Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics

Journal of Biological Chemistry

Volumn 279, Issue 32, 2004, Pages 33919-33927

  Lobo, Ingrid A ^a   Mascia, Maria Paola ^b   Trudell, James R ^c   Harris, R Adron ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; AMINO ACIDS; ANESTHETICS; DRUG PRODUCTS;

CHANNEL GATING; CONFORMATIONAL CHANGES; DRUG EFFECTS;

BIOCHEMISTRY;

ALCOHOL; AMINO ACID; ANESTHETIC AGENT; CYSTEINE; GLYCINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1 SUBUNIT; ISOLEUCINE; MESYLIC ACID DERIVATIVE; MUTANT PROTEIN; RECEPTOR SUBUNIT; SERINE; SULFONIC ACID DERIVATIVE; THIOL GROUP; THREONINE; UNCLASSIFIED DRUG; VALINE;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; XENOPUS LAEVIS;

ALCOHOLS; ANESTHETICS; ANIMALS; BINDING SITES; CELL MEMBRANE; CYSTEINE; ELECTROPHYSIOLOGY; FEMALE; GENE EXPRESSION; HUMANS; ION CHANNEL GATING; MESYLATES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, GLYCINE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; XENOPUS LAEVIS;

ANIMALIA; XENOPUS LAEVIS;

EID: 4043094149     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313941200     Document Type: Article

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