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Volumn 52, Issue 1, 2008, Pages 43-53

Spa-1 regulates the maintenance and differentiation of human embryonic stem cells

Author keywords

Differentiation; Fate decision; Gene regulation; Signal transduction

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN SPA 1; RAF PROTEIN; RAP1 PROTEIN; REGULATOR PROTEIN; RNA; UNCLASSIFIED DRUG;

EID: 38749138094     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: 10.1387/ijdb.072274yl     Document Type: Article
Times cited : (5)

References (63)
  • 1
    • 0038724937 scopus 로고    scopus 로고
    • Role of Raf in vascular protection from distinct apoptotic stimuli
    • ALAVI, A., HOOD, J.D., FRAUSTO, R. STUPACK, D.G. and CHERESH, D.A. (2003). Role of Raf in vascular protection from distinct apoptotic stimuli. Science 301: 94-96.
    • (2003) Science , vol.301 , pp. 94-96
    • ALAVI, A.1    HOOD, J.D.2    FRAUSTO, R.3    STUPACK, D.G.4    CHERESH, D.A.5
  • 2
    • 1242276404 scopus 로고    scopus 로고
    • Feeder layer- and serum-free culture of human embryonic stem cells
    • AMIT, M., SHARIKI, C., MARGULETS, V. and ITSKOVITZ-ELDOR, J. (2004). Feeder layer- and serum-free culture of human embryonic stem cells. Biol. Reprod. 70: 837-845.
    • (2004) Biol. Reprod , vol.70 , pp. 837-845
    • AMIT, M.1    SHARIKI, C.2    MARGULETS, V.3    ITSKOVITZ-ELDOR, J.4
  • 3
    • 33744758028 scopus 로고    scopus 로고
    • The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis
    • ARMSTRONG, L., HUGHES, O., YUNG, S., HYSLOP, L., STEWART, R., WAPPLER, I., PETERS, H., WALTER, T., STOJKOVIC, P., EVANS, J., STOJKOVIC, M. and LAKO, M. (2006). The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis. Hum. Mol. Genet. 15: 1894-1913.
    • (2006) Hum. Mol. Genet , vol.15 , pp. 1894-1913
    • ARMSTRONG, L.1    HUGHES, O.2    YUNG, S.3    HYSLOP, L.4    STEWART, R.5    WAPPLER, I.6    PETERS, H.7    WALTER, T.8    STOJKOVIC, P.9    EVANS, J.10    STOJKOVIC, M.11    LAKO, M.12
  • 4
    • 0021447637 scopus 로고
    • Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro
    • ANDREWS, P.W. (1984). Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev. Biol. 103: 285-293.
    • (1984) Dev. Biol , vol.103 , pp. 285-293
    • ANDREWS, P.W.1
  • 5
    • 0021745096 scopus 로고
    • Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells
    • ANDREWS,.PW., BANTING, G., DAMJANOV, I., ARNAUD, D. and AVNER, P. (1984) Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells. Hybridoma 3: 347-361.
    • (1984) Hybridoma , vol.3 , pp. 347-361
    • ANDREWS, P.W.1    BANTING, G.2    DAMJANOV, I.3    ARNAUD, D.4    AVNER, P.5
  • 6
    • 33846917472 scopus 로고    scopus 로고
    • Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells
    • BABAIE, Y., HERWIG, R., GREBER, B., BRINK, T.C., WRUCK, W., GROTH, D., LEHRACH, H., BURDON, T., ADJAYE, J. (2007). Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells 25: 500-510.
    • (2007) Stem Cells , vol.25 , pp. 500-510
    • BABAIE, Y.1    HERWIG, R.2    GREBER, B.3    BRINK, T.C.4    WRUCK, W.5    GROTH, D.6    LEHRACH, H.7    BURDON, T.8    ADJAYE, J.9
  • 7
    • 0035347262 scopus 로고    scopus 로고
    • BOS, J.L., DE, ROOIJ. J. and REEDQUIST, K.A. (2001). Rap1 signalling: adhering to new models. Nat. Rev. Mol. Cell. Biol. 2: 369-377.
    • BOS, J.L., DE, ROOIJ. J. and REEDQUIST, K.A. (2001). Rap1 signalling: adhering to new models. Nat. Rev. Mol. Cell. Biol. 2: 369-377.
  • 9
    • 0032747233 scopus 로고    scopus 로고
    • Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells
    • BURDON, T., CHAMBERS, I., STRACEY, C., NIWA, H. and SMITH, A. (1999). Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells. Cells Tissues Organs. 165: 131-143.
    • (1999) Cells Tissues Organs , vol.165 , pp. 131-143
    • BURDON, T.1    CHAMBERS, I.2    STRACEY, C.3    NIWA, H.4    SMITH, A.5
  • 10
    • 0037474221 scopus 로고    scopus 로고
    • The requirement of specific membrane domains for Raf-1 phosphorylation and activation
    • CAREY, K.D., WATSON, R.T., PESSIN, J.E. and STORK, P.J. (2003). The requirement of specific membrane domains for Raf-1 phosphorylation and activation. J. Biol. Chem. 278: 3185-3196.
    • (2003) J. Biol. Chem , vol.278 , pp. 3185-3196
    • CAREY, K.D.1    WATSON, R.T.2    PESSIN, J.E.3    STORK, P.J.4
  • 11
    • 0037329747 scopus 로고    scopus 로고
    • Cellular functions of the Rap1 GTP-binding protein: A pattern emerges
    • CARON, E. (2003). Cellular functions of the Rap1 GTP-binding protein: a pattern emerges. J. Cell. Sci. 116: 435-440.
    • (2003) J. Cell. Sci , vol.116 , pp. 435-440
    • CARON, E.1
  • 12
    • 0035099881 scopus 로고    scopus 로고
    • S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
    • CHILOECHES, A., MASON, C.S. and MARAIS, R. (2001). S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. Mol. Cell. Biol. 21: 2423-2434.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 2423-2434
    • CHILOECHES, A.1    MASON, C.S.2    MARAIS, R.3
  • 13
    • 0027170176 scopus 로고
    • RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts
    • COOK, S.J., RUBINFELD, B., ALBERT, I. and MCCORMICK, F. (1993). RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J. 12: 3475-3485.
    • (1993) EMBO J , vol.12 , pp. 3475-3485
    • COOK, S.J.1    RUBINFELD, B.2    ALBERT, I.3    MCCORMICK, F.4
  • 14
    • 0035853782 scopus 로고    scopus 로고
    • DUPUY, A.J., MORGAN, K., VON, LINTIG, F.C., SHEN, H., ACAR, H., HASZ, D.E., JENKINS, N.A., COPELAND, N.G., BOSS, G.R. and LARGAESPADA, D.A. (2001). Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia. J. Biol. Chem. 276: 11804-11811.
    • DUPUY, A.J., MORGAN, K., VON, LINTIG, F.C., SHEN, H., ACAR, H., HASZ, D.E., JENKINS, N.A., COPELAND, N.G., BOSS, G.R. and LARGAESPADA, D.A. (2001). Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia. J. Biol. Chem. 276: 11804-11811.
  • 15
    • 25444503012 scopus 로고    scopus 로고
    • Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells
    • DVORAK, P., DVORAKOVA, D., KOSKOVA, S., VODINSKA, M., NAJVIRTOVA, M., KREKAC, D. and HAMPL, A. (2005). Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells. Stem Cells 23: 1200-1211.
    • (2005) Stem Cells , vol.23 , pp. 1200-1211
    • DVORAK, P.1    DVORAKOVA, D.2    KOSKOVA, S.3    VODINSKA, M.4    NAJVIRTOVA, M.5    KREKAC, D.6    HAMPL, A.7
  • 16
    • 0023266095 scopus 로고
    • Glycolipid core structure switching from globo- to lacto-and ganglio-series during retinoic acid-induced differentiation of TERA-2-derived human embryonal carcinoma cells
    • FENDERSON, B.A., ANDREWS, P.W., NUDELMAN, E., CLAUSEN, H. and HAKOMORI, S. (1987). Glycolipid core structure switching from globo- to lacto-and ganglio-series during retinoic acid-induced differentiation of TERA-2-derived human embryonal carcinoma cells. Dev. Biol. 122: 21-34.
    • (1987) Dev. Biol , vol.122 , pp. 21-34
    • FENDERSON, B.A.1    ANDREWS, P.W.2    NUDELMAN, E.3    CLAUSEN, H.4    HAKOMORI, S.5
  • 17
    • 0032952586 scopus 로고    scopus 로고
    • The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation
    • GAO, Q., SRINIVASAN, S., BOYER, S.N., WAZER, D.E. and BAND, V. (1999). The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. Mol. Cell. Biol. 19: 733-744.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 733-744
    • GAO, Q.1    SRINIVASAN, S.2    BOYER, S.N.3    WAZER, D.E.4    BAND, V.5
  • 18
    • 0035051806 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells
    • GAO, Q., SINGH, L., KUMAR, A., SRINIVASAN, S., WAZER, D.E. and BAND, V. (2001) Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells. J. Virol. 75: 4459-4466.
    • (2001) J. Virol , vol.75 , pp. 4459-4466
    • GAO, Q.1    SINGH, L.2    KUMAR, A.3    SRINIVASAN, S.4    WAZER, D.E.5    BAND, V.6
  • 19
    • 33846931113 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal
    • GREBER, B., LEHRACH, H., ADJAYE, J. (2007). Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells 25: 455-464.
    • (2007) Stem Cells , vol.25 , pp. 455-464
    • GREBER, B.1    LEHRACH, H.2    ADJAYE, J.3
  • 20
    • 0028947758 scopus 로고
    • Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression
    • HATTORI, M., TSUKAMOTO, N., NUR-E-KAMAL, M.S., RUBINFELD, B., IWAI, K., KUBOTA, H., MARUTA, H. and MINATO, N. (1995). Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. Mol. Cell. Biol. 15: 552-560.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 552-560
    • HATTORI, M.1    TSUKAMOTO, N.2    NUR-E-KAMAL, M.S.3    RUBINFELD, B.4    IWAI, K.5    KUBOTA, H.6    MARUTA, H.7    MINATO, N.8
  • 23
    • 16244400050 scopus 로고    scopus 로고
    • TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
    • JAMES, D., LEVINE, A.J., BESSER, D. and HEMMATI-BRIVANLOU, A. (2005). TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 132: 1273-1282.
    • (2005) Development , vol.132 , pp. 1273-1282
    • JAMES, D.1    LEVINE, A.J.2    BESSER, D.3    HEMMATI-BRIVANLOU, A.4
  • 25
    • 0030780650 scopus 로고    scopus 로고
    • Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rapl GAP gene product
    • KURACHI, H., WADA, Y., TSUKAMOTO, N., MAEDA, M., KUBOTA, H., HATTORI, M., IWAI, K. and MINATO, N. (1997). Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rapl GAP gene product. J. Biol. Chem. 272: 28081-28088.
    • (1997) J. Biol. Chem , vol.272 , pp. 28081-28088
    • KURACHI, H.1    WADA, Y.2    TSUKAMOTO, N.3    MAEDA, M.4    KUBOTA, H.5    HATTORI, M.6    IWAI, K.7    MINATO, N.8
  • 26
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-[/Delta][/Delta]C(T) ) method
    • LIVAK, K. J. and SCHMITTGEN, T.D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-[/Delta][/Delta]C(T) ) method. Method 25: 402-408
    • (2001) Method , vol.25 , pp. 402-408
    • LIVAK, K.J.1    SCHMITTGEN, T.D.2
  • 27
    • 0033517123 scopus 로고    scopus 로고
    • STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
    • MATSUDA, T., NAKAMURA, T., NAKAO, K., ARAI, T., KATSUKI, M., HEIKE, T. and YOKOTA, T. (1999). STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J. 18: 4261-4269.
    • (1999) EMBO J , vol.18 , pp. 4261-4269
    • MATSUDA, T.1    NAKAMURA, T.2    NAKAO, K.3    ARAI, T.4    KATSUKI, M.5    HEIKE, T.6    YOKOTA, T.7
  • 28
    • 0038697566 scopus 로고    scopus 로고
    • Raf proteins and cancer: B-Raf is identified as a mutational target
    • MERCER, K.E. and PRITCHARD, C.A. (2003). Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim. Biophys. Acta. 1653: 25-40.
    • (2003) Biochim. Biophys. Acta , vol.1653 , pp. 25-40
    • MERCER, K.E.1    PRITCHARD, C.A.2
  • 32
    • 0032091098 scopus 로고    scopus 로고
    • Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification
    • MORRISON, T.B., WEIS, J.J. and WITTWER, C.T. (1998). Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification. Biotechniques 24: 954-958.
    • (1998) Biotechniques , vol.24 , pp. 954-958
    • MORRISON, T.B.1    WEIS, J.J.2    WITTWER, C.T.3
  • 33
    • 0032127977 scopus 로고    scopus 로고
    • Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
    • NIWA, H., BURDON, T., CHAMBERS, I. and SMITH, A. (1998). Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes. Dev. 12: 2048-2060.
    • (1998) Genes. Dev , vol.12 , pp. 2048-2060
    • NIWA, H.1    BURDON, T.2    CHAMBERS, I.3    SMITH, A.4
  • 34
    • 0034837080 scopus 로고    scopus 로고
    • Molecular mechanism to maintain stem cell renewal of ES cells
    • NIWA, H. (2001). Molecular mechanism to maintain stem cell renewal of ES cells. Cell Struct. Funct. 26: 137-148.
    • (2001) Cell Struct. Funct , vol.26 , pp. 137-148
    • NIWA, H.1
  • 35
    • 1342301559 scopus 로고    scopus 로고
    • Conferring specificity on the ubiquitous Raf/MEK signalling pathway
    • O'NEILL, E. and KOLCH, W. (2004). Conferring specificity on the ubiquitous Raf/MEK signalling pathway. Br. J. Cancer 90: 283-288.
    • (2004) Br. J. Cancer , vol.90 , pp. 283-288
    • O'NEILL, E.1    KOLCH, W.2
  • 36
    • 0035797521 scopus 로고    scopus 로고
    • Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP
    • PAK, D.T., YANG, S., RUDOLPH-CORREIA, S., KIM, E. and SHENG, M. (2001). Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31: 289-303.
    • (2001) Neuron , vol.31 , pp. 289-303
    • PAK, D.T.1    YANG, S.2    RUDOLPH-CORREIA, S.3    KIM, E.4    SHENG, M.5
  • 37
    • 0021706059 scopus 로고
    • Interactions between diploid embryonal carcinoma cells and early embryonic cells
    • PAPAIOANNOU, V.E., WATERS, B.K. and ROSSANT, J. (1984). Interactions between diploid embryonal carcinoma cells and early embryonic cells. Cell Differ. 15: 175-179.
    • (1984) Cell Differ , vol.15 , pp. 175-179
    • PAPAIOANNOU, V.E.1    WATERS, B.K.2    ROSSANT, J.3
  • 38
    • 0344738990 scopus 로고    scopus 로고
    • Establishment and maintenance of human embryonic stem cells on STO, a permanently growing cell line
    • PARK, J.H., KIM, S.J., OH, E.J., MOON, S.Y., ROH, S.I., KIM, C.G. and YOON, H.S. (2003). Establishment and maintenance of human embryonic stem cells on STO, a permanently growing cell line. Biol. Reprod. 69: 2007-2014.
    • (2003) Biol. Reprod , vol.69 , pp. 2007-2014
    • PARK, J.H.1    KIM, S.J.2    OH, E.J.3    MOON, S.Y.4    ROH, S.I.5    KIM, C.G.6    YOON, H.S.7
  • 39
    • 0025000915 scopus 로고
    • Isolation of embryonic stem (ES) cells in media supplemented with recombinant leukemia inhibitory factor (LIF)
    • PEASE, S., BRAGHETTA, P., GEARING, D., GRAIL, D. and WILLIAMS, R.L. (1990). Isolation of embryonic stem (ES) cells in media supplemented with recombinant leukemia inhibitory factor (LIF). Dev. Biol. 141: 344-352.
    • (1990) Dev. Biol , vol.141 , pp. 344-352
    • PEASE, S.1    BRAGHETTA, P.2    GEARING, D.3    GRAIL, D.4    WILLIAMS, R.L.5
  • 40
    • 16344369393 scopus 로고    scopus 로고
    • PROWSE, A.B., MCQUADE, L.R., BRYANT, K.J., VAN, DYK, D.D., TUCH, B.E. and GRAY, P.P. (2005). A proteome analysis of conditioned media from human neonatal fibroblasts used in the maintenance of human embryonic stem cells. Proteomics 5: 978-989.
    • PROWSE, A.B., MCQUADE, L.R., BRYANT, K.J., VAN, DYK, D.D., TUCH, B.E. and GRAY, P.P. (2005). A proteome analysis of conditioned media from human neonatal fibroblasts used in the maintenance of human embryonic stem cells. Proteomics 5: 978-989.
  • 42
    • 0034101804 scopus 로고    scopus 로고
    • Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
    • REUBINOFF, B.E., PERA, M.F., FONG, C.Y., TROUNSON, A. and BONGSO, A. (2000). Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat. Biotechnol. 18: 399-404.
    • (2000) Nat. Biotechnol , vol.18 , pp. 399-404
    • REUBINOFF, B.E.1    PERA, M.F.2    FONG, C.Y.3    TROUNSON, A.4    BONGSO, A.5
  • 43
    • 0021669108 scopus 로고
    • The relationship between embryonic, embryonal carcinoma and embryo-derived stem cells
    • ROSSANT, J. and PAPAIOANNOU, V.E. (1984). The relationship between embryonic, embryonal carcinoma and embryo-derived stem cells. Cell Differ. 15: 155-161.
    • (1984) Cell Differ , vol.15 , pp. 155-161
    • ROSSANT, J.1    PAPAIOANNOU, V.E.2
  • 44
    • 0025324441 scopus 로고
    • Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12, p13, 12q14, and 13q34, respectively
    • ROUSSEAU-MERCK, M.F., PIZON, V., TAVITIAN, A. and BERGER, R. (1990). Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12, p13, 12q14, and 13q34, respectively. Cytogenet. Cell Genet. 53: 2-4.
    • (1990) Cytogenet. Cell Genet , vol.53 , pp. 2-4
    • ROUSSEAU-MERCK, M.F.1    PIZON, V.2    TAVITIAN, A.3    BERGER, R.4
  • 46
    • 0035998270 scopus 로고    scopus 로고
    • SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus
    • ROY, B.C., KOHU, K., MATSUURA, K., YANAI, H. and AKIYAMA, T. (2002). SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus. Genes Cells 7: 607-617.
    • (2002) Genes Cells , vol.7 , pp. 607-617
    • ROY, B.C.1    KOHU, K.2    MATSUURA, K.3    YANAI, H.4    AKIYAMA, T.5
  • 47
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
    • SATO, N., MEIJER, L., SKALTSOUNIS, L., GREENGARD, P. and BRIVANLOU, A.H. (2004). Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 10: 55-63.
    • (2004) Nat. Med , vol.10 , pp. 55-63
    • SATO, N.1    MEIJER, L.2    SKALTSOUNIS, L.3    GREENGARD, P.4    BRIVANLOU, A.H.5
  • 48
    • 0034996666 scopus 로고    scopus 로고
    • Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1
    • SCHMITT, J.M. and STORK, P.J. (2001). Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1. Mol. Cell. Biol. 21: 3671-3683.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 3671-3683
    • SCHMITT, J.M.1    STORK, P.J.2
  • 52
    • 0038741814 scopus 로고    scopus 로고
    • Does Rap1 deserves a bad Rap?
    • STORK, P.J. (2003). Does Rap1 deserves a bad Rap? Trends. Biochem. Sci. 28: 267-275.
    • (2003) Trends. Biochem. Sci , vol.28 , pp. 267-275
    • STORK, P.J.1
  • 54
    • 0033961920 scopus 로고    scopus 로고
    • Human embryonic stem cell and embryonic germ cell lines
    • THOMSON, J.A. and ODORICO, J.S. (2000). Human embryonic stem cell and embryonic germ cell lines. Trends. Biotechnol. 18: 53-57.
    • (2000) Trends. Biotechnol , vol.18 , pp. 53-57
    • THOMSON, J.A.1    ODORICO, J.S.2
  • 55
    • 0030963439 scopus 로고    scopus 로고
    • cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
    • VOSSLER, M.R., YAO, H., YORK, R.D., PAN, M.G., RIM, C.S. and STORK, P.J. (1997). cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89: 73-82.
    • (1997) Cell , vol.89 , pp. 73-82
    • VOSSLER, M.R.1    YAO, H.2    YORK, R.D.3    PAN, M.G.4    RIM, C.S.5    STORK, P.J.6
  • 56
    • 0031025185 scopus 로고    scopus 로고
    • Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human
    • WADA, Y., KUBOTA, H., MAEDA, M., TANIWAKI, M., HATTORI, M., IMAMURA, S., IWAI, K. and MINATO, N. (1997). Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human. Genomics 39: 66-73.
    • (1997) Genomics , vol.39 , pp. 66-73
    • WADA, Y.1    KUBOTA, H.2    MAEDA, M.3    TANIWAKI, M.4    HATTORI, M.5    IMAMURA, S.6    IWAI, K.7    MINATO, N.8
  • 57
    • 0038561134 scopus 로고    scopus 로고
    • Expression of Wnt and Notch pathway genes in a pluripotent human embryonal carcinoma cell line and embryonic stem cell
    • WALSH, J. and ANDREWS, P.W. (2003). Expression of Wnt and Notch pathway genes in a pluripotent human embryonal carcinoma cell line and embryonic stem cell. Apmis 111: 197-210.
    • (2003) Apmis , vol.111 , pp. 197-210
    • WALSH, J.1    ANDREWS, P.W.2
  • 58
    • 0032858647 scopus 로고    scopus 로고
    • 11q13 is a cytogenetically promiscuous site in hematologic malignancies
    • WONG, K.F. (1999). 11q13 is a cytogenetically promiscuous site in hematologic malignancies. Cancer Genet. Cytogenet. 113: 93-95.
    • (1999) Cancer Genet. Cytogenet , vol.113 , pp. 93-95
    • WONG, K.F.1
  • 60
    • 1342294092 scopus 로고    scopus 로고
    • Normalization for cDNA microarray data: A robust composite method addressing single and multiple slide systematic variation
    • YANG, Y.H., DUDOIT, S., LUU, P., LIN, D.M., PENG, V., NAGI, J. and SPEED, T.P. (2002). Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucl. Acid. Res. 30: e15
    • (2002) Nucl. Acid. Res , vol.30
    • YANG, Y.H.1    DUDOIT, S.2    LUU, P.3    LIN, D.M.4    PENG, V.5    NAGI, J.6    SPEED, T.P.7
  • 61
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    • YING, Q.L., NICHOLS, J., CHAMBERS, I. and SMITH, A. (2003). BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115: 281-292.
    • (2003) Cell , vol.115 , pp. 281-292
    • YING, Q.L.1    NICHOLS, J.2    CHAMBERS, I.3    SMITH, A.4
  • 62
    • 0028011911 scopus 로고
    • Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways
    • YOSHIDA, K., CHAMBERS, I., NICHOLS, J., SMITH, A., SAITO, M., YASUKAWA, K., SHOYAB, M., TAGA, T. and KISHIMOTO, T. (1994). Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways. Mech. Dev. 45: 163-171.
    • (1994) Mech. Dev , vol.45 , pp. 163-171
    • YOSHIDA, K.1    CHAMBERS, I.2    NICHOLS, J.3    SMITH, A.4    SAITO, M.5    YASUKAWA, K.6    SHOYAB, M.7    TAGA, T.8    KISHIMOTO, T.9
  • 63
    • 0034675919 scopus 로고    scopus 로고
    • Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
    • ZHANG, B.H. and GUAN, K.L. (2000). Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO. J. 19: 5429-5439.
    • (2000) EMBO. J , vol.19 , pp. 5429-5439
    • ZHANG, B.H.1    GUAN, K.L.2


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