Distinguishing between GABAA receptors responsible for tonic and phasic conductances

Neurochemical Research

Volumn 26, Issue 8-9, 2001, Pages 907-913

  Mody, Istvan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

GABA; GABAA receptors; Inhibition; Neuronal excitability

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CHLORIDE CHANNEL;

ARTICLE; CELL COMMUNICATION; CHANNEL GATING; GABAERGIC SYSTEM; NERVE CELL EXCITABILITY; NERVE CONDUCTION; NEUROENDOCRINE SYSTEM; PRIORITY JOURNAL; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION;

ANIMALS; ION CHANNEL GATING; RECEPTORS, GABA-A;

EID: 0034764735     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012376215967     Document Type: Article

References (61)

1. Molecular regulators of brain function: A new view
2. Nonsynaptic diffusion neurotransmission (NDN) in the brain
3. Intercellular communication in the brain: Wiring versus volume transmission
4. Wiring and volume transmission in the central nervous system: The concept of closed and open synapses
5. Role of high-affinity receptors and membrane transporters in nonsynaptic communication and drug action in the central nervous system
6. Volume transmission in the CNS and its relevance for neuropsychopharmacology
7. Mismatches between neurotransmitter and receptor localizations in brain: Observations and implications
8. Intersynaptic diffusion of neurotransmitter
9. Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release
10. A receptors
11. A receptor channels
12. Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes
13. A channel subtypes
14. A receptor/chloride channel complex in anesthesia
15. Molecular and cellular mechanisms of general anaesthesia
16. The impact of receptor desensitization on fast synaptic transmission
17. A receptors underlying inhibitory synaptic currents in neocortical pyramidal neurons
18. Chlorpromazine inhibits miniature GABAergic currents by reducing the binding and by increasing the unbinding rate of GABAA receptors
19. Cell type- and synapse specific variability in GABAA receptor occupancy
20. A receptors on cerebellar granule cells as determined by a quantitative immunogold method
21. 6 subunit gene inactivation inhibits δ subunit expression
22. In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis
23. Regional distribution and extracellular levels of amino acids in rat central nervous system
24. Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons
25. Differential activation of glutamate receptors by spontaneously released transmitter in slices of neocortex
26. A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system
27. Development of action potential-dependent and independent spontaneous GABAA receptor-mediated currents in granule cells of postnatal rat cerebellum
28. Spillover-mediated transmission at inhibitory synapses promoted by high affinity alpha6 subunit GABA(A) receptors and glomerular geometry
29. A-receptor subtypes really occur in the brain?
30. Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin
31. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton
32. A receptors
33. Tonic benzodiazepine-sensitive GABAergic inhibition in cultured rodent cerebellar granule cells
34. Single-channel properties of synaptic and extrasynaptic GABAA receptors suggest differential targeting of receptor subtypes
35. Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
36. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells
37. Colocalization of multiple GABA(A) receptor subtypes with gephyrin at postsynaptic sites
38. A receptor subunits: Role of the δ subunit
39. Distinct deactivation and desensitization kinetics of recombinant GABAA receptors
40. A receptors containing gamma2 or δ subtypes expressed with α1 and β3 subtypes in mouse L929 cells
41. GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts
42. Preferential coassembly of alpha4 and delta subunits of the gamma-aminobutyric acidA receptor in rat thalamus
43. A receptor subunits exist in distinct neuronal subpopulations
44. A receptors
45. Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice
46. A receptors containing the α4-subunit. Prevalence, distribution, pharmacology, and subunit architecture in situ
47. A receptor subunit expression and function in temporal lobe epilepsy
48. A significant part of native gamma-aminobutyric AcidA receptors containing alpha4 subunits do not contain gamma or delta subunits
49. Sensitivity of the rat hippocampal GABA(A) receptor alpha 4 subunit to electroshock seizures
50. Expression of GABA(A) receptor subunits in the hippocampus of the rat after kainic acid-induced seizures
51. A receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid
52. Withdrawal from 3alpha-OH-5alpha-pregnan-20-One using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor alpha4 subunit in association with increased anxiety
53. Chronic blockade of N-methyl-D-aspartate receptors alters gamma-aminobutyric acid type A receptor peptide expression and function in the rat
54. A-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivo
55. Channel properties determine the transient activation kinetics of recombinant GABA(A) receptors
56. Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures
57. Slow desensitization regulates the availability of synaptic GABA(A) receptors
58. Spontaneously opening GABA(A) channels in CA1 pyramidal neurones of rat hippocampus
59. Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons
60. Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology