Ligand-induced overexpression of a constitutively active β2-adrenergic receptor: Pharmacological creation of a phenotype in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 1, 1997, Pages 137-141

  Samama, Philippe ^a,d   Bond, Richard A ^b   Rockman, Howard A ^c   Milano, Carmelo A ^a   Lefkowitz, Robert J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d PHARMACOPEIA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MUS MUSCULUS;

BETA 2 ADRENERGIC RECEPTOR;

ANIMAL CELL; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HEART MUSCLE CONTRACTILE FORCE; LIGAND BINDING; MOLECULAR INTERACTION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN STABILITY; RECEPTOR GENE; RECEPTOR UPREGULATION; TRANSGENIC MOUSE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ATRIAL FUNCTION; HEART; HUMANS; ISOMETRIC CONTRACTION; ISOPROTERENOL; LIGANDS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PHENOTYPE; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA-2; UP-REGULATION; VENTRICULAR FUNCTION, LEFT;

EID: 0031031054     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.1.137     Document Type: Article

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