Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia

Blood

Volumn 107, Issue 5, 2006, Pages 2061-2069

  Schmidt, Stefan ^b   Rainer, Johannes ^b   Riml, Stefan ^b   Ploner, Christian ^b   Jesacher, Simone ^b   Achmüller, Clemens ^b   Presul, Elisabeth ^b   Skvortsov, Sergej ^b   Crazzolara, Roman ^b   Fiegl, Michael ^b   Raivio, Taneli ^b   Jänne, Olli A ^b   Geley, Stephan ^b   Meister, Bernhard ^b   Kofler, Reinhard ^a  

^a TYROLEAN CANCER RESEARCH INSTITUTE   (Austria)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; BUTYROPHILIN LIKE 9 PROTEIN; CYCLIC AMP REGULATED PP21 PROTEIN; DEXAMETHASONE; EPIPLAKIN 1; FK 506 BINDING PROTEIN; GALECTIN 3; GLUCOCORTICOID; GUANINE NUCLEOTIDE BINDING 4 PROTEIN; GUANOSINE TRIPHOSPHATASE; KINESIN; MYC PROTEIN; PREDNISOLONE; PROTEIN; PROTEINASE INHIBITOR; PURINE P2Y RECEPTOR; SNF1 LIKE KINASE; SRC LIKE ADAPTOR PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRISTETRAPROLIN; UNCLASSIFIED DRUG;

ACUTE LYMPHOCYTIC LEUKEMIA; ADOLESCENT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER THERAPY; CHILD; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; COMPARATIVE GENE MAPPING; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; HORMONE RESPONSE; HORMONE SENSITIVITY; HUMAN; HUMAN CELL; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL LINE; LYMPHOBLAST; MALE; MOUSE; NONHUMAN; ONCOGENE C MYC; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PURIFICATION; STATISTICAL SIGNIFICANCE; THYMOCYTE;

EID: 33644542448     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-07-2853     Document Type: Article

References (76)

1. Ashwell JD, Lu FW, Vacchio MS. Glucocorticoids in T cell development and function. Annu Rev Immunol. 2000;18:309-345.
2. Pui CH, Relling MV, Downing JR. Acute lymphoblastic leukemia. N Engl J Med. 2004;350:1535-1548.
3. Dordelmann M, Reiter A, Borkhardt A, et al. Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia. Blood. 1999;94:1209-1217.
4. Schmidt S, Rainer J, Ploner C, et al. Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance. Cell Death Differ. 2004;11:S45-S55.
5. Distelhorst CW. Recent insights into the mechanism of glucocorticosteroid-induced apoptosis. Cell Death Differ. 2002;9:6-19.
6. Planey SL, Litwack G. Glucocorticoid-induced apoptosis in lymphocytes. Biochem Biophys Res Commun. 2000;279:307-312.
7. Cidlowski JA, King KL, Evans-Storms RB, et al. The biochemistry and molecular biology of glucocorticoid-induced apoptosis in the immune system. Recent Prog Horm Res. 1996;51:457-490.
8. Bachmann PS, Gorman R, MacKenzie KL, Lutze-Mann L, Lock RB. Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor. Blood. 2005;105:2519-2526.
9. Haarman EG, Kaspers GJ, Veerman AJ. Glucocorticoid resistance in childhood leukaemia: mechanisms and modulation. Br J Haematol. 2003;120:919-929.
10. Schaaf MJ, Cidlowski JA. Molecular mechanisms of glucocorticoid action and resistance. J Steroid Biochem Mol Biol. 2002;83:37-48.
11. Kofler R, Schmidt S, Kofler A, Ausserlechner MJ. Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemia. J Endocrinol. 2003;178:19-27.
12. Bamberger CM, Schulte HM, Chrousos GP. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev. 1996;17:245-261.
13. Laudet V, Gronemeyer H. The nuclear receptor facts book. London, United Kingdom: Academic Press; 2002.
14. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998;281:1322-1326.
15. Krammer PH. CD95's deadly mission in the immune system. Nature. 2000;407:789-795.
16. Nagata S. Apoptosis by death factor. Cell. 1997;88:355-365.
17. Nicholson DW. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ. 1999;6:1028-1042.
18. Shi Y. Caspase activation: revisiting the induced proximity model. Cell. 2004;117:855-858.
19. Wang Z, Malone MH, He H, McColl KS, Distelhorst CW. Microarray analysis uncovers the induction of the pro-apoptotic BH3-only protein Bim in multiple models of glucocorticoid induced apoptosis. J Biol Chem. 2003;278:23861-23867.
20. Yamada M, Hirasawa A, Shiojima S, Tsujimoto G. Granzyme A mediates glucocorticoid-induced apoptosis in leukemia cells. FASEB J. 2003;17:1712-1714.
21. Malone MH, Wang Z, Distelhorst CW. The glucocorticoid-induced gene tdag8 encodes a proapoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis. J Biol Chem. 2004;279:52850-52859.
22. Löffler M, Tonko M, Hartmann BL, et al. c-myc does not prevent glucocorticoid-induced apoptosis of human leukemic lymphoblasts. Oncogene. 1999;18:4626-4631.
23. Medh RD, Wang A, Zhou F, Thompson EB. Constitutive expression of ectopic c-Myc delays glucocorticoid-evoked apoptosis of human leukemic CEM-C7 cells. Oncogene. 2001;20:4629-4639.
24. Tonko M, Ausserlechner MJ, Bernhard D, Helmberg A, Kofler R. Gene expression profiles of proliferating versus G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis. FASEB J. 2001;15:693-699.
25. Obexer P, Certa U, Kofler R, Helmberg A. Expression profiling of glucocorticoid-treated T-ALL cell lines: rapid repression of multiple genes involved in RNA-, protein- and nucleotide synthesis. Oncogene. 2001;20:4324-4336.
26. Kofler R. The molecular basis of glucocorticoidinduced apoptosis of lymphoblastic leukemia cells. Histochem Cell Biol. 2000;114:1-7.
27. Miller AL, Webb MS, Copik AJ, et al. p38 MAP kinase is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211. Mol Endocrinol. 2005;19:1569-1583.
28. Strasser-Wozak EMC, Hattmannstorfer R, Hála M, et al. Splice site mutation in the glucocorticoid receptor gene causes resistance to glucocorticoid-induced apoptosis in a human acute leukemic cell line. Cancer Res. 1995;55:348-353.
29. Findley HW Jr, Cooper MD, Kim TH, Alvarado C, Ragab AH. Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes. Blood. 1982;60:1305-1309.
30. Geley S, Hartmann BL, Hala M, et al. Resistance to glucocorticoid-induced apoptosis in human Tcell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression. Cancer Res. 1996;56:5033-5038.
31. Hala M, Hartmann BL, Böck G, Geley S, Kofler R. Glucocorticoid receptor gene defects and resistance to glucocorticoid-induced apoptosis in human leukemic cell lines. Int J Cancer. 1996;68:663-668.
32. Raivio T, Palvimo JJ, Kannisto S, Voutilainen R, Janne OA. Transactivation assay for determination of glucocorticoid bioactivity in human serum. J Clin Endocrinol Metab. 2002;87:3740-3744.
33. Ross ME, Zhou X, Song G, et al. Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood. 2003;102:2951-2959.
34. Zawydiwski R, Harmon JM, Thompson EB. Glucocorticoid-resistant human acute lymphoblastic leukemic cell line with functional receptor. Cancer Res. 1983;43:3865-3873.
35. Reichardt HM, Kaestner KH, Tuckermann J et al. DNA binding of the glucocorticoid receptor is not essential for survival. Cell. 1998;93:531-541.
36. Abrams MT, Robertson NM, Yoon K, Wickstrom E. Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM with siRNA and shRNA. J Biol Chem. 2004;279:55809-55817.
37. Whitfield ML, Sherlock G, Saldanha AJ, et al. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell. 2002;13:1977-2000.
38. Fontijn RD, Goud B, Echard A, et al. The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis. Mol Cell Biol. 2001;21:2944-2955.
39. Ausserlechner MJ, Obexer P, Böck G, Geley S, Kofler R. Cyclin D3 and c-myc control glucocorticoid-induced cell cycle arrest but not apoptosis in lymphoblastic leukemia cells. Cell Death Differ. 2004;11:165-174.
40. Nieto MA, González A, Gambón F, Díaz-Espada F, López-Rivas A. Apoptosis in human thymocytes after treatment with glucocorticoids. Clin Exp Immunol. 1992;88:341-344.
41. Brunetti M, Martelli N, Colasante A, et al. Spontaneous and glucocorticoid-induced apoptosis in human mature T lymphocytes. Blood. 1995;86:4199-4205.
42. Ramdas J, Liu W, Harmon JM. Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells. Cancer Res. 1999;59:1378-1385.
43. Riml S, Schmidt S, Ausserlechner MJ, Geley S, Kofler R. Glucocorticoid receptor heterozygosity combined with lack of receptor auto-induction causes glucocorticoid resistance in Jurkat acute lymphoblastic leukemia cells. Cell Death Differ. 2004;11:S65-S72.
44. Tiley C, Grimwade D, Findlay M, et al. Tumour lysis following hydrocortisone prior to a blood product transfusion in T-cell acute lymphoblastic leukaemia. Leuk Lymphoma. 1992;8:143-146.
45. Claudio JO, Masih-Khan E, Tang H et al. A molecular compendium of genes expressed in multiple myeloma. Blood. 2002;100:2175-2186.
46. U M, Miyashita T, Shikama Y, Tadokoro K, Yamada M. Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family. FEBS Lett. 2001;509:135-141.
47. Vermeer H, Hendriks-Stegeman BI, van Suylekom D, et al. An in vitro bioassay to determine individual sensitivity to glucocorticoids: induction of FKBP51 mRNA in peripheral blood mononuclear cells. Mol Cell Endocrinol. 2004;218:49-55.
48. Vermeer H, Hendriks-Stegeman BI, van der Burg B, Buul-Offers SC, Jansen M. Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability. J Clin Endocrinol Metab. 2003;88:277-284.
49. U M, Shen L, Oshida T, et al. Identification of novel direct transcriptional targets of glucocorticoid receptor. Leukemia. 2004;18:1850-1856.
50. Wochnik GM, Ruegg J, Abel GA, et al. FKBP51 and FKBP52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. J Biol Chem. 2004;280:4609-4616.
51. Davies TH, Ning YM, Sanchez ER. A new first step in activation of steroid receptors: hormoneinduced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem. 2002;277:4597-4600.
52. Shoshani T, Faerman A, Mett I, et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol. 2002;22:2283-2293.
53. Wang Z, Malone MH, Thomenius MJ, et al. Dexamethasone-induced gene 2 (dig2) is a novel prosurvival stress gene induced rapidly by diverse apoptotic signals. J Biol Chem. 2003;278:27053-27058.
54. Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004;36:40-45.
55. Brene S, Lindefors N, Ehrlich M, et al. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. J Neurosci. 1994;14:985-998.
56. Cambot M, Aresta S, Kahn-Perles B, de Gunzburg J, Romeo PH. Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells. Blood. 2002;99:3293-3301.
57. Helmberg A, Auphan N, Caelles C, Karin M. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J. 1995;14:452-460.
58. Stephenson A, Huang GY, Nguyen NT, et al. snf1lk encodes a protein kinase that may function in cell cycle regulation. Genomics. 2004;83:1105-1115.
59. Pien S, Wyrzykowska J, Fleming AJ. Novel marker genes for early leaf development indicate spatial regulation of carbohydrate metabolism within the apical meristem. Plant J. 2001;25:663-674.
60. Miki H, Setou M, Kaneshiro K, Hirokawa N. All kinesin superfamily protein, KIF, genes in mouse and human. Proc Natl Acad Sci U S A. 2001;98:7004-7011.
61. Peterson JA, Scallan CD, Ceriani RL, Hamosh M. Structural and functional aspects of three major glycoproteins of the human milk fat globule membrane. Adv Exp Med Biol. 2001;501:179-187.
62. Sosinowski T, Pandey A, Dixit VM, Weiss A. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. J Exp Med. 2000;191:463-474.
63. Costoya JA, Hobbs RM, Barna M, et al. Essential role of Plzf in maintenance of spermatogonial stem cells. Nat Genet. 2004;36:653-659.
64. Buaas FW, Kirsh AL, Sharma M, et al. Plzf is required in adult male germ cells for stem cell self-renewal. Nat Genet. 2004;36:647-652.
65. Barna M, Hawe N, Niswander L, Pandolfi PP. Plzf regulates limb and axial skeletal patterning. Nat Genet. 2000;25:166-172.
66. He L, Bhaumik M, Tribioli C, et al. Two critical hits for promyelocytic leukemia. Mol Cell. 2000;6:1131-1141.
67. Chen SJ, Zelent A, Tong JH, et al. Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. J Clin Invest. 1993;91:2260-2267.
68. Okar DA, Manzano A, Navarro-Sabate A, et al. PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate. Trends Biochem Sci. 2001;26:30-35.
69. Hammerman PS, Fox CJ, Thompson CB. Beginnings of a signal-transduction pathway for bioenergetic control of cell survival. Trends Biochem Sci. 2004;29:586-592.
70. Plas DR, Rathmell JC, Thompson CB. Homeostatic control of lymphocyte survival: potential origins and implications. Nat Immunol. 2002;3:515-521.
71. Warburg O. Ist die aerobe Glykolyse spezifisch für die Tumoren? [Is anaerobic glycolysis specific of tumors?] Biochem Z. 1929;204:482-487.
72. Dang CV, Semenza GL. Oncogenic alterations of metabolism. Trends Biochem Sci. 1999;24:68-72.
73. Munck A. Metabolic site and time course of cortisol action on glucose uptake, lactic acid output, and glucose 6-phosphate levels of rat thymus cells in vitro. J Biol Chem. 1968;243:1039-1042.
74. Holleman A, Cheok MH, den Boer ML, et al. Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. N Engl J Med. 2004;351:533-542.
75. Cario G, Stanulla M, Fine BM, et al. Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia. Blood. 2005;105:821-826.
76. Lugthart S, Cheok MH, den Boer ML, et al. Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia. Cancer Cell. 2005;7:375-386.