Inability to process and store proinsulin in transdifferentiated pancreatic acinar cells lacking the regulated secretory pathway

Journal of Endocrinology

Volumn 196, Issue 1, 2008, Pages 33-43

  Alidibbiat, A ^a   Marriott, C E ^b   Scougall, K T ^a   Campbell, S C ^a   Huang, G C ^c   Macfarlane, W M ^b   Shaw, Jim A M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BRIGHTON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FURIN; GLUCAGON LIKE PEPTIDE 1; GLUCOKINASE; GLUCOSE TRANSPORTER 2; HEPATOCYTE NUCLEAR FACTOR 3BETA; INSULIN; MATRIGEL; PANCREAS POLYPEPTIDE; PREPROINSULIN; PROINSULIN; TRANSCRIPTION FACTOR PDX 1; FOXA2 PROTEIN, RAT; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; PROTEIN PRECURSOR; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ACINAR CELL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INSULIN RELEASE; INSULIN SYNTHESIS; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETORY CELL; SENSITIVITY AND SPECIFICITY; TRANSGENE; WESTERN BLOTTING; WILD TYPE; ANIMAL; BIOSYNTHESIS; CELL LINE; CHEMISTRY; CYTOLOGY; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; PANCREAS ISLET BETA CELL; PHYSIOLOGY; SECRETION; WISTAR RAT;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCAGON-LIKE PEPTIDE 1; GLUCOKINASE; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; MALE; PANCREATIC POLYPEPTIDE; PHENOTYPE; PROINSULIN; PROTEIN PRECURSORS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; TRANSFECTION; TRANSGENES;

EID: 38849145237     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-07-0397     Document Type: Article

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