Novel plasmid-mediated 16S rRNA methylase, RmtC, found in a Proteus mirabilis isolate demonstrating extraordinary high-level resistance against various aminoglycosides

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 1, 2006, Pages 178-184

  Wachino, Jun Ichi ^a,b   Yamane, Kunikazu ^a   Shibayama, Keigo ^a   Kurokawa, Hiroshi ^a   Shibata, Naohiro ^a   Suzuki, Satowa ^a   Doi, Yohei ^a   Kimura, Kouji ^a   Ike, Yasuyoshi ^b   Arakawa, Yoshichika ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE; HABEKACIN; HISTIDINE; ISEPAMICIN; KANAMYCIN; NEOMYCIN; PROTEIN ARMA; PROTEIN RMTA; PROTEIN RMTB; RNA 16S; RNA METHYLTRANSFERASE; SISOMICIN; TOBRAMYCIN; UNCLASSIFIED DRUG;

ACTINOMYCETACEAE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; CLONING; ELECTROPORATION; ENTEROBACTERIACEAE; GRAM NEGATIVE BACTERIUM; HOSPITAL PATIENT; JAPAN; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROTEUS MIRABILIS; RMTC GENE;

AMINO ACID SEQUENCE; AMINOGLYCOSIDES; DRUG RESISTANCE, MICROBIAL; GENES, RRNA; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PHYLOGENY; PLASMIDS; PROTEUS MIRABILIS;

EID: 29944441901     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.50.1.178-184.2006     Document Type: Article

References (29)

1. Beauclerk, A. A., and E. Cundliffe. 1987. Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides. J. Mol. Biol. 193:661-671.
2. Boyd, D. A., S. Tyler, S. Christianson, A. McGeer, M. P. Muller, B. M. Willey, E. Bryce, M. Gardam, P. Nordmann, and M, R. Mulvey, 2004. Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTXM-15 extended-spectrum β-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada. Antimicrob. Agents Chcmother. 48:3758-3764.
3. Bryan, L. E. 1988. General mechanisms of resistance to antibiotics. J. Antimicrob. Chemother. 22(Suppl. A):1-15.
4. Cao, V., T. Lambert, and P. Courvalin. 2002. ColE1-like plasmid p1P843 of Klebsiella pneumoniae encoding extended-spectrum β-lactamase CTX-M-17. Antimicrob. Agents Chemother. 46:1212-1217.
5. Demydchuk, J., Z. Oliynyk, and V. Fedorenko. 1998. Analysis of a kanamycin resistance gene (kmr) from Streptomyces kanamyceticus and a mutant with increased aminoglycoside resistance. J. Basic Microbiol. 38:231-239.
6. Doi, Y., K. Yokohama, K. Yamane, J. Wachino, N. Shibata, T. Yagi, K. Shibayama, H. Kato, and Y. Arakawa. 2004. Plasmid-mediated 16S rRNA methylase in Serratia marcescens conferring high-level resistance to aminoglycosides. Antimicrob. Agents Chemother. 48:491-496.
7. Galimand, M., P. Courvalin, and T. Lambert. 2003. Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation. Antimicrob. Agents Chemother. 47:2565-2571.
8. Galimand, M., S. Sabtcheva, P. Courvalin, and T. Lambert. 2005. Worldwide disseminated armA aminoglycoside resistance methylase gene is borne by composite transposon Tn1548. Antimicrob. Agents Chemother. 49:2949-2953.
9. Gilbert, D. N., Jr., R. C. Moellering, and M. A. Sande. 2003. The Sanford guide to antimicrobial therapy 2003. Antimicrobial Therapy, Inc., Hyde Park, N.Y.
10. CMY-2 from multiple Salmonella plasmid backbones. Antimicrob. Agents Chemother. 48:2845-2852.
11. González-Zorn, B., A. Catalan, J. A. Escudero, L. Dominguez, T. Teshager, C. Porrero, and M. A. Moreno. 2005. Genetic basis for dissemination of armA. J. Antimicrob. Chemother. 56:583-585.
12. González-Zorn, B., T. Teshager, M. Casas, M. C. Porrero, M. A. Moreno, P. Courvalin, and L. Dominguez. 2005. armA and aminoglycoside resistance in Escherichia coll. Emerg. Infect. Dis. 11:954-956.
13. Holmes, D. J., and E. Cundliffe. 1991. Analysis of a ribosomal RNA methylase gene from Streptomyces tenebrarius which confers resistance to gentamicin. Mol. Gen. Genet. 229:229-237.
14. Kado, C. I., and S. T. Liu. 1981. Rapid procedure for detection and isolation of large and small plasmids. J. Bacteriol. 145:1365-1373.
15. Kelemen, G. H., E. Cundliffe, and I. Financsek. 1991. Cloning and characterization of gentamiein-resistance genes from Micromimospora purpurea and Micromonospora rosea. Gene 98:53-60.
16. Kojic, M., L. Topisirovic, and B. Vasiljevic. 1992. Cloning and characterization of an aminoglycoside resistance determinant from Micromonospora zinensis. J. Bacteriol. 174:7868-7872.
17. Kotra, L. P., J. Haddad, and S. Mobashery. 2000. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. Antimicrob. Agents Chemother. 44:3249-3256.
18. National Committee for Clinical Laboratory Standards. 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 5th ed. Document M7-A5. National Committee for Clinical Laboratory Standards, Wayne, Pa.
19. Ohta, T., and M. Hasegawa. 1993. Analysis of the self-defense gene (fmrO) of a fortimicin A (astromicin) producer, Micromonospora olivasterospora: comparison with other aminoglyeoside-resistance-encoding genes. Gene 127:63-69.
20. CTX-M β-lactamase gene. Antimicrob. Agents Chemother. 47:2938-2945.
21. CTX-M in Escherichia coli. Antimicrob. Agents Chemother. 49:447-450.
22. Saladin, M., V. T. Cao, T. Lambert, J. L. Donay, J. L. Herrmann, Z. Ould-Hocine, C. Verdet, F. Delisle, A. Philippen, and G. Ariel. 2002. Diversity of CTX-M β-lactamases and their promoter regions from Enterobacteriaceae isolated in three Parisian hospitals. FEMS. Microbiol. Lett. 209:161-168.
23. Samhrook, J., E. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
24. Shaw, K. J., P. N. Rather, R. S. Hare, and G. H. Miller. 1993. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglyeoside-modifying enzymes. Microbiol. Rev. 57:138-163.
25. Skeggs, P. A., J. Thompson, and E. Cundliffe. 1985. Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis. Mol. Gen. Genet. 200:415-421.
26. Yamane, K., Y. Doi, K. Yokoyama, T. Yagi, H. Kurokawa, N. Shibata, K. Shibayama, H. Kato, and Y. Arakawa. 2004. Genetic environments of the nntA gene in Pseudomonas aeruginosa clinical isolates. Antimicrob. Agents Chemother. 48:2069-2074.
27. Yamane, K., J. Wachino, Y. Doi, H. Kurokawa, and Y. Arakawa. 2005. Global spread of multiple-aminoglycoside-resistanee genes. Emerg. Infect. Dis. 11:951-953.
28. Yan, J. J., J. J. Wu, W. C, Ko, S. H. Tsai, C. L. Chuang, H. M. Wu, Y. J, Lu, and J. D. Li, 2004. Plasmid-mediated 16S rRNA methylases conferring high-level aminoglycoside resistance in Escherichia coli and Klebsiella pneumoniae isolates from two Taiwanese hospitals. J. Antimicrob. Chemother. 54:1007-1012.
29. Yokoyama, K., Y. Doi, K. Yamane, H. Kurokawa, N. Shibata, K. Shibayama, T. Yagi, H. Kato, and Y. Arakawa. 2003. Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa. Lancet 362:1888-1893.