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Volumn 98, Issue 1, 2006, Pages 41-47

Dehydroepiandrosterone (DHEA) metabolism in the brain: Identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia

Author keywords

3 hydroxy 4 androstene 17 one; DHEA; Microglia

Indexed keywords

ANDROSTANEDIONE; ANDROSTANOLONE; ANDROSTENEDIONE; PRASTERONE;

EID: 30944454658     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2005.07.006     Document Type: Article
Times cited : (20)

References (23)
  • 1
    • 0028309503 scopus 로고
    • Dehydroepiandrosterone (DHEA)-the multifunctional steroid. Effects on the CNS, cell proliferation, metabolic and vascular, clinical and other effects. Mechanism of action?
    • W. Regelson, and M. Kalimi Dehydroepiandrosterone (DHEA)-the multifunctional steroid. Effects on the CNS, cell proliferation, metabolic and vascular, clinical and other effects. Mechanism of action? Ann. N. Y. Acad. Sci. 719 1994 564 575
    • (1994) Ann. N. Y. Acad. Sci. , vol.719 , pp. 564-575
    • Regelson, W.1    Kalimi, M.2
  • 2
    • 0029552972 scopus 로고
    • Neuronal actions of dehydroepiandrosterone: Possible roles in the brain development, aging, memory and affect
    • M.D. Majewska Neuronal actions of dehydroepiandrosterone: possible roles in the brain development, aging, memory and affect Ann. N. Y. Acad. Sci. 774 1995 111 120
    • (1995) Ann. N. Y. Acad. Sci. , vol.774 , pp. 111-120
    • Majewska, M.D.1
  • 3
    • 0027408686 scopus 로고
    • Astrocytes and neurosteroids: Metabolism of pregnenolone and dehydroepiandrosterone, regulation by cell density
    • Y. Akwa, N. Sananes, M. Gouezou, P. Ropel, E.E. Baulieu, and C. Goascogne Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone, regulation by cell density J. Cell Biol. 121 1993 135 143
    • (1993) J. Cell Biol. , vol.121 , pp. 135-143
    • Akwa, Y.1    Sananes, N.2    Gouezou, M.3    Ropel, P.4    Baulieu, E.E.5    Goascogne, C.6
  • 4
    • 0032910967 scopus 로고    scopus 로고
    • Dehydroepiandrosterone: Biosynthesis and metabolism in the brain
    • I.H. Zwain, and S.S.C. Yen Dehydroepiandrosterone: biosynthesis and metabolism in the brain Endocrinology 140 1999 880 887
    • (1999) Endocrinology , vol.140 , pp. 880-887
    • Zwain, I.H.1    Yen, S.S.C.2
  • 5
    • 0029924284 scopus 로고    scopus 로고
    • Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury and amyloid β-peptide toxicity in hippocampal neurons
    • Y. Goodman, A.J. Bruce, B. Cheng, and M.P. Mattson Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury and amyloid β-peptide toxicity in hippocampal neurons J. Neurochem. 66 1996 1836 1844
    • (1996) J. Neurochem. , vol.66 , pp. 1836-1844
    • Goodman, Y.1    Bruce, A.J.2    Cheng, B.3    Mattson, M.P.4
  • 7
    • 0031432937 scopus 로고    scopus 로고
    • Steroid hormone modulation of hippocampal dependent spatial memory
    • V.N. Luine Steroid hormone modulation of hippocampal dependent spatial memory Stress 2 1997 21 36
    • (1997) Stress , vol.2 , pp. 21-36
    • Luine, V.N.1
  • 8
    • 0032192065 scopus 로고    scopus 로고
    • Estradiol enhances learning and memory in spatial memory task and affects levels of monoaminergic neurotransmitters
    • V.N. Luine, S.T. Richards, V.Y. Wu, and K.D. Beck Estradiol enhances learning and memory in spatial memory task and affects levels of monoaminergic neurotransmitters Horm. Behav. 34 1998 149 162
    • (1998) Horm. Behav. , vol.34 , pp. 149-162
    • Luine, V.N.1    Richards, S.T.2    Wu, V.Y.3    Beck, K.D.4
  • 9
    • 0033970185 scopus 로고    scopus 로고
    • Estrogen is more than just a "sex hormone": Novel sites for estrogen action in the hippocampus and cerebral cortex
    • P.G. Shughrue, and I. Merchenthaler Estrogen is more than just a "sex hormone": novel sites for estrogen action in the hippocampus and cerebral cortex Front. Neuroendocrinol. 21 2000 95 101
    • (2000) Front. Neuroendocrinol. , vol.21 , pp. 95-101
    • Shughrue, P.G.1    Merchenthaler, I.2
  • 10
    • 0035089767 scopus 로고    scopus 로고
    • Minireview: Neuroprotective effects of estrogen - New insights into mechanisms of action
    • P.M. Wise, D.B. Dubal, M.E. Wilson, S.W. Rau, and M. Bottner Minireview: neuroprotective effects of estrogen - new insights into mechanisms of action Endocrinology 142 2001 969 973
    • (2001) Endocrinology , vol.142 , pp. 969-973
    • Wise, P.M.1    Dubal, D.B.2    Wilson, M.E.3    Rau, S.W.4    Bottner, M.5
  • 11
    • 0002845980 scopus 로고    scopus 로고
    • Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages
    • M. Schmidt, M. Kruetz, G. Loffler, J. Scholmerich, and R.H. Straub Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages J. Endocrinol. 164 2000 161 169
    • (2000) J. Endocrinol. , vol.164 , pp. 161-169
    • Schmidt, M.1    Kruetz, M.2    Loffler, G.3    Scholmerich, J.4    Straub, R.H.5
  • 13
    • 0035162296 scopus 로고    scopus 로고
    • Metabolism of dehydroepiandrosterone by rat hippocampal cells in culture: Possible role of aromatization and 7-hydroxylation in neuroprotection
    • P.H. Jellinck, S.J. Lee, and B.S. McEwen Metabolism of dehydroepiandrosterone by rat hippocampal cells in culture: possible role of aromatization and 7-hydroxylation in neuroprotection J. Steroid Biochem. Mol. Biol. 78 2001 313 317
    • (2001) J. Steroid Biochem. Mol. Biol. , vol.78 , pp. 313-317
    • Jellinck, P.H.1    Lee, S.J.2    McEwen, B.S.3
  • 14
    • 0032814562 scopus 로고    scopus 로고
    • Neurological activation in the injured brain: Graded response, molecular mechanisms and cues to physiological function
    • G. Raivich, M. Bohatschek, C.U.A. Kloss, A. Werner, L.L. Jones, and G.W. Kruetzberg Neurological activation in the injured brain: graded response, molecular mechanisms and cues to physiological function Brain Res. Rev. 30 1999 77 105
    • (1999) Brain Res. Rev. , vol.30 , pp. 77-105
    • Raivich, G.1    Bohatschek, M.2    Kloss, C.U.A.3    Werner, A.4    Jones, L.L.5    Kruetzberg, G.W.6
  • 17
    • 0015979492 scopus 로고
    • 5-3β- hydroxysteroid dehydrogenase system of sheep adrenal cortical microsomes
    • 5-3β-hydroxysteroid dehydrogenase system of sheep adrenal cortical microsomes J. Biol. Chem. 249 1974 1363 1368
    • (1974) J. Biol. Chem. , vol.249 , pp. 1363-1368
    • Ford, H.C.1    Engel, L.L.2
  • 18
    • 0030925341 scopus 로고    scopus 로고
    • Molecular endocrinology of hydroxysteroid dehydrogenases
    • T.M. Penning Molecular endocrinology of hydroxysteroid dehydrogenases Endocr. Rev. 18 1997 281 305
    • (1997) Endocr. Rev. , vol.18 , pp. 281-305
    • Penning, T.M.1
  • 19
    • 4644373998 scopus 로고    scopus 로고
    • Enzymatic mechanisms for catalysis of enolization: Ketosteroid isomerase
    • R.M. Pollack Enzymatic mechanisms for catalysis of enolization: ketosteroid isomerase Bioorg. Chem. 32 2004 341 353
    • (2004) Bioorg. Chem. , vol.32 , pp. 341-353
    • Pollack, R.M.1
  • 20
    • 0002680532 scopus 로고
    • Ultraviolet absorption of steroids
    • L. Dorfman Ultraviolet absorption of steroids Chem. Rev. 1 1953 47 144
    • (1953) Chem. Rev. , vol.1 , pp. 47-144
    • Dorfman, L.1
  • 21
    • 11444251209 scopus 로고    scopus 로고
    • Sex steroids, APOE genotype and the innate immune system
    • C.A. Colton, C.M. Brown, and M.P. Vitek Sex steroids, APOE genotype and the innate immune system Neurobiol. Aging 26 2005 363 372
    • (2005) Neurobiol. Aging , vol.26 , pp. 363-372
    • Colton, C.A.1    Brown, C.M.2    Vitek, M.P.3
  • 22
    • 30944432969 scopus 로고
    • Enzymatic formation of 3β-hydroxy-4-androstene-17-one
    • H. Breuer, K. Dahm, and J.K. Norymberski Enzymatic formation of 3β-hydroxy-4-androstene-17-one J. Endocrinol. 27 1963 357 358
    • (1963) J. Endocrinol. , vol.27 , pp. 357-358
    • Breuer, H.1    Dahm, K.2    Norymberski, J.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.