Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in long-term training

Journal of Applied Physiology

Volumn 86, Issue 4, 1999, Pages 1436-1442

  Koziris, L P ^a   Hickson, R C ^a   Chatterton Jr , R T ^b   Groseth, R T ^c   Christie, J M ^a   Goldflies, D G ^c   Unterman, T G ^d  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d VA Westside Medical Center   (United States)

Author keywords

Cortisol; Exercise; Insulin like growth factor I; Insulin like growth factor binding protein 1; Insulin like growth factor binding protein 3; Men; Women

Indexed keywords

HYDROCORTISONE; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 3;

ADULT; ARTICLE; BODY MASS; FEMALE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN SECRETION; SKINFOLD; SWIMMING; TRAINING;

EID: 0032947177     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.86.4.1436     Document Type: Article

References (36)

1. Adams, G. R., and F. Haddad. The relationships among IGF-I, DNA content, and protein accumulation during skeletal muscle hypertrophy. J. Appl. Physiol. 81: 2509-2516, 1996.
2. Bang, P., J. Brandt, M. Degerblad, G. Enberg, L. Kaiser, M. Thoren, and K. Hall. Exercise-induced changes in insulin-like growth factors and their low molecular weight binding proteins in healthy subjects and patients with growth hormone deficiency. Eur. J. Clin. Invest. 20: 285-292, 1990.
3. Baxter, R. C., A. M. Suikkari, and J. L. Martin. Characterization of the binding defect in insulin-like growth factor binding protein-3 from pregnancy serum. Biochem. J. 294: 847-852, 1993.
4. Binoux, M. GH, IGFs, IGF-binding protein-3 and acid-labile subunit: what is the pecking order? Eur. J. Endocrinol. 137: 605-609, 1997.
5. Blat, C., J. Villaudy, and M. Binoux. In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells. J. Clin. Invest. 93: 2286-2290, 1994.
6. Cappon, J., J. Brasel, S. Mohan, and D. M. Cooper. Effect of brief exercise on circulating insulin-like growth factor I. J. Appl. Physiol. 76: 2490-2496, 1994.
7. Chatterton, R. T., Jr., K. M. Vogelsong, Y.-C. Lu, and G. A. Hudgens. Hormonal responses to psychological stress in men preparing for skydiving. J. Clin. Endocrinol. Metab. 82: 2503-2509, 1997.
8. Czerwinski, S. M., J. M. Martin, and P. J. Bechtel. Modulation of IGF mRNA abundance during stretch-induced skeletal muscle hypertrophy and regression. J. Appl. Physiol. 76: 2026-2030, 1994.
9. Donath, M. Y., R. Jenni, H.-P. Brunner, M. Anrig, S. Kohli, Y. Glatz, and E. R. Froesch. Cardiovascular and metabolic effects of insulin-like growth factor I at rest and during exercise in humans. J. Clin. Endocrinol. Metab. 81: 4089-4094, 1996.
10. Eliakim, A., M. Moromisato, D. Moromisato, J. Brasel, C. Roberts, and D. M. Cooper. Increase in muscle IGF-I protein but not IGF-I mRNA after 5 days of endurance training in young rats. Am. J. Physiol. 273 (Regulatory Integrative Comp. Physiol. 42): R1557-R1561, 1997.
11. Freestone, N. S., S. Ribaric, and W. T. Mason. The effect of insulin-like growth factor-I on adult rat cardiac contractility. Mol. Cell. Biochem. 163/164: 223-229, 1996.
12. Frystyk, J., C. Skjaerbaek, B. Dinesen, and H. Orskov. Free insulin-like growth factors (IGF-I and IGF-II) in human serum. FEBS Lett. 348: 185-191, 1994.
13. Frystyk, J., E. Vesbo, C. Skjaerbaek, C. Mogensen, and H. Orskov. Free insulin-like growth factors in human obesity. Metabolism 44, Suppl. 4: 37-44, 1995.
14. Hagberg, J. M., D. R. Seals, J. E. Yerg, J. Gavin, R. Gingrich, B. Premachandra, and J. O. Holloszy. Metabolic responses to exercise in young and older athletes and sedentary men. J. Appl. Physiol. 65: 900-908, 1982.
15. Hellenius, M.-L., K. E. Brismar, B. H. Berglund, and U. H. De Faire. Effects on glucose tolerance, insulin secretion, insulin-like growth factor I and its binding protein, IGFBP-1, in a randomized controlled diet and exercise study in healthy, middle-aged men. J. Intern. Med. 238: 121-130, 1995.
16. Hill, R. A., and J. M. Pell. Regulation of insulin-like growth factor I (IGF-I) bioactivity in vivo: further characterization of an IGF-I-enchancing antibody. Endocrinology 139: 1278-1287, 1998.
17. Hokama, J. Y., R. S. Streeper, and E. J. Henriksen. Voluntary exercise training enhances glucose transport in muscle stimulated by insulin-like growth factor I. J. Appl. Physiol. 82: 508-512, 1997.
18. Hopkins, N. J., P. M. Jakeman, S. Cwyfan Hughes, and J. M. P. Holly. Changes in circulating insulin-like growth factor-binding protein-1 (IGFBP-1) during prolonged exercise: effect of carbohydrate feeding. J. Clin. Endocrinol. Metab. 79: 1887-1890, 1994.
19. Kim, H. S., S. R. Nagalla, Y. Oh, E. Wilson, C. T. Roberts, Jr., and R. G. Rosenfeld. Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily. Proc. Natl. Acad. Sci. USA 94: 12981-12986, 1997.
20. Koistinen, H., R. Koistinen, L. Selenius, O. Ylikorkala, and M. Seppala. Effect of marathon run on serum IGF-I and IGF-binding protein 1 and 3 levels. J. Appl. Physiol. 80: 760-764, 1996.
21. Kraemer, W. J., L. Marchitelli, and S. E. Gordon. Hormonal and growth factor responses to heavy resistance exercise protocols. J. Appl. Physiol. 69: 1442-1450, 1990.
22. Lassarre, C., C. Lalou, L. Perin, and M. Binoux. Protease-induced alteration of insulin-like growth factor binding protein-3 as detected by radioimmunoassay. Agreement with ligand blotting data. Growth Regul. 4: 48-55, 1994.
23. Lee, P. D. K., L. C. Giudice, C. A. Conover, and D. R. Powell. Insulin-like growth factor binding protein-1: recent findings and new directions. Proc. Soc. Exp. Biol. Med. 216: 319-357, 1997.
24. Miles, L. E. M., D. A. Lipschitz, C. P. Bieber, and J. D. Cook. Measurement of serum ferritin by a 2-site immunoradiometric assay. Anal. Biochem. 61: 209-224, 1974.
25. Poehlman, E. T., and K. C. Copeland. Influence of physical activity on insulin-like growth factor-I in healthy younger and older men. J. Clin. Endocrinol. Metab. 71: 1468-1473, 1990.
26. Poehlman, E. T., C. J. Rosen, and K. C. Copeland. The influence of endurance training on insulin-like growth factor-I in older individuals. Metabolism 43: 1401-1405, 1994.
27. Roelen, C. A. M., W. R. deVries, H. P. F. Koppeschaar, C. Vervoorn, J. H. H. Thijssin, and M. A. Blankenstein. Plasma insulin-like growth factor-I and high affinity growth hormone-binding protein levels increase after two weeks of strenuous physical training. Int. J. Sports Med. 18: 238-241, 1997.
28. Rutishauser, J., C. Schmid, C. Hauri, E. R. Froesch, and J. Zapf. Growth hormone, but not insulin-like growth factor I, induces a serum protease activity for insulin-like growth factor binding protein-3 in hypophysectomized rats in vivo. FEBS Lett. 334: 23-26, 1993.
29. Schwarz, A. J., J. A. Brasel, R. L. Hintz, S. Mohan, and D. M. Cooper. Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF), I, II, and IGF-binding protein-3 and its proteolysis in young healthy men. J. Clin. Endocrinol. Metab. 81: 3492-3497, 1996.
30. Shimasaki, S., and N. Ling. Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5, -6). Prog. Growth Factor Res. 3: 243-266, 1991.
31. Skjaerbaek, C., J. Frystyk, J. Moller, J. S. Christiansen, and H. Orskov. Free and total insulin-like growth factors and insulin-like growth factor binding proteins during 14 days of growth hormone administration in healthy adults. Eur. J. Endocrinol. 135: 672-677, 1996.
32. Suikkari, A. M., T. Sane, M. Seppala, H. Yki Jarvinen, S. L. Karonen, and V. A. Koivisto. Prolonged exercise increases serum insulin-like growth factor-binding protein concentrations. J. Clin. Endocrinol. Metab. 68: 141-144, 1989.
33. Unterman, T. G., D. T. Oehler, L. J. Murphy, and R. G. Lacson. Multihormonal regulation of insulin-like growth factor-binding protein-1 in rat H4IIE Hepatoma cells: the dominant role of insulin. Endocrinology 128: 2693-2701, 1991.
34. Vetter, U., C. Kupferschmid, D. Lang, and S. Pentz. Insulin-like growth factors and insulin increase the contractility of neonatal rat cardiocytes in vitro. Basic Res. Cardiol. 83: 647-654, 1988.
35. Villanueva, A. L., C. Schlosser, B. Hopper, J. H. Liu, D. I. Hoffman, and R. W. Rebar. Increased cortisol production in women runners. J. Clin. Endocrinol. Metab. 63: 133-136, 1986.
36. Wilkinson, L. SYSTAT: The System for Statistics. Evanston, IL: SYSTAT Inc., 1987.