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Volumn 12, Issue 1, 2008, Pages 59-68

Targeting synuclein-γ to counteract drug resistance in cancer

Author keywords

Adjuvant therapy; Checkpoint signaling; Drug resistance; Peptide inhibitor; Protein protein interaction

Indexed keywords

ANKYRIN; ANTINEOPLASTIC AGENT; BUB1 RELATED PROTEIN; ESTROGEN RECEPTOR ALPHA; GAMMA SYNUCLEIN; MATRIX METALLOPROTEINASE; MESSENGER RNA; PACLITAXEL; SYNTHETIC PEPTIDE;

EID: 39049158181     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.12.1.59     Document Type: Review
Times cited : (20)

References (102)
  • 1
    • 39049103671 scopus 로고    scopus 로고
    • Homepage. Available from: URL:, last accessed 27 November, 2007
    • American Cancer Society. Homepage. Available from: URL: www.cancer.org [last accessed 27 November, 2007]
  • 2
    • 39049084630 scopus 로고    scopus 로고
    • Homepage. Available from: URL:, last accessed 27 November, 2007
    • Datamonitor. Homepage. Available from: URL: www.datamonitor.com [last accessed 27 November, 2007]
  • 3
    • 0032787785 scopus 로고    scopus 로고
    • Prospective randomized trial of docetaxel versus doxorubicin in patients with metastatic breast cancer
    • Chan S, Friedrichs K, Noel D, et al. Prospective randomized trial of docetaxel versus doxorubicin in patients with metastatic breast cancer. J Clin Oncol 1999;17(8):2341-54
    • (1999) J Clin Oncol , vol.17 , Issue.8 , pp. 2341-2354
    • Chan, S.1    Friedrichs, K.2    Noel, D.3
  • 4
    • 0031758794 scopus 로고    scopus 로고
    • A Phase II study of docetaxel in patients with paclitaxel-resistant metastatic breast cancer
    • Valero V, Jones SE, Von Hoff DD, et al. A Phase II study of docetaxel in patients with paclitaxel-resistant metastatic breast cancer. J Clin Oncol 1998;16(10):3362-8
    • (1998) J Clin Oncol , vol.16 , Issue.10 , pp. 3362-3368
    • Valero, V.1    Jones, S.E.2    Von Hoff, D.D.3
  • 5
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxua brevifolia
    • Wani MC, Taylor HL, Wall ME, et al. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxua brevifolia. J Am Chem Soc 1971;93(9):2325-7
    • (1971) J Am Chem Soc , vol.93 , Issue.9 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3
  • 6
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • Schiff PB, Fant J, Horwitz SB. Promotion of microtubule assembly in vitro by taxol. Nature 1979;277(5698):665-7
    • (1979) Nature , vol.277 , Issue.5698 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 7
    • 0031040149 scopus 로고    scopus 로고
    • The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents
    • Rowinsky EK. The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents. Ann Rev Med 1997;48:353-74
    • (1997) Ann Rev Med , vol.48 , pp. 353-374
    • Rowinsky, E.K.1
  • 8
    • 0027511187 scopus 로고
    • Mechanisms and modulation of resistance to chemotherapy in ovarian cancer
    • Perez RP, Hamilton TC, Ozols RF, Young RC. Mechanisms and modulation of resistance to chemotherapy in ovarian cancer. Cancer 1993;71(4 Suppl):1571-80
    • (1993) Cancer , vol.71 , Issue.4 SUPPL. , pp. 1571-1580
    • Perez, R.P.1    Hamilton, T.C.2    Ozols, R.F.3    Young, R.C.4
  • 9
    • 0036815596 scopus 로고    scopus 로고
    • Tumor senescence as a determinant of drug response in vivo
    • Roninson IB. Tumor senescence as a determinant of drug response in vivo. Drug Resist Updat 2002;5(5):204-8
    • (2002) Drug Resist Updat , vol.5 , Issue.5 , pp. 204-208
    • Roninson, I.B.1
  • 10
    • 0036551756 scopus 로고    scopus 로고
    • Survivin expression and resistance to anticancer treatments: Perspectives for new therapeutic interventions
    • Zaffaroni N, Daidone MG. Survivin expression and resistance to anticancer treatments: perspectives for new therapeutic interventions. Drug Resist Update 2002;5(2):65-72
    • (2002) Drug Resist Update , vol.5 , Issue.2 , pp. 65-72
    • Zaffaroni, N.1    Daidone, M.G.2
  • 11
    • 0025007511 scopus 로고
    • Pharmacology of drugs that alter multidrug resistance in cancer
    • Ford JM, Hait WN. Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev 1990;42(3):155-99
    • (1990) Pharmacol Rev , vol.42 , Issue.3 , pp. 155-199
    • Ford, J.M.1    Hait, W.N.2
  • 12
    • 0242331206 scopus 로고    scopus 로고
    • Drug resistance reversal - are we getting closer?
    • Baird RD, Kaye SB. Drug resistance reversal - are we getting closer? Eur J Cancer 2003;39(17):2450-61
    • (2003) Eur J Cancer , vol.39 , Issue.17 , pp. 2450-2461
    • Baird, R.D.1    Kaye, S.B.2
  • 13
    • 0036815597 scopus 로고    scopus 로고
    • p53 as a therapeutic target: Unresolved issues on the road to cancer therapy targeting mutant p53
    • Fojo T. p53 as a therapeutic target: unresolved issues on the road to cancer therapy targeting mutant p53. Drug Resist Update 2002;5(5):209-16
    • (2002) Drug Resist Update , vol.5 , Issue.5 , pp. 209-216
    • Fojo, T.1
  • 14
    • 0141996464 scopus 로고    scopus 로고
    • Microtubules, microtubule-interfering agents and apoptosis
    • Mollinedo F, Gajate C. Microtubules, microtubule-interfering agents and apoptosis. Apoptosis 2003;8(5):413-50
    • (2003) Apoptosis , vol.8 , Issue.5 , pp. 413-450
    • Mollinedo, F.1    Gajate, C.2
  • 15
    • 0043122940 scopus 로고    scopus 로고
    • AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2
    • Fahy BN, Schlieman M, Virudachalam S, Bold RJ. AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2. Br J Cancer 2003;89(2):391-7
    • (2003) Br J Cancer , vol.89 , Issue.2 , pp. 391-397
    • Fahy, B.N.1    Schlieman, M.2    Virudachalam, S.3    Bold, R.J.4
  • 16
    • 18644367630 scopus 로고    scopus 로고
    • The function of multiple IkappaB: NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis
    • Dong QG, Sclabas GM, Fujioka S, et al. The function of multiple IkappaB: NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. Oncogene 2002;21(42):6510-19
    • (2002) Oncogene , vol.21 , Issue.42 , pp. 6510-6519
    • Dong, Q.G.1    Sclabas, G.M.2    Fujioka, S.3
  • 17
    • 13444291204 scopus 로고    scopus 로고
    • A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway
    • Menendez JA, Vellon L, Mehmi I, et al. A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway. Oncogene 2005;24(5):761-79
    • (2005) Oncogene , vol.24 , Issue.5 , pp. 761-779
    • Menendez, J.A.1    Vellon, L.2    Mehmi, I.3
  • 18
    • 33644977169 scopus 로고    scopus 로고
    • Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules
    • Hari M, Loganzo F, Annable T, et al. Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules. Mol Cancer Ther 2006;5(2):270-8
    • (2006) Mol Cancer Ther , vol.5 , Issue.2 , pp. 270-278
    • Hari, M.1    Loganzo, F.2    Annable, T.3
  • 19
    • 0034078907 scopus 로고    scopus 로고
    • Modulation of paclitaxel resistance by annexin IV in human cancer cell lines
    • Han EK, Tahir SK, Cherian SP, et al. Modulation of paclitaxel resistance by annexin IV in human cancer cell lines. Br J Cancer 2000;83(1):83-8
    • (2000) Br J Cancer , vol.83 , Issue.1 , pp. 83-88
    • Han, E.K.1    Tahir, S.K.2    Cherian, S.P.3
  • 20
    • 33846636785 scopus 로고    scopus 로고
    • Chk1 is required for spindle checkpoint function
    • Zachos G, Black EJ, Walker M, et al. Chk1 is required for spindle checkpoint function. Dev Cell 2007;12(2):247-260
    • (2007) Dev Cell , vol.12 , Issue.2 , pp. 247-260
    • Zachos, G.1    Black, E.J.2    Walker, M.3
  • 21
    • 33749022747 scopus 로고    scopus 로고
    • Anticancer drugs induce mdr1 gene expression in recurrent ovarian cancer
    • Hille S, Rein DT, Riffelmann M, et al. Anticancer drugs induce mdr1 gene expression in recurrent ovarian cancer. Anticancer Drugs 2006;17(9):1041-4
    • (2006) Anticancer Drugs , vol.17 , Issue.9 , pp. 1041-1044
    • Hille, S.1    Rein, D.T.2    Riffelmann, M.3
  • 22
    • 33748063941 scopus 로고    scopus 로고
    • Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance
    • McCubrey JA, Steelman LS, Abrams SL, et al. Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Adv Enzyme Regul 2006;46:249-79
    • (2006) Adv Enzyme Regul , vol.46 , pp. 249-279
    • McCubrey, J.A.1    Steelman, L.S.2    Abrams, S.L.3
  • 23
    • 33746449598 scopus 로고    scopus 로고
    • Susceptibility of nanoparticle-encapsulated paclitaxel to P-glycoprotein-mediated drug efflux
    • Chavanpatil MD, Patil Y, Panyam J. Susceptibility of nanoparticle-encapsulated paclitaxel to P-glycoprotein-mediated drug efflux. Int J Pharm 2006;320(1-2):150-6
    • (2006) Int J Pharm , vol.320 , Issue.1-2 , pp. 150-156
    • Chavanpatil, M.D.1    Patil, Y.2    Panyam, J.3
  • 25
    • 33847164892 scopus 로고    scopus 로고
    • Biophysical characterization of MDR breast cancer cell lines reveals the cytoplasm is critical in determining drug sensitivity
    • Coley HM, Labeed FH, Thomas H, Hughes MB Biophysical characterization of MDR breast cancer cell lines reveals the cytoplasm is critical in determining drug sensitivity. Biochim Biophys Acta 2007;1770(4):601-8
    • (2007) Biochim Biophys Acta , vol.1770 , Issue.4 , pp. 601-608
    • Coley, H.M.1    Labeed, F.H.2    Thomas, H.3    Hughes, M.B.4
  • 27
    • 0022972654 scopus 로고
    • Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
    • Chen CJ, Chin JE, Ueda K, et al. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 1986;47(3):381-9
    • (1986) Cell , vol.47 , Issue.3 , pp. 381-389
    • Chen, C.J.1    Chin, J.E.2    Ueda, K.3
  • 28
    • 0027095653 scopus 로고
    • Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
    • Cole SR, Bhardwaj G, Gerlach JH, et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 1992;258(5088):1650-4
    • (1992) Science , vol.258 , Issue.5088 , pp. 1650-1654
    • Cole, S.R.1    Bhardwaj, G.2    Gerlach, J.H.3
  • 29
    • 0001744641 scopus 로고    scopus 로고
    • Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ ABCG2)
    • Allen JD, Schinkel AH. Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ ABCG2). Mol Cancer Ther 2002;1(6):427-34
    • (2002) Mol Cancer Ther , vol.1 , Issue.6 , pp. 427-434
    • Allen, J.D.1    Schinkel, A.H.2
  • 30
    • 0031708908 scopus 로고    scopus 로고
    • Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy
    • Vargas-Roig LM, Gago FE, Tello O, et al. Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy. Int J Cancer 1998;79(5):468-75
    • (1998) Int J Cancer , vol.79 , Issue.5 , pp. 468-475
    • Vargas-Roig, L.M.1    Gago, F.E.2    Tello, O.3
  • 31
    • 0345304252 scopus 로고    scopus 로고
    • Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1
    • Gupta A, Inaba S, Wong OK, et al. Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1. Oncogene 2003;22(48):7593-9
    • (2003) Oncogene , vol.22 , Issue.48 , pp. 7593-7599
    • Gupta, A.1    Inaba, S.2    Wong, O.K.3
  • 32
    • 33846650691 scopus 로고    scopus 로고
    • Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs
    • Singh VK, Zhou Y, Marsh JA, et al. Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs. Cancer Res 2007;67(2):626-33
    • (2007) Cancer Res , vol.67 , Issue.2 , pp. 626-633
    • Singh, V.K.1    Zhou, Y.2    Marsh, J.A.3
  • 33
    • 33751512999 scopus 로고    scopus 로고
    • Zhou Y, Inaba S, Liu J. Inhibition of synuclein-gamma expression increases the sensitivity of breast cancer cells to paclitaxel treatment. Int J Oncol 200;29(1):289-95
    • Zhou Y, Inaba S, Liu J. Inhibition of synuclein-gamma expression increases the sensitivity of breast cancer cells to paclitaxel treatment. Int J Oncol 200;29(1):289-95
  • 34
    • 0036150971 scopus 로고    scopus 로고
    • George JM. The synucleins. Genome Biol 2002;3(1):REVIEWS3002
    • George JM. The synucleins. Genome Biol 2002;3(1):REVIEWS3002
  • 35
    • 0031763264 scopus 로고    scopus 로고
    • The synuclein family
    • Lavedan C. The synuclein family. Genome Res 1998;8(9):871-80
    • (1998) Genome Res , vol.8 , Issue.9 , pp. 871-880
    • Lavedan, C.1
  • 36
    • 5444260407 scopus 로고    scopus 로고
    • Synucleins and their relationship to Parkinson's disease
    • Bohlen Und HO. Synucleins and their relationship to Parkinson's disease. Cell Tissue Res 2004;318(1):163-74
    • (2004) Cell Tissue Res , vol.318 , Issue.1 , pp. 163-174
    • Bohlen Und, H.O.1
  • 37
    • 0034718160 scopus 로고    scopus 로고
    • Properties of NACP/alpha-synuclein and its role in Alzheimer's disease
    • Iwai A. Properties of NACP/alpha-synuclein and its role in Alzheimer's disease. Biochim Biophys Acta 2000;1502(1):95-109
    • (2000) Biochim Biophys Acta , vol.1502 , Issue.1 , pp. 95-109
    • Iwai, A.1
  • 39
    • 0031045589 scopus 로고    scopus 로고
    • Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing
    • Ji H, Liu YE, Jia T, et al. Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res 1997;57(4):759-64
    • (1997) Cancer Res , vol.57 , Issue.4 , pp. 759-764
    • Ji, H.1    Liu, Y.E.2    Jia, T.3
  • 40
    • 0031705984 scopus 로고    scopus 로고
    • Identification, localization and characterization of the human gamma-synuclein gene
    • Lavedan C, Leroy E, Dehejia A, et al. Identification, localization and characterization of the human gamma-synuclein gene. Hum Genet 1998;103(1):106-12
    • (1998) Hum Genet , vol.103 , Issue.1 , pp. 106-112
    • Lavedan, C.1    Leroy, E.2    Dehejia, A.3
  • 41
    • 0033812004 scopus 로고    scopus 로고
    • Transcriptional suppression of synuclein gamma (SNCG) expression in human breast cancer cells by the growth inhibitory cytokine oncostatin M
    • Liu J, Spence MJ, Zhang YL, et al. Transcriptional suppression of synuclein gamma (SNCG) expression in human breast cancer cells by the growth inhibitory cytokine oncostatin M. Breast Cancer Res Treat 2000;62(2):99-107
    • (2000) Breast Cancer Res Treat , vol.62 , Issue.2 , pp. 99-107
    • Liu, J.1    Spence, M.J.2    Zhang, Y.L.3
  • 42
    • 0037200098 scopus 로고    scopus 로고
    • Blockade of AP1 transactivation abrogates the abnorma expression of breast cancer-specific gene 1 in breast cancer cells
    • Lu A, Zhang F, Gupta A, Liu J. Blockade of AP1 transactivation abrogates the abnorma expression of breast cancer-specific gene 1 in breast cancer cells. J Biol Chem 2002;277(35):31364-72
    • (2002) J Biol Chem , vol.277 , Issue.35 , pp. 31364-31372
    • Lu, A.1    Zhang, F.2    Gupta, A.3    Liu, J.4
  • 43
    • 3042702990 scopus 로고    scopus 로고
    • Gamma synuclein, a novel heat-shock protein-associated chaperone, stimulates ligand-dependent estrogen receptor alpha signaling and mammary tumorigenesis
    • Jiang Y, Liu YE, Goldberg ID, Shi YE. Gamma synuclein, a novel heat-shock protein-associated chaperone, stimulates ligand-dependent estrogen receptor alpha signaling and mammary tumorigenesis. Cancer Res 2004;64(13):4539-46
    • (2004) Cancer Res , vol.64 , Issue.13 , pp. 4539-4546
    • Jiang, Y.1    Liu, Y.E.2    Goldberg, I.D.3    Shi, Y.E.4
  • 44
    • 0043175493 scopus 로고    scopus 로고
    • Stimulation of estrogen receptor signaling by gamma synuclein
    • Jiang Y, Liu YE, Lu A, et al. Stimulation of estrogen receptor signaling by gamma synuclein. Cancer Res 2003;63(14):3899-903
    • (2003) Cancer Res , vol.63 , Issue.14 , pp. 3899-3903
    • Jiang, Y.1    Liu, Y.E.2    Lu, A.3
  • 45
    • 0033083049 scopus 로고    scopus 로고
    • Stimulation of breast cancer invasion and metastasis by synuclein gamma
    • Jia T, Liu YE, Liu J, Shi YE. Stimulation of breast cancer invasion and metastasis by synuclein gamma. Cancer Res 1999;59(3):742-7
    • (1999) Cancer Res , vol.59 , Issue.3 , pp. 742-747
    • Jia, T.1    Liu, Y.E.2    Liu, J.3    Shi, Y.E.4
  • 46
    • 0034193239 scopus 로고    scopus 로고
    • Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary
    • Bruening W, Giasson BI, Klein-Szanto AJ, et al. Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer 2000;88(9):2154-63
    • (2000) Cancer , vol.88 , Issue.9 , pp. 2154-2163
    • Bruening, W.1    Giasson, B.I.2    Klein-Szanto, A.J.3
  • 47
    • 0141452072 scopus 로고    scopus 로고
    • Stage-specific expression of breast cancer-specific gene gamma-synuclein
    • Wu K, Weng Z, Tao Q, et al. Stage-specific expression of breast cancer-specific gene gamma-synuclein. Cancer Epidemiol Biomarkers Prev 2003;12(9):920-5
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , Issue.9 , pp. 920-925
    • Wu, K.1    Weng, Z.2    Tao, Q.3
  • 48
    • 33646841848 scopus 로고    scopus 로고
    • Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration
    • Zhao W, Liu H, Liu W, et al. Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration. Int J Oncol 2006;28(5):1081-8
    • (2006) Int J Oncol , vol.28 , Issue.5 , pp. 1081-1088
    • Zhao, W.1    Liu, H.2    Liu, W.3
  • 49
    • 0141606784 scopus 로고    scopus 로고
    • Down-regulation of gamma-synuclein in human esophageal squamous cell carcinoma
    • Zhou CQ, Liu S, Xue LY, et al. Down-regulation of gamma-synuclein in human esophageal squamous cell carcinoma. World J Gastroenterol 2003;9(9):1900-3
    • (2003) World J Gastroenterol , vol.9 , Issue.9 , pp. 1900-1903
    • Zhou, C.Q.1    Liu, S.2    Xue, L.Y.3
  • 50
    • 0037592405 scopus 로고    scopus 로고
    • Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas
    • Fung KM, Rorke LB, Giasson B, et al. Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas. Acta Neuropathol (Berl) 2003;106(2):167-75
    • (2003) Acta Neuropathol (Berl) , vol.106 , Issue.2 , pp. 167-175
    • Fung, K.M.1    Rorke, L.B.2    Giasson, B.3
  • 51
    • 35948969417 scopus 로고    scopus 로고
    • Ahmad M, Attoub S, Singh MN, et al. {Gamma}-synuclein and the progression of cancer. FASEB J 2007;21:3419-30
    • Ahmad M, Attoub S, Singh MN, et al. {Gamma}-synuclein and the progression of cancer. FASEB J 2007;21:3419-30
  • 52
    • 33748685471 scopus 로고    scopus 로고
    • The role of CpG islands hypomethylation and abnormal expression of neuronal protein synuclein-gamma (SNCG) in ovarian cancer
    • Czekierdowski A, Czekierdowska S, Wielgos M, et al. The role of CpG islands hypomethylation and abnormal expression of neuronal protein synuclein-gamma (SNCG) in ovarian cancer. Neuro Endocrinol Lett 27(3):381-6
    • Neuro Endocrinol Lett , vol.27 , Issue.3 , pp. 381-386
    • Czekierdowski, A.1    Czekierdowska, S.2    Wielgos, M.3
  • 53
    • 0037328249 scopus 로고    scopus 로고
    • Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells
    • Surgucheva IG, Sivak JM, Fini ME, et al. Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells. Arch Biochem Biophys 2003;410(1):167-76
    • (2003) Arch Biochem Biophys , vol.410 , Issue.1 , pp. 167-176
    • Surgucheva, I.G.1    Sivak, J.M.2    Fini, M.E.3
  • 54
    • 1842583600 scopus 로고    scopus 로고
    • Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines
    • Yanagawa N, Tamura G, Honda T, et al. Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines. Clin Cancer Res 2004;10(7):2447-51
    • (2004) Clin Cancer Res , vol.10 , Issue.7 , pp. 2447-2451
    • Yanagawa, N.1    Tamura, G.2    Honda, T.3
  • 55
    • 19944429012 scopus 로고    scopus 로고
    • Diagnostic potential in bladder cancer of a panel of tumor markers (calreticulin, gamma-synuclein, and catechol-o-methyltransferase) identified by proteomic analysis
    • Iwaki H, Kageyama S, Isono T, et al. Diagnostic potential in bladder cancer of a panel of tumor markers (calreticulin, gamma-synuclein, and catechol-o-methyltransferase) identified by proteomic analysis. Cancer Sci 2004;95(12):955-61
    • (2004) Cancer Sci , vol.95 , Issue.12 , pp. 955-961
    • Iwaki, H.1    Kageyama, S.2    Isono, T.3
  • 56
    • 0037310198 scopus 로고    scopus 로고
    • Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma
    • Gupta A, Godwin AK, Vanderveer L, et al. Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma. Cancer Res 2003;63(3):664-73
    • (2003) Cancer Res , vol.63 , Issue.3 , pp. 664-673
    • Gupta, A.1    Godwin, A.K.2    Vanderveer, L.3
  • 57
    • 24744445401 scopus 로고    scopus 로고
    • Loss of epigenetic control of synuclein-gamma gene as a molecular indicator of metastasis in a wide range of human cancers
    • Liu H, Liu W, Wu Y, et al. Loss of epigenetic control of synuclein-gamma gene as a molecular indicator of metastasis in a wide range of human cancers. Cancer Res 2005;65(17):7635-43
    • (2005) Cancer Res , vol.65 , Issue.17 , pp. 7635-7643
    • Liu, H.1    Liu, W.2    Wu, Y.3
  • 58
    • 36348957365 scopus 로고    scopus 로고
    • Breast cancer progression: Insights into multifaceted matrix metalloproteinases
    • 30 Oct, doi:10.1007/s10585-007-9113-7
    • Chabottaux V, Noel A. Breast cancer progression: insights into multifaceted matrix metalloproteinases. Clin Exp Metastasis 2007: published online 30 Oct 2007, doi:10.1007/s10585-007-9113-7
    • (2007) Clin Exp Metastasis 2007: Published online
    • Chabottaux, V.1    Noel, A.2
  • 59
    • 9144242386 scopus 로고    scopus 로고
    • Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability
    • Shin HJ, Baek KH, Jean AH, et al. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell 2003;4(6):483-97
    • (2003) Cancer Cell , vol.4 , Issue.6 , pp. 483-497
    • Shin, H.J.1    Baek, K.H.2    Jean, A.H.3
  • 60
    • 0036304838 scopus 로고    scopus 로고
    • G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells
    • Blajeski AL, Phan VA, Kottke TJ, Kaufmann SH. G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. J Clin Invest 2002;110(1):91-9
    • (2002) J Clin Invest , vol.110 , Issue.1 , pp. 91-99
    • Blajeski, A.L.1    Phan, V.A.2    Kottke, T.J.3    Kaufmann, S.H.4
  • 61
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer 2004;4(4):253-65
    • (2004) Nat Rev Cancer , vol.4 , Issue.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 62
    • 0038216623 scopus 로고    scopus 로고
    • Taxanes: Microtubule and centrosome targets, and cell cycle dependent mechanisms of action
    • Abal M, Andreu JM, Barasoain I. Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action. Curr Cancer Drug Targets 2003;3(3):193-203
    • (2003) Curr Cancer Drug Targets , vol.3 , Issue.3 , pp. 193-203
    • Abal, M.1    Andreu, J.M.2    Barasoain, I.3
  • 63
    • 0037459109 scopus 로고    scopus 로고
    • Centromeres and kinetochores: From epigenetics to mitotic checkpoint signaling
    • Cleveland DW, Mao Y, Sullivan KF. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 2003;112(4):407-21
    • (2003) Cell , vol.112 , Issue.4 , pp. 407-421
    • Cleveland, D.W.1    Mao, Y.2    Sullivan, K.F.3
  • 64
    • 35048828950 scopus 로고    scopus 로고
    • Aneuploidy and cancer
    • Chi YH, Jeang KT. Aneuploidy and cancer. J Cell Biochem 2007;102(3):531-8
    • (2007) J Cell Biochem , vol.102 , Issue.3 , pp. 531-538
    • Chi, Y.H.1    Jeang, K.T.2
  • 65
    • 34247333444 scopus 로고    scopus 로고
    • The spindle-assembly checkpoint in space and time
    • Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 2007;8(5):379-93
    • (2007) Nat Rev Mol Cell Biol , vol.8 , Issue.5 , pp. 379-393
    • Musacchio, A.1    Salmon, E.D.2
  • 66
    • 33947324209 scopus 로고    scopus 로고
    • Weakened spindle checkpoint with reduced BubR1 expression in paclitaxel-resistant ovarian carcinoma cell line SKOV3-TR30
    • Fu Y, Ye D, Chen H, et al. Weakened spindle checkpoint with reduced BubR1 expression in paclitaxel-resistant ovarian carcinoma cell line SKOV3-TR30. Gynecol Oncol 2007;105(1):66-73
    • (2007) Gynecol Oncol , vol.105 , Issue.1 , pp. 66-73
    • Fu, Y.1    Ye, D.2    Chen, H.3
  • 67
    • 22244478043 scopus 로고    scopus 로고
    • Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death
    • Weaver BA, Cleveland DW. Decoding the links between mitosis, cancer, and chemotherapy: the mitotic checkpoint, adaptation, and cell death. Cancer Cell 2005;8(1):7-12
    • (2005) Cancer Cell , vol.8 , Issue.1 , pp. 7-12
    • Weaver, B.A.1    Cleveland, D.W.2
  • 68
    • 24744435804 scopus 로고    scopus 로고
    • Synuclein gamma inhibits the mitotic checkpoint function and promotes chromosomal instability of breast cancer cells
    • Inaba S, Li C, Shi YE, et al. Synuclein gamma inhibits the mitotic checkpoint function and promotes chromosomal instability of breast cancer cells. Breast Cancer Res Treat 2005;94(1):25-35
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.1 , pp. 25-35
    • Inaba, S.1    Li, C.2    Shi, Y.E.3
  • 69
    • 0034877473 scopus 로고    scopus 로고
    • Gamma synuclein: Subcellular localization in neuronal and non-neuronal cells and effect on signal transduction
    • Surguchov A, Palazzo RE, Surgucheva I. Gamma synuclein: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction. Cell Motil Cytoskeleton 2001;49(4):218-28
    • (2001) Cell Motil Cytoskeleton , vol.49 , Issue.4 , pp. 218-228
    • Surguchov, A.1    Palazzo, R.E.2    Surgucheva, I.3
  • 70
    • 0037586498 scopus 로고    scopus 로고
    • AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
    • Anand S, Penrhyn-Lowe S, Venkitaraman AR. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 2003;3(1):51-62
    • (2003) Cancer Cell , vol.3 , Issue.1 , pp. 51-62
    • Anand, S.1    Penrhyn-Lowe, S.2    Venkitaraman, A.R.3
  • 71
    • 20544463659 scopus 로고    scopus 로고
    • Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol
    • Kienitz A, Vogel C, Morales I, et al. Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol. Oncogene 2005;24(26):4301-10
    • (2005) Oncogene , vol.24 , Issue.26 , pp. 4301-4310
    • Kienitz, A.1    Vogel, C.2    Morales, I.3
  • 72
    • 4444245218 scopus 로고    scopus 로고
    • Inactivation of the mitotic checkpoint as a determinant of the efficacy of microtubule-targeted drugs in killing human cancer cells
    • Lee EA, Keutmann MK, Dowling ML, et al. Inactivation of the mitotic checkpoint as a determinant of the efficacy of microtubule-targeted drugs in killing human cancer cells. Mol Cancer Ther 2004;3(6):661-9
    • (2004) Mol Cancer Ther , vol.3 , Issue.6 , pp. 661-669
    • Lee, E.A.1    Keutmann, M.K.2    Dowling, M.L.3
  • 73
    • 1942474378 scopus 로고    scopus 로고
    • Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint
    • Sudo T, Nitta M, Says H, Ueno NT. Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint. Cancer Res 2004;64(7):2502-8
    • (2004) Cancer Res , vol.64 , Issue.7 , pp. 2502-2508
    • Sudo, T.1    Nitta, M.2    Says, H.3    Ueno, N.T.4
  • 74
    • 0037144401 scopus 로고    scopus 로고
    • Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways
    • Pan ZZ, Bruening W, Giasson BI, et al. Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways. J Biol Chem 2002;277(38):35050-60
    • (2002) J Biol Chem , vol.277 , Issue.38 , pp. 35050-35060
    • Pan, Z.Z.1    Bruening, W.2    Giasson, B.I.3
  • 75
    • 0035450447 scopus 로고    scopus 로고
    • Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells
    • Lanzi C, Cassinelli G, Cuccuru G, et al. Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells. Prostate 2001;48(4):254-64
    • (2001) Prostate , vol.48 , Issue.4 , pp. 254-264
    • Lanzi, C.1    Cassinelli, G.2    Cuccuru, G.3
  • 76
    • 0035949576 scopus 로고    scopus 로고
    • Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics
    • Goncalves A, Braguer D, Kamath K, et al. Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics. Proc Natl Acad Sci USA 2001;98(20):11737-42
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.20 , pp. 11737-11742
    • Goncalves, A.1    Braguer, D.2    Kamath, K.3
  • 77
    • 0034735853 scopus 로고    scopus 로고
    • Estrogen receptor beta in the breast: Role in estrogen responsiveness and development of breast cancer
    • Gustafsson JA, Warner M. Estrogen receptor beta in the breast: role in estrogen responsiveness and development of breast cancer. J Steroid Biochem Mol Biol 2000;74(5):245-8
    • (2000) J Steroid Biochem Mol Biol , vol.74 , Issue.5 , pp. 245-248
    • Gustafsson, J.A.1    Warner, M.2
  • 78
    • 20444425521 scopus 로고    scopus 로고
    • Estrogen receptor expression and sensitivity to paclitaxel in breast cancer
    • Dougherty MK, Schumaker LM, Jordan VC, et al. Estrogen receptor expression and sensitivity to paclitaxel in breast cancer. Cancer Biol Ther 2004;3(5):460-7
    • (2004) Cancer Biol Ther , vol.3 , Issue.5 , pp. 460-467
    • Dougherty, M.K.1    Schumaker, L.M.2    Jordan, V.C.3
  • 79
    • 33750610998 scopus 로고    scopus 로고
    • Drugs targeting protein-protein interactions
    • Chene P. Drugs targeting protein-protein interactions. ChemMedChem 2006;1(4):400-11
    • (2006) ChemMedChem , vol.1 , Issue.4 , pp. 400-411
    • Chene, P.1
  • 80
    • 3142781225 scopus 로고    scopus 로고
    • Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
    • Arkin MR, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov 2004;3(4):301-17
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.4 , pp. 301-317
    • Arkin, M.R.1    Wells, J.A.2
  • 81
    • 0033613904 scopus 로고    scopus 로고
    • Protein surface roughness and small molecular binding sites
    • Pettit FK, Bowie JU. Protein surface roughness and small molecular binding sites. J Mol Biol 1999;285(4):1377-82
    • (1999) J Mol Biol , vol.285 , Issue.4 , pp. 1377-1382
    • Pettit, F.K.1    Bowie, J.U.2
  • 82
    • 33751552347 scopus 로고    scopus 로고
    • Comparison of secondary structure propensities calculated from chemical shifts in α- and γ-synuclein: Implications for fibrillation and the evolution of intrinsically disordered proteins
    • Marsh JA, Singh VK, Jia Z, Forman-Kay JD. Comparison of secondary structure propensities calculated from chemical shifts in α- and γ-synuclein: Implications for fibrillation and the evolution of intrinsically disordered proteins. Protein Sci 2006;12:2795-804
    • (2006) Protein Sci , vol.12 , pp. 2795-2804
    • Marsh, J.A.1    Singh, V.K.2    Jia, Z.3    Forman-Kay, J.D.4
  • 83
    • 14644435825 scopus 로고    scopus 로고
    • Intrinsically unstructured proteins and their functions
    • Dyson HJ, Wright PE. Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol 2005;6(3):197-208
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.3 , pp. 197-208
    • Dyson, H.J.1    Wright, P.E.2
  • 84
    • 13844255387 scopus 로고    scopus 로고
    • Natively unfolded proteins
    • Fink AL. Natively unfolded proteins. Curr Opin Struct Biol 2005;15(1):35-41
    • (2005) Curr Opin Struct Biol , vol.15 , Issue.1 , pp. 35-41
    • Fink, A.L.1
  • 85
    • 33750639677 scopus 로고
    • The key-lock theory and the induced fit theory
    • Koshland DE Jr. The key-lock theory and the induced fit theory. Angew Chem Int Ed Eng 1995;33(23-24):2375-8
    • (1995) Angew Chem Int Ed Eng , vol.33 , Issue.23-24 , pp. 2375-2378
    • Koshland Jr., D.E.1
  • 86
    • 13844256697 scopus 로고    scopus 로고
    • Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer
    • Wadia JS, Dowdy SF. Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer. Adv. Drug Deliv Rev 2005;57(4):579-96
    • (2005) Adv. Drug Deliv Rev , vol.57 , Issue.4 , pp. 579-596
    • Wadia, J.S.1    Dowdy, S.F.2
  • 87
    • 34548164388 scopus 로고    scopus 로고
    • Tatp-mediated intracellular delivery of pharmaceutical nanocarriers
    • Torchilin VP. Tatp-mediated intracellular delivery of pharmaceutical nanocarriers. Biochem Soc Trans 2007;35(Pt 4):816-20
    • (2007) Biochem Soc Trans , vol.35 , Issue.PART 4 , pp. 816-820
    • Torchilin, V.P.1
  • 88
    • 34548101128 scopus 로고    scopus 로고
    • Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer
    • Guo J, Shou C, Meng L, et al. Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer. Int J Cancer 2007;121(6):1296-305
    • (2007) Int J Cancer , vol.121 , Issue.6 , pp. 1296-1305
    • Guo, J.1    Shou, C.2    Meng, L.3
  • 89
    • 33846471635 scopus 로고    scopus 로고
    • Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis
    • Wu K, Quan Z, Weng Z, et al. Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis. Breast Cancer Res Treat 2007;101(3):259-67
    • (2007) Breast Cancer Res Treat , vol.101 , Issue.3 , pp. 259-267
    • Wu, K.1    Quan, Z.2    Weng, Z.3
  • 90
    • 33747607074 scopus 로고    scopus 로고
    • Inhibitors of alpha-synuclein oligomerization and toxicity: A future therapeutic strategy for Parkinson's disease and related disorders
    • Amer DA, Irvine GB, El Agnaf OM. Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders. Exp Brain Res 2006;173(2):223-33
    • (2006) Exp Brain Res , vol.173 , Issue.2 , pp. 223-233
    • Amer, D.A.1    Irvine, G.B.2    El Agnaf, O.M.3
  • 91
    • 9444229299 scopus 로고    scopus 로고
    • A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders
    • El Agnaf OM, Paleologou KE, Greer B, et al. A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders. FASEB J 2004;18(11):1315-7
    • (2004) FASEB J , vol.18 , Issue.11 , pp. 1315-1317
    • El Agnaf, O.M.1    Paleologou, K.E.2    Greer, B.3
  • 92
    • 1842608890 scopus 로고    scopus 로고
    • Inhibition of fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogue
    • Bodles AM, El Agnaf OM, Greet B, et al. Inhibition of fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogue. Neurosci Lett 2004;359(1-2):89-93
    • (2004) Neurosci Lett , vol.359 , Issue.1-2 , pp. 89-93
    • Bodles, A.M.1    El Agnaf, O.M.2    Greet, B.3
  • 93
    • 38349174536 scopus 로고    scopus 로고
    • On the biomedical promise of cell penetrating peptides: Limits versus prospects
    • 30 Aug, doi:10.1002/jps.21117
    • Foerg C, Merkle HP. On the biomedical promise of cell penetrating peptides: limits versus prospects. J Pharm Sci 2007: published online 30 Aug 2007, doi:10.1002/jps.21117
    • (2007) J Pharm Sci 2007: Published online
    • Foerg, C.1    Merkle, H.P.2
  • 94
    • 33750971440 scopus 로고    scopus 로고
    • Carrier-mediated delivery of peptidic drugs for cancer therapy
    • Dass CR, Choong PF. Carrier-mediated delivery of peptidic drugs for cancer therapy. Peptides 2006;27(11):3020-8
    • (2006) Peptides , vol.27 , Issue.11 , pp. 3020-3028
    • Dass, C.R.1    Choong, P.F.2
  • 95
    • 13844280947 scopus 로고    scopus 로고
    • Liposomalized oligopeptides in cancer therapy
    • Asai T, Oku N. Liposomalized oligopeptides in cancer therapy. Methods Enzymol 2005;391:163-76
    • (2005) Methods Enzymol , vol.391 , pp. 163-176
    • Asai, T.1    Oku, N.2
  • 96
    • 0034001783 scopus 로고    scopus 로고
    • Peptide-mediated cellular delivery
    • Schwartz JJ, Zhang S. Peptide-mediated cellular delivery. Curr Opin Mol Ther 2000;2(2):162-7
    • (2000) Curr Opin Mol Ther , vol.2 , Issue.2 , pp. 162-167
    • Schwartz, J.J.1    Zhang, S.2
  • 97
    • 0032535999 scopus 로고    scopus 로고
    • Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
    • Arap W, Pasqualini R, Ruoslahti E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 1998;279(5349):377-80
    • (1998) Science , vol.279 , Issue.5349 , pp. 377-380
    • Arap, W.1    Pasqualini, R.2    Ruoslahti, E.3
  • 98
    • 0032819838 scopus 로고    scopus 로고
    • Anti-cancer activity of targeted pro-apoptotic peptides
    • Ellerby HM, Map W, Ellerby LM, et al. Anti-cancer activity of targeted pro-apoptotic peptides. Nat Med 1999;5(9):1032-8
    • (1999) Nat Med , vol.5 , Issue.9 , pp. 1032-1038
    • Ellerby, H.M.1    Map, W.2    Ellerby, L.M.3
  • 99
    • 0033764170 scopus 로고    scopus 로고
    • Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13)
    • Curnis F, Sacchi A, Borgna L, et al. Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13). Nat Biotechnol 2000;18(11):1185-90
    • (2000) Nat Biotechnol , vol.18 , Issue.11 , pp. 1185-1190
    • Curnis, F.1    Sacchi, A.2    Borgna, L.3
  • 100
    • 0037303101 scopus 로고    scopus 로고
    • Paclitaxel resistance: Molecular mechanisms and pharmacologic manipulation
    • Yusuf RZ, Duan Z, Lamendola DE, et al. Paclitaxel resistance: molecular mechanisms and pharmacologic manipulation. Curr Cancer Drug Targets 2003;3(1):1-19
    • (2003) Curr Cancer Drug Targets , vol.3 , Issue.1 , pp. 1-19
    • Yusuf, R.Z.1    Duan, Z.2    Lamendola, D.E.3
  • 101
    • 33746609814 scopus 로고    scopus 로고
    • Chromosomal instability, colorectal cancer and taxane resistance
    • Swanton C, Tomlinson I, Downward J. Chromosomal instability, colorectal cancer and taxane resistance. Cell Cycle 2006;5(8):818-23
    • (2006) Cell Cycle , vol.5 , Issue.8 , pp. 818-823
    • Swanton, C.1    Tomlinson, I.2    Downward, J.3
  • 102
    • 14944340997 scopus 로고    scopus 로고
    • Anti-tumor chemotherapy utilizing peptide-based approaches - apoptotic pathways, kinases, and proteasome as targets
    • Mendoza FJ, Espino PS, Cann KL, et al. Anti-tumor chemotherapy utilizing peptide-based approaches - apoptotic pathways, kinases, and proteasome as targets. Arch Immunol Ther Exp 2005;53(1):47-60
    • (2005) Arch Immunol Ther Exp , vol.53 , Issue.1 , pp. 47-60
    • Mendoza, F.J.1    Espino, P.S.2    Cann, K.L.3


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