Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC′ redefines the substrate-binding site and suggests a model for protein-RNA interactions

Nucleic Acids Research

Volumn 31, Issue 16, 2003, Pages 4941-4949

  Maravić, Gordana ^a,b   Bujnicki, Janusz M ^c   Feder, Marcin ^c   Pongor, Sándor ^a   Flögel, Mirna ^b  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSEROTONIN METHYLTRANSFERASE; ALANINE; AMINO ACID; ANTIBIOTIC AGENT; ERYTHROMYCIN; LINCOSAMIDE; MACROLIDE; METHYLTRANSFERASE; MIKAMYCIN B; MUTANT PROTEIN; RIBOSOME RNA; RNA; RNA 23S;

ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS SUBTILIS; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; ESCHERICHIA COLI; EXPERIMENTAL MODEL; IN VITRO STUDY; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR RECOGNITION; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PREDICTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN RNA BINDING; RNA BINDING; RNA METHYLATION; RNA STRUCTURE; STRUCTURE ANALYSIS;

ALANINE; AMINO ACID SEQUENCE; BINDING SITES; CELL DIVISION; DRUG RESISTANCE, BACTERIAL; ERYTHROMYCIN; ESCHERICHIA COLI; KINETICS; METHYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; RNA, BACTERIAL; RNA, RIBOSOMAL; RNA, RIBOSOMAL, 23S; RNA-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

BACILLUS SUBTILIS; ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA;

EID: 0142138438     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg666     Document Type: Article

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