No association between the G308A polymorphism of the tumor necrosis factor-alpha gene and schizophrenia

European Archives of Psychiatry and Clinical Neuroscience

Volumn 252, Issue 5, 2002, Pages 232-234

  Riedel, Michael ^a   Krönig, Holger ^a   Schwarz, Markus J ^a   Engel, Rolf R ^a   Kühn, Kai Uwe ^b   Sikorski, Christopher ^a   Sokullu, Safet ^a   Ackenheil, Manfred ^a   Möller, Hans Jürgen ^a   Müller, Norbert ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Chromosome 6; Ethnic differences; G308A polymorphism; Schizophrenia; Tumor necrosis factor alpha

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ALLELE; ARTICLE; CHROMOSOME 6P; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; GERMANY; HUMAN; ITALY; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; AGED; ALLELES; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DNA PRIMERS; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; SCHIZOPHRENIA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 12244261868     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00406-002-0386-1     Document Type: Article

References (14)

1. Andrews JS, Berger AE, Ware CF (1990) Characterization of the receptor for tumor necrosis factor (TNF) and lymphotoxin (LT) on human T lymphocytes. TNF and LT differ in their receptor binding properties and the induction of MHC class I proteins on a human CD4+ T cell hybridoma (Published Erratum Appears in J Immunol 1990 Jul 15;144(12):4906). J Immunol 144:2582-2591
2. Boin F, Zanardini R, Pioli R, Altamura CA, Maes M, Gennarelli M (2001) Association between -G308A tumor necrosis factor alpha gene polymorphism and schizophrenia. Mol Psychiatry 6:79-82
3. Gallagher G, Eskdale J, Oh HH, Richards SD, Campbell DA, Field M (1997) Polymorphisms in the TNF gene cluster and MHC serotypes in the West of Scotland. Immunogenetics 45:188-194
4. Jablensky A (2000) Epidemiology of schizophrenia: the global burden of disease and disability. Eur Arch Psychiatry Clin Neurosci 250:274-285
5. Kay SR, Fiszbein A, Opler LA (1987) The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull 13: 261-276
6. Lichtermann D, Karbe E, Maier W (2000) The genetic epidemiology of schizophrenia and of schizophrenia spectrum disorders. Eur Arch Psychiatry Clin Neurosci 250:304-310
7. Lindholm E, Ekholm B, Balciuniene J, Johansson G, Castensson A, Koisti M, Nylander PO, Pettersson U, Adolfsson R, Jazin E (1999) Linkage analysis of a large Swedish kindred provides further support for a susceptibility locus for schizophrenia on chromosome 6p23. Am J Med Genet 88:369-377
8. Milicic A, Lindheimer F, Laval S, Rudwaleit M, Ackerman H, Wordsworth P, Hohler T, Brown MA (2000) Interethnic studies of TNF polymorphisms confirm the likely presence of a second MHC susceptibility locus in ankylosing spondylitis. Genes Immun 1:418-422
9. Monteleone P, Fabrazzo M, Tortorella A, Maj M (1997) Plasma levels of interleukin-6 and tumor necrosis factor alpha in chronic schizophrenia: effects of clozapine treatment. Psychiatry Res 71: 11-17
10. Schwab SG, Albus M, Hallmayer J, Honig S, Borrmann M, Lichtermann D, Ebstein RP, Ackenheil M, Lerer B, Risch N, et al. (1995) Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nat Genet 11:325-327
11. Schwarz MJ, Chiang S, Müller N, Ackenheil M (2001) T-helper-1 and T-helper-2 responses in psychiatric disorders. Brain Behav Immun 15:340-370
12. Toyota T, Watanabe A, Shibuya H, Nankai M, Hattori E, Yamada K, Kurumaji A, Karkera JD, Detera-Wadleigh SD, Yoshikawa T (2000) Association study on the DUSP6 gene, an affective disorder candidate gene on 12q23, performed by using fluorescence resonance energy transfer-based melting curve analysis on the light-cycler. Mol Psychiatry 5:489-494
13. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW (1997) Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA 94:3195-3199
14. Winchester EC, Millwood IY, Rand L, Penny MA, Kessling AM (2000) Association of the TNF-Alpha-308 (G→A) polymorphism with self-reported history of childhood asthma. Hum Genet 107: 591-596