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Volumn , Issue 72, 2007, Pages 269-280

The immunological basis of glutamatergic disturbance in schizophrenia: Towards an integrated view

Author keywords

COX 2; glutamate; immune system; NMDA receptor; PGE2; Schizophrenia

Indexed keywords

CARRIER PROTEIN; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; DOPAMINE; DTNBP1 PROTEIN, HUMAN; GLUTAMINE; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEU DIFFERENTIATION FACTOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; TRYPTOPHAN; TRYPTOPHAN 2,3 DIOXYGENASE; UNCLASSIFIED DRUG;

EID: 38449100525     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-211-73574-9_33     Document Type: Review
Times cited : (98)

References (122)
  • 1
    • 0033999887 scopus 로고    scopus 로고
    • Regulation of T-cell responses by CNS antigen-presenting cells: Different roles for microglia and astrocytes
    • Aloisi F, Ria F, Adorini L (2000) Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. Immunol Today 21:141-147
    • (2000) Immunol. Today , vol.21 , pp. 141-147
    • Aloisi, F.1    Ria, F.2    Adorini, L.3
  • 2
    • 0026467216 scopus 로고
    • Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Assessment with xenon 133 single-photon emission computed tomography and the Tower of London
    • Andreasen NC, Rezai K, Alliger R, Swayze VW, Flaum M, Kirchner P, et al. (1992) Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Assessment with xenon 133 single-photon emission computed tomography and the Tower of London. Arch Gen Psychiatry 49:943-958
    • (1992) Arch. Gen. Psychiatry , vol.49 , pp. 943-958
    • Andreasen, N.C.1    Rezai, K.2    Alliger, R.3    Swayze, V.W.4    Flaum, M.5    Kirchner, P.6
  • 3
    • 18844454972 scopus 로고    scopus 로고
    • Increased Th1 and Th2 immune reactivity with relative Th2 dominance in patients with acute exacerbation of schizophrenia
    • Avgustin B, Wraber B, Tavcar R (2005) Increased Th1 and Th2 immune reactivity with relative Th2 dominance in patients with acute exacerbation of schizophrenia. Croat Med J 46:268-274
    • (2005) Croat Med. J. , vol.46 , pp. 268-274
    • Avgustin, B.1    Wraber, B.2    Tavcar, R.3
  • 4
    • 0033588276 scopus 로고    scopus 로고
    • Evidence for activation of microglia in patients with psychiatric illnesses
    • Bayer TA, Buslei R, Havas L, Falkai P (1999) Evidence for activation of microglia in patients with psychiatric illnesses. Neurosci Lett 271:126-128
    • (1999) Neurosci. Lett. , vol.271 , pp. 126-128
    • Bayer, T.A.1    Buslei, R.2    Havas, L.3    Falkai, P.4
  • 5
    • 0037774724 scopus 로고    scopus 로고
    • CSF filtration as experimental therapy in therapyresistant psychoses in Borna disease virus-seropositive patients
    • Bechter K, Schreiner V, Herzog S, Breitinger N, Wollinsky KH, Brinkmeier H, et al. (2003) CSF filtration as experimental therapy in therapyresistant psychoses in Borna disease virus-seropositive patients. Psychiatr Prax 30:216-220
    • (2003) Psychiatr. Prax , vol.30 , pp. 216-220
    • Bechter, K.1    Schreiner, V.2    Herzog, S.3    Breitinger, N.4    Wollinsky, K.H.5    Brinkmeier, H.6
  • 8
    • 0024247522 scopus 로고
    • The current status of the dopamine hypothesis of schizophrenia
    • Carlsson A (1988) The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1:179-186
    • (1988) Neuropsychopharmacology , vol.1 , pp. 179-186
    • Carlsson, A.1
  • 9
    • 33644827689 scopus 로고    scopus 로고
    • The neurochemical circuitry of schizophrenia
    • Carlsson A (2006) The neurochemical circuitry of schizophrenia. Pharmacopsychiatry 39 Suppl 1: S10-S14
    • (2006) Pharmacopsychiatry , vol.39 , Issue.1 SUPPL.
    • Carlsson, A.1
  • 11
    • 0036569812 scopus 로고    scopus 로고
    • Inhibition of COX-2 reduces the age-dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat
    • Casolini P, Catalani A, Zuena AR, Angelucci L (2002) Inhibition of COX-2 reduces the age-dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat. J Neurosci Res 68:337-343
    • (2002) J. Neurosci. Res. , vol.68 , pp. 337-343
    • Casolini, P.1    Catalani, A.2    Zuena, A.R.3    Angelucci, L.4
  • 14
    • 11244255430 scopus 로고    scopus 로고
    • Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia
    • Chakos MH, Schobel SA, Gu H, Gerig G, Bradford D, Charles C, et al. (2005) Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia. Br J Psychiatry 186:26-31
    • (2005) Br. J. Psychiatry , vol.186 , pp. 26-31
    • Chakos, M.H.1    Schobel, S.A.2    Gu, H.3    Gerig, G.4    Bradford, D.5    Charles, C.6
  • 16
    • 0030035748 scopus 로고    scopus 로고
    • Kynurenine disposition in blood and brain of mice: Effects of selective inhibitors of kynurenine hydroxylase and of kynureninase
    • Chiarugi A, Carpenedo R, Moroni F (1996) Kynurenine disposition in blood and brain of mice: effects of selective inhibitors of kynurenine hydroxylase and of kynureninase. J Neurochem 67:692-698
    • (1996) J. Neurochem. , vol.67 , pp. 692-698
    • Chiarugi, A.1    Carpenedo, R.2    Moroni, F.3
  • 17
    • 0242499301 scopus 로고    scopus 로고
    • The genetics of schizophrenia: Glutamate not dopamine?
    • Collier DA, Li T (2003) The genetics of schizophrenia: glutamate not dopamine? Eur J Pharmacol 480:177-184
    • (2003) Eur. J. Pharmacol. , vol.480 , pp. 177-184
    • Collier, D.A.1    Li, T.2
  • 18
    • 0035653671 scopus 로고    scopus 로고
    • Genetics of susceptibility to human infectious disease
    • Cook GS, Hill DR (2001) Genetics of susceptibility to human infectious disease. Nat Rev Genet 2:967-977
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 967-977
    • Cook, G.S.1    Hill, D.R.2
  • 19
    • 0031954102 scopus 로고    scopus 로고
    • Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects
    • Das I, Khan NS (1998) Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects. Prostaglandins Leukot Essent Fatty Acids 58:165-168
    • (1998) Prostaglandins Leukot Essent Fatty Acids , vol.58 , pp. 165-168
    • Das, I.1    Khan, N.S.2
  • 22
    • 0035798252 scopus 로고    scopus 로고
    • Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
    • Erhardt S, Blennow K, Nordin C, Skogh E, Lindstrom LH, Engberg G (2001a) Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia. Neurosci Lett 313:96-98
    • (2001) Neurosci. Lett. , vol.313 , pp. 96-98
    • Erhardt, S.1    Blennow, K.2    Nordin, C.3    Skogh, E.4    Lindstrom, L.H.5    Engberg, G.6
  • 23
    • 0035005620 scopus 로고    scopus 로고
    • Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons
    • Erhardt S, Oberg H, Mathe JM, Engberg G (2001b) Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons. Amino Acids 20:353-362
    • (2001) Amino Acids , vol.20 , pp. 353-362
    • Erhardt, S.1    Oberg, H.2    Mathe, J.M.3    Engberg, G.4
  • 25
    • 0029646097 scopus 로고
    • Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: Potential relevance to schizophrenia?
    • Farber NB, Wozniak DF, Price MT, Labruyere J, Huss J, St PH, et al. (1995) Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: potential relevance to schizophrenia? Biol Psychiatry 38:788-796
    • (1995) Biol. Psychiatry , vol.38 , pp. 788-796
    • Farber, N.B.1    Wozniak, D.F.2    Price, M.T.3    Labruyere, J.4    Huss, J.5    St, P.H.6
  • 26
    • 0003261873 scopus 로고    scopus 로고
    • Is the association between obstretic complications and schizophrenia mediated by glutaminergic excitotoxic damage of the foetal/neonatal brain?
    • Revely M, Deacon B eds, Chapman and Hall, London
    • Fearon P, Cotter P, Murray RM (2000) Is the association between obstretic complications and schizophrenia mediated by glutaminergic excitotoxic damage of the foetal/neonatal brain? In: Revely M, Deacon B (eds), Psychopharmacology of schizophrenia. Chapman and Hall, London, 21-40
    • (2000) Psychopharmacology of Schizophrenia , pp. 21-40
    • Fearon, P.1    Cotter, P.2    Murray, R.M.3
  • 27
    • 0023626250 scopus 로고
    • Clinical and laboratory evidence of autoimmunity in acute schizophrenia
    • Ganguli R, Rabin BS, Kelly RH, Lyte M, Ragu U (1987) Clinical and laboratory evidence of autoimmunity in acute schizophrenia. Ann NY Acad Sci 496:676-685
    • (1987) Ann. NY Acad. Sci. , vol.496 , pp. 676-685
    • Ganguli, R.1    Rabin, B.S.2    Kelly, R.H.3    Lyte, M.4    Ragu, U.5
  • 29
    • 0038215374 scopus 로고    scopus 로고
    • Tolerance, DCs and tryptophan: Much ado about IDO
    • Grohmann U, Fallarino F, Puccetti P (2003) Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol 24:242-248
    • (2003) Trends Immunol. , vol.24 , pp. 242-248
    • Grohmann, U.1    Fallarino, F.2    Puccetti, P.3
  • 30
    • 9644270316 scopus 로고    scopus 로고
    • Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease
    • Guidetti P, Luthi-Carter RE, Augood SJ, Schwarcz R (2004) Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease. Neurobiol Dis 17:455-461
    • (2004) Neurobiol. Dis. , vol.17 , pp. 455-461
    • Guidetti, P.1    Luthi-Carter, R.E.2    Augood, S.J.3    Schwarcz, R.4
  • 34
    • 0030832112 scopus 로고    scopus 로고
    • Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types
    • Heyes MP, Chen CY, Major EO, Saito K (1997) Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types. Biochem J 326:351-356
    • (1997) Biochem. J. , vol.326 , pp. 351-356
    • Heyes, M.P.1    Chen, C.Y.2    Major, E.O.3    Saito, K.4
  • 35
    • 0029895717 scopus 로고    scopus 로고
    • Genetics of infectious disease resistance
    • Hill AV (1996) Genetics of infectious disease resistance. Curr Opin Genet Dev 6:348-353
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 348-353
    • Hill, A.V.1
  • 36
    • 0035478066 scopus 로고    scopus 로고
    • The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: Physiopathological implications
    • Hilmas C, Pereira EF, Alkondon M, Rassoulpour A, Schwarcz R, Albuquerque EX (2001) The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. J Neurosci 21:7463-7473
    • (2001) J. Neurosci. , vol.21 , pp. 7463-7473
    • Hilmas, C.1    Pereira, E.F.2    Alkondon, M.3    Rassoulpour, A.4    Schwarcz, R.5    Albuquerque, E.X.6
  • 37
    • 0020659971 scopus 로고
    • Das Konzept substratnaher Basissymptome und seine Bedeutung für Theorie und THerapie schizophrener Erkrankungen [The concept of substrate-close basic symptoms and its significance for the theory and therapy of schizophrenic diseases]
    • Huber G (1983) Das Konzept substratnaher Basissymptome und seine Bedeutung für Theorie und THerapie schizophrener Erkrankungen [The concept of substrate-close basic symptoms and its significance for the theory and therapy of schizophrenic diseases]. Nervenarzt 54:23-32
    • (1983) Nervenarzt , vol.54 , pp. 23-32
    • Huber, G.1
  • 38
    • 0022904075 scopus 로고
    • Prenatal developmental disturbances in the limbic allocortex in schizophrenics
    • Jakob H, Beckmann H (1986) Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm 65:303-326
    • (1986) J. Neural. Transm. , vol.65 , pp. 303-326
    • Jakob, H.1    Beckmann, H.2
  • 39
    • 0032903301 scopus 로고    scopus 로고
    • The neuropsychopharmacology of phencyclidine: From NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia
    • Jentsch JD, Roth RH (1999) The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 20:201-225
    • (1999) Neuropsychopharmacology , vol.20 , pp. 201-225
    • Jentsch, J.D.1    Roth, R.H.2
  • 41
    • 0032078401 scopus 로고    scopus 로고
    • Administration of interleukin-1 at birth affects dopaminergic neurons in adult mice
    • Kabiersch A, Furukawa H, del RA, Besedovsky HO (1998) Administration of interleukin-1 at birth affects dopaminergic neurons in adult mice. Ann NY Acad Sci 840:123-127
    • (1998) Ann. NY Acad. Sci. , vol.840 , pp. 123-127
    • Kabiersch, A.1    Furukawa, H.2    Del, R.A.3    Besedovsky, H.O.4
  • 44
    • 0024564076 scopus 로고
    • A glycine site associated with N-methyl-D-aspartic acid receptors: Characterization and identification of a new class of antagonists
    • Kessler M, Terramani T, Lynch G, Baudry M (1989) A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists. J Neurochem 52:1319-1328
    • (1989) J. Neurochem. , vol.52 , pp. 1319-1328
    • Kessler, M.1    Terramani, T.2    Lynch, G.3    Baudry, M.4
  • 45
  • 46
    • 0019293020 scopus 로고
    • Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia
    • Kim JS, Kornhuber HH, Schmid-Burgk W, Holzmuller B (1980) Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20:379-382
    • (1980) Neurosci. Lett. , vol.20 , pp. 379-382
    • Kim, J.S.1    Kornhuber, H.H.2    Schmid-Burgk, W.3    Holzmuller, B.4
  • 47
    • 12244252752 scopus 로고    scopus 로고
    • The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: Effects of psychotropic drugs
    • Kim YK, Suh IB, Kim H, Han CS, Lim CS, Choi SH, et al. (2002) The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs. Mol Psychiatry 7:1107-1114
    • (2002) Mol. Psychiatry , vol.7 , pp. 1107-1114
    • Kim, Y.K.1    Suh, I.B.2    Kim, H.3    Han, C.S.4    Lim, C.S.5    Choi, S.H.6
  • 50
    • 0343725649 scopus 로고    scopus 로고
    • Fibrin degradation products in post mortem brain tissue of schizophrenics: A possible marker for underlying inflammatory processes
    • Körschenhausen DA, Hampel HJ, Ackenheil M, Penning R, Müller N (1996) Fibrin degradation products in post mortem brain tissue of schizophrenics: a possible marker for underlying inflammatory processes. Schizophr Res 19:103-109
    • (1996) Schizophr Res. , vol.19 , pp. 103-109
    • Körschenhausen, D.A.1    Hampel, H.J.2    Ackenheil, M.3    Penning, R.4    Müller, N.5
  • 51
    • 0028323167 scopus 로고
    • Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses
    • Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD, et al. (1994) Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 51:199-214
    • (1994) Arch. Gen. Psychiatry , vol.51 , pp. 199-214
    • Krystal, J.H.1    Karper, L.P.2    Seibyl, J.P.3    Freeman, G.K.4    Delaney, R.5    Bremner, J.D.6
  • 52
    • 0029787944 scopus 로고    scopus 로고
    • Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects
    • Laruelle M, Abi-Dargham A, van Dyck CH, Gil R, D'Souza CD, Erdos J, et al. (1996) Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci USA 93:9235-9240
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9235-9240
    • Laruelle, M.1    Abi-Dargham, A.2    Van Dyck, C.H.3    Gil, R.4    D'Souza, C.D.5    Erdos, J.6
  • 53
    • 25144509345 scopus 로고    scopus 로고
    • Mechanism of action of antipsychotic drugs: From dopamine D (2) receptor antagonism to glutamate NMDA facilitation
    • Laruelle M, Frankle WG, Narendran R, Kegeles LS, bi-Dargham A (2005) Mechanism of action of antipsychotic drugs: from dopamine D (2) receptor antagonism to glutamate NMDA facilitation. Clin Ther 27 Suppl A: S16-S24
    • (2005) Clin. Ther. , vol.27 , Issue.SUPPL. A
    • Laruelle, M.1    Frankle, W.G.2    Narendran, R.3    Kegeles, L.S.4    Bi-Dargham, A.5
  • 54
    • 0037338316 scopus 로고    scopus 로고
    • Significant frequency deviation of the class I polymorphism HLA-A10 in schizophrenic patients
    • Laumbacher B, Müller N, Bondy B, Schlesinger B, Gu S, Fellerhoff B, et al. (2003) Significant frequency deviation of the class I polymorphism HLA-A10 in schizophrenic patients. J Med Genet 40:217-219
    • (2003) J. Med. Genet. , vol.40 , pp. 217-219
    • Laumbacher, B.1    Müller, N.2    Bondy, B.3    Schlesinger, B.4    Gu, S.5    Fellerhoff, B.6
  • 56
    • 0032694583 scopus 로고    scopus 로고
    • Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus
    • Litherland SA, Xie XT, Hutson AD, Wasserfall C, Whittaker DS, She JX, et al. (1999) Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus. J Clin Invest 104:515-523
    • (1999) J. Clin. Invest. , vol.104 , pp. 515-523
    • Litherland, S.A.1    Xie, X.T.2    Hutson, A.D.3    Wasserfall, C.4    Whittaker, D.S.5    She, J.X.6
  • 58
    • 0001237437 scopus 로고
    • General anesthetics
    • Goodman LS, Gilman A, Rall TW, et al. eds, Pergamon Press, New York
    • Marshall BE, Longnecker DE (1990) General anesthetics. In: Goodman LS, Gilman A, Rall TW, et al. (eds), The pharmacological basis of therapeutics. Pergamon Press, New York, pp 285-310
    • (1990) The Pharmacological Basis of Therapeutics , pp. 285-310
    • Marshall, B.E.1    Longnecker, D.E.2
  • 59
    • 0043092018 scopus 로고    scopus 로고
    • Analysis of a polymorphism in the promoter region of the tumor necrosis factor alpha gene in schizophrenia and bipolar disorder: Further support for an association with schizophrenia
    • Meira-Lima IV, Pereira AC, Mota GF, Floriano M, Araujo F, Mansur AJ, et al. (2003) Analysis of a polymorphism in the promoter region of the tumor necrosis factor alpha gene in schizophrenia and bipolar disorder: further support for an association with schizophrenia. Mol Psychiatry 8:718-720
    • (2003) Mol. Psychiatry , vol.8 , pp. 718-720
    • Meira-Lima, I.V.1    Pereira, A.C.2    Mota, G.F.3    Floriano, M.4    Araujo, F.5    Mansur, A.J.6
  • 60
    • 1842419381 scopus 로고    scopus 로고
    • Expression of the kynurenine pathway enzyme tryptophan 2, 3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia
    • Miller CL, Llenos IC, Dulay JR, Barillo MM, Yolken RH, Weis S (2004) Expression of the kynurenine pathway enzyme tryptophan 2, 3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia. Neurobiol Dis 15:618-629
    • (2004) Neurobiol. Dis. , vol.15 , pp. 618-629
    • Miller, C.L.1    Llenos, I.C.2    Dulay, J.R.3    Barillo, M.M.4    Yolken, R.H.5    Weis, S.6
  • 61
    • 33644963618 scopus 로고    scopus 로고
    • Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder
    • Miller CL, Llenos IC, Dulay JR, Weis S (2006) Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res 1073-1074:25-37
    • (2006) Brain Res. , vol.1073-1074 , pp. 25-37
    • Miller, C.L.1    Llenos, I.C.2    Dulay, J.R.3    Weis, S.4
  • 62
    • 0030010055 scopus 로고    scopus 로고
    • Effects of MK-801on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats
    • Miller DW, Abercrombie ED (1996) Effects of MK-801on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats. Brain Res Bull 40:57-62
    • (1996) Brain Res. Bull. , vol.40 , pp. 57-62
    • Miller, D.W.1    Abercrombie, E.D.2
  • 65
    • 34250921122 scopus 로고
    • Hyposensitivity to foreign protein in schizophrenic patients
    • Molholm HB (1942) Hyposensitivity to foreign protein in schizophrenic patients. Psychiatr Quart 16:565-571
    • (1942) Psychiatr. Quart , vol.16 , pp. 565-571
    • Molholm, H.B.1
  • 66
    • 4744354436 scopus 로고    scopus 로고
    • Immunological and infectious aspects of schizophrenia
    • Müller N (2004) Immunological and infectious aspects of schizophrenia. Eur Arch Psychiatry Clin Neurosci 254:1-3
    • (2004) Eur. Arch. Psychiatry Clin. Neurosci. , vol.254 , pp. 1-3
    • Müller, N.1
  • 67
    • 0025765830 scopus 로고
    • Cellular immunity in schizophrenic patients before and during neuroleptic treatment
    • Müller N, Ackenheil M, Hofschuster E, Mempel W, Eckstein R (1991) Cellular immunity in schizophrenic patients before and during neuroleptic treatment. Psychiatry Res 37:147-160
    • (1991) Psychiatry Res. , vol.37 , pp. 147-160
    • Müller, N.1    Ackenheil, M.2    Hofschuster, E.3    Mempel, W.4    Eckstein, R.5
  • 68
    • 0028796495 scopus 로고
    • Immunoglobulin and albumin content of cerebrospinal fluid in schizophrenic patients: Relationship to negative symptomatology
    • Müller N, Ackenheil M (1995) Immunoglobulin and albumin content of cerebrospinal fluid in schizophrenic patients: relationship to negative symptomatology. Schizophr Res 14:223-228
    • (1995) Schizophr Res. , vol.14 , pp. 223-228
    • Müller, N.1    Ackenheil, M.2
  • 69
    • 0031434889 scopus 로고    scopus 로고
    • Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia
    • Müller N, Empl M, Riedel M, Schwarz M, Ackenheil M (1997a) Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia. Eur Arch Psychiatry Clin Neurosci 247:308-313
    • (1997) Eur. Arch. Psychiatry Clin. Neurosci. , vol.247 , pp. 308-313
    • Müller, N.1    Empl, M.2    Riedel, M.3    Schwarz, M.4    Ackenheil, M.5
  • 70
    • 0005149639 scopus 로고    scopus 로고
    • Immunomodulatory effects of neuroleptics to the cytokine system and the cellular immune system in schizophrenia
    • Wieselmann G ed, Springer, Wien New York
    • Müller N, Riedel M, Schwarz MJ, et al. (1997b) Immunomodulatory effects of neuroleptics to the cytokine system and the cellular immune system in schizophrenia. In: Wieselmann G (ed), Current update in psychoimmunology. Springer, Wien New York, pp 57-67
    • (1997) Current Update in Psychoimmunology , pp. 57-67
    • Müller, N.1    Riedel, M.2    Schwarz, M.J.3
  • 71
    • 0031950741 scopus 로고    scopus 로고
    • Psychoneuroimmunology and the cytokine action in the CNS: Implications for psychiatric disorders
    • Müller N, Ackenheil M (1998) Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry 22:1-33
    • (1998) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.22 , pp. 1-33
    • Müller, N.1    Ackenheil, M.2
  • 72
    • 0342439882 scopus 로고    scopus 로고
    • Increase in expression of adhesion molecule receptors on T helper cells during antipsychotic treatment and relationship to blood-brain barrier permeability in schizophrenia
    • Müller N, Riedel M, Hadjamu M, Schwarz MJ, Ackenheil M, Gruber R (1999) Increase in expression of adhesion molecule receptors on T helper cells during antipsychotic treatment and relationship to blood-brain barrier permeability in schizophrenia. Am J Psychiatry 156:634-636
    • (1999) Am. J. Psychiatry , vol.156 , pp. 634-636
    • Müller, N.1    Riedel, M.2    Hadjamu, M.3    Schwarz, M.J.4    Ackenheil, M.5    Gruber, R.6
  • 73
    • 0034309738 scopus 로고    scopus 로고
    • Cellular and humoral immune system in schizophrenia: A conceptual re-evaluation
    • Müller N, Riedel M, Ackenheil M, Schwarz MJ (2000) Cellular and humoral immune system in schizophrenia: a conceptual re-evaluation. World J Biol Psychiatry 1:173-179
    • (2000) World J. Biol. Psychiatry , vol.1 , pp. 173-179
    • Müller, N.1    Riedel, M.2    Ackenheil, M.3    Schwarz, M.J.4
  • 74
    • 0036272768 scopus 로고    scopus 로고
    • Beneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia
    • Müller N, Riedel M, Scheppach C, Brandstätter B, Sokullu S, Krampe K, et al. (2002) Beneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia. Am J Psychiatry 159:1029-1034
    • (2002) Am. J. Psychiatry , vol.159 , pp. 1029-1034
    • Müller, N.1    Riedel, M.2    Scheppach, C.3    Brandstätter, B.4    Sokullu, S.5    Krampe, K.6
  • 75
    • 8844287740 scopus 로고    scopus 로고
    • Psychotropic effects of COX-2 inhibitors - A possible new approach for the treatment of psychiatric disorders
    • Müller N, Riedel M, Schwarz MJ (2004a) Psychotropic effects of COX-2 inhibitors - a possible new approach for the treatment of psychiatric disorders. Pharmacopsychiatry 37:266-269
    • (2004) Pharmacopsychiatry , vol.37 , pp. 266-269
    • Müller, N.1    Riedel, M.2    Schwarz, M.J.3
  • 78
    • 0023638471 scopus 로고
    • Is schizophrenia a neurodevelopmental disorder?
    • Clin Res Ed
    • Murray RM, Lewis SW (1987) Is schizophrenia a neurodevelopmental disorder? Br Med J (Clin Res Ed) 295:681-682
    • (1987) Br. Med. J. , vol.295 , pp. 681-682
    • Murray, R.M.1    Lewis, S.W.2
  • 79
    • 8444250206 scopus 로고    scopus 로고
    • Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia
    • Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, et al. (2004) Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet 13:2699-2708
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 2699-2708
    • Numakawa, T.1    Yagasaki, Y.2    Ishimoto, T.3    Okada, T.4    Suzuki, T.5    Iwata, N.6
  • 80
    • 0028850552 scopus 로고
    • Glutamate receptor dysfunction and schizophrenia
    • Olney JW, Farber NB (1995) Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 52:998-1007
    • (1995) Arch. Gen. Psychiatry , vol.52 , pp. 998-1007
    • Olney, J.W.1    Farber, N.B.2
  • 82
    • 0034749995 scopus 로고    scopus 로고
    • Schizophrenia and viral infection during neurodevelopment: A focus on mechanisms
    • Pearce BD (2001) Schizophrenia and viral infection during neurodevelopment: a focus on mechanisms. Mol Psychiatry 6:634-646
    • (2001) Mol. Psychiatry , vol.6 , pp. 634-646
    • Pearce, B.D.1
  • 84
    • 0034117093 scopus 로고    scopus 로고
    • Prostaglandin E (2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: Regulation by interleukin-2, interleukin-10, and bovine leukemia virus
    • Pyeon D, Diaz FJ, Splitter GA (2000) Prostaglandin E (2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: regulation by interleukin-2, interleukin-10, and bovine leukemia virus. J Virol 74:5740-5745
    • (2000) J. Virol. , vol.74 , pp. 5740-5745
    • Pyeon, D.1    Diaz, F.J.2    Splitter, G.A.3
  • 85
    • 0000697163 scopus 로고    scopus 로고
    • Immunological states associated with schizophrenia
    • Ader A, Felten DL, Cohnen N eds, 3rd edn. Academic Press, San Diego, CA
    • Rapaport MH, Müller N (2001) Immunological states associated with schizophrenia. In: Ader A, Felten DL, Cohnen N (eds), Psychoneuroimmunology, vol 2, 3rd edn. Academic Press, San Diego, CA, pp 373-382
    • (2001) Psychoneuroimmunology , vol.2 , pp. 373-382
    • Rapaport, M.H.1    Müller, N.2
  • 88
    • 0035671763 scopus 로고    scopus 로고
    • Review of immunological and immunopathological findings in schizophrenia
    • Rothermundt M, Arolt V, Bayer TA (2001) Review of immunological and immunopathological findings in schizophrenia. Brain Behav Immun 15:319-339
    • (2001) Brain Behav. Immun. , vol.15 , pp. 319-339
    • Rothermundt, M.1    Arolt, V.2    Bayer, T.A.3
  • 91
    • 1642413342 scopus 로고    scopus 로고
    • Zytokinnetzwerke bei Patienten mit Schizophrenie und ihre Bedeutung für die Pathophysiologie der Erkrankung [Cytokine network in patients with schizophrenia and its significance for the pathophysiology of the illness]
    • Schuld A, Hinze-Selch D, Pollmacher T (2004) Zytokinnetzwerke bei Patienten mit Schizophrenie und ihre Bedeutung für die Pathophysiologie der Erkrankung [Cytokine network in patients with schizophrenia and its significance for the pathophysiology of the illness]. Nervenarzt 75:215-226
    • (2004) Nervenarzt , vol.75 , pp. 215-226
    • Schuld, A.1    Hinze-Selch, D.2    Pollmacher, T.3
  • 92
    • 0033647377 scopus 로고    scopus 로고
    • A genome-wide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: Support for loci on chromosome 10p and 6
    • Schwab SG, Hallmayer J, Albus M, Lerer B, Eckstein GN, Borrmann M, et al. (2000) A genome-wide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: support for loci on chromosome 10p and 6. Mol Psychiatry 5:638-649
    • (2000) Mol. Psychiatry , vol.5 , pp. 638-649
    • Schwab, S.G.1    Hallmayer, J.2    Albus, M.3    Lerer, B.4    Eckstein, G.N.5    Borrmann, M.6
  • 94
    • 0036784518 scopus 로고    scopus 로고
    • Manipulation of brain kynurenines: Glial targets, neuronal effects, and clinical opportunities
    • Schwarcz R, Pellicciari R (2002) Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities. J Pharmacol Exp Ther 303:1-10
    • (2002) J. Pharmacol. Exp. Ther. , vol.303 , pp. 1-10
    • Schwarcz, R.1    Pellicciari, R.2
  • 95
    • 0032968669 scopus 로고    scopus 로고
    • Antibodies to heat shock proteins in schizophrenic patients: Implications for the mechanism of the disease
    • Schwarz MJ, Riedel M, Gruber R, Ackenheil M, Müller N (1999) Antibodies to heat shock proteins in schizophrenic patients: implications for the mechanism of the disease. Am J Psychiatry 156:1103-1104
    • (1999) Am. J. Psychiatry , vol.156 , pp. 1103-1104
    • Schwarz, M.J.1    Riedel, M.2    Gruber, R.3    Ackenheil, M.4    Müller, N.5
  • 96
    • 0034653179 scopus 로고    scopus 로고
    • Decreased levels of soluble intercellular adhesion molecule-1 (sICAM-1) in unmedicated and medicated schizophrenic patients
    • Schwarz MJ, Riedel M, Ackenheil M, Müller N (2000) Decreased levels of soluble intercellular adhesion molecule-1 (sICAM-1) in unmedicated and medicated schizophrenic patients. Biol Psychiatry 47:29-33
    • (2000) Biol. Psychiatry , vol.47 , pp. 29-33
    • Schwarz, M.J.1    Riedel, M.2    Ackenheil, M.3    Müller, N.4
  • 99
    • 1842510585 scopus 로고    scopus 로고
    • Clozapine modulates midbrain dopamine neuron firing via interaction with the NMDA receptor complex
    • Schwieler L, Engberg G, Erhardt S (2004) Clozapine modulates midbrain dopamine neuron firing via interaction with the NMDA receptor complex. Synapse 52:114-122
    • (2004) Synapse , vol.52 , pp. 114-122
    • Schwieler, L.1    Engberg, G.2    Erhardt, S.3
  • 100
    • 20944441781 scopus 로고    scopus 로고
    • Prostaglandinmediated control of rat brain kynurenic acid synthesis - Opposite actions by COX-1 and COX-2 isoforms
    • Schwieler L, Erhardt S, Erhardt C, Engberg G (2005) Prostaglandinmediated control of rat brain kynurenic acid synthesis - opposite actions by COX-1 and COX-2 isoforms. J Neural Transm 112:863-872
    • (2005) J. Neural. Transm. , vol.112 , pp. 863-872
    • Schwieler, L.1    Erhardt, S.2    Erhardt, C.3    Engberg, G.4
  • 101
    • 0027389647 scopus 로고
    • On the production and disposition of quinolinic acid in rat brain and liver slices
    • Speciale C, Schwarcz R (1993) On the production and disposition of quinolinic acid in rat brain and liver slices. J Neurochem 60:212-218
    • (1993) J. Neurochem. , vol.60 , pp. 212-218
    • Speciale, C.1    Schwarcz, R.2
  • 102
    • 0030597322 scopus 로고    scopus 로고
    • (R, S)-3, 4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats
    • Speciale C, Wu HQ, Cini M, Marconi M, Varasi M, Schwarcz R (1996) (R, S)-3, 4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats. Eur J Pharmacol 315:263-267
    • (1996) Eur. J. Pharmacol. , vol.315 , pp. 263-267
    • Speciale, C.1    Wu, H.Q.2    Cini, M.3    Marconi, M.4    Varasi, M.5    Schwarcz, R.6
  • 103
    • 0005107114 scopus 로고    scopus 로고
    • Measurement of neopterin, kynurenine and tryptophan in sera of schizophrenic patients
    • Müller N ed, Springer, Wien New York
    • Sperner-Unterweger B, Miller C, Holzner B, et al. (1999) Measurement of neopterin, kynurenine and tryptophan in sera of schizophrenic patients. In: Müller N (ed), Psychiatry, psychoimmunology and viruses. Springer, Wien New York, pp 115-119
    • (1999) Psychiatry, Psychoimmunology and Viruses , pp. 115-119
    • Sperner-Unterweger, B.1    Miller, C.2    Holzner, B.3
  • 104
    • 0033979545 scopus 로고    scopus 로고
    • Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis
    • Stolina M, Sharma S, Lin Y, Dohadwala M, Gardner B, Luo J, et al. (2000) Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. J Immunol 164:361-370
    • (2000) J. Immunol. , vol.164 , pp. 361-370
    • Stolina, M.1    Sharma, S.2    Lin, Y.3    Dohadwala, M.4    Gardner, B.5    Luo, J.6
  • 105
    • 0027486072 scopus 로고
    • Neuropharmacology of quinolinic and kynurenic acids
    • Stone TW (1993) Neuropharmacology of quinolinic and kynurenic acids. Pharmacol Rev 45:309-379
    • (1993) Pharmacol. Rev. , vol.45 , pp. 309-379
    • Stone, T.W.1
  • 107
    • 1942539345 scopus 로고    scopus 로고
    • Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: Relation to negative symptoms
    • Sumiyoshi T, Anil AE, Jin D, Jayathilake K, Lee M, Meltzer HY (2004) Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: relation to negative symptoms. Int J Neuropsychopharmacol 7:1-8
    • (2004) Int. J. Neuropsychopharmacol. , vol.7 , pp. 1-8
    • Sumiyoshi, T.1    Anil, A.E.2    Jin, D.3    Jayathilake, K.4    Lee, M.5    Meltzer, H.Y.6
  • 108
    • 22344441029 scopus 로고    scopus 로고
    • Prediction of the ability of clozapine to treat negative symptoms from plasma glycine and serine levels in schizophrenia
    • Sumiyoshi T, Jin D, Jayathilake K, Lee M, Meltzer HY (2005) Prediction of the ability of clozapine to treat negative symptoms from plasma glycine and serine levels in schizophrenia. Int J Neuropsychopharmacol 8:451-455
    • (2005) Int. J. Neuropsychopharmacol. , vol.8 , pp. 451-455
    • Sumiyoshi, T.1    Jin, D.2    Jayathilake, K.3    Lee, M.4    Meltzer, H.Y.5
  • 109
    • 0023013615 scopus 로고
    • Tryptophan degradation in mice initiated by indoleamine 2, 3-dioxygenase
    • Takikawa O, Yoshida R, Kido R, Hayaishi O (1986) Tryptophan degradation in mice initiated by indoleamine 2, 3-dioxygenase. J Biol Chem 261:3648-3653
    • (1986) J. Biol. Chem. , vol.261 , pp. 3648-3653
    • Takikawa, O.1    Yoshida, R.2    Kido, R.3    Hayaishi, O.4
  • 110
    • 2342512304 scopus 로고    scopus 로고
    • Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
    • Talbot K, Eidem WL, Tinsley CL, Benson MA, Thompson EW, Smith RJ, et al. (2004) Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. J Clin Invest 113:1353-1363
    • (2004) J. Clin. Invest. , vol.113 , pp. 1353-1363
    • Talbot, K.1    Eidem, W.L.2    Tinsley, C.L.3    Benson, M.A.4    Thompson, E.W.5    Smith, R.J.6
  • 111
    • 0003135255 scopus 로고
    • Enhancement of NMDA-mediated transmission in schizophrenia: Effects of milacemide
    • Meltzer HY ed, Raven Press, New York
    • Tamminga CA, Cascella N, Fakouhl TD, et al. (1992) Enhancement of NMDA-mediated transmission in schizophrenia: effects of milacemide. In: Meltzer HY (ed), Novel antipsychotic drugs. Raven Press, New York, pp 171-177
    • (1992) Novel Antipsychotic Drugs , pp. 171-177
    • Tamminga, C.A.1    Cascella, N.2    Fakouhl, T.D.3
  • 113
    • 0031558802 scopus 로고    scopus 로고
    • Seasonality of births in schizophrenia and bipolar disorder: A review of the literature
    • Torrey EF, Miller J, Rawlings R, Yolken RH (1997) Seasonality of births in schizophrenia and bipolar disorder: a review of the literature. Schizophr Res 28:1-38
    • (1997) Schizophr Res. , vol.28 , pp. 1-38
    • Torrey, E.F.1    Miller, J.2    Rawlings, R.3    Yolken, R.H.4
  • 114
    • 0002082510 scopus 로고    scopus 로고
    • Relationship between immune and behavioral measures in schizophrenia
    • Wieselmann G ed, Springer, Wien New York
    • van Kammen DP, McAllister-Sistilli CG, Kelley ME (1997) Relationship between immune and behavioral measures in schizophrenia. In: Wieselmann G (ed), Current update in psychoimmunology. Springer, Wien New York, pp 51-55
    • (1997) Current Update in Psychoimmunology , pp. 51-55
    • Van Kammen, D.P.1    McAllister-Sistilli, C.G.2    Kelley, M.E.3
  • 115
    • 0032751465 scopus 로고    scopus 로고
    • Exposure to prenatal and childhood infections and the risk of schizophrenia: Suggestions from a study of sibship characteristics and influenza prevalence
    • Westergaard T, Mortensen PB, Pedersen CB, Wohlfahrt J, Melbye M (1999) Exposure to prenatal and childhood infections and the risk of schizophrenia: suggestions from a study of sibship characteristics and influenza prevalence. Arch Gen Psychiatry 56:993-998
    • (1999) Arch. Gen. Psychiatry , vol.56 , pp. 993-998
    • Westergaard, T.1    Mortensen, P.B.2    Pedersen, C.B.3    Wohlfahrt, J.4    Melbye, M.5
  • 118
    • 77957356273 scopus 로고    scopus 로고
    • Kynurenic acid leads, dopamine follows: A new case of volume transmission in the brain?
    • Wu HQ, Rassoulpour A, Schwarcz R (2006) Kynurenic acid leads, dopamine follows: a new case of volume transmission in the brain? J Neural Transm
    • (2006) J. Neural. Transm.
    • Wu, H.Q.1    Rassoulpour, A.2    Schwarcz, R.3
  • 119
    • 0032703087 scopus 로고    scopus 로고
    • Is there a balance between microglia and astrocytes in regulating Th1/Th2-cell responses and neuropathologies?
    • Xiao BG, Link H (1999) Is there a balance between microglia and astrocytes in regulating Th1/Th2-cell responses and neuropathologies? Immunol Today 20:477-479
    • (1999) Immunol. Today , vol.20 , pp. 477-479
    • Xiao, B.G.1    Link, H.2
  • 121
    • 0028859619 scopus 로고
    • Viruses, schizophrenia, and bipolar disorder
    • Yolken RH, Torrey EF (1995) Viruses, schizophrenia, and bipolar disorder. Clin Microbiol Rev 8:131-145
    • (1995) Clin. Microbiol. Rev. , vol.8 , pp. 131-145
    • Yolken, R.H.1    Torrey, E.F.2
  • 122
    • 13844276635 scopus 로고    scopus 로고
    • Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring
    • Zuckerman L, Weiner I (2005) Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring. J Psychiatr Res 39:311-323
    • (2005) J. Psychiatr. Res. , vol.39 , pp. 311-323
    • Zuckerman, L.1    Weiner, I.2


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