Hepatic free fatty acids accumulate in experimental steatohepatitis: Role of adaptive pathways

Journal of Hepatology

Volumn 48, Issue 4, 2008, Pages 638-647

  Larter, Claire Z ^a,b   Yeh, Matthew M ^c   Haigh, W Geoffrey ^d   Williams, Jacqueline ^a   Brown, Sandie ^b   Bell Anderson, Kim S ^b   Lee, Sum P ^d   Farrell, Geoffrey C ^a  

^a The Australian National University   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Hepatic lipid synthesis; Lipid composition; Lipotoxicity; Non alcoholic fatty liver disease; Saturated fatty acid

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CHOLINE; FATTY ACID; METHIONINE; STEROL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE SEVERITY; FAT INTAKE; FATTY LIVER; FEMALE; GENE EXPRESSION; HEPATITIS; LIPID ANALYSIS; LIPOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETYL-COA CARBOXYLASE; ANIMALS; CHROMATOGRAPHY, GAS; DIACYLGLYCEROL O-ACYLTRANSFERASE; DIETARY FATS; DIETARY FATS, UNSATURATED; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FATTY ACID DESATURASES; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; FEMALE; GENE EXPRESSION; LIPOGENESIS; LIVER; MICE; MICE, INBRED C57BL; PLANT OILS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 39849103404     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.12.011     Document Type: Article

References (37)

1. Larter C.Z., and Farrell G.C. Insulin resistance, adiponectin, cytokines in NASH: which is the best target to treat?. J Hepatol 44 (2006) 253-261
2. Farrell G.C., and Larter C.Z. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43 (2006) S99-S112
3. McClain C.J., Barve S., and Deaciuc I. Good fat/bad fat. Hepatology 45 (2007) 1343-1346
4. Lupi R., Dotta F., Marselli L., Del Guerra S., Masini M., Santangelo C., et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51 (2002) 1437-1442
5. Feldstein A.E., Werneburg N.W., Canbay A., Guicciardi M.E., Bronk S.F., Rydzewski R., et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 40 (2004) 185-194
6. Malhi H., Bronk S.F., Werneburg N.W., and Gores G.J. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem 281 (2006) 12093-12101
7. Wei Y., Wang D., Topczewski F., and Pagliassotti M.J. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab 291 (2006) E275-E281
8. Eitel K., Staiger H., Brendel M.D., Brandhorst D., Bretzel R.G., Haring H.U., et al. Different role of saturated and unsaturated fatty acids in beta-cell apoptosis. Biochem Biophys Res Commun 299 (2002) 853-856
9. Malhi H., Barreyro F.J., Isomoto H., Bronk S.F., and Gores G.J. Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut 56 (2007) 1124-1131
10. dela Pena A., Leclercq I., Field J., George J., Jones B., and Farrell G. NF-κB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology 129 (2005) 1663-1674
11. Schattenberg J.M., Singh R., Wang Y., Lefkowitch J.H., Rigoli R.M., Scherer P.E., et al. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology 43 (2006) 163-172
12. Joshi-Barve S., Barve S.S., Amancherla K., Gobejishvili L., Hill D., Cave M., et al. Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. Hepatology 46 (2007) 823-830
13. Musso G., Gambino R., De Michieli F., Cassader M., Rizzetto M., Durazzo M., et al. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology 37 (2003) 909-916
14. Solga S., Alkhuraishe A.R., Clark J.M., Torbenson M., Greenwald A., Diehl A.M., et al. Dietary composition and nonalcoholic fatty liver disease. Dig Dis Sci 49 (2004) 1578-1583
15. Cortez-Pinto H., Jesus L., Barros H., Lopes C., Moura M.C., and Camilo M.E. How different is the dietary pattern in non-alcoholic steatohepatitis patients?. Clin Nutr 25 (2006) 816-823
16. Puri P., Baillie R.A., Wiest M.M., Mirshahi F., Choudhury J., Cheung O., et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 46 (2007) 1081-1090
17. de Almeida I.T., Cortez-Pinto H., Fidalgo G., Rodrigues D., and Camilo M.E. Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis. Clin Nutr 21 (2002) 219-223
18. Rizki G., Arnaboldi L., Gabrielli B., Yan J., Lee G.S., Ng R.K., et al. Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with suppression of SCD-1. J Lipid Res 47 (2006) 2280-2290
19. Yamaguchi K., Yang L., McCall S., Huang J., Yu X.X., Pandey S.K., et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 45 (2007) 1366-1374
20. Kleiner D.E., Brunt E.M., Van Natta M., Behling C., Contos M.J., Cummings O.W., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41 (2005) 1313-1321
21. Rombaut R., Camp J.V., and Dewettinck K. Analysis of phospho- and sphingolipids in dairy products by a new HPLC method. J Dairy Sci 88 (2005) 482-488
22. Rasband WS, Image J, US National Institutes of Health, Bethesda, Maryland, USA, http://rsb.info.nih.gov/ij/, 1997-2007.
23. Arsov T., Larter C.Z., Nolan C.J., Petrovski N., Goodnow C.C., Teoh N.C., et al. Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biochem Biophys Res Comm 342 (2006) 1152-1159
24. Day C.P. From fat to inflammation. Gastroenterology 130 (2006) 207-210
25. Lalor P.F., Faint J., Aarbodem Y., Hubscher S.G., and Adams D.H. The role of cytokines and chemokines in the development of steatohepatitis. Semin Liver Dis 27 (2007) 173-193
26. Chalasani N., Gorski J.C., Asghar M.S., Asghar A., Foresman B., Hall S.D., et al. Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis. Hepatology 37 (2003) 544-550
27. Nocito A., Dahm F., Jochum W., Jang J.H., Georgiev P., Bader M., et al. Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis. Gastroenterology 133 (2007) 608-618
28. Bonanome A., Bennett M., and Grundy S.M. Metabolic effects of dietary stearic acid in mice: changes in the fatty acid composition of triglycerides and phospholipids in various tissues. Atherosclerosis 94 (1992) 119-127
29. Donnelly K.L., Smith C.I., Schwarzenberg S.J., Jessurun J., Boldt M.D., and Parks E.J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115 (2005) 1343-1351
30. Biddinger S.B., Almind K., Miyazaki M., Kokkotou E., Ntambi J.M., and Kahn C.R. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1 and the development of the metabolic syndrome. Diabetes 54 (2005) 1314-1323
31. Deng Q., She H., Cheng J.H., French S.W., Koop D.R., Xiong S., et al. Steatohepatitis induced by intragastric overfeeding in mice. Hepatology 42 (2005) 905-914
32. Shimomura I., Bashmakov Y., and Horton J.D. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 274 (1999) 30028-30032
33. Yao Z.M., and Vance D.E. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem 263 (1988) 2998-3004
34. Miyazaki M., Kim Y.-C., and Ntambi J.M. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J Lipid Res 42 (2001) 1018-1024
35. Larter CZ, Yeh MM, Cheng J, Williams J, Brown S, Dela Pena A, et al. Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. J Gastroenterol Hepatol 2007;doi:10.1111/j.1440-1746.2007.05157.x.
36. Cnop M., Hannaert J.C., Hoorens A., Eizirk D.L., and Pipeleers D.G. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 54 (2005) 2917-2924
37. Monetti M., Levin M.C., Watt M.J., Sajan M.P., Marmor S., Hubbard B.K., et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab 6 (2007) 69-78