Tryptophan Scanning Mutagenesis in the αM3 Transmembrane Domain of the Torpedo californica Acetylcholine Receptor: Functional and Structural Implications

Biochemistry

Volumn 42, Issue 42, 2003, Pages 12243-12250

  Guzmán, Gisila R ^a   Santiago, John ^a   Ricardo, Ariamsi ^a   Martí Arbona, Ricardo ^a   Rojas, Legier V ^b   Lasalde Dominicci, José A ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^b Universidad Central del Caribe School of Medicine   (Puerto Rico)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; ELECTRODES; LIPIDS; MUTAGENESIS; PROTEINS; SCANNING;

MUTANTS;

BIOCHEMISTRY;

ALPHA BUNGAROTOXIN I 125; CHOLINERGIC RECEPTOR; ION CHANNEL; LIPID; NICOTINIC RECEPTOR; TRYPTOPHAN;

ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; MOLECULAR INTERACTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; STRUCTURE ACTIVITY RELATION; TORPEDO CALIFORNICA; VOLTAGE CLAMP; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; BUNGAROTOXINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; RADIOLIGAND ASSAY; RECEPTORS, CHOLINERGIC; SEQUENCE HOMOLOGY, AMINO ACID; TORPEDO; XENOPUS;

TORPEDO; TORPEDO CALIFORNICA;

EID: 0142031490     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034764d     Document Type: Article

References (36)

1. Corringer, P. J., Le Novere, N., and Changeux, J. P. (2000) Annu. Rev. Pharmacol. Toxicol. 40, 431-458.
2. Karlin, A., and Akabas, M. H. (1995) Neuron 15, 1231-1244.
3. Unwin, N. (1998) J. Struct. Biol. 127, 181-190.
4. Noda, M., Takahashi, H., Tanabe, T., Toyosato, M., Kikyotani, S., Furutani, Y., Hirose, T., Takashima, H., Inayama, S., Miyata, T., and Numa, S. (1983) Nature 302, 528-532.
5. Hucho, F., Tsetlin, V. I., and Machold, J. (1996) Eur. J. Biochem. 239, 539-557.
6. Akabas, M. H., and Karlin, A. (1995) Biochemistry 34, 12496-12500.
7. Blanton, M. P., and Cohen, J. B. (1992) Biochemistry 31, 3738-3750.
8. Blanton, M. P., and Cohen, J. B. (1994) Biochemistry 33, 2859-2872.
9. Lee, Y. H., Li, L., Lasalde, J., Rojas, L., McNamee, M., Ortiz-Miranda, S. I., and Pappone, P. (1994) Biophys. J 66, 646-653.
10. Lasalde, J. A., Tamamizu, S., Butler, D. H., Vibat, C. R., Hung, B., and McNamee, M. G. (1996) Biochemistry 35, 14139-14148.
11. Ortiz-Miranda, S. I., Lasalde, J. A., Pappone, P. A., and McNamee, M. G. (1997) J. Membr. Biol. 158, 17-30.
12. Tamamizu, S., Lee, Y., Hung, B., McNamee, M. G., and Lasalde-Dominicci, J. A. (1999) J. Membr. Biol. 170, 157-164.
13. Tamamizu, S., Guzman, G. R., Santiago, J., Rojas, L. V., McNamee, M. G., and Lasalde-Dominicci, J. A. (2000) Biochemistry 39, 4666-4673.
14. Bouzat, C., Roccamo, A. M., Garbus, I., and Barrantes, F. J. (1998) Mol. Pharmacol. 54, 146-153.
15. Bouzat, C., Barrantes, F., and Sine, S. (2000) J. Gen. Physiol. 115, 663-672.
16. Bouzat, C., Gumilar, F., del Carmen Esandi, M., and Sine, S. M. (2002) Biophys. J. 82, 1920-1929.
17. Giraudat, J., Montecucco, C., Bisson, R., and Changeux, J. P. (1985) Biochemistry 24, 3121-3127.
18. Campos-Caro, A., Rovira, J. C., Vicente-Agullo, F., Ballesta, J. J., Sala, S., Criado, M., and Sala, F. (1997) Biochemistry 36, 2709-2715.
19. Lugovskoy, A. A., Maslennikov, I. V., Utkin, Y. N., Tsetlin, V. I., Cohen, J. B., and Arseniev, A. S. (1998) Eur. J. Biochem. 255, 455-461.
20. Wang, H. L., Milone, M., Ohno, K., Shen, X. M., Tsujino, A., Batocchi, A. P., Tonali, P., Brengman, J., Engel, A. G., and Sine, S. M. (1999) Nat. Neurosci. 2, 226-233.
21. Cruz-Martin, A., Mercado, J. L., Rojas, L. V., McNamee, M. G., and Lasalde-Dominicci, J. A. (2001) J. Membr. Biol. 183, 61-70.
22. De Rosa, M. J., Rayes, D., Spitzmaul, G., and Bouzat, C. (2002) Mol. Pharmacol. 62, 406-414.
23. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene 77, 51-59.
24. Unwin, N. (1993) Cell 72 Suppl, 31-41.
25. Claudio, T., Ballivet, M., Patrick, J., and Heinemann, S. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 1111-1115.
26. Baenziger, J. E., and Methot, N. (1995) J Biol Chem 270, 29129-29137.
27. Methot, N., and Baenziger, J. E. (1998) Biochemistry 37, 14815-14822.
28. Baenziger, J. E., Morris, M. L., Darsaut, T. E., and Ryan, S. E. (2000) J. Biol. Chem. 275, 777-784.
29. Hasler, U., Crambert, G., Horisberger, J. D., and Geering, K. (2001) J. Biol. Chem. 276, 16356-16364.
30. Sharp, L. L., Zhou, J., and Blair, D. F. (1995) Biochemistry 34, 9166-9171.
31. Sharp, L. L., Zhou, J., and Blair, D. F. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 7946-7950.
32. Ueno, S., Lin, A., Nikolaeva, N., Trudell, J. R., Mihic, S. J., Harris, R. A., and Harrison, N. L. (2000) Br. J. Pharmacol. 137, 296-302.
33. Jenkins, A., Andreasen, A., Trudell, J. R., and Harrison, N. L. (2002) Neuropharmacology 43, 669-678.
34. Grosman, C., Zhou, M., and Auerbach, A. (2000) Nature 403, 773-776.
35. Williams, D. B., and Akabas, M. H. (1999) Biophys. J. 77 (5) 2563-2574.
36. Chothia, C. (1975) Nature 254, 304-308.