Cytoskeletal rearrangement and signal transduction in TGF-β1-stimulated mesangial cell collagen accumulation

Journal of the American Society of Nephrology

Volumn 14, Issue 8, 2003, Pages 1969-1980

  Hubchak, Susan C ^a   Runyan, Constance E ^a   Kreisberg, Jeffrey I ^b   Schnaper, H William ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; CYTOCHALASIN D; GELATINASE A; JASPAMIDE; LATRUNCULIN B; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RNA; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GLOMERULUS; HUMAN; HUMAN CELL; MESANGIUM CELL; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; STRESS FIBER;

EID: 0041842627     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000076079.02452.92     Document Type: Article

References (48)

1. Bruijn JA, Roos A, de Geus B, de Heer E: Transforming growth factor-β and the glomerular extracellular matrix in renal pathology. J Lab Clin Med 123: 34-47, 1994
2. Kitamura M, Suto TS: TGF-β and glomerulonephritis: Anti-inflammatory versus prosclerotic actions. Nephrol Dial Transplant 12: 669-679, 1997
3. Sanderson N, Factor V, Nagy P, Kopp J, Kondaiah P, Wakefield L, Roberts AB, Sporn MB, Thorgeirsson SS: Hepatic expression of mature transforming growth factor β1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci U S A 92: 2572-2576, 1995
4. Border WA, Okuda S, Languino LR, Sporn MB, Ruoslahti E: Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1. Nature 346: 371-374, 1990
5. Border WA, Noble NA, Yamamoto T, Harper JR, Yamaguchi Y, Pierschbacher MD, Ruoslahti E: Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease. Nature 360: 361-364, 1992
6. Akagi Y, Isaka Y, Arai M, Kaneko T, Takenaka M, Moriyama T, Kaneda Y, Ando A, Orita Y, Kamada T, Ucda N, Imai E: Inhibition of TGF-β1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis. Kidney Int 50: 148-155, 1996
7. Poncelet A-C, Schnaper HW: Regulation of human mesangial cell collagen expression by transforming growth factor-β1. Am J Physiol 275: F458-F466, 1998
8. Suzuki S, Ebihara I, Tomino Y, Koide H. Transcriptional activation of matrix genes by transforming growth factor β1 in mesangial cells. Exp Nephrol 1: 229-237, 1993
9. McKay NG, Khong TF, Haites NE, Power DA: The effect of transforming growth factor-β on mesangial cell fibronectin synthesis: Increased incorporation into the extracellular matrix and reduced pI but no effect on alternative splicing. Exp Mol Pathol 59: 211-224, 1993
10. Tomooka S, Border WA, Marshall BC, Noble NA: Glomerular matrix accumulation is linked to inhibition of the plasmin protease system. Kidney Int 42: 1462-1469, 1992
11. Wilson HM, Reid FJ, Brown PA, Power DA, Haites NE, Booth NA: Effect of transforming growth factor-β1 on plasminogen activators and plasminogen activator inhibitor-1 in renal glomerular cells. Exp Nephrol 1: 343-350, 1993
12. Massague J: TGFbeta signaling: Receptors, transducers, and Mad proteins. Cell 85: 947-950, 1996
13. Josso N, di Clemente N: Serine/threonine kinase receptors and ligands. Curr Opin Genet Dev 7: 371-377, 1997
14. Kretzschmar M, Massague J: SMADs: mediators and regulators of TGF-β signaling. Curr Opin Genet Dev 8: 103-111, 1998
15. Heldin CH, Miyazono K, ten Dijke P: TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-471, 1997
16. Piek E, Heldin CH, Ten Dijke P: Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J 13: 2105-2124, 1999
17. Attisano L, Wrana JL: Smads as transcriptional co-modulators. Curr Opin Cell Biol 12: 235-243, 2000
18. Massague J, Wotton D: Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 19: 1745-1754, 2000
19. Poncelet A-C, de Caestecker MP, Schnaper HW: The transforming growth factor-β/SMAD signaling pathway is present and functional in human mesangial cells. Kidney Int 56: 1354-1365, 1999
20. Poncelet A-C, Schnaper HW: Sp1 and Smad proteins cooperate to mediate transforming growth factor-β1-induced α2(I) collagen expression in human glomerular mesangial cells. J Biol Chem 276: 6983-6992, 2001
21. Hayashida T, Poncelet A-C, Hubchak SC, Schnaper HW: TGF-β1 activates MAP kinase in human mesangial cells: A possible role in collagen expression. Kidney Int 56: 1710-1720, 1999
22. Yasuda T, Kondo S, Homma T, Harris RC: Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells. J Clin Invest 98: 1991-2000, 1996
23. Nobes CD, Hall A: Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81: 53-62, 1995
24. Kreisberg JI, Ghosh-Choudhury N, Radnik RA, Schwartz MA: Role of Rho and myosin phosphorylation in actin stress fiber assembly in mesangial cells. Am J Physiol 273: F283-F288, 1997
25. Hill CS, Wynne J, Treisman R: The Rho family GTPases RhoA, Rac 1, and CD C42Hs regulate transcriptional activation by SRF. Cell 81: 1159-1170, 1995
26. Perona R, Montaner S, Saniger L, Sanchez-Perez I, Bravo R, Lacal JC: Activation of the nuclear factor-kappaB by Rho, CDC 42, and Rac-1 proteins. Genes Dev 11: 463-475, 1997
27. Schnaper HW, Kopp JB, Poncelet AC, Hubchak SC, Stetler-Stevenson WG, Klotman PE, Kleinman HK: Increased expression of extracellular matrix proteins and decreased expression of matrix proteases after serial passage of glomerular mesangial cells. J Cell Sci 109: 2521-2528, 1996
28. Chen TR: In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. Exp Cell Res 104: 255-262, 1977
29. Polette M, Huet E, Birembaut P, Maquart FX, Hornebeck W, Emonard H: Influence of oleic acid on the expression, activation and activity of gelatinase A produced by oncogene-transformed human bronchial epithelial cells. Int J Cancer 80: 751-755, 1999
30. Riser BL, Ladson-Wofford S, Sharba A, Cortes P, Drake K, Guerin CJ, Yee J, Choi ME, Segarini PR, Narins RG: TGF-β receptor expression and binding in rat mesangial cells: Modulation by glucose and cyclic mechanical strain. Kidney Int 56: 428-439, 1999
31. Allenberg M, Weinstein T, Li I, Silverman M: Activation of procollagenase IV by cytochalasin D and concanavalin A in cultured rat mesangial cells: Linkage to cytoskeletal reorganization. J Am Soc Nephrol 4: 1760-1770, 1994
32. Ailenberg M, Silverman M: Cellular activation of mesangial gelatinase A by cytochalasin D is accompanied by enhanced mRNA expression of both gelatinase A and its membrane-associated gelatinase A activator (MT-MMP). Biochem J 313: 879-884, 1996
33. Ellerbroek SM, Fishman DA, Kearns AS, Bafetti LM, Stack MS: Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through betal integrin. Cancer Res 59: 1635-1641, 1999
34. Jester JV, Huang J, Barry-Lane PA, Kao WW, Petroll WM, Cavanagh HD: Transforming growth factor β-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly. Invest Ophthalmol Vis Sci 40: 1959-1967, 1999
35. Lee KM, Park J, Kim JH, Yie SW, Chun GT, Kim PH, Choi EY: Reorganization of myosin and focal adhesion proteins in Swiss 3T3 fibroblasts induced by transforming growth factor beta. Cell Biol Int 23: 507-517, 1999
36. Riedy MC, Brown MC, Molloy CJ, Turner CE: Activin A and TGF-β stimulate phosphorylation of focal adhesion proteins and cytoskeletal reorganization in rat aortic smooth muscle cells. Exp Cell Res 251: 194-202, 1999
37. Garbi C, Colletta G, Cirafici AM, Marchisio PC, Nitsch L: Transforming growth factor-beta induces cytoskeleton and extracellular matrix modifications in FRTL-5 thyroid epithelial cells. Eur J Cell Biol 53: 281-289, 1990
38. Humes HD, Nakamura T, Cieslinski DA, Miller D, Emmons RV, Border WA: Role of proteoglycans and cytoskeleton in the effects of TGF-beta 1 on renal proximal tubule cells. Kidney Int 43: 575-584, 1993
39. Coomber BL: Cytoskeleton in TFG-β- and bFGF-modulated endothelial monolayer repair. Exp Cell Res 194: 42-47, 1991
40. Imai E, Arai M, Isaka Y, Wada A, Sugiura T, Akagi Y, Miyazaki M, Fujiwara Y, Ueda N, Kamada T: Phenotypic change of the mesangial cells is induced by overexpression of the TGF-β in in vivo glomerulus [Abstract]. J Am Soc Nephrol 5: 782, 1994
41. Johnson RJ, Floege J, Yoshimura A, Iida H, Couser WG, Alpers CE: The activated mesangial cell: A glomerular "myofibroblast"? J Am Soc Nephrol 2: S190-S197, 1992
42. Utsunomiya Y, Kawamura T, Abe A, Imai H, Hirano K, Maruyama N, Hosoya T, Sakai O: Significance of mesangial expression of alpha-smooth muscle actin in the progression of IgA nephropathy. Am J Kidney Dis 34: 902-910, 1999
43. Yao J, Morioka T, Li B, Oite T: Endothelin is a potent inhibitor of matrix metalloproteinase-2 secretion and activation in rat mesangial cells. Am J Physiol Renal Physiol 280: F628-F635, 2001
44. Edlund S, Landstrom M, Heldin CH, Aspenstrom P: Transforming growth factor-β-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell 13: 902-914, 2002
45. Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses HL: Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 12: 27-36, 2001
46. Murata T, Arii S, Nakamura T, Mori A, Kaido T, Furuyama H, Furumoto K, Nakao T, Isobe N, Imamura M: Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells. J Hepatol 35: 474-481, 2001
47. Nagatoya K, Moriyama T, Kawada N, Takeji M, Oseto S, Murozono T, Ando A, Imai E, Hori M: Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction. Kidney Int 61: 1684-1695, 2002
48. Dong C, Li Z, Alvarez R Jr, Feng XH, Goldschmidt-Clermont PJ: Microtubule binding to Smads may regulate TGF β activity. Mol Cell 5: 27-34, 2000