Modeling and experimental analyses reveal a two-domain structure and amino acids important for the activity of aminoglycoside resistance methyltransferase Sgm

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1784, Issue 4, 2008, Pages 582-590

  Vlahoviček, Gordana Maravić ^a   Čubrilo, Sonja ^a   Tkaczuk, Karolina L ^b,c   Bujnicki, Janusz M ^b,d  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

^c LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^d ADAM MICKIEWICZ UNIVERSITY   (Poland)

Author keywords

Antibiotic resistance; Methylation; Modeling; Site directed mutagenesis

Indexed keywords

AMINO ACID; ENZYME SGM; KANAMYCIN; METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME STRUCTURE; ESCHERICHIA COLI; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROMONOSPORA; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; COMPUTATIONAL BIOLOGY; DRUG RESISTANCE, BACTERIAL; GENTAMICINS; KANAMYCIN; METHYLTRANSFERASES; MICROMONOSPORA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHYLOGENY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS);

EID: 40749086775     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2007.09.009     Document Type: Article

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