Effect of resistance exercise and growth hormone on bone density in older men

Clinical Endocrinology

Volumn 47, Issue 2, 1997, Pages 223-229

  Yarasheski, Kevin E ^a   Campbell, Jill A ^a   Kohrt, Wendy M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; OSTEOCALCIN; SOMATOMEDIN C;

AGED; ARTICLE; BODY COMPOSITION; BONE DENSITY; BONE MINERAL; BONE REMODELING; BONE TURNOVER; CONTROLLED STUDY; DIETARY INTAKE; DUAL ENERGY X RAY ABSORPTIOMETRY; EXERCISE; HORMONE SUBSTITUTION; HUMAN; HUMAN EXPERIMENT; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

EID: 0030801116     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1997.2461060.x     Document Type: Article

References (38)

1. Aloia, J.F., Roginsky, M.S., Jowsey, J., Dombrowski, C.S., Shukla, K.K. & Cohn, S.H. (1972) Skeletal metabolism and body composition in acromegaly. Journal of Clinical Endocrinology and Metabolism, 35, 543-551.
2. Baum, H.B.A., Biller, B.M.K., Baker, B.E. & Klibanski, A. (1994) Physiologic growth hormone (GH) replacement improves body composition and bone density in men with adult-onset GH-deficiency. Endocrine Society Abstracts, 279.
3. Beshyah, S.A., Freemantle, C., Thomas, E., Rutherford, O., Page, B., Murphy, M. & Johnston, D.G. (1995a) Abnormal body composition and reduced bone mass in growth hormone deficient adults. Clinical Endocrinology, 42, 179-189.
4. Beshyah, S.A., Kyd, P., Thomas, E., Fairney, E. & Johnston, D.G. (1995b) The effects of prolonged growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults. Clinical Endocrinology, 42, 249-254.
5. Binnerts, A., Swan, G.R., Wilson, J.H.P., Hoogerbruge, N., Pols, H.A.P., Birkenhager, J.C. & Lamberts, S.W.J. (1992) The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as body composition. Clinical Endocrinology, 37, 79-87.
6. Clemmesen, B., Overgaard, K., Riis, B. & Christiansen, C. (1993) Human growth hormone and growth hormone releasing hormone: a double-masked, placebo-controlled study of their effects on hone metabolism in elderly women. Osteoporosis International, 3, 330-336.
7. Davenport, M.L., Svoboda, M.E., Korber, K.L.J., Van Wyk, J., Clemmons, D.R. & Underwood, L.E. (1988) Serum concentrations of insulin-like growth factor II are not changed by short term fasting and refeeding. Journal of Clinical Endocrinology and Metabolism, 67, 1231-1236.
8. Degerblad, M. Bengtsson, B.A., Bramnert, M., Johnell, O., Manhem, P., Rosén, T. & Thorén, M. (1995) Reduced bone mineral density in adults with growth hormone (GH) deficiency: increased bone turnover during 12 months of GH substitution therapy. European Journal of Endocrinology, 133, 180-188.
9. Gleeson, P.B., Protas, E.J., LeBlanc, A.D., Schneider, V.S. & Evans, H.J. (1990) Effects of weight lifting on bone mineral density in premenopausal women. Journal of Bone and Mineral Research, 5, 153-158.
10. Gundberg, C.M., Wilson, P.S., Gallop, P.M. & Parfitt, A.M. (1985) Determination of osteocalcin in human serum: results with two kits compared with those by a well-characterized assay. Clinical Chemistry, 31, 1720-1723.
11. Holloway, L., Butterfield, G., Hintz, R.L., Gesundheit, N. & Marcus, R. (1994) Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women. Journal of Clinical Endocrinology and Metabolism, 79, 470-479.
12. Holmes, S.J., Economou, G., Whitehouse, R.W., Adams, J.E. & Shalet, S.M. (1994) Reduced bone mineral density in patients with adult onset growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism, 78, 669-674.
13. Holmes, S.J., Whitehouse, R.W., Swindell, R., Economou, G., Adams, J.E. & Shalet, S.M. (1995) Effect of growth hormone on bone mass in adults with adult onset growth hormone deficiency. Clinical Endocrinology, 42, 627-633.
14. Johansen, J.S., Pedersen, S.A., Jorgensen, J.O.L., Riis, B.J., Christiansen, C., Christiansen, J.S. & Skakkebaek, N.B. (1990) Effects of growth hormone (GH) on plasma bone Gla protein in GH-deficient adults. Journal of Clinical Endocrinology and Metabolism, 70, 916-919.
15. Kohrt, W.M., Malley, M.T., Dalsky, G.P. & Holloszy, J.O. (1992) Body composition of healthy sedentary and trained young and older men and women. Medicine and Science in Sports and Exercise, 24, 832-837.
16. Kotzmann, H., Bernecker, P., Hubsch, P., Pietschmann, P., Woloszczuk, W., Svoboda, T., Geyer, G. & Luger, A. (1993) Bone mineral density and parameters of bone metabolism in patients with acromegaly. Journal of Bone and Mineral Research, 8, 459-465.
17. Menkes, A., Mazel, S., Redmond, R.A., Koffler, K., Libanati, C.R., Gundberg, C.M., Zizic, T.M., Hagberg, J.M., Pratley, R.E. & Hurley, B.F. (1993) Strength training increases bone mineral density and bone remodeling in middle-aged and older men. Journal of Applied Physiology, 74, 2478-2484.
18. Nelson, M.E., Fiatarone, M.A., Morganti, C.M., Trice, I., Greenberg, R. A. & Evans, W.J. (1994) Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures: a randomized control trial. Journal of the American Medical Association, 272, 1909-1914.
19. O'Halloran, D.J., Tsatsoulis, A., Whitehouse, R.W., Holmes, S.J., Adams, J.E. & Shalet, S.M. (1993) Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency. Journal of Clinical Endocrinology and Metabolism, 76, 1344-1348.
20. Parfitt, A.M. (1987) Bone remodeling and bone loss: understanding the pathophysiology of osteoporosis. Clinical Obstetrics and Gynecology, 30, 789-811.
21. Rockwell, J.C., Sorensen, A.M., Baker, S., Leahy, D., Stock, J.L., Michaels, J. & Baran, D.T. (1990) Weight training decreases vertebral bone density in premenopausal women: a prospective study. Journal of Clinical Endocrinology and Metabolism, 71, 988-993.
22. Rosén, T., Johannsson, G., Hallgren, P., Caidahl, K., Bosaeus, I. & Bengtsson, B.A. (1994) Beneficial effects of 12 months replacement therapy with recombinant human growth hormone to growth hormone deficient adults. Endocrinology and Metabolism, 1, 55-56.
23. Rubin, C.T. & Lanyon, L.E. (1984) Regulation of bone formation by applied dynamic loads. Journal of Bone and Joint Surgery - American Volume, 66, 397-402.
24. Rubin, C.T. & Lanyon, L.E. (1985) Regulation of bone mass by mechanical strain magnitude. Calcified Tissue International, 37, 411-417.
25. Rudman, D., Feller, A.G., Nagraj, H.S., Gergans, G.A., Lalitha, P.Y., Goldberg, A.F., Schlenker, R.A., Cohn, L., Rudman, I.W. & Mattson, D.E. (1990) Effects of human growth hormone in men over 60 years old. New England Journal of Medicine, 323, 1-6.
26. Ryan, A.S., Treuth, M.S., Rubin, M.A., Miller, J.P., Nicklas, B.J., Landis, D.M., Pratley, R.E., Libanati, C.R., Gundberg, C.M. & Hurley, B.F. (1994) Effects of strength training on bone mineral density: hormonal and bone turnover relationships. Journal of Applied Physiology, 77, 1678-1684.
27. Snow-Harter, C., Bouxsein, M.L., Lewis, B.T., Carter, D.R. & Marcus, R. (1992) Effects of resistance and endurance exercise on bone mineral status of young women: a randomized exercise intervention trial. Journal of Bone and Mineral Research, 7, 761-769.
28. Stiegler, C. & Leb, G. (1994) One year of replacement therapy in adults with growth hormone deficiency. Endocrinology and Metabolism. 1 (Suppl A), 37-42.
29. Thorèn, M., Soop, M., Degerblad, M. & Sääf, M. (1993) Preliminary study of the effects of growth hormone substitution therapy on bone mineral density and serum osteocalcin levels in adults with growth hormone deficiency. Acta Endocrinologica, 128 (Suppl. 2), 41-43.
30. Vandeweghe, M., Taelman, P. & Kaufman, J.M. (1993) Short- and long-term effects of growth hormone treatment on bone turnover and bone mineral content in adult growth hormone-deficient males. Clinical Endocrinology, 39, 409-415.
31. Yarasheski, K.E., Campbell, J.A., Holloszy, J.O. & Bier, D.M. (1990) Effect of strength training and growth hormone administration on serum insulin-like growth factor-1 and bone Gla-protein. Endocrine Society Abstracts, 295.
32. Yarasheski, K.E. & Zachwieja, J.J. (1993) Growth hormone therapy for the elderly: fountain of youth? Journal of the American Medical Association, 270, 1694.
33. Yarasheski, K.E., Zachwieja, J.J., Campbell, J.A. & Bier, D.M. (1995) Effect of growth hormone and resistance exercise on muscle growth and function in older men. American Journal of Physiology, 268 (Endocrinology and Metabolism, 31), E268-E276.
34. Yen, J.K. & Aloia, J.F. (1990) Effect of physical activity on calciotropic hormones and calcium balance in rats. American Journal of Physiology, 258 (Endocrinology and Metabolism, 21), E263-E268.
35. Yen, J.K., Liu, C.C. & Aloia, J.F. (1993) Effects of exercise and immobilization on bone formation and resorption in young rats. American Journal of Physiology, 264 (Endocrinology and Metabolism, 27), E182-E189.
36. Yeh, J.K., Aloia, J.F., Chen, M., Ling, N., Koo, H.-C. & Millard, W.J. (1994a) Effect of growth hormone administration and treadmill exercise on serum and skeletal IGF-I in rats. American Journal of Physiology, 266 (Endocrinology and Metabolism, 29), E129-E135.
37. Yeh, J.K., Aloia, J.F. & Chen, M. (1994b) Growth hormone administration potentiates the effect of treadmill exercise on long bone formation but not on the vertebrae in middle-aged rats. Calcified Tissue International, 54, 38-43.
38. Yeh, J.K., Aloia, J.F., Chen, M. & Sprintz, S. (1994c) Effect of growth hormone administration and treadmill exercise on the body composition of rats. Journal of Applied Physiology, 77, 23-29.