Review of physical activity and the IGF family

Journal of Physical Activity and Health

Volumn 1, Issue 4, 2004, Pages 291-320

  Orenstein, M R ^a   Friedenreich, C M ^a  

^a Alberta Cancer Board   (Canada)

Author keywords

Exercise; Insulin like growth factors; Systematic review

Indexed keywords

EID: 39749116049     PISSN: 15433080     EISSN: 15435474     Source Type: Journal    
DOI: 10.1123/jpah.1.4.291     Document Type: Review

References (161)

1. Monzavi R, Cohen P. IGFs and IGFBPs: role in health and disease. Best Pract Res Clin Endocrinol Metab. 2002;16:433-447.
2. Yu H, Berkel H. Insulin-like growth factors and cancer. J La State Med Soc .1999;151: 218-223.
3. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 1995;16:3-34.
4. Lacour JR, Kostka T, Bonnefoy M. [Physical activity to delay the effects of aging on mobility]. Presse Med. 2002;31:1185-1192.
5. Naughton G, Farpour-Lambert NJ, Carlson J, Bradney M, Van Praagh E. Physiological issues surrounding the performance of adolescent athletes. Sports Med. 2000;30:309-325.
6. Hameed M, Harridge SD, Goldspink G. Sarcopenia and hypertrophy: a role for insulin-like growth factor-1 in aged muscle? Exerc Sport Sci Rev. 2002;30:15-9.
7. Pollak M. The question of a link between insulin-like growth factor physiology and neoplasia. Growth Horm IGF Res. 2000;10 Suppl B:S21-S24.
8. Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst. 2000;92:1472-1489.
9. Werner H, Le Roith D. New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia. Cell Mol Life Sci. 2000;57:932-942.
10. Tirakitsoontorn P, Nussbaum E, Moser C, Hill M, Cooper DM. Fitness, acute exercise, and anabolic and catabolic mediators in cystic fibrosis. Am J Respir Crit Care Med. 2001;164:1432-1437.
11. Ambrosio MR, Valentini A, Trasforini G, et al. Function of the GH/IGF-1 axis in healthy middle-aged male runners. Neuroendocrinology. 1996;63:498-503.
12. Horber FF, Kohler SA, Lippuner K, Jaeger P. Effect of regular physical training on age-associated alteration of body composition in men. Eur J Clin Invest. 1996;26: 279-285.
13. Poehlman ET, Copeland KC. Influence of physical activity on insulin-like growth factor-I in healthy younger and older men. J Clin Endocrinol Metab. 1990;71:1468-1473.
14. Porch JV, Jain K, Reilly A, et al. Aging, physical activity, insulin-like growth factor I, and body composition in Guatemalan women. Am J Clin Nutr. 1997;66:874-879.
15. Kelly PJ, Eisman JA, Stuart MC, Pocock NA, Sambrook PN, Gwinn TH. Somato-medin-C, physical fitness, and bone density. J Clin Endocrinol Metab. 1990;70: 718-723.
16. Davee AM, Rosen CJ, Adler RA. Exercise patterns and trabecular bone density in college women. J Bone Miner Res. 1990;5:245-250.
17. Nelson ME, Meredith CN, Dawson-Hughes B, Evans WJ. Hormone and bone mineral status in endurance-trained and sedentary postmenopausal women. J Clin Endocrinol Metab. 1988;66:927-933.
18. Ravaglia G, Forti P, Maioli F, et al. Regular moderate intensity physical activity and blood concentrations of endogenous anabolic hormones and thyroid hormones in aging men. Mech Ageing Dev. 2001;122:191-203.
19. Lukanova A, Toniolo P, Akhmedkhanov A, et al. A cross-sectional study of IGF-I determinants in women. Eur J Cancer Prev. 2001;10:443-452.
20. Italian Association for Research on Brain Aging (AIRIC) Multicenter Study Group. Function of GH/IGF-I axis in aging: multicenter study in 152 healthy elderly subjects with different degrees of physical activity. Aging (Milano). 1997;9:185-192.
21. Tissandier O, Peres G, Fiet J, Piette F. Testosterone, dehydroepiandrosterone, insulin-like growth factor 1, and insulin in sedentary and physically trained aged men. Eur J Appl Physiol. 2001;85:177-184.
22. Kostka T, Patricot MC, Mathian B, Lacour JR, Bonnefoy M. Anabolic and catabolic hormonal responses to experimental two-set low-volume resistance exercise in sedentary and active elderly people. Aging Clin Exp Res. 2003;15:123-130.
23. Hornum M, Cooper DM, Brasel JA, Bueno A, Sietsema KE. Exercise-induced changes in circulating growth factors with cyclic variation in plasma estradiol in women. J Appl Physiol. 1997;82:1946-1951.
24. Chadan SG, Dill RP, Vanderhoek K, Parkhouse WS. Influence of physical activity on plasma insulin-like growth factor-1 and insulin-like growth factor binding proteins in healthy older women. Mech Ageing Dev. 1999;109:21-34.
25. Eliakim A, Oh Y, Cooper DM. Effect of single wrist exercise on fibroblast growth factor-2, insulin-like growth factor, and growth hormone. Am J Physiol Regul Integr Comp Physiol. 2000;279:R548-R553.
26. Nguyen UN, Mougin F, Simon-Rigaud ML, Rouillon JD, Marguet P, Regnard J. Influence of exercise duration on serum insulin-like growth factor and its binding proteins in athletes. Eur J Appl Physiol Occup Physiol. 1998;78:533-537.
27. Dall R, Lange KH, Kjaer M, et al. No evidence of insulin-like growth factor-binding protein 3 proteolysis during a maximal exercise test in elite athletes. J Clin Endocrinol Metab. 2001;86:669-674.
28. Kraemer WJ, Gordon SE, Fleck SJ, et al. Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. Int J Sports Med. 1991;12:228-235.
29. Elias AN, Pandian MR, Wang L, Suarez E, James N, Wilson AF. Leptin and IGF-I levels in unconditioned male volunteers after short-term exercise. Psychoneuroen-docrinology. 2000;25:453-61.
30. Bosco C, Tihanyl J, Rivalta L, et al. Hormonal responses in strenuous jumping effort. Jpn J Physiol. 1996;46:93-98.
31. Kraemer WJ, Harman FS, Vos NH, et al. Effects of exercise and alkalosis on serum insulin-like growth factor I and IGF-binding protein-3. Can J Appl Physiol. 2000;25: 127-138.
32. Wallace JD, Cuneo RC, Baxter R, et al. Responses of the growth hormone (GH) and insulin-like growth factor axis to exercise, GH administration, and GH withdrawal in trained adult males: a potential test for GH abuse in sport. J Clin Endocrinol Metab. 1999;84:3591-3601.
33. Youl KH, Hwan KS, Jun LW, Byrne HK. Effects of Ginseng Ingestion on Growth Hormone, Testosterone, Cortisol, and Insulin-Like Growth Factor 1 Responses to Acute Resistance Exercise. J Strength Cond Res. 2002;16:179-183.
34. Schwarz AJ, Brasel JA, Hintz RL, Mohan S, Cooper DM. Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men. J Clin Endocrinol Metab. 1996;81:3492-3497.
35. Cappon J, Brasel JA, Mohan S, Cooper DM. Effect of brief exercise on circulating insulin-like growth factor I. J Appl Physiol. 1994;76:2490-2496.
36. Dall R, Kanaley J, Hansen TK, et al. Plasma ghrelin levels during exercise in healthy subjects and in growth hormone-deficient patients. Eur J Endocrinol. 2002;147:65-70.
37. Ehrnborg C, Lange KH, Dall R, et al. The growth hormone/insulin-like growth factor-I axis hormones and bone markers in elite athletes in response to a maximum exercise test. J Clin Endocrinol Metab. 2003;88:394-401.
38. Brahm H, Piehl-Aulin K, Saltin B, Ljunghall S. Net fluxes over working thigh of hormones, growth factors and biomarkers of bone metabolism during short lasting dynamic exercise. Calcif Tissue Int. 1997;60:175-180.
39. Koziris LP, Hickson RC, Chatterton RT, Jr., et al. Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in long-term training. J Appl Physiol. 1999;86:1436-1442.
40. Pyka G, Taaffe DR, Marcus R. Effect of a sustained program of resistance training on the acute growth hormone response to resistance exercise in older adults. Horm Metab Res. 1994;26:330-333.
41. Parkhouse WS, Coupland DC, Li C, Vanderhoek KJ. IGF-1 bioavailability is increased by resistance training in older women with low bone mineral density. Mech Ageing Dev. 2000;113:75-83.
42. Chicharro JL, Lopez-Calderon A, Hoyos J, et al. Effects of an endurance cycling competition on resting serum insulin-like growth factor I (IGF-I) and its binding proteins IGFBP-1 and IGFBP-3. Br J Sports Med. 2001;35:303-307.
43. Marx JO, Ratamess NA, Nindl BC, et al. Low-volume circuit versus high-volume periodized resistance training in women. Med Sci Sports Exerc. 2001;33:635-643.
44. Borst SE, De Hoyos DV, Garzarella L, et al. Effects of resistance training on insulin-like growth factor-I and IGF binding proteins. Med Sci Sports Exerc. 2001;33:648-653.
45. Roelen CA, de Vries WR, Koppeschaar HP, Vervoorn C, Thijssen JH, Blankenstein MA. Plasma insulin-like growth factor-I and high affinity growth hormone-binding protein levels increase after two weeks of strenuous physical training. Int J Sports Med. 1997;18:238-241.
46. Kraemer WJ, Hakkinen K, Triplett-McBride NT, et al. Physiological changes with periodized resistance training in women tennis players. Med Sci Sports Exerc. 2003;35: 157-168.
47. Manetta J, Brun JF, Maimoun L, Fedou C, Prefaut C, Mercier J. The effects of intensive training on insulin-like growth factor I (IGF-I) and IGF binding proteins 1 and 3 in competitive cyclists: relationships with glucose disposal. J Sports Sci. 2003;21:147-154.
48. Eliakim A, Scheett TP, Newcomb R, Mohan S, Cooper DM. Fitness, training, and the growth hormoneinsulin-like growth factor I axis in prepubertal girls. J Clin Endocrinol Metab. 2001;86:2797-2802.
49. Bermon S, Ferrari P, Bernard P, Altare S, Dolisi C. Responses of total and free insulinlike growth factor-I and insulin-like growth factor binding protein-3 after resistance exercise and training in elderly subjects. Acta Physiol Scand. 1999;165:51-56.
50. Poehlman ET, Rosen CJ, Copeland KC. The influence of endurance training on insulin-like growth factor-1 in older individuals. Metabolism. 1994;43:1401-1405.
51. Bonnefoy M, Kostka T, Patricot MC, Berthouze SE, Mathian B, Lacour JR. Influence of acute and chronic exercise on insulin-like growth factor-I in healthy active elderly men and women. Aging. (Milano) 1999;11:373-379.
52. McCall GE, Byrnes WC, Fleck SJ, Dickinson A, Kraemer WJ. Acute and chronic hormonal responses to resistance training designed to promote muscle hypertrophy. Can J Appl Physiol. 1999;24:96-107.
53. Hagberg JM, Seals DR, Yerg JE, et al. Metabolic responses to exercise in young and older athletes and sedentary men. J Appl Physiol. 1988;65:900-908.
54. Kostka T, Arsac LM, Patricot MC, Berthouze SE, Lacour JR, Bonnefoy M. Leg extensor power and dehydroepiandrosterone sulfate, insulin-like growth factor-I and testosterone in healthy active elderly people. Eur J Appl Physiol. 2000;82:83-90.
55. Bonnefoy M, Kostka T, Patricot MC, Berthouze SE, Mathian B, Lacour JR. Physical activity and dehydroepiandrosterone sulphate, insulin-like growth factor I and testosterone in healthy active elderly people. Age Ageing. 1998;27:745-751.
56. Bonnefoy M, Patricot MC, Lacour JR, Rahmani A, Berthouze S, Kostka T. [Relation between physical activity, muscle function and IGF-1, testosterone and DHEAS concentrations in the elderly]. Rev Med Interne. 2002;23:819-827.
57. Kiel DP, Puhl J, Rosen CJ, Berg K, Murphy JB, MacLean DB. Lack of an association between insulin-like growth factor-I and body composition, muscle strength, physical performance or self-reported mobility among older persons with functional limitations. J Am Geriatr Soc. 1998;46:822-828.
58. Cooper CS, Taaffe DR, Guido D, Packer E, Holloway L, Marcus R. Relationship of chronic endurance exercise to the somatotropic and sex hormone status of older men. Eur J Endocrinol. 1998;138:517-523.
59. Deuschle M, Blum WF, Frystyk J, et al. Endurance training and its effect upon the activity of the GH-IGFs system in the elderly. Int J Sports Med. 1998;19:250-254.
60. Haydar ZR, Blackman MR, Tobin JD, Wright JG, Fleg JL. The relationship between aerobic exercise capacity and circulating IGF-1 levels in healthy men and women. J Am Geriatr Soc. 2000;48:139-145.
61. Teramukai S, Rohan T, Eguchi H, Oda T, Shinchi K, Kono S. Anthropometric and behavioral correlates of insulin-like growth factor I and insulin-like growth factor binding protein 3 in middle-aged Japanese men. Am J Epidemiol. 2002;156:344-348.
62. Laughlin GA, Yen SS. Nutritional and endocrine-metabolic aberrations in amenorrheic athletes. J Clin Endocrinol Metab. 1996;81:4301-4309.
63. Jorgensen JO, Vahl N, Hansen TB, et al. Determinants of serum insulin-like growth factor I in growth hormone deficient adults as compared to healthy subjects. Clin Endocrinol. (Oxford) 1998;48:479-486.
64. Rollero A, Murialdo G, Fonzi S, et al. Relationship between cognitive function, growth hormone and insulin-like growth factor I plasma levels in aged subjects. Neuropsy-chobiology. 1998;38:73-79.
65. Goodman-Gruen D, Barrett-Connor E. Epidemiology of insulin-like growth factor-I in elderly men and women. The Rancho Bernardo Study. Am J Epidemiol. 1997;145: 970-976.
66. Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, et al. Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clin Endocrinol. (Oxford) 1994;41:351-357.
67. Hansen RD, Allen BJ. Habitual physical activity, anabolic hormones, and potassium content of fat-free mass in postmenopausal women. Am J Clin Nutr. 2002;75:314-320.
68. Thorsen K, Nordstrom P, Lorentzon R, Dahlen GH. The relation between bone mineral density, insulin-like growth factor I, lipoprotein (a), body composition, and muscle strength in adolescent males. J Clin Endocrinol Metab. 1999;84:3025-3029.
69. Voskuil DW, de Mesquita HB, Kaaks R, et al. Determinants of circulating insulinlike growth factor (IGF)-I and IGF binding proteins 1-3 in premenopausal women: physical activity and anthropometry (Netherlands). Cancer Causes Control. 2001;12: 951-958.
70. Holmes MD, Pollak MN, Hankinson SE. Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prev. 2002;11:862-867.
71. Baibas N, Bamia C, Vassilopoulou E, Sdrolias J, Trichopoulou A, Trichopoulos D. Dietary and lifestyle factors in relation to plasma insulin-like growth factor I in a general population sample. Eur J Cancer Prev. 2003;12:229-234.
72. Allen NE, Appleby PN, Kaaks R, Rinaldi S, Davey GK, Key TJ. Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women. Cancer Causes Control. 2003;14:65-74.
73. Koistinen H, Koistinen R, Selenius L, Ylikorkala Q, Seppala M. Effect of marathon run on serum IGF-I and IGF-binding protein 1 and 3 levels. J Appl Physiol. 1996;80: 760-764.
74. Di Luigi L, Guidetti L, Nordio M, Baldari C, Romanelli F. Acute effect of physical exercise on serum insulin-like growth factor-binding protein 2 and 3 in healthy men: role of exercise-linked growth hormone secretion. Int J Sports Med. 2001;22:103-110.
75. Nindl BC, Kraemer WJ, Marx JO, et al. Overnight responses of the circulating IGF-I system after acute, heavy-resistance exercise. J Appl Physiol. 2001;90:1319-1326.
76. Copeland JL, Consitt LA, Tremblay MS. Hormonal responses to endurance and resistance exercise in females aged 19-69 years. J Gerontol A Biol Sci Med Sci. 2002;57: B158-B165.
77. Kraemer WJ, Volek JS, Bush JA, Putukian M, Sebastianelli WJ. Hormonal responses to consecutive days of heavy-resistance exercise with or without nutritional supplementation. J Appl Physiol. 1998;85:1544-1555.
78. Jahreis G, Hesse V, Schmidt HE, Scheibe J. Effect of endurance exercise on somatomedin-C/insulin-like growth factor I concentration in male and female runners. Exp Clin Endocrinol. 1989;94:89-96.
79. Bang P, Brandt J, Degerblad M, et al. Exercise-induced changes in insulin-like growth factors and their low molecular weight binding protein in healthy subjects and patients with growth hormone deficiency. Eur J Clin Invest. 1990;20:285-292.
80. Kraemer RR, Kilgore JL, Kraemer GR, Castracane VD. Growth hormone, IGF-I, and testosterone responses to resistive exercise. Med Sci Sports Exerc. 1992;24:1346-1352.
81. Kraemer WJ, Fleck SJ, Dziados JE, et al. Changes in hormonal concentrations after different heavy-resistance exercise protocols in women. J Appl Physiol. 1993;75: 594-604.
82. Hopkins NJ, Jakeman PM, Hughes SC, Holly JM. Changes in circulating insulinlike growth factor-binding protein-1 (IGFBP-1) during prolonged exercise: effect of carbohydrate feeding. J Clin Endocrinol Metab. 1994;79:1887-1890.
83. Kraemer WJ, Aguilera BA, Terada M, et al. Responses of IGF-I to endogenous increases in growth hormone after heavy-resistance exercise. J Appl Physiol. 1995;79:1310-1315.
84. Di Luigi L, Conti FG, Casini A, et al. Growth hormone and insulin-like growth factor I responses to moderate submaximal acute physical exercise in man: effects of octreotide, a somatostatin analogue, administration. Int J Sports Med. 1997;18:257-263.
85. Manetta J, Brun JF, Maimoun L, Callis A, Prefaut C, Mercier J. Effect of training on the GH/IGF-I axis during exercise in middle-aged men: relationship to glucose homeostasis. Am J Physiol Endocrinol Metab. 2002;283:E929-E936.
86. Lange KH, Larsson B, Flyvbjerg A, et al. Acute growth hormone administration causes exaggerated increases in plasma lactate and glycerol during moderate to high intensity bicycling in trained young men. J Clin Endocrinol Metab. 2002;87:4966-4975.
87. Nemet D, Rose-Gottron CM, Mills PJ, Cooper DM. Effect of water polo practice on cytokines, growth mediators, and leukocytes in girls. Med Sci Sports Exerc. 2003;35: 356-363.
88. Chandler RM, Byrne HK, Patterson JG, Ivy JL. Dietary supplements affect the anabolic hormones after weight-training exercise. J Appl Physiol. 1994;76:839-845.
89. Gursel Y, Ergin S, Ulus Y, Erdogan MF, Yalcin P, Evcik D. Hormonal responses to exercise stress test in patients with fibromyalgia syndrome. Clin Rheumatol. 2001;20: 401-405.
90. Kemmler W, Wildt L, Engelke K, et al. Acute hormonal responses of a high impact physical exercise session in early postmenopausal women. Eur J Appl Physiol. 2003;90: 199-209.
91. De Palo EF, Gatti R, Lancerin F, et al. Effects of acute, heavy-resistance exercise on urinary peptide hormone excretion in humans. Clin Chem Lab Med. 2003;41:1308-1313.
92. Raastad T, Glomsheller T, Bjoro T, Hallen J. Recovery of skeletal muscle contractility and hormonal responses to strength exercise after two weeks of high-volume strength training. Scand J Med Sci Sports. 2003;13:159-168.
93. Raastad T, Glomsheller T, Bjoro T, Hallen J. Changes in human skeletal muscle contractility and hormone status during 2 weeks of heavy strength training. Eur J Appl Physiol. 2001;84:54-63.
94. Hakkinen K, Pakarinen A, Kraemer WJ, Hakkinen A, Valkeinen H, Alen M. Selective muscle hypertrophy, changes in EMG and force, and serum hormones during strength training in older women. J Appl Physiol. 2001;91:569-580.
95. Kraemer WJ, Hakkinen K, Newton RU, et al. Effects of heavy-resistance training on hormonal response patterns in younger vs. older men. J Appl Physiol. 1999;87:982-992.
96. Vitiello MV, Wilkinson CW, Merriam GR, et al. Successful 6-month endurance training does not alter insulin-like growth factor-I in healthy older men and women. J Gerontol A Biol Sci Med Sci. 1997;52:M149-M154.
97. Maddalozzo GF, Snow CM. High intensity resistance training: effects on bone in older men and women. Calcif Tissue Int. 2000;66:399-404.
98. Lange KH, Lorentsen J, Isaksson F, et al. Endurance training and GH administration in elderly women: effects on abdominal adipose tissue lipolysis. Am J Physiol Endocrinol Metab. 2001;280:E886-E897.
99. Yarasheski KE, Campbell JA, Kohrt WM. Effect of resistance exercise and growth hormone on bone density in older men. Clin Endocrinol. (Oxford) 1997;47:223-229.
100. Nicklas BJ, Ryan AJ, Treuth MM, et al. Testosterone, growth hormone and IGF-I responses to acute and chronic resistive exercise in men aged 55-70 years. Int J Sports Med. 1995;16:445-450.
101. Hellenius ML, Brismar KE, Berglund BH, de Faire UH. Effects on glucose tolerance, insulin secretion, insulin-like growth factor 1 and its binding protein, IGFBP-1, in a randomized controlled diet and exercise study in healthy, middle-aged men. J Intern Med. 1995;238:121-130.
102. Hakkinen K, Pakarinen A, Hannonen P, et al. Effects of strength training on muscle strength, cross-sectional area, maximal electromyographic activity, and serum hormones in premenopausal women with fibromyalgia. J Rheumatol. 2002;29:1287-1295.
103. Hering S, Jost C, Schulz H, Hellmich B, Schatz H, Pfeiffer H. Circulating transforming growth factor beta1 (TGFbeta1) is elevated by extensive exercise. Eur J Appl Physiol. 2002;86:406-410.
104. Milliken LA, Going SB, Houtkooper LB, et al. Effects of exercise training on bone remodeling, insulin-like growth factors, and bone mineral density in postmenopausal women with and without hormone replacement therapy. Calcif Tissue Int. 2003.
105. Hennessey JV, Chromiak JA, DellaVentura S, et al. Growth hormone administration and exercise effects on muscle fiber type and diameter in moderately frail older people. J Am Geriatr Soc. 2001;49:852-858.
106. Borst SE, Vincent KR, Lowenthal DT, Braith RW. Effects of resistance training on insulin-like growth factor and its binding proteins in men and women aged 60 to 85. J Am Geriatr Soc. 2002;50:884-888.
107. Buckley JD, Abbott MJ, Brinkworth GD, Whyte PB. Bovine colostrum supplementation during endurance running training improves recovery, but not performance. J Sci Med Sport. 2002;5:65-79.
108. Eliakim A, Brasel JA, Mohan S, Barstow TJ, Berman N, Cooper DM. Physical fitness, endurance training, and the growth hormone-insulin-like growth factor I system in adolescent females. J Clin Endocrinol Metab. 1996;81:3986-3992.
109. Eliakim A, Nemet D, Bar-Sela S, Higer Y, Falk B. Changes in circulating IGF-I and their correlation with self-assessment and fitness among elite athletes. Int J Sports Med. 2002;23:600-603.
110. Chang S, Wu X, Yu H, Spitz MR. Plasma concentrations of insulin-like growth factors among healthy adult men and postmenopausal women: associations with body composition, lifestyle, and reproductive factors. Cancer Epidemiol Biomarkers Prev. 2002;11:758-766.
111. Rudman D, Mattson DE. Serum insulin-like growth factor I in healthy older men in relation to physical activity. J Am Geriatr Soc. 1994;42:71-76.
112. Scheett TP, Mills PJ, Ziegler MG, Stoppani J, Cooper DM. Effect of exercise on cytokines and growth mediators in prepubertal children. Pediatr Res. 1999;46:429-434.
113. Zaccaria M, Varnier M, Piazza P, Noventa D, Ermolao A. Blunted growth hormone response to maximal exercise in middle-aged versus young subjects and no effect of endurance training. J Clin Endocrinol Metab. 1999;84:2303-2307.
114. Kohrt WM, Snead DB, Slatopolsky E, Birge SJ, Jr. Additive effects of weight-bearing exercise and estrogen on bone mineral density in older women. J Bone Miner Res. 1995;10:1303-1311.
115. Jahreis G, Kauf E, Frohner G, Schmidt HE. Influence of intensive exercise on insulinlike growth factor I, thyroid and steroid hormones in female gymnasts. Growth Regul. 1991;1:95-99.
116. Eliakim A, Brasel JA, Mohan S, Wong WL, Cooper DM. Increased physical activity and the growth hormone-IGF-I axis in adolescent males. Am J Physiol. 1998;275: R308-R314.
117. Nemet D, Oh Y, Kim HS, Hill M, Cooper DM. Effect of intense exercise on inflammatory cytokines and growth mediators in adolescent boys. Pediatrics. 2002;110: 681-689.
118. Daly RM, Rich PA, Klein R, Bass S. Effects of high-impact exercise on ultrasonic and biochemical indices of skeletal status: A prospective study in young male gymnasts. J Bone Miner Res. 1999;14:1222-1230.
119. Bell NH, Godsen RN, Henry DP, Shary J, Epstein S. The effects of muscle-building exercise on vitamin D and mineral metabolism. J Bone Miner Res. 1988;3:369-373.
120. Bamman MM, Shipp JR, Jiang J, et al. Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans. Am J Physiol Endocrinol Metab. 2001;280:E383-E390.
121. Schmitz KH, Ahmed RL, Yee D. Effects of a 9-month strength training intervention on insulin, insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and IGFBP-3 in 30-50-year-old women. Cancer Epidemiol Biomarkers Prev. 2002;11: 1597-1604.
122. Scheett TP, Nemet D, Stoppani J, Maresh CM, Newcomb R, Cooper DM. The effect of endurance-type exercise training on growth mediators and inflammatory cytokines in pre-pubertal and early pubertal males. Pediatr Res. 2002;52:491-497.
123. Barnard RJ, Ngo TH, Leung PS, Aronson WJ, Golding LA. A low-fat diet or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro. Prostate. 2003;56:201-206.
124. Filaire E, Jouanel P, Colombier M, Begue RJ, Lac G. Effects of 16 weeks of training prior to a major competition on hormonal and biochemical parameters in young elite gymnasts. J Pediatr Endocrinol Metab. 2003;16:741-750.
125. Wabitsch M, Blum WF, Muche R, et al. Insulin-like growth factors and their binding proteins before and after weight loss and their associations with hormonal and metabolic parameters in obese adolescent girls. Int J Obes Relat Metab Disord. 1996;20: 1073-1080.
126. Sartorio A, Lafortuna C, Capodaglio P, Vangeli V, Narici MV, Faglia G. Effects of a 16-week progressive high-intensity strength training (HIST) on indexes of bone turnover in men over 65 years: a randomized controlled study. J Endocrinol Invest. 2001;24:882-886.
127. Nindl BC, Friedl KE, Frykman PN, Marchitelli LJ, Shippee RL, Patton JF. Physical performance and metabolic recovery among lean, healthy men following a prolonged energy deficit. Int J Sports Med. 1997;18:317-324.
128. Zajadacz B. Adipose tissue distribution and behaviour of selected gastro-entero-pan-creatic hormones, glycaemia, growth hormone and somatomedin C in obese children. Mater Med Pol. 1998;30:20-27.
129. Roemmich JN, Sinning WE. Weight loss and wrestling training: effects on growth-related hormones. J Appl Physiol. 1997;82:1760-1764.
130. Zanker CL, Swaine IL. Responses of bone turnover markers to repeated endurance running in humans under conditions of energy balance or energy restriction. Eur J Appl Physiol. 2000;83:434-440.
131. Smith AT, Clemmons DR, Underwood LE, Ben Ezra V, McMurray R. The effect of exercise on plasma somatomedin-C/insulinlike growth factor I concentrations. Metabolism. 1987;36:533-537.
132. Nemet D, Connolly PH, Pontello-Pescatello AM, et al. Negative energy balance plays a major role in the IGF-I response to exercise training. J Appl Physiol. 2003; 96(1):276-282.
133. Yarasheski KE, Campbell JA, Smith K, Rennie MJ, Holloszy JO, Bier DM. Effect of growth hormone and resistance exercise on muscle growth in young men. Am J Physiol. 1992;262:E261-E267.
134. Wideman L, Weltman JY, Shah N, Story S, Veldhuis JD, Weltman A. Effects of gender on exercise-induced growth hormone release. J Appl Physiol. 1999;87:1154-1162.
135. Eliakim A, Brasel JA, Cooper DM. GH response to exercise: assessment of the pituitary refractory period, and relationship with circulating components of the GH-IGF-I axis in adolescent females. J Pediatr Endocrinol Metab. 1999;12:47-55.
136. Meeking DR, Wallace JD, Cuneo RC, Forsling M, Russell-Jones DL. Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects. Eur J Endocrinol. 1999;141:22-26.
137. Abbasi A, Duthie EH, Jr., Sheldahl L, et al. Association of dehydroepiandrosterone sulfate, body composition, and physical fitness in independent community-dwelling older men and women. J Am Geriatr Soc. 1998;46:263-273.
138. Ronsen O, Haug E, Pedersen BK, Bahr R. Increased neuroendocrine response to a repeated bout of endurance exercise. Med Sci Sports Exerc. 2001;33:568-575.
139. Eliakim A, Brasel JA, Barstow TJ, Mohan S, Cooper DM. Peak oxygen uptake, muscle volume, and the growth hormone-insulin-like growth factor-I axis in adolescent males. Med Sci Sports Exerc. 1998;30:512-517.
140. Consitt LA, Copeland JL, Tremblay MS. Hormone responses to resistance vs. endurance exercise in premenopausal females. Can J Appl Physiol. 2001;26:574-587.
141. Figueroa A, Going SB, Milliken LA, et al. Effects of exercise training and hormone replacement therapy on lean and fat mass in postmenopausal women. J Gerontol A Biol Sci Med Sci. 2003;58:M266-M270.
142. Raastad T, Bjoro T, Hallen J. Hormonal responses to high- and moderate-intensity strength exercise. Eur J Appl Physiol. 2000;82:121-128.
143. Schmidt W, Dore S, Hilgendorf A, Strauch S, Gareau R, Brisson GR. Effects of exercise during normoxia and hypoxia on the growth hormone-insulin-like growth factor I axis. Eur J Appl Physiol Occup Physiol. 1995;71:424-430.
144. Neri Serneri GG, Boddi M, Modesti PA, et al. Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes. Circ Res. 2001;89:977-982.
145. Suikkari AM, Sane T, Seppala M, Yki-Jarvinen H, Karonen SL, Koivisto VA. Prolonged exercise increases serum insulin-like growth factor-binding protein concentrations. J Clin Endocrinol Metab. 1989;68:141-144.
146. De Palo EF, Gatti R, Lancerin F, et al. Urinary insulin-like growth factor I in athletes, before and after physical exercise, and in sedentary subjects. Clin Chim Acta. 2002;322: 51-57.
147. Singh MA, Ding W, Manfredi TJ, et al. Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. Am J Physiol. 1999;277:E135-E143.
148. Bamman MM, Hill VJ, Adams GR, et al. Gender differences in resistance-training-induced myofiber hypertrophy among older adults. J Gerontol A Biol Sci Med Sci. 2003;58:108-116.
149. Banfi G, Marinelli M, Roi GS, et al. Growth hormone and insulin-like growth factor I in athletes performing a marathon at 4000 m of altitude. Growth Regul. 1994;4:82-86.
150. Poehlman ET, Toth MJ, Ades PA, Rosen CJ. Menopause-associated changes in plasma lipids, insulin-like growth factor I and blood pressure: a longitudinal study. Eur J Clin Invest. 1997;27:322-326.
151. Nindl BC, Castellani JW, Young AJ, et al. Differential responses of IGF-I molecular complexes to military operational field training. J Appl Physiol. 2003;95:1083-1089.
152. Hug M, Mullis PE, Vogt M, Ventura N, Hoppeler H. Training modalities: over-reaching and over-training in athletes, including a study of the role of hormones. Best Pract Res Clin Endocrinol Metab. 2003;17:191-209.
153. Ghigo E, Aimaretti G, Gianotti L, Bellone J, Arvat E, Camanni F. New approach to the diagnosis of growth hormone deficiency in adults. Eur J Endocrinol. 1996;134: 352-356.
154. Nemet D, Cooper DM. Exercise, diet, and childhood obesity: the GH-IGF-I connection. J Pediatr Endocrinol Metab. 2002;15 Suppl 2:751-757.
155. Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst. 2000;92:1472-1489.
156. Duclos M. [Effects of physical training on endocrine functions]. Ann Endocrinol. (Paris) 2001;62:19-32.
157. Mazzeo RS. Aging, immune function, and exercise: hormonal regulation. Int J Sports Med. 2000;21 Suppl 1:S10-S13.
158. Consitt LA, Copeland JL, Tremblay MS. Endogenous anabolic hormone responses to endurance versus resistance exercise and training in women. Sports Med. 2002;32: 1-22.
159. Sandhu MS, Dunger DB, Giovannucci EL. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst. 2002;94:972-980.
160. Bang P, Ahlsen M, Berg U, Carlsson-Skwirut C. Free insulin-like growth factor I: are we hunting a ghost? Horm Res. 2001;55 Suppl 2:84-93.
161. Clemmons DR. Commercial assays available for insulin-like growth factor I and their use in diagnosing growth hormone deficiency. Horm Res. 2001;55 Suppl 2:73-79.