Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 4, 2008, Pages 1874-1883

  Chen, Kevin X ^a   Vibulbhan, Bancha ^a   Yang, Weiying ^a   Cheng, Kuo Chi ^a   Liu, Rong ^a   Pichardo, John ^a   Butkiewicz, Nancy ^a   Njoroge, F George ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

HCV; Ketoamide; Peptide; Protease inhibitor

Indexed keywords

1,1 DIMETHYLETHYL [1 CYCLOHEXYL 2 [6,6 DICHLORO 2 [[[1 [1,2 DIOXO 2 (2 PROPENYLAMINO)ETHYL]BUTYL]AMINO]CARBONYL] 3 AZA BICYCLO[3.1.0]HEXAN 3 YL] 2 OXOETHYL]CARBAMATE; 1,1 DIMETHYLETHYL [1 CYCLOHEXYL 2 [6,6 DICHLORO 2 [[[1 [2 [[2 [[2 (DIMETHYLAMINO) 2 OXO 1 PHENYLETHYL]AMINO] 2 OXOETHYL]AMINO] 1,2 DIOXOETHYL]BUTYL]AMINO]CARBONYL] 3 AZA BICYCLO[3.1.0]HEXAN 3 YL] 2 OXOETHYL]CARBAMATE; 1,1 DIMETHYLETHYL [2 [2 [[[1 (2 AMINO 1,2 DIOXOETHYL)BUTYL]AMINO]CARBONYL] 6,6 DICHLORO 3 AZA BICYCLO[3.1.0]HEXAN 3 YL] 1 CYCLOHEXY 2 OXOETHYL]CARBAMATE; 1,1 DIMETHYLETHYL [2 [6,6 DICHLORO 2 [[[1 (CYCLOBUTYYLMETHYL) 3 [[2 [[2 (DIMETHYLAMINO) 2 OXO 1 PHENYLETHYL]AMINO] 2 OXOETHYL]AMINO] 2,3 DIOXOPROPYL]AMINO]CARBONYL] 3 AZA BICYCLO[3.1.0]HEXAN 3 YL] 1 CYCLOHEXYL 2 OXOETHYL]CARBAMATE; 1,1 DIMETHYLETHYL [2 [6,6 DICHLORO 2 [[[1 (CYCLOPROPYLMETHYL) 3 [[2 [[2 (DIMETHYLAMINO) 2 OXO 1 PHENYLETHYL]AMINO] 2 OXOETHYL]AMINO] 2,3 DIOXOPROPYL]AMINO]CARBONYL] 3 AZA BICYCLO[3.1.0]HEXAN 3 YL] 1 CYCLOHEXYL 2 OXOETHYL]CARBAMATE; 2,2,2 TRIFLUORO 1,1 DIMETHYLETHYL [2 [2 [[[3 AMINO 1 (CYCLOBUTYLMETHYL) 2,3 DIOXOPROPYL]AMINO]CARBONYL] 6,6 DICHLORO 3 AZA BICYCLO[3.1.0]HEXAN 3 YL] 1 CYCLOHEXYL 2 OXOETHYL]CARBAMATE; 3 [2 (3 TERT BUTYL UREIDO) 2 INDAN 2 YL ACETYL] 6,6 DICHLORO 3 AZA BICYCLO[3.1.0]HEXANE 2 CARBOXYLIC ACID (2 CARBAMOYL 1 CYCLOBUTYLMETHYL 2 OXOETHYL)AMIDE; 3 [2 (3 TERT BUTYL UREIDO) 3,3 DIMETHYLBUTYRYL] 6,6 DICHLORO 3 AZA BICYCLO[3.1.0]HEXANE 2 CARBOXYLIC ACID (2 CARBAMOYL 1 CYCLOBUTYLMETHYL 2 OXOETHYL)AMIDE; 3,4 DICHLOROCYCLOPROPYL PROLINE; 6,6 DICHLORO 3 [2 CYCLOHEXYL 2 (3 CYCLOHEXYLUREIDO)ACETYL] 3 AZA BICYCLO[3.1.0]HEXANE 2 CARBOXYLIC ACID (2 CARBAMOYL 1 CYCLOBUTYLMETHYL 2 OXOETHYL)AMIDE; 6,6 DICHLORO 3 [CYCLOHEXYL [[[(1,1 DIMETHYLETHYL)AMINO]CARBONYL]AMINO]ACETYL] N [1 [1,2 DIOXO 2 (2 PROPENYLAMINO)ETHYL]BUTYL] 3 AZA BICYCLO[3.1.0]HEXAN 2 CARBOXAMIDE; [1 [2 (2 CARBAMOYL 1 CYCLOBUTYLMETHYL 2 OXOETHYLCARBAMOYL) 6,6 DICHLORO 3 AZA BICYCLO[3.1.0]HEXANE 3 CARBONYL] 2,3 DIMETHYLPROPYL]CARBAMIC ACID TERT BUTYL ESTER; [2 [2 (2 CARBAMOYL 1 CYCLOBUTYLMETHYL 2 OXOETHYLCARBAMOYL) 6,6 DICHLORO 3 AZA BICYCLO[3.1.0]HEXY 3 YL] 1 INDAN 2 YL 2 OXOETHYL]CARBAMIC ACID TERT BUTYL ESTER; ALIPHATIC COMPOUND; CARBAMIC ACID; CARBENE; ELASTASE; N [3 AMINO 1 (CYCLOBUTYLMETHYL) 2,3 DIOXOPROPYL] 3 [2 (3 TERT BUTYLUREIDO) 3,3 DIMETHYL 1 OXOBUTYL] 6,6 DIMETHYL 3 AZABICYCLO[3.1.0]HEXANE 2 CARBOXAMIDE; NONSTRUCTURAL PROTEIN 3; PENTAPEPTIDE; PROLINE DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; EXPERIMENTAL DOG; EXPERIMENTAL MONKEY; HEPATITIS C; HEPATITIS C VIRUS; MOLECULAR SIZE; NONHUMAN; RAT; REPLICON; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL AVAILABILITY; HAPLORHINI; HEPACIVIRUS; PROLINE; RATS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; VIRAL NONSTRUCTURAL PROTEINS;

ANIMALIA; CANIS FAMILIARIS; HEPATITIS C VIRUS; RATTUS;

EID: 38949168474     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.002     Document Type: Article

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