B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4

Journal of Clinical Investigation

Volumn 107, Issue 7, 2001, Pages 881-887

  Mandelbrot, Didier A ^a   Oosterwegel, Mariette A ^b   Shimizu, Koichi ^a   Yamada, Akira ^a,c   Freeman, Gordon J ^d   Mitchell, Richard N ^a   Sayegh, Mohammed H ^a   Sharpe, Arlene H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; GENETIC TRANSFECTION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

EID: 0035057078     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11710     Document Type: Article

References (24)

1. The role or B7 co-stimulation in activation and differentiation of CD4+ and CD8+ T cells
2. CTLA-4 and T cell activation
3. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
4. Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28
5. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts
6. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan destruction, revealing a critical negative regulatory role of CTLA-4
7. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
8. The role of CTLA-4 in regulating Th2 differentiation
9. Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation
10. Costimulation of IL-4 production by murine B7-1 and B7-2 molecules
11. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection
12. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
13. Thymocyte development is normal in CTLA-4-deficient mice
14. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28
15. CD28 costimulation promotes the production of Th2 cytokines
16. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival
17. Differential T cell costimulatory requirements in CD28-deficient mice
18. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
19. Absence of B7-dependent responses in CD28 deficient mice
20. CTLA4-B7 interaction is sufficient to costimulate T cell clonal expansion
21. T-cell stimulation: An abundance of B7s
22. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
23. T cells: A proliferation of costimulatory molecules
24. LICOS, a primordial costimulatory ligand?