Modes and models of GABAA receptor gating

Journal of Physiology

Volumn 572, Issue 1, 2006, Pages 183-200

  Lema, Gareth M C ^a   Auerbach, Anthony ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; CHLORIDE ION; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1BETA1GAMMA2S; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL STRAIN HEK293; CHANNEL GATING; CHLORIDE TRANSPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO; HUMAN; HUMAN CELL; MAXIMUM LIKELIHOOD METHOD; MEMBRANE PERMEABILITY; NERVE CELL INHIBITION; PRIORITY JOURNAL; PROBABILITY; PROCESS MODEL; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; RECEPTOR OCCUPANCY; RECEPTOR UPREGULATION; CHEMICAL BINDING; ELECTRIC CURRENT; ELECTROSTIMULATION; HEK293 CELL LINE; MOLECULAR MODEL; PROTEIN FUNCTION;

EID: 33645326499     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.099093     Document Type: Article

References (52)

1. A receptors. J Physiol 558, 59-74.
2. 2S subunits produce unique ion channels with dissimilar single-channel properties J Neurosci 13, 1429-1440.
3. Auerbach A (2005). Gating of acetylcholine receptor channels: Brownian motion across a broad transition state. Proc Natl Acad Sci U S A 102, 1408-1412.
4. Auerbach A & Zhou Y (2005). Gating reaction mechanisms for NMDA receptor channels. J Neurosci 25, 7914-7923.
5. Bailey DJ, Tetzlaff JE, Cook JM, He X & Helmstetter FJ (2002). Effects of hippocampal injections of a novel ligand selective for the α5β2γ2 subunits of the GABA/benzodiazepine receptor on Pavlovian conditioning. Neurobiol Learn Mem 78, 1-10.
6. Baulac S, Huberfeld G, Gourfinkel-An I, Mitropoulou G, Beranger A, Prud'homme JF, Baulac M, Brice A, Bruzzone R & LeGuern E (2001). First genetic evidence of GABA A receptor dysfunction in epilepsy: A mutation in the γ2-subunit gene. Nat Genet 28, 46-48.
7. A receptor channels from low- to high-efficacy gating patterns. J Neurosci 23, 10934-10943.
8. A receptor: Evidence for a β-strand. J Neurosci 19, 4847-4854.
9. A receptor activity: A first latency and Po/o analysis. J Neurosci 21, 7026-7036.
10. Burzomato V, Beato M, Groot-Kormelink PJ, Colquhoun D & Sivilotti LG (2004). Single-channel behavior of heteromeric α1β glycine receptors: An attempt to detect a conformational change before the channel opens. J Neurosci 24, 10924-10940.
11. Celentano JJ & Hawkes AG (2004). Use of the covariance matrix in directly fitting kinetic parameters: Application to GABA A receptors. Biophys J 87, 276-294.
12. A receptor clustering and modulates the channel kinetics. Proc Natl Acad Sci U S A 97, 11557-11562.
13. Colquhoun D & Hawkes AG (1987). A note on correlations in single ion channel records. Proc R Soc Lond B Biol Sci 230, 15-52.
14. Cromer BA, Morton CJ & Parker MW (2002). Anxiety over GABA A receptor structure relieved by AChBP. Trends Biochem Sci 27, 280-287.
15. Elenes S & Auerbach A (2002). Desensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels. J Physiol 541, 367-383.
16. A receptors composed of single or multiple β subunit subtypes. Neuropharmacology 36, 1601-1610.
17. Fredkin DR, Montal M & Rice JA (1985). Identification of aggregated markovian models: Application to the nicotinic acetylcholine receptor. In Proceedings of the Berkley Conference in Honor of Jerzy Neyman and Jack Kiefer, ed. LeCam LM & Olshen RA. Wadsworth Publishing Co., Belmont, CA, USA.
18. A receptor gating kinetics on the α-subunit isoform: Implications for structure-function relations and synaptic transmission. J Physiol 489, 529-543.
19. A receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement. Neuropharmacology 42, 502-521.
20. A receptor currents in mouse fibroblasts. J Physiol 514, 27-45.
21. A receptor currents. J Neurosci 23, 11698-11710.
22. A receptor agonists from antagonists. Biophys J 81, 2660-2670.
23. A channel responses to brief agonist pulses. Neuron 15, 181-191.
24. A) receptor. Biochem Soc Trans 32, 540-546.
25. Kienker P (1989). Equivalence of aggregated Markov models of ion-channel gating. Proc R Soc Lond B Biol Sci 236, 269-309.
26. Koltchine VV, Finn SE, Jenkins A, Nikolaeva N, Lin A & Harrison NL (1999). Agonist gating and isoflurane potentiation in the human γ-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue. Mol Pharmacol 56, 1087-1093.
27. A receptor β subunit controls a binding cavity for propofol and other alkylphenol general anesthetics. Neuropharmacology 41, 952-964.
28. Kucken AM, Wagner DA, Ward PR, Teissere JA, Boileau AJ & Czajkowski C (2000). Identification of benzodiazepine binding site residues in the γ2 subunit of the γ-aminobutyric acid A receptor. Mol Pharmacol 57, 932-939.
29. Labarca P, Rice JA, Fredkin DR & Montal M (1985). Kinetic analysis of channel gating. Application to the cholinergic receptor channel and the chloride channel from Torpedo californica. Biophys J 47, 469-478.
30. A receptor channels are dependent on α-subunit isoform. Biophys J 73, 2518-2526.
31. A receptors. J Physiol 515, 711-727.
32. A receptor main conductance state of mouse spinal cord neurones in culture. J Physiol 410, 479-499.
33. A receptors open? Neuron 12, 61-71.
34. A receptors expressed in HEK293 and in QT6 cells show different kinetics. Neurosci Lett 352, 195-198.
35. Mozrzymas JW, Barberis A, Mercik K & Zarnowska ED (2003). Binding sites, singly bound states, and conformation coupling shape GABA-evoked currents. J Neurophysiol 89, 871-883.
36. Newland CF, Colquhoun D & Cull-Candy SG (1991). Single channels activated by high concentrations of GABA in superior cervical ganglion neurones of the rat. J Physiol 432, 203-233.
37. Nusser Z, Naylor D & Mody I (2001). Synapse-specific contribution of the variation of transmitter concentration to the decay of inhibitory postsynaptic currents. Biophys J 80, 1251-1261.
38. A receptors affects the kinetic properties of GABAergic currents in cultured hippocampal neurons. J Biol Chem 278, 16271-16279.
39. Popescu G & Auerbach A (2003). Modal gating of NMDA receptors and the shape of their synaptic response. Nat Neurosci 6, 476-483.
40. Popescu G, Robert A, Howe JR & Auerbach A (2004). Reaction mechanism determines NMDA receptor response to repetitive stimulation. Nature 430, 790-793.
41. Qin F (2004). Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling. Biophys J 86, 1488-1501.
42. Qin F, Auerbach A & Sachs F (1996). Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events. Biophys J 70, 264-280.
43. Salamone FN, Zhou M & Auerbach A (1999). A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics. J Physiol 516, 315-330.
44. Sanford LD, Tang X, Xiao J, Ross RJ & Morrison AR (2003). GABAergic regulation of REM sleep in reticularis pontis oralis and caudalis in rats. J Neurophysiol 90, 938-945.
45. A receptors. Neurochem Int 34, 379-385.
46. A receptor subunit upregulation following steroid exposure. Neuropharmacology 47, 9-16.
47. A receptors: Building the bridge between subunit mRNAs, their promoters, and cognate transcription factors. Pharmacol Ther 101, 259-281.
48. A receptor channel gating by pentobarbital. J Physiol 537, 715-733.
49. A α5 receptor inverse agonists as cognition enhancers. J Med Chem 47, 2176-2179.
50. A receptor main conductance state of mouse spinal cord neurones in culture. J Physiol 423, 193-220.
51. A receptor γ2-subunit in childhood absence epilepsy and febrile seizures. Nat Genet 28, 49-52.
52. - channels determined from stability plots, dwell-time distributions, and adjacent-interval durations. J Neurosci 9, 1314-1324.