Functional interactions between Sae2 and the Mre11 complex

Genetics

Volumn 178, Issue 2, 2008, Pages 711-723

  Kim, Hee Sook ^a   Vijayakumar, Sangeetha ^a   Reger, Mike ^c   Harrison, Jacob C ^b   Haber, James E ^b   Weil, Clifford ^c   Petrini, John H J ^a,d  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; MRE11 PROTEIN; PROTEIN SAE2; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; GENE INTERACTION; NONHUMAN; OLIGOMERIZATION; PHENOTYPE; PRIORITY JOURNAL;

DNA DAMAGE; DNA REPAIR; DNA, FUNGAL; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; GENE DELETION; GENES, FUNGAL; MEIOSIS; METHYL METHANESULFONATE; MUTAGENESIS; POLYMERASE CHAIN REACTION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; ULTRAVIOLET RAYS;

EID: 40849094757     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.107.081331     Document Type: Article

References (53)

1. BARONI, E., V. VISCARDI, H. CARTAGENA- LIROLA, G. LUCCHINI and M. P. LONGHESE, 2004 The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol. Cell. Biol. 24: 4151-4165.
2. BLOCH, V., Y. YANG, E. MARGEAT, A. CHAVANIEU, M. T. AUGE et al., 2003 The H-NS dimerization domain defines a new fold contributing to DNA recognition. Nat. Struct. Biol. 10: 212-218.
3. BORDE, V., W. LIN, E. NOVIKOv, J. H. PETRINI, M. LICHTEN et al., 2004 Association of Mre11p with double-strand break sites during yeast meiosis. Mol. Cell 13: 389-401.
4. CAO, L., E. ALANI and N. KLECKNER, 1990 A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae. Cell 61: 1089-1101.
5. CLERICI, M., D. MANTIERO, G. LUCCHINI and M. P. LONGHESE, 2006 The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling. EMBO Rep. 7: 212-218
6. D'ADDA DI FAGAGNA, F., P. M. REAPER, L. CLAY-FARRACE, H. FIEGLER, P. CARR et al., 2003 A DNA damage checkpoint response in telomere-initiated senescence. Nature 426: 194-198.
7. DAME, R. T., C. WYMAN and N. GOOSEN, 2000 H-NS mediated compaction of DNA visualised by atomic force microscopy. Nucleic Acids Res. 28: 3504-3510.
8. D'AMOURS, D., and S. P. JACKSON, 2002 The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nat. Rev. Mol. Cell Biol. 3: 317-327.
9. DEBRAUWERE, H., S. LOEILLET, W. LIN, J. LOPES and A. NICOLAS, 2001 Links between replication and recombination in Saccharomyces cerevisiae: a hypersensitive requirement for homologous recombination in the absence of Rad27 activity. Proc. Natl. Acad. Sci. USA 98: 8263-8269.
10. DENG, C., J. A. BROWN, D. YOU and J. M. BROWN, 2005 Multiple endonucleases function to repair covalent topoisomerase I complexes in Saccharomyces cerevisiae. Genetics 170: 591-600.
11. DORMAN, C. J., 2004 H-NS: a universal regulator for a dynamic genome. Nat. Rev. Microbiol. 2: 391-400.
12. ESPOSITO, D., A. PETROVIC, R. HARRIS, S. ONO, J. F. ECCLESTON et al., 2002 H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein. J. Mol. Biol. 324: 841-850.
13. ITO, T., T. CHIBA, R. OZAWA, M. YOSHIDA, M. HATTORI et al., 2001 A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc. Natl. Acad. Sci. USA 98: 4569-4574.
14. KEENEY, S., and N. KLECKNER, 1995 Covalent protein-DNA complexes at the 5′ strand termini of meiosis- specific double-strand breaks in yeast. Proc. Natl. Acad. Sci. USA 92: 11274-11278.
15. KEENEY, S., C. N. GIROUX and N. KLECKNER, 1997 Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell 88: 375-384.
16. KIRONMAI, K. M., and K. MUNIYAPPA, 1997 Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae. Genes Cells 2: 443-455.
17. LEE, S. E., J. K. MOORE, A. HOLMES, K. UMEZU, R. D. KOLODNER et al., 1998 Saccharomyces Ku70, Mre11/Rad50, and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94: 399-409.
18. LEE, S. E., D. A. BRESSAN, J. H. J. PETRINI and J. E. HABER, 2002 Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance. DNA Repair 1: 27-40.
19. LENGSFELD, B. M., A. J. RATTRAY, V. BHASKARA, R. GHIRLANDO and T. T. PAULL, 2007 Sae2 Is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol. Cell 28: 638-651.
20. LEROY, C., S. E. LEE, M. B. VAZE, F. OCHSENBIEN, R. GUEROIS et al., 2003 PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol. Cell 11: 827-835.
21. LISBY, M., J. H. BARLOW, R. C. BURGESS and R. ROTHSTEIN, 2004 Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 118: 699-713.
22. LOBACHEV, K. S., D. A. GORDENIN and M. A. RESNICK, 2002 The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell 108: 183-193.
23. LUNDBLAD, V., 2002 Telomere maintenance without telomerase. Oncogene 21: 522-531.
24. MCKEE, A. H., and N. KLECKNER, 1997 A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2. Genetics 146: 797-816.
25. MILNER, J., and E. A. MEDCALF, 1991 Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation. Cell 65: 765-774.
26. MORALES, M., J. W. THEUNISSEN, C. F. KIM, R. KITAGAWA, M. B. KASTAN et al., 2005 The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev. 19: 3043-3054.
27. MOREAU, S., J. R. FERGUSON and L. S. SYMINGTON, 1999 The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol. 19: 556-566.
28. MOREAU, S., E. A. MORGAN and L. S. SYMINGTON, 2001 Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism. Genetics 159: 1423-1433.
29. NAIRZ, K., and F. KLEIN, 1997 mre11S: a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis. Genes Dev. 11: 2272-2290.
30. PANDITA, T. K., 2002 ATM function and telomere stability. Oncogene 21: 611-618.
31. PELLICIOLI, A., S. E. LEE, C. LUCCA, M. FOIANI and J. E. HABER, 2001 Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest. Mol. Cell 7: 293-300.
32. PENKNER, A., Z. PORTIK-DOBOS, L. TANG, R. SCHNABEL, M. NOVATCHKOVA et al., 2007 A conserved function for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination. EMBO J. 26: 5071-5082.
33. PETRINI, J. H., and T. H. STRACKER, 2003 The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol. 13: 458-462.
34. PRINZ, S., A. AMON and F. KLEIN, 1997 Isolation of COM1, a new gene required to complete meiotic double- strand break-induced recombination in Saccharomyces cerevisiae. Genetics 146: 781-795.
35. RATTRAY, A. J., C. B. MCGILL, B. K. SHAFER and J. N. STRATHERN, 2001 Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1. Genetics 158: 109-122.
36. RITCHIE, K. B., and T. D. PETES, 2000 The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155: 475-479.
37. SARTORI, A. A., C. LUKAS, J. COATES, M. MISTRIK, S. FU et al., 2007 Human CtIP promotes DNA end resection. Nature 450: 509-514.
38. SHIMA, H., M. SUZUKI and M. SHINOHARA, 2005 Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae. Genetics 170: 71-85.
39. SHROFF, R., A. ARBEL-EDEN, D. PILCH, G. IRA, W. M. BONNER et al., 2004 Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr. Biol. 14: 1703-1711.
40. STRACKER, T. H., J. W. THEUNISSEN, M. MORALES and J. H. PETRINI, 2004 The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair (Amst.) 3: 845-854.
41. SUN, Y., Z. DONG, K. NAKAMURA and N. H. COLBURN, 1993 Dosage-dependent dominance over wild-type p53 of a mutant p53 isolated from nasopharyngeal carcinoma. FASEB J. 7: 944-950.
42. UANSCHOU, C., T. SIWIEC, A. PEDROSA- HARAND, C. KERZENDORFER, E. SANCHEZ-MORAN et al., 2007 A novel plant gene essential for meiosis is related to the human CtIP and the yeast COM1/SAE2 gene. EMBO J. 26: 5061-5070.
43. UEGUCHI, C., T. SUZUKI, T. YOSHIDA, K. TANAKA and T. MIZUNO, 1996 Systematic mutational analysis revealing the functional domain organization of Escherichia coli nucleoid protein H-NS. J. Mol. Biol. 263: 149-162.
44. UEGUCHI, C., C. SETO, T. SUZUKI and T. MIZUNO, 1997 Clarification of the dimerization domain and its functional significance for the Escherichia coli nucleoid protein H-NS. J. Mol. Biol. 274: 145-151.
45. USUI, T., H. OGAWA and J. H. PETRINI, 2001 A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol. Cell 7: 1255-1266.
46. USUI, T., J. H. PETRINI and M. MORALES, 2006 Rad50S alleles of the Mre11 complex: questions answered and questions raised. Exp. Cell Res. 312: 2694-2699.
47. VANCE, J. R., and T. E. WILSON, 2002 Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage. Proc. Natl. Acad. Sci. USA 99: 13669-13674.
48. VAZE, M. B., A. PELLICIOLI, S. E. LEE, G. IRA, G. LIBERI et al., 2002 Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase. Mol. Cell 10: 373-385.
49. WANG, P., M. REED, Y. WANG, G. MAYR, J. E. STENGER et al., 1994 p53 domains: structure, oligomerization, and transformation. Mol. Cell. Biol. 14: 5182-5191.
50. WEIL, C. F., and R. KUNZE, 2000 Transposition of maize Ac/Ds transposable elements in the yeast Saccharomyces cerevisiae. Nat. Genet. 26: 187-190.
51. WILLIAMS, R. M., S. RIMSKY and H. BUC, 1996 Probing the structure, function, and interactions of the Escherichia coli H-NS and StpA proteins by using dominant negative derivatives. J. Bacteriol. 178: 4335-4343.
52. YU, J., K. MARSHALL, M. YAMAGUCHI, J. E. HABER and C. F. WEIL, 2004 Microhomology-dependent end joining and repair of transposon-induced DNA hairpins by host factors in Saccharomyces cerevisiae. Mol. Cell. Biol. 24: 1351-1364.
53. ZHOU, B. B., and S. J. ELLEDGE, 2000 The DNA damage response: putting checkpoints in perspective. Nature 408: 433-439.