adult female rat in a dose- and time-dependent manner. J. Comp. Neurol. 481 (2005) 252-265
    • (2005) J. Comp. Neurol. , vol.481 , pp. 252-265
    • Tanapat, P.1    Hastings, N.B.2    Gould, E.3
  • 19
    • 33750702540 scopus 로고    scopus 로고
    • Extranuclear estrogen receptor beta immunoreactivity is on doublecortin-containing cells in the adult and neonatal rat dentate gyrus
    • Herrick S.P., Waters E.M., Drake C.T., McEwen B.S., and Milner T.A. Extranuclear estrogen receptor beta immunoreactivity is on doublecortin-containing cells in the adult and neonatal rat dentate gyrus. Brain Res. 1121 (2006) 46-58
    • (2006) Brain Res. , vol.1121 , pp. 46-58
    • Herrick, S.P.1    Waters, E.M.2    Drake, C.T.3    McEwen, B.S.4    Milner, T.A.5
  • 21
    • 0027361454 scopus 로고
    • Estrogen and androgen receptor mediated stimulation and inhibition of proliferation by androst-5-ene-3β,17β-diol in human mammary cancer cells
    • Hakenberg R., Turgetto I., Filmer A., and Schultz K.D. Estrogen and androgen receptor mediated stimulation and inhibition of proliferation by androst-5-ene-3β,17β-diol in human mammary cancer cells. J. Steroid Biochem. Mol. Biol. 46 (1993) 597-603
    • (1993) J. Steroid Biochem. Mol. Biol. , vol.46 , pp. 597-603
    • Hakenberg, R.1    Turgetto, I.2    Filmer, A.3    Schultz, K.D.4
  • 22
    • 0018257665 scopus 로고
    • Properties of dehydroepiandrosterone metabolism by human mammary tumors and their influence on estradiol receptor binding
    • Li K., Foo T., and Adams J.B. Properties of dehydroepiandrosterone metabolism by human mammary tumors and their influence on estradiol receptor binding. Steroids 31 (1978) 113-127
    • (1978) Steroids , vol.31 , pp. 113-127
    • Li, K.1    Foo, T.2    Adams, J.B.3
  • 23
    • 0017746493 scopus 로고
    • The derivation and characterization of neuronal cell lines from rat and mouse brain
    • Bulloch K., Stallcup W.B., and Cohn M. The derivation and characterization of neuronal cell lines from rat and mouse brain. Brain Res. 135 (1977) 25-36
    • (1977) Brain Res. , vol.135 , pp. 25-36
    • Bulloch, K.1    Stallcup, W.B.2    Cohn, M.3
  • 24
    • 0017798296 scopus 로고
    • A new method for the establishment of neuronal cell lines from mouse brain
    • Bulloch K., Stallcup W.B., and Cohn M. A new method for the establishment of neuronal cell lines from mouse brain. Life Sci. 22 (1978) 495-504
    • (1978) Life Sci. , vol.22 , pp. 495-504
    • Bulloch, K.1    Stallcup, W.B.2    Cohn, M.3
  • 25
    • 0028810283 scopus 로고
    • Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system
    • Compagnone N.A., Bulfone A., Rubenstein J.L.R., and Mellon S.H. Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system. Endocrinology 136 (1995) 5212-5223
    • (1995) Endocrinology , vol.136 , pp. 5212-5223
    • Compagnone, N.A.1    Bulfone, A.2    Rubenstein, J.L.R.3    Mellon, S.H.4
  • 26
    • 0032956181 scopus 로고    scopus 로고
    • Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system
    • Mensah-Nyagan A.G., Do-Rego J.L., Beaujean D., Luu-The V., Pelletier G., and Vaudry H. Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system. Pharmacol. Rev. 51 (1999) 63-81
    • (1999) Pharmacol. Rev. , vol.51 , pp. 63-81
    • Mensah-Nyagan, A.G.1    Do-Rego, J.L.2    Beaujean, D.3    Luu-The, V.4    Pelletier, G.5    Vaudry, H.6
  • 27
    • 0037162691 scopus 로고    scopus 로고
    • Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    • Nakatomi H., Kuriu T., Okabe S., Yamamoto S., Hatano O., Kawahara N., Tamura A., Kirino T., and Nakafuku M. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 110 (2002) 429-444
    • (2002) Cell , vol.110 , pp. 429-444
    • Nakatomi, H.1    Kuriu, T.2    Okabe, S.3    Yamamoto, S.4    Hatano, O.5    Kawahara, N.6    Tamura, A.7    Kirino, T.8    Nakafuku, M.9
  • 28
    • 0032586817 scopus 로고    scopus 로고
    • 17β-Hydroxysteroid dehydrogenase HSD/17-ketosteroid reductase KSR family; nomenclature and main characteristics of the 17HSD/KSR enzymes
    • Peltoketo H., Luu-The V., Simard J., and Adamski J. 17β-Hydroxysteroid dehydrogenase HSD/17-ketosteroid reductase KSR family; nomenclature and main characteristics of the 17HSD/KSR enzymes. J. Mol. Endocrinol. 23 (1999) 1-11
    • (1999) J. Mol. Endocrinol. , vol.23 , pp. 1-11
    • Peltoketo, H.1    Luu-The, V.2    Simard, J.3    Adamski, J.4
  • 29
    • 30944454658 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) metabolism in the brain: identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia
    • Jellinck P.H., Kaufmann M., Gottfried-Blackmore A., Croft G., Byford V., McEwen B.S., Jones G., and Bulloch K. Dehydroepiandrosterone (DHEA) metabolism in the brain: identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia. J. Steroid Biochem. Mol. Biol. 98 (2006) 41-47
    • (2006) J. Steroid Biochem. Mol. Biol. , vol.98 , pp. 41-47
    • Jellinck, P.H.1    Kaufmann, M.2    Gottfried-Blackmore, A.3    Croft, G.4    Byford, V.5    McEwen, B.S.6    Jones, G.7    Bulloch, K.8
  • 30
    • 30944432969 scopus 로고
    • Enzymatic formation of 3β-hydroxy-4-androstene-17-one
    • Breuer H., Dahm K., and Norymberski J.K. Enzymatic formation of 3β-hydroxy-4-androstene-17-one. J. Endocrinol. 27 (1963) 357-358
    • (1963) J. Endocrinol. , vol.27 , pp. 357-358
    • Breuer, H.1    Dahm, K.2    Norymberski, J.K.3
  • 34
    • 0021794392 scopus 로고
    • 5-steroids of the human adrenal gland
    • 5-steroids of the human adrenal gland. Mol. Cell. Endocrinol. 41 (1985) 1-17
    • (1985) Mol. Cell. Endocrinol. , vol.41 , pp. 1-17
    • Adams, J.B.1
  • 35
    • 0016808184 scopus 로고
    • Androgens in postmenopausal breast cancer: excretion, production and interaction with estrogens
    • Thussen J.H.H., Poortman J., and Schwarz F. Androgens in postmenopausal breast cancer: excretion, production and interaction with estrogens. J. Steroid Biochem. Mol. Biol. 6 (1975) 729-734
    • (1975) J. Steroid Biochem. Mol. Biol. , vol.6 , pp. 729-734
    • Thussen, J.H.H.1    Poortman, J.2    Schwarz, F.3
  • 36
    • 0032217322 scopus 로고    scopus 로고
    • 19 steroids activity in human breast cancer cell lines: importance of dehydroepiandrosterone sulfate at physiological plasma concentration
    • 19 steroids activity in human breast cancer cell lines: importance of dehydroepiandrosterone sulfate at physiological plasma concentration. Steroids 63 (1998) 678-683
    • (1998) Steroids , vol.63 , pp. 678-683
    • Le Bail, J.C.1    Marre-Fournier, F.2    Claud Nicholas, J.3    Habroux, G.4
  • 37
    • 0018743787 scopus 로고
    • 3H-labeled androgens to the estrogen receptor
    • 3H-labeled androgens to the estrogen receptor. Endocrinology 104 (1979) 1797-1804
    • (1979) Endocrinology , vol.104 , pp. 1797-1804
    • Garcia, M.1    Rochefort, H.2
  • 38
    • 0021025029 scopus 로고
    • The androgenic and antiestrogenic activities of androgens in female target tissues
    • Rochefort H., and Garcia M. The androgenic and antiestrogenic activities of androgens in female target tissues. Pharmacol. Ther. 23 (1984) 193-216
    • (1984) Pharmacol. Ther. , vol.23 , pp. 193-216
    • Rochefort, H.1    Garcia, M.2
  • 39
    • 31444454058 scopus 로고    scopus 로고
    • Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor
    • Ishikawa T., Glidewell-Kenny C., and Jameson J.L. Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor. J. Steroid Biochem. Mol. Biol. 98 (2006) 133-138
    • (2006) J. Steroid Biochem. Mol. Biol. , vol.98 , pp. 133-138
    • Ishikawa, T.1    Glidewell-Kenny, C.2    Jameson, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.