Gene therapies that enhance hippocampal neuron survival after an excitotoxic insult are not equivalent in their ability to maintain synaptic transmission

Experimental Neurology

Volumn 166, Issue 1, 2000, Pages 180-189

  Dumas, T C ^a   McLaughlin, J R ^a   Ho, D Y ^b   Lawrence, M S ^a   Sapolsky, R M ^a  

^a STANFORD UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

Bcl 2; Excitatoiry postsynaptic potential; Gene therapy; Glucose transporter; Herpes simplex virus; Kainic acid; Long term potentiation; Mossy fiber; Paired pulse facilitation; Post tetanic potentiation

Indexed keywords

GLUCOSE TRANSPORTER; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; GENE OVEREXPRESSION; GENE THERAPY; LONG TERM POTENTIATION; MALE; MOSSY FIBER; NERVE INJURY; NEUROPROTECTION; NONHUMAN; POST TETANIC POTENTIATION; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

EID: 0033763269     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7500     Document Type: Article

References (40)

1. Intracellular electrophysiology of CA1 pyramidal neurones in slices of the kainic acid lesioned hippocampus of the rat
2. Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain
3. Paired-pulse and frequency facilitation in the CA1 region of the in vitro rat hippocampus
4. A herpes simplex virus vector overexpressing the glucose transporter gene protects the rat dentate gyrus from an antimetabolite toxin
5. Infection of dentate granule cells with herpes simplex viral vectors does not alter synaptic transmission
6. Defective herpes simplex virus vectors expressing the rat brain stress-inducible heat shock protein 72 protect cultured neurons from severe heat shock
7. Adenovirus-mediated over-expression of interleukin-1 receptor antagonist reduces susceptibility to excitotoxic brain injury in perinatal rats
8. Spatial memory following damage to hippocampal CA3 pyramidal cells with Kainic acid: Impairment and recovery with preoperative training
9. Amplicon-based herpes simplex virus vectors
10. Herpes simplex virus vector system: Analysis of its in vivo and in vitro cytopathic effects
11. Defective herpes simplex virus vectors expressing the rat brain glucose transporter protect cultured neurons from necrotic insults
12. Selective hippocampal lesions and behavior: Effects of kainic acid lesions on performance of place and cue tasks
13. A bcl-2 expressing viral vector protects cortical neurons from excitotoxicity even when administered several hours after the toxic insult
14. Biphasic effect of hydrogen peroxide on field potentials in rat hippocampal slices
15. Adenoviral vectors in ischemic injury
16. A Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss
17. Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo
18. Herpes simplex viral vectors expressing Bcl-2 are neuroprotective when delivered after a stroke
19. Overexpression of the glucose transporter gene with a herpes simplex viral vector protects striatal neurons against stroke
20. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia
21. Sparing neuronal function postseizure with gene therapy
22. Gene transfer of calbindin D28k cDNA via herpes simplex virus amplicon vector decreases cytoplasmic calcium ion response and enhances neuronal survival following glutamatergic challenge but not following cyanide
23. Increased expression of calbindin D28k via herpes simplex virus amplicon vector decreases calcium ion mobilization and enhances neuronal survival after hypoglycemic challenge
24. Essential role for TrkB receptors in hippocampus-mediated learning
25. Anatomical distributions of four pharmacologically distinct 3H-glutamate binding sites
26. Kainic acid neurotoxicity toward hippocampal formation: Dependence on specific excitatory pathways
27. Use of brain slices in the study of free-radical actions
28. Calbindin D28K gene transfer via herpes simplex virus amplicon vector decreases hippocampal damage in vivo following neurotoxic insults
29. Limitations in the neuroprotective potential of gene therapy with Bcl-2
30. Nonuniform probability of glutamate release at a hippocampal synapse
31. Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease
32. Status epilepticus-induced hippocampal damage is modulated by glucose availability
33. Mossy fiber potentiation and long-term potentiation involve different expression mechanisms
34. Excitatory synaptic potentials in kainic acid-denervated rat CA1 pyramidal neurons
35. Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms
36. A comparative in vitro study of the kainic acid and bicuculline treated hippocampus: Chronic and acute models of foral epilepsy
37. Presynaptic calcium is increased during normal synaptic transmission and paired-pulse facilitation but not in long-term potentiation in area CA1 of hippocampus
38. Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus
39. Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus
40. Comparison of two forms of long-term potentiation in single hippocampal neurons