Residues involved in the catalysis, base specificity, and cytotoxicity of ribonuclease from Rana catesbeiana based upon mutagenesis and x-ray crystallography

Journal of Biological Chemistry

Volumn 278, Issue 9, 2003, Pages 7300-7309

  Leu, Ying Jen ^a,c   Chern, Shuenn Shing ^b   Wang, Sui Chi ^a   Hsiao, Ya Yun ^a   Amiraslanov, Imameddin ^b   Liaw, Yen Chywan ^b   Liao, You Di ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^c NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CATALYSTS; CELLS; ENZYMES; HYDROGEN BONDS; MUTAGENESIS; RNA; TOXICITY; TUMORS;

CYTOTOXICITY;

BIOCHEMISTRY;

ADENINE; ASPARAGINE; CYTOSINE; DINUCLEOTIDE; GLUTAMINE; GUANINE; HISTIDINE; LYSINE; PYRIMIDINE; PYROGLUTAMIC ACID; RIBONUCLEASE; THREONINE; COMPLEMENTARY DNA; GLUTAMIC ACID; HYDROGEN; PANCREATIC RIBONUCLEASE; RECOMBINANT PROTEIN; RNA;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME SUBSTRATE; FROG; GENETIC RECOMBINATION; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; GENE VECTOR; GENETICS; HUMAN; KINETICS; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; MUTATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

ANURA; RANA CATESBEIANA;

AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; CELL SURVIVAL; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DNA, COMPLEMENTARY; GENETIC VECTORS; GLUTAMIC ACID; GUANINE; HUMANS; HYDROGEN; KINETICS; LYSINE; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PROTEIN STRUCTURE, TERTIARY; RANA CATESBEIANA; RECOMBINANT PROTEINS; RIBONUCLEASE, PANCREATIC; RIBONUCLEASES; RNA; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; THREONINE;

EID: 0037470067     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206701200     Document Type: Article

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