Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude

Chest

Volumn 131, Issue 5, 2007, Pages 1473-1478

  Baillie, J Kenneth ^a   Bates, Matthew G D ^a   Thompson, A A Roger ^a   Waring, W Stephen ^a   Partridge, Roland W ^a   Schnopp, Martin F ^a   Simpson, Alistair ^a   Gulliver Sloan, Fiona ^a   Maxwell, Simon R J ^a   Webb, David J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Altitude; Free radicals; Hypoxia; Oxidative stress; Uric acid

Indexed keywords

8 ISOPROSTANE; ANTIOXIDANT; BIOLOGICAL MARKER; ISOPROSTANE DERIVATIVE; SULFONIC ACID DERIVATIVE; URATE;

ADULT; ALTITUDE; ANTIOXIDANT ACTIVITY; ARTICLE; BOLIVIA; CHEMOLUMINESCENCE; CLINICAL RESEARCH; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MEASUREMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; SPECTROMETRY; TRAVEL; URIC ACID URINE LEVEL;

EID: 34248566913     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.06-2235     Document Type: Article

References (35)

1. Cheeseman KH, Slater TF. An introduction to free radical biochemistry. BMJ Bull 1993; 49:481-493
2. Hackett PH, Roach RC. High-altitude illness. N Engl J Med 2001; 345:107-114
3. Nakanishi K, Tajima F, Nakamura A et al. Effects of hypobaric hypoxia on antioxidant enzymes in rats. J Physiol (Lond) 1995; 489:869-876
4. Guzel NA, Sayan H, Erbas D. Effects of moderate altitude on exhaled nitric oxide, erythrocytes lipid peroxidation and superoxide dismutase levels. Jpn J Physiol 2000; 50:187-190
5. Magalhaes J, Ascensao A, Marques F, et al. Effect of a high-altitude expedition to a Himalayan peak (Pumori, 7,161 m) on plasma and erythrocyte antioxidant profile. Eur J Appl Physiol 2005; 93:726-732.
6. Maxwell SR, Thomason H, Sandler D, et al. Antioxidant status in patients with uncomplicated insulin-dependent and non-insulin-dependent diabetes mellitus. Eur J Clin Invest 1997; 27:484-490
7. Fox IH. Metabolic basis for disorders of purine nucleotide degradation. Metabolism 1981; 30:616-634
8. Mathru M, Dries DJ, Barnes L et al. Tourniquet-induced exsanguination in patients requiring lower limb surgery: an ischemia-reperfusion model of oxidant and antioxidant metabolism. Anesthesiology 1996; 84:14-22
9. Jefferson JA, Escudero E, Hurtado ME, et al. Hyperuricemia, hypertension, and proteinuria associated with high-altitude polycythemia. Am J Kidney Dis 2002; 39:1135-1142
10. Vij AG, Dutta R, Satija NK. Acclimatization to oxidative stress at high altitude. High Alt Med Biol 2005; 6:301-310
11. Chao WH, Askew EW, Roberts DE, et al. Oxidative stress in humans during work at moderate altitude. J Nutr 1999; 129:2009-2012
12. Vasankari TJ, Kujala UM, Rusko H, et al. The effect of endurance exercise at moderate altitude on serum lipid peroxidation and antioxidative functions in humans. Eur J Appl Physiol 1997; 75:396-399
13. Pfeiffer JM, Askew EW, Roberts DE, et al. Effect of antioxidant supplementation on urine and blood markers of oxidative stress during extended moderate-altitude training. Wilderness Environ Med 1999; 10:66-74
14. Maxwell SR, Jakeman P, Thomason H, et al. Changes in plasma antioxidant status during eccentric exercise and the effect of vitamin supplementation. Free Radic Res Commun 1993; 19:191-202
15. Jefferson JA, Simoni J, Escudero E, et al. Increased oxidative stress following acute and chronic high altitude exposure. High Alt Med Biol 2004; 5:61-69
16. Roach RC, Bartsch P, Oelz O, et al. The Lake Louise acute mountain sickness scoring system. In: Sutton JR, Houston CS, Coates G, ed. Hypoxia and molecular medicine. Burlington, VT: Queen City Printers, 1993; 272-274
17. Waring WS, Webb DJ, Maxwell SR. Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers. J Cardiovasc Pharmacol 2001; 38:365-371
18. Miller NJ, Rice-Evans C, Davies MJ, et al. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci (Colch) 1993; 84:407-412
19. Gochman N, Schmitz JM. Automated determination of uric acid, with use of a uricase-peroxidase system. Clin Chem 1971; 17:1154-1159
20. Wang Z, Ciabattoni G, Cremmon C, et al. Immunological characterization of urinary 8-epi-prostaglandin F2 α excretion in man. J Pharmacol Exp Ther 1995; 275:94-100
21. Sahebjani H. Changes in urinary uric acid excretion in obstructive sleep apnea before and after therapy with nasal continuous positive airway pressure. Chest 1998; 113:1604-1608
22. Wannamethee SG, Shaper AG, Whincup PH. Serum urate and the risk of major coronary heart disease events. Heart 1997; 78:147-153
23. Weir CJ, Muir SW, Walters MR, et al. Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke. Stroke 2003; 34:1951-1956
24. Waring WS, Convery A, Mishra V, et al. Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci (Lond) 2003; 105:42.5-430
25. Ward MP, Milledge JS, West JB. High altitude medicine and physiology. London, UK: Chapman and Hall Medical, 1995
26. Rose MS, Houston CS, Fulco CS, et al. Operation Everest: nutrition and body composition. J Appl Physiol 1988; 65: 2545-2551
27. Fox IH, Palella TD, Kelley WN. Hyperuricemia: a marker for cell energy crisis. N Engl J Med 1987; 317:111-112
28. Enomoto A, Kimura H, Chairoungdua A, et al. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 2002; 417:447-452
29. Yamamoto T, Moriwaki Y, Takahashi S, et al. Effect of norepinephrine on the urinary excretion of purine bases and oxypurinol. Metabolism 2001; 50:1230-1233
30. Steele TH, Rieselbach RE. The renal mechanism for urate homeostasis in normal man. Am J Med 1967; 43:868-875
31. Hoshikawa Y, Ono S, Suzuki S, et al. Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia. J Appl Physiol 2001; 90:1299-1306
32. Wu XW, Muzny DM, Lee CC, et al. Two independent mutational events in the loss of urate oxidase during hominoid evolution. J Mol Evol 1992; 34:78-84
33. Kramer EF Jr, Hale HB, Williams EW. Physiological effects of an 18-hour flight in F-4c aircraft. Aerosp Med 1966; 37:1095-1098
34. Joanny P, Steinberg J, Robach P, et al. Operation Everest III (Comex'97): the effect of simulated sever hypobaric hypoxia on lipid peroxidation and antioxidant defence systems in human blood at rest and after maximal exercise. Resuscitation 2001; 49:307-314
35. Gundestrup M, Storm HH. Radiation-induced acute myeloid leukaemia and other cancers in commercial jet cockpit crew: a population-based cohort study. Lancet 1999; 354:2029-2031