Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genes

Human Molecular Genetics

Volumn 17, Issue 3, 2008, Pages 331-344

  Thifault, Stéphane ^a   Ondrej S Seda ^a   Sun, Yulin ^a   Fortin, Anny ^b   Skamene, Emil ^c   Lalonde, Robert ^a   Tremblay, Johanne ^a   Hamet, Pavel ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; CALCIUM ION; CALMODULIN; ELECTROLYTE; GENE PRODUCT; SODIUM CHLORIDE;

A J MOUSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; C57BL 6 MOUSE; CALCIUM EXCRETION; CARDIOVASCULAR DISEASE; CHROMOSOME 1; CHROMOSOME 11; CHROMOSOME 12; CONTROLLED STUDY; CORE TEMPERATURE; DOWN REGULATION; EMOTIONALITY; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HEART; HYPERTENSION; IMMOBILIZATION; LINKAGE ANALYSIS; MALE; MAZE TEST; MOUSE; MOUSE STRAIN; NONHUMAN; OPEN FIELD TEST; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RECOMBINANT CONGENIC STRAIN; REGULATORY SEQUENCE; SALT LOADING; SEQUENCE ANALYSIS; STRAIN DIFFERENCE; STRESS; TELEMETRY;

ANIMALIA; MUS;

EID: 38449086373     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddm277     Document Type: Article

References (116)

1. Seda, O., Tremblay, J., Sedova, L. and Hamet, P. (2005) Integrating genomics and transcriptomics with geo-ethnicity and the environment for the resolution of complex cardiovascular diseases. Curr. Opin. Mol. Ther., 7, 583-587.
2. Gill, K.J. and Boyle, A.E. (2005) Quantitative trait loci for novelty/ stress-induced locomotor activation in recombinant inbred (RI) and recombinant congenic (RC) strains of mice. Behav. Brain Res., 161, 113-124.
3. Woo, D.D. and Kurtz, I. (2003) Mapping blood pressure loci in (A/J x B6)F2 mice. Physiol. Genomics, 15, 236-242.
4. Smoller, J.W., Rosenbaum, U., Biederman, J., Susswein, L.S., Kennedy, J., Kagan, J., Snidman, N., Laird, N., Tsuang, M.T., Faraone. S.V. et al. (2001) Genetic association analysis of behavioral inhibition using candidate loci from mouse models. Am. J. Med. Genet., 105 226-235.
5. Fullerton, J. (2006) New approaches to the genetic analysis of neuroticism and anxiety. Behav. Genet., 36, 147-161.
6. Imumorin, I.G., Dong, Y., Zhu, H., Poole, J.C., Harshfield, G.A., Treiber, F. A. and Snieder, H. (2005) A gene-environment interaction model of stress-induced hypertension. Cardiavasc. Toxicol., 5 109-132.
7. Fortin, A., Diez, E., Rochefort, D., Laroche, L., Malo, D., Rouleau, G.A., Gros, P. and Skamene, E. (2001) Recombinant congenic strains derived from A/J and C57BL/6J: A tool for genetic dissection of complex traits. Genomics, 74, 21-35.
8. Bolivar, V.J., Caldarone, B.J., Reilly, A.A. and Flaherty, L. (2000) Habituation of activity in an open field: A survey of inbred strains and F1 hybrids. Behav. Genet., 30, 285-293.
9. Garrett, K.M., Niekrasz, I., Haque, D., Parker, K.M. and Seale, T.W. (1998) Genotypic differences between C57BL/6 and A inbred mice in anxiolytic and sedative actions of diazepam. Behav. Genet., 28 125-136.
10. Logue, S.F., Owen, E.H., Rasmussen, D.L. and Weliner, J.M. (1997) Assessment of locomotor activity, acoustic and tactile startle, and prepulse inhibition of startle in inbred mouse strains and F1 hybrids: implications of genetic background for single gene and quantitative trait loci analyses. Neuroscience, 80, 1075-1086.
11. Gershenfeld, H.K., Neumann, P.E., Mathis, C., Crawley, J.N., Li, X. and Paul, S.M. (1997) Mapping quantitative trait loci for open-field behavior in mice. Behav. Genet., 27, 201-210.
12. Thifault, S., Lalonde, R., Sanon, N. and Harriet, P. (2002) Comparisons between C57BL/6J and A/J mice in motor activity and coordination, hole-poking, and spatial learning. Brain Res. Bull., 58, 213-218.
13. Trullas, R. and Skolnick, P. (1993) Differences in fear motivated behaviors among inbred mouse strains. Psychopharmacology (Berl.), 111, 323-331.
14. van Gaalen, M.M. and Steckler, T. (2000) Behavioural analysis of four mouse strains in an anxiety test battery. Behav. Brain Res., 115, 95-106.
15. Bouwknecht, J.A. and Paylor, R. (2002) Behavioral and physiological mouse assays for anxiety: A survey in nine mouse strains. Behav. Brain Res., 136, 489-501.
16. Gershenfeld, H.K. and Paul, S.M. (1997) Mapping quantitative trait loci for fear-like behaviors in mice. Genomics, 46, 1-8.
17. Bolivar, V.J., Pooler, O. and Flaherty, L. (2001) Inbred strain variation in contextual and cued fear conditioning behavior. Mamm. Genome, 12, 651-656.
18. Cohen, R-M., Kang, A. and Gulick, C. (2001) Quantitative trait loci affecting the behavior of A/J and CBA/J intercross mice in the elevated plus maze. Mamm. Genome, 12, 501-507.
19. Mathis, C., Neumann, P.E., Gershenfeld, H., Paul, S.M. and Crawley, J.N. (1995) Genetic analysis of anxiety-related behaviors and responses to benzodiazepine-related drugs in AXB and BXA recombinant inbred mouse strains. Behav. Genet., 25, 557-568.
20. Gill, K., Boyle, A., Lake, K. and Desaulniers, N. (2000) Alcohol-induced locomotor activation in C57BL/6J, A/J, and AXB/BXA recombinant inbred mice: Strain distribution patterns and quantitative trait loci analysis. Psychopharmacology (Berl.), 150, 412-421.
21. Boyle, A.E. and Gill, K. (2001) Sensitivity of AXB/BXA recombinant inbred lines of mice to the locomotor activating effects of cocaine: A quantitative trait loci analysis. Pharmacogenetics, 11, 255-264.
22. Demant, P. and Hart, A.A.M. (1986) Recombinant congenic strains - a new tool for analyzing genetic traits determined by more than one gene. Immunogenetics, 24, 416-422.
23. Fortin, A., Cardon, L.R., Tam, M., Skamene, E., Stevenson, M.M. and Gros, P. (2001) Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice. Proc. Natl Acad. Sci. USA, 98, 10793-10798.
24. Roy, M.F., Riendeau, N., Loredo-Osti, J.C. and Malo, D. (2006) Complexity in the host response to Salmonella Typhimurium infection in AcB and BcA recombinant congenic strains. Genes Immun., 7, 655-666.
25. Joober, R., Zarate, J.M., Rouleau, G.A., Skamene, E. and Boksa, P. (2002) Provisional mapping of quantitative trait loci modulating the acoustic startle response and prepulse inhibition of acoustic startle. Neuropsychopharmacology, 27, 765-781.
26. Gill, K. and Boyle, A.E. (2005) Genetic analysis of alcohol intake in recombinant inbred and congenic stains derived from A/J and C57BL/6J progenitors. Mamm. Genome, 16, 319-331.
27. Torkamanzehi, A., Boksa, P., Ayoubi, M., Fortier, M.E., Ng Ying Kin, N.M., Skamene, E., Rouleau, G. and Joober, R. (2006) Identification of informative strains and provisional QTL mapping of amphetamine (AMPH)-induced locomotion in recombinant congenic strains (RCS) of mice. Behav. Genet., 36, 903-913.
28. Gill, YU and Boyle, A.E. (2003) Confirmation of quantitative trait loci for cocaine-induced activation in the AcB/BcA series of recombinant congenic strains. Pharmacogenetics, 13, 329-338.
29. Gill, K.J. and Boyle, A.E. (2005) Genetic basis for the psychostimulant effects of nicotine: A quantitative trait locus analysis in AcB/BcA recombinant congenic mice. Genes Brain Behav., 4, 401-411.
30. Dumas, P., Pausova, Z., Kren, V., Krenova, D., Pravenec, M., Dumont, M., Ely, D., Turner, M., Sun, Y., Tremblay, J. and Hamet, P. (2000) Contribution of autosomal loci and the Y chromosome to the stress response in rat. Hypertension, 35, 568-573.
31. Pausova, Z., Sedova, L., Berube, J., Hamet, P., Tremblay, J., Dumont; M., Gaudet, D., Pravenec, M., Kren, V. and Kunes, J. (2003) Segment of rat chromosome 20 regulates diet-induced augmentations in adiposity, glucose intolerance, and blood pressure. Hypertension, 41, 1047-1055.
32. Malo, D., Schlager, G., Tremblay, J. and Hamer, P. (1989) Thermosensitivity, a possible new locus involved in genetic hypertension. Hypertension, 14, 121-128.
33. Dumas, P., Sun, Y., Corbeil, G., Tremblay, S., Pausova, Z., Kren, V., Krenova, D., Pravenec, M., Hamet, P. and Tremblay, J. (2000) Mapping of quantitative trait loci (QTL) of differential stress gene expression in rat recombinant inbred strains. J. Hypertens., 18, 545-551.
34. Dumas, P., Kren, V., Krenova, D., Pravenec, M., Hamet, P. and Tremblay, J. (2002) Identification and chromosomal localization of ecogenetic components of electrolyte excretion. J. Hypertens., 20, 209-217.
35. Hamet, P., Kong, D., Pravenec, M., Kunes, J., Kren, V., Klir, P., Sun, Y.L. and Tremblay, J. (1992) Restriction fragment length polymorpbism of hsp 70 gene, localized in the RT1 complex, is associated with hypertension in spontaneously hypertensive rats. Hypertension, 19, 611-614.
36. Pausova, Z., Kunes, J., Kren, V., Krenova, D., Pravenec, M., Tremblay, J. and Hamet, P. (1999) Contribution of the TNF alpha gene region of rat chromosome 20 to the body temperature response to endotoxin. Transplant Proc., 31; 1622-1623.
37. Hamet, P. and Tremblay, J. (2002) Genetic determinants of the stress response in cardiovascular disease. Metabolism, 51, 15-24.
38. Leon, L.R., Kozak, W., Rudolph, K. and Kluger, M.J. (1999) An antipyretic role for interleukin-10 in LPS fever in mice. Am. J. Physiol., 276, R81-R89.
39. Pravenec, M., Sun, Y.L., Kunes, J., Kong, D., Kren, V., Klir, P., Tremblay, J. and Hamet, P. (1991) Environmental susceptibility in hypertension: Potential role of HSP70 and TNFα genes. J. Vasc. Med. Biol., 3, 297-302.
40. Ezzati, M., Lopez, A.D., Rodgers, A., Vander, H.S. and Murray, C.J. (2002) Selected major risk factors and global and regional burden of disease. Lancet, 360, 1347-1360.
41. Singer, J.B., Hill, A.E., Nadeau, J.H. and Lander, E.S. (2005) Mapping quantitative trait loci for anxiety in chromosome substitution strains of mice. Genetics, 169, 855-862.
42. Flint, J., Corley, R., DeFries, J.C., Fulker, D.W., Gray, J.A., Miller, S. and Collins, A.C. (1995) A simple genetic basis for a complex psychological trait in laboratory mice. Science, 269, 1432-1435.
43. Patel, N.V. and Hitzemann, R.J. (1999) Detection and mapping of quantitative trait loci for haloperidol-induced catalepsy in a C57BL/6J x DBA/2J F2 intercross. Behav. Genet., 29, 303-310.
44. Turi, M.G., Talbot, C.J., Radcliffe, R.A., Wehner, J.M. and Flint, J. (1999) High-resolution mapping of quantitative trait loci for emotionality in selected strains of mice. Mamm. Genome, 10, 1098-1101.
45. Turri, M.G., Henderson, N.D., DeFries, J.C. and Flint, J. (2001) Quantitative trait locus mapping in laboratory mice derived from a replicated selection experiment for open-field activity. Genetics, 158, 1217-1226.
46. Risinger, F.O., Quick, E. and Belknap, J.K. (2000) Quantitative trait loci for acute behavioral sensitivity to paraoxon. Neurotoxicol. Teratol., 22, 667-674.
47. Mayeda, A.R., Hofstetter, J.R., Belknap, J.K. and Numberger, J.I., Jr (1996) Hypothetical quantitative trait loci (QTL) for circadian period of locomotor activity in CXB recombinant inbred strains of mice. Behav. Genet., 26, 505-511.
48. Sugiyama, F., Churchill, G.A., Higgins, D.C., Johns, C., Makaritsis, K.P., Gavras, H. and Paigen, B. (2001) Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics, 71, 70-77.
49. DiPetrillo, K., Tsaih, S.W., Sheehan, S., Johns, C., Kelmenson, P., Gavras, H., Churchill, G.A. and Paigen, B. (2004) Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice. Physiol. Genomics, 17 215-220.
50. Phelan, S.A., Beier, D.R., Higgins, D.C. and Paigen, B. (2002) Confirmation and high resolution mapping of an atherosclerosis susceptibility gene in mice on Chromosome 1. Mamm. Genome, 13 548-553.
51. Wang, X., Phelan, S.A., Forsman-Semb, K., Taylor, E.F., Petros, C., Brown, A., Lerner, C.P. and Paigen, B. (2003) Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J. Biol. Chem., 278, 25179-25190.
52. Gross, V. and Luft, F.C. (2003) Exercising restraint in measuring blood pressure in conscious mice. Hypertension, 41, 879-881.
53. Hamet, P., Merlo, E., Seda, O., Broeckel, U., Tremblay, J., Kaldunski, M., Gaudet D., Bouchard, G., Deslauriers, B., Gagnon, F. et al. (2005) Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension. Am. J. Hum. Genet., 76, 815-832.
54. Ueno, T., Tremblay, J., Kunes, J., Zicha, J., Dobesova, Z., Pausova, Z., Deng, A.Y., Sun, Y.L., Jacob, H.J. and Hamet, P. (2004) Rat model of familial combined hyperlipidemia as a result of comparative mapping. Physiol. Genomics, 17, 38-47.
55. Hubner, N., Wallace, C.A., Zimdahl, H., Petretto, E., Schulz, H., Maciver, F., Mueller, M., Hummel, O., Monti, J., Zidek, V. et al. (2005) Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat. Genet., 37, 243-253.
56. Stoll, M., Kwitek-Black, A.E., Cowley, A.W., Jr, Harris, E.L., Harrap, S.B., Krieger, J.E., Printz, M.P., Provoost, A.P., Sassard, J. and Jacob, H.J. (2000) New target regions for human hypertension via comparative genomics. Genome Res., 10, 473-482.
57. Matthews, D.B., Bhave, S.V., Belknap, J.K., Brittingham, C., Chesler, E.J., Hitzemann, R.J., Hoffmann, P.L., Lu, L., McWeeney, S., Miles, M.F. et al. (2005) Complex genetics of interactions of alcohol and CNS function and behavior. Alcohol Clin. Exp. Res., 29, 1706-1719.
58. Ikeda, K., Onaka, T., Yamakado, M., Nakai, J., Ishikawa, T.O., Taketo, M.M. and Kawakami, K. (2003) Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump alpha2 subunit (Atp1a2)-deficient mice. J. Neurosci., 23, 4667-4676.
59. Moseley, A.E., Williams, M.T., Schaefer, T.L., Bohanan, C.S., Neumann, J.C., Behbehani, M.M., Vorhees, C.V. and Lingrel, J.B. (2007) Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice. J. Neurosci., 27, 616-626.
60. Schimanski, L.A. and Nguyen, P.V. (2005) Mouse models of impaired fear memory exhibit deficits in amygdalar LTP. Hippocampus, 15, 502-517.
61. Blaustein, M.P., Zhang, J., Chen, L. and Hamilton, B.P. (2006) How does salt retention raise blood pressure? Am. J. Physiol. Regul. Integr. Comp. Physiol., 290, R514-R523.
62. Zhang, J., Lee, M.Y., Cavalli, M., Chen, L., Berra-Romani, R., Balke, C.W., Bianchi, G., Ferrari, P., Hamlyn, J.M., Iwamoto, T. et al. (2005) Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice. J. Physiol., 569, 243-256.
63. Akimova, O., Tremblay, J., Hamet, P. and Orlov, S.N. (2006) The Na(+)tK(+)-ATPase as [K(+)](o) sensor: Role in cardiovascular disease pathogenesis and augmented production of endogenous cardiotonic steroids. Pathophysiology, 13, 209-216.
64. De Fusco, M., Marconi, R., Silvestri, L., Atorino, L., Rampoldi, L., Morgante, L., Ballabio, A., Aridon, P. and Casari, G. (2003) Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat. Genet., 33, 192-196.
65. Ochrietor, J.D., Harrison, K.A., Zahedi, K. and Mortensen, R.F. (2000) Role of STAT3 and C/EBP in cytokine-eependent expression of the mouse serum amyloid P-component (SAP) and C-reactive protein (CRP) genes. Cytokine, 12, 888-899.
66. Vongpatanasin, W., Thomas, G.D., Schwartz, R., Cassis, L.A., Osborne-Lawrence, S., Hahner, L., Gibson, L.L., Black, S., Samols, D. and Shaul, P.W. (2007) C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice. Circulation, 115, 1020-1028.
67. Grad, E., Golomb, M., Mor-Yosef, I., Koroukhov, N., Lotan, C., Edelman, E.R. and Danenberg, H.D. (2007) Transgenic expression of human C-reactive protein suppresses endothelial nitric oxide synthase expression and bioactivity following vascular injury. Am. J. Physiol. Heart Circ. Physiol., 293, 489-495.
68. Chandola, T., Brunner, E. and Marmot, M. (2006) Chronic stress at work and the metabolic syndrome: Prospective study. BMJ, 332, 521-525.
69. Epel, E.S., Lin, J., Wilhelm, F.H., Wolkowitz, O.M., Cawthon, R., Adler, N.E., Dolbier, C., Mendes, W.B. and Blackburn,. E.H. (2006) Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology, 31, 277-287.
70. Yalcin, B., Willis-Owen, S.A., Fullerton, J., Meesaq, A., Deacon, R.M., Rawlins, J.N., Copley, R.R., Morris, A.P., Flint, J. and Mott, R. (2004) Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat. Genet., 36, 1197-1202.
71. Yalcin, B., Flint, J. and Mott, R. (2005) Using progenitor strain information to identify quantitative trait nucleotides in outbred mice. Genetics, 171, 573-681.
72. Heximer, S.P., Knutsen, R.H., Sun, X., Kaltenbronn, K.M., Rhee, M.H., Peng, N., Oliveira-dos-Santos, A., Penninger, J.M., Muslin, A.J., Steinberg, T.H. et al. (2003) Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J. Clin. Invest. 111, 445-452.
73. Lee, P.D., Ge, B., Greenwood, C.M., Sinnett, D., Fortin, Y., Brunet, S., Fortin, A., Takane, M., Skamene, E., Pastinen, T. et al. (2006) Mapping cis-acting regulatory variation in recombinant congenic strains. Physiol. Genomics, 25, 294-302.
74. Miner, L.L. and Marley, R.J. (1995) Chromosomal mapping of the psychomotor stimulant effects of cocaine in BXD recombinant inbred mice. Psychopharmacology (Berl.), 122, 209-214.
75. Ramos, A., Moisan, M.P., Chaouloff, F., Mormede, C. and Mormede, P. (1999) Identification of female-specific QTLs affecting an emotionality-related behavior in rats. Mol. Psychiatry, 4, 453-462.
76. Fernandez-Teruel, A., Escorihuela, R.M., Gray, J.A., Aguilar, R., Gil, L., Gimenez-Llort, L., Tobena, A., Bhomra, A., Nicod, A., Mott, R. et al. (2002) A quantitative trait locus influencing anxiety in the laboratory rat. Genome Res., 12, 618-626.
77. Conti, L.H., Jirout, M., Breen, L., Vanella, J.J., Schork, N.J. and Printz, M.P. (2004) Identification of quantitative trait loci for anxiety and locomotion phenotypes in rat recombinant inbred strains. Behav Genet., 34, 93-103.
78. Jaworski, R.L., Jirout, M., Closson, S., Breen, L., Flodman, P.L., Spence, M.A., Kren, V., Krenova, D., Pravenec, M. and Printz, M.P. (2002) Heart mte and blood pressure quantitative trait loci for the airpuff startle reaction. Hypertension, 39, 348-352.
79. Kren, V., Pravenec, M., Lu, S., Krenova, D., Wang, J.M., Wang, M., Merriouns, T., Wong, A., St Lezin, E., Lau, D. et al. (1997) Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. J. Clin. Invest., 99, 577-581.
80. Garrett, M.R., Saad, Y., Dene, H. and Rapp, J.P. (2000) Blood-pressure QTL that differentiate dahl salt-sensitive and spontaneously hypertensive rats. Physiol. Genomics, 3, 33-38.
81. Seda, O. (2004) Comparative gene map of hypertriglyceridaemia. Folia Biol. (Praha), 50, 43-57.
82. Borglum, A.D., Kirov, G., Craddock, N., Mors, O., Muir, W., Murray, V., McKee, I., Collier, D.A., Ewald, H., Owen, M.J. et al. (2003) Possible parent-of-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder. Am. J. Med. Genet., 117B, 18-22.
83. Tivesten, A., Bollano, E., Andersson, I., Fitzgerald, S., Caidahl, K., Sjogren, K., Skott, O., Liu, J.L., Mobini, R., Isriksson, O.G. et al (2002) Liver-derived insulin-like growth factor-I is involved in the regulation of blood pressure in mice. Endocrinology, 143, 4235-4242.
84. Anunciado, R.V., Ohno, T., Mori, M., Ishikawa, A., Tanaka, S., Horio, F., Nishimura, M. and Namikawa, T. (2000) Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis. Exp. Anim., 49, 217-224.
85. Kamprath, K., Marsicano, G., Tang, J., Monory, K., Bisogno, T., Di, M.V., Lutz, B. and Wotjak, C.T. (2006) Cannabinoid CBI receptor mediates fear extinction via habituation-like processes. J. Neurosci., 26, 6677-6686.
86. Osei-Hyiaman, D., DePetrillo, M., Pacher, P., Liu, J., Radaeva, S., Batkai, S., Harvey-White, J., Mackie, K., Offertaler, L., Wang, L. et al. (2005) Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J. Clin. Invest., 115, 1298-1305.
87. Batkai, S., Pacher, P., Osei-Hyiaman, D., Radaeva, S., Liu, J., Harvey-White, J., Offertaler, L., Mackie, K., Rudd, M.A.,Bukoski, R.D. et al. (2004) Erdocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation, 110, 1996-2002.
88. Pietri, M., Schneider, B., Mouillet-Richard, S., Ermonval, M., Mutel, V., Launay, J.M. and Kellermarm, O. (2005) Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells. FASEB J., 19, 1078-1087.
89. Salmena, L., Lemmers, B., Hakem, A., Matysiak-Zablocki, E., Murakami, K., Au, P.Y., Berry, D.M., Tamblyn, L., Shehabeldin, A., Migon, E. et al. (2003) Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev., 17, 883-895.
90. Chrousos, G.P. (2000) The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: Neuro-endocrine and target tissue-related causes. Int. J. Obes., 24, S50-S55.
91. Smoller, J.W., Acierno, J.S., Jr, Rosenbaum, J.F., Biederman, J., Pollack, M.H., Meminger, S., Pava, J.A., Chadwick L.H., White, C., Bulzacchelli, M. et al. (2001) Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions. Am. J. Med. Genet., 105, 195-206.
92. Klimes, I., Weston, K., Gasperikova, D., Kovacs, P., Kvetnansky, R., Jezova, D., Dixon, R., Thompson, J.R., Sebokova, E. and Samani, N.J. (2005) Mapping of genetic determinants of the sympathoneural response to stress. Physiol. Genomics, 20, 183-187.
93. Palijan, A., Lambert, R., Dutil, J., Sivo, Z. and Deng, A.Y. (2003) Comprehensive congenic coverage revealing multiple blood pressure quantitative trait loci on Dahl rat chromosome 10. Hypertension, 42, 515-522.
94. Obata, K., Nagata, K., Iwase, M., Odashima, M., Nagasaka, T., Izawa, H., Murohara, T., Yamada, Y. and Yokota, M. (2005) Overexpression of calmodulin induces cardiac hypertrophy by a calcineurin-dependent pathway. Biochem. Biophys. Res. Commun., 338, 1299-1305.
95. Pacak, K. and Palkovits, M. (2001) Stressor specificity of central neuroendocrine responses: Implications for stress-related disorders. Endocr. Rev., 22, 502-548.
96. Daly, M.J., Rioux, J.D., Schaffner, S.F., Hudson, T.J. and Lander, E.S. (2001) High-resolution haplotype structure in the human genome. Nat. Genet., 29, 229-232.
97. Marshall, K.E., Godden, E.L., Yang, F., Burgers, S., Buck, K.J. and Sikela, J.M. (2002) In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Genome Biol., 3, Epub November 27, 2002.
98. Hitzemann, R., Malmanger, B., Reed, C., Lawler, M., Hitzemann, B., Coulombe, S., Buck, K, Rademacher, B., Walter, N., Polyakov, Y. et al. (2003) A strategy for the integration of QTL, gene expression, and sequence analyses. Mamm. Genome, 14, 733-747.
99. DiPetrillo, K., Wang, X., Stylianou, I.M. and Paigen, B. (2005) Bioinformatics toolbox for narrowing rodent quantitative trait loci. Trends Genet., 21, 683-692.
100. Lee, S.J., Liu, J., Qi, N., Guamera, R.A., Lee, S.Y. and Cicila, G.T. (2003) Use of a panel of congenic strains to evaluate diffffentially expressed genes as candidate genes for blood pressure quantitative trait loci. Hypertens. Res., 26, 75-87.
101. Goh, K.I., Cusick, M.E., Valle, D., Childs, B., Vidal, M. and Barabasi, A.L. (2007) The human disease network. Proc. Natl Acad. Sci. USA, 104, 8685-8690.
102. Tietz, N.W., Pruden, E.L. and Siggaard-Anderson, O. (1987) Tietz, N.W. (ed.), Fundamentals of Clinical Chemistry, W.B. Saunders, Philadelphia, pp. 616-620.
103. Pybus, J., Feldman, F.J. and Bowers, G.N., Jr (1970) Measurement of total calcium in serum by atomic absorption spectrophotometry, with use of a strontium internal reference. Clin. Chem., 16, 998-1007.
104. Owen, E.H., Logue, S.F., Rasmussen, D.L. and Weliner, J.M. (1997) Assessment of learning by the Morris water task and fear conditioning in inbred niouse strains and F1 hybrids: Implications of genetic background for single gene mutations and quantitative trait loci analyses. Neuroscience, 80, 1087-1099.
105. Manly, K.F., Cudmore, R.H., Jr and Meer, J.M. (2001) Map Manager QTX, cross-platform software for genetic mapping. Mamm. Genome, 12 930-932.
106. Doerge, R.W. and Churchill, G.A. (1996) Permutation tests for multiple loci affecting a quantitative chararter. Genetics, 142, 285-294.
107. Fortin, A., Stevenson, M.M. and Gros, P. (2002) Complex genetic control of susceptibility to malaria in mice. Genes Immun., 3, 177-186.
108. Flint, J. (2003) Analysis of quantitative trait loci that influence animal behavior. J. Neurobiol., 54, 46-77.
109. Rapp, J.P. (2000) Genetic analysis of inherited hypertension in the rat. Physiol. Rev., 80, 135-172.
110. Palmer, A.A. and Airey, D.C. (2003) Inappropriate choice of the experimental unit leads to a dramatic overestimation of the significance of quantitative trait loci for prepulse inhibition and startle response in recombinant congenic mice. Neuropsychopharmacology, 28, 818-819.
111. Xie, X., Lu, J., Kulbokas, E.J., Golub, T.R., Mootha, V., Lindblad-Toh, K., Lander, E.S. and Kellis, M. (2005) Systematic discovery of regulatory motifs in human promoters and 3′-UTRs by comparison of several mammals. Nature, 434, 338-345.
112. Wilkie, G.S., Dickson, K.S. and Gray, N.K. (2003) Regulation of mRNA translation by 5′- and 3′-UTR-binding factors. Trends Biochem. Sci., 28, 182-188.
113. Saklatvala, J., Dean, J. and Clark, A. (2003) Control of the expression of inflammatory response genes. Biochem. Soc. Symp., 70, 95-106.
114. Svoboda, P. and Cara, A.D. (2006) Hairpin RNA: A secondary structure of primary importance. Cell Mol. Life Sci., 63, 901-908.
115. Rozen, S. and Skaletsky, H. (2000) Krawetz, S. and Misener, S. (eds), Bioinformatics Methods and Protocols: Methods in Molecular Biology, Humana Press, Totowa, NJ, 365-386.
116. Pfaffl, M.W. (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res., 29, e45.,