Identification of female-specific QTLs affecting an emotionality-related behavior in rats

Molecular Psychiatry

Volumn 4, Issue 5, 1999, Pages 453-462

  Ramos, A ^a,b   Moisan, M P ^a   Chaouloff, F ^a   Mormede C ^a   Mormede P ^a  

^a INSTITUT FRANÇOIS MAGENDIE   (France)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Anxiety; Behavior genetics; Blood pressure; Elevated plus maze; Emotionality; Open field; QTL; Quantitative trait locus; Rat; Sex differences

Indexed keywords

SUBSTANCE P RECEPTOR;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BLOOD PRESSURE; CHROMOSOME 4; CONTROLLED STUDY; EMOTION; FEMALE; GENE MAPPING; HEREDITY; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RAT; SEX DIFFERENCE;

EID: 0032724991     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000546     Document Type: Article

References (77)

1. 1 Rogan MT, LeDoux JE. Emotion: systems, cells, synaptic plasticity. Cell 1996; 85: 469-475.
2. 2 Cabib S, Oliverio A, Ventura R, Lucchese F, Puglisi-Allegra S. Brain dopamine receptor plasticity: testing a diathesis-stress hypothesis in an animal model. Psychopharmalogy 1997; 132: 153-160.
3. 3 Eley TC, Plomin R. Genetic analysis of emotionality. Curr Opin Neurobiol 1997; 7: 279-284.
4. 4 Walker EF, Diforio D. Schizophrenia: a neural diathesis-stress model. Psychol Rev 1997; 104: 667-685.
5. 5 Lépine JP, Lellouch J. Classification and epidemiology of anxiety disorders. In: Darcourt G, Mendlewicz J, Racagni G, Brunello N (eds). Current Therapeutic Approaches to Panic and other Anxiety Disorders (International Academy for Biomedical and Drug Research). Karger: Basel, 1994, pp 1-14.
6. 6 Blanchard DC, Griebel G, Blanchard RJ. Gender bias in the preclinical psychopharmacology of anxiety: male models for (predominantly) female disorders. J Psychopharmacol 1995; 9: 79-82.
7. 7 Topolski TD, Hewitt JK, Eaves LJ, Silberg JL, Meyer JM, Rutter M et al. Genetic and environmental influences on child reports of manifest anxiety and symptoms of separation anxiety and overanxious disorders: a community-based twin study. Behav Genet 1997; 27: 15-28.
8. 8 Bouchard TJ Jr. Genes, environment, and personality. Science 1994; 264: 1700-1701.
9. 9 Bouchard TJ Jr, Lykken DT, Tellegen A, McGue M. Genes, drives, environment and experience: EPD theory revised. In: Benbow CP, Lubinski D (eds). Intellectual Talent: Psychometrics and Social Issues. John Hopkins University Press: Baltimore, 1996, pp 5-43.
10. 10 Gustavsson JP, Pedersen NL, Åsberg M, Schalling D. Origins of individual differences in anxiety proneness: a twin/adoption study of the anxiety-related scales from the Karolinska Scales of Personality (KSP). Acta Psychiatr Scand 1996; 93: 460-469.
11. 11 Evans J, Battersby S, Ogilvic AD, Smith CAD, Harmar AJ, Nutt DJ et al. Association of short alleles of a VNTR of the serotonin transporter gene with anxiety symptoms in patients presenting after deliberate self harm. Neuropharmacology 1997; 36: 439-443.
12. 12 Perna G, Caldirola D, Arancio C, Bellodi L. Panic attacks: a twin study. Psychiatry Res 1997; 66: 69-71.
13. 13 Tambs K, Harris JR, Magnus P. Genetic and environmental contributions to the correlation between alcohol consumption and symptoms of anxiety and depression. Results from a bivariate analysis of Norwegian twin data. Behav Genet 1997; 27: 241-250.
14. 14 Berrettini WH, Ferraro TN, Alexander RC, Buchberg AM, Vogel WH. Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. Nature Genet 1994; 7: 54-58.
15. 15 Melo JA, Shendure J, Pociask K, Silver LM. Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/6 mice. Nature Genet 1996; 13: 147-153.
16. 16 Buck KJ, Metten P, Belknap JK, Crabbe JC. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci 1997; 17: 3946-3955.
17. 17 Grisel JE, Belknap JK, O'Toole LA, Helms ML, Wenger CD, Crabbe JC. Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains. J Neurosci 1997; 17: 745-754.
18. 18 Flint J, Corley R, DeFries JC, Fulker DW, Gray JA, Miller S et al. A simple basis for a complex psychological trait in laboratory mice. Science 1995; 269: 1432-1435.
19. 19 Caldarone B, Saavedra C, Tartaglia K, Wehner JM, Dudek BC, Flaherty L. Quantitative trail locus analysis affecting contextual conditioning in mice. Nature Genet 1997; 17: 335-337.
20. 20 Gershenfeld HK, Paul SM. Mapping quantitative trait loci for fear-like behaviors in mice. Genomics 1997; 46: 1-8.
21. 21 Wehner JM, Radcliffe RA, Rosmann ST, Christensen SC, Rasmussen DL, Fulker DW et al. Quantitative trail locus analysis of contextual fear conditioning in mice. Nature Genet 1997; 17: 331-334.
22. 22 Moisan M-P, Courvoisier H, Bihoreau M-T, Gauguier D, Hendley ED, Lathrop M et al. A major quantitative trait locus influences hyperactivity in the WKHA rat. Nature Genet 1996; 14: 471-473.
23. 23 Ramos A, Berton O, Mormède P, Chaouloff F. A multiple-test study of anxiety-related behaviours in six inbred rat strains. Behav Brain Res 1997; 85: 57-69.
24. 24 Ramos A, Mellerin Y, Mormède P, Chaouloff F. A genetic and multifactorial analysis of anxiety-related behaviours in Lewis and SHR intercrosses. Behav Brain Res 1998; 96: 195-205.
25. 25 Lister RG. Ethologically-based animal models of anxiety disorders. Pharmacol Ther 1990; 46: 321-340.
26. 26 Crawley JN. Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazopines. Pharmacol Biochem Behav 1981; 15: 695-699.
27. 27 Pellow S, Chopin P, File SE, Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Math 1985; 14: 149-167.
28. 28 Treit D, Fundytus M. Thigmotaxis as a test for anxiolytic activity in rats. Pharmacol Biochem Behav 1989; 31: 959-962.
29. 29 Simon P, Dupuis R, Costentin J. Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions. Behav Brain Res 1994; 61: 59-64.
30. 30 Ramos A, Mormède P. Stress and emotionality: a multidimensional and genetic approach. Neurosci Biobehav Rev 1998; 22: 33-57.
31. 31 Archer J. Tests for emotionality in rats and mice: a review. Anim Behav 1973; 21: 205-235.
32. 32 Gray JA. Emotionality in male and female rodents: a reply to Archer. Br J Psychol 1979; 70: 425-440.
33. 33 Gentsch C, Lichtsteiner M, Feer H. Open field and elevated plus-maze: a behavioural comparison between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats and the effects of chlordiazepoxide. Behav Brain Res 1987; 25: 101-107.
34. A receptor complex ligands in two models of anxiety. J Neural Transm 1997; 104: 733-746.
35. 35 Angrini M, Leslie JC, Shephard RA. Effects of propanolol, buspirone, pCPA, reserpine, and chlordiazepoxide on open-field behavior. Pharmacol Biochem Behav 1998; 59: 387-397.
36. 36 Lincoln SE, Daly MJ, Lander ES. Mapping Genes Controlling Quantitative Traits using MAPMAKER/QTL Version 1.1: a Tutorial and Reference Manual. Whitehead Institute for Biomedical Research: Cambridge, 1993.
37. 37 Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet 1995; 11: 241-247.
38. 38 Banko ML, Allen KM, Dolina S, Neumann P, Seyfried TN. Genomic imprinting and audiogenic seizures in mice. Behav Genet 1997; 27: 465-475.
39. 39 Teixeira RM, Santos ARS, Ribeiro SJ, Calixto JB, Rae GA, De Lima TCM. Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice. Eur J Pharmacol 1996; 311: 7-14.
40. 40 Britton KT, Southerland S, Van Uden E, Kirby D, Rivier J, Koob G. Anxiolytic activity of NPY receptor agonists in the conflict test. Psychopharmacology 1997; 132: 6-13.
41. 1 receptor antagonist in the social interaction test. Pharmacol Biochem Behav 1997; 58: 747-752.
42. 42 Hasenöhrl RU, Jentjens O, Silva AS, Tomaz C, Huston JP. Anxiolytic-like action of neurokinin substance P administered systemically or into the nucleus basalis magnocellularis region. Eur J Pharmacol 1998; 354: 123-133.
43. 43 Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ et al. Distinct mechanisms for antidepressant activity by blockade of central substance P receptors. Science 1998; 281: 1640-1645.
44. 44 Barrett JE, Vanover KE. 5-HT receptors as targets for the development of novel anxiolytic drugs: models, mechanisms and future directions. Psychopharmacology 1993; 112: 1-12.
45. 45 Handley SL, McBlane JW. 5HT drugs in animal models of anxiety. Psychopharmacology 1993; 112: 13-20.
46. 46 Belzung C, Le Pape G. Comparison of different behavioral test situations used in psychopharmacology for measurement of anxiety. Physiol Behav 1994; 56: 623-628.
47. A Receptors and Anxiety: from Neurobiology to Treatment. Raven Press: New York, 1995, pp 93-113.
48. 40 Blanchard RJ, Griebel G, Henrie JA, Blanchard DC. Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries. Neurosci Biobehav Rev 1997; 21: 783-789.
49. 49 Lazarus RS. Emotion and Adaptation. Oxford University Press: Oxford, 1991.
50. 50 Schork NJ, Nath SP, Lindpaintner K, Jacob HJ. Extensions to quantitative trait locus mapping in experimental organisms. Hypertension 1996; 28: 1104-1111.
51. 51 Clark JS, Jeffs B, Davidson AO, Lee WK, Anderson NH, Bihoreau M-T et al. Quantitative trait loci in genetically hypertensive rats: possible sex specificity. Hypertension 1996; 28: 898-906.
52. 52 Mogil JS, Richards SP, O'Toole LA, Helms ML, Mitchell SR, Kest B et al. Identification of a sex-specific quantitative trait locus mediating nonopioid stress-induced analgesia in female mice. J Neurosci 1997; 17: 7995-8002.
53. 53 Johnston AL, File SE. Sex differences in animal tests of anxiety. Physiol Behav 1991; 49: 245-250.
54. 54 Sherman SL. Evolving methods in genetic epidemiology. IV. Approaches to non-Mendelian inheritance. Epidemiol Rev 1997; 19: 44-51.
55. 55 Durcan MJ, Goldman D. Genomic imprinting: implications for behavioral genetics. Behav Genet 1993; 23: 137-143.
56. 56 Hall JG. Genomic imprinting: nature and clinical relevance. Annu Rev Med 1997; 48: 35-44.
57. 57 Hadchouel M, Farza H, Simon D, Tiollais P, Pourcel C. Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation. Nature 1987; 329: 454-456.
58. 58 Chandra HS, Nanjundiah V. The evolution of genomic imprinting. Development 1990; Suppl: 47-53.
59. 59 Follette PJ, Laird CD. Estimating the stability of the proposed imprinted state of the fragile-X mutation when transmitted by females. Hum Genet 1992; 88: 335-343.
60. 60 Glassman ML, de Groot N, Hochberg A. Relaxation of imprinting in carcinogenesis. Cancer Genet Cytogenet 1996; 89: 69-73.
61. 61 Oda H, Shimizu S, Minami K, Kaneko K, Ishikawa T. Loss of imprinting of the 1GF2 gene in a Wilms' tumour in an adult. J Nat Cancer Instit 1997; 89: 1813-1814.
62. 62 Schapira AHV. Mitochondrial disorders. Curr Opin Genet Develop 1993; 3: 457-465.
63. 63 Johns DR. Mitochondrial DNA and disease. N Engl J Med 1995; 333: 638-644.
64. 64 Harada S, Okubo T, Tsutsumi M, Takase S, Muramatsu T. Investigation of genetic risk factors associated with alcoholism. Alcohol Clin Exp Res 1996; 20: 293-296.
65. 65 Gershenfeld HK, Neumann PE, Mathis C, Crawley JN, Li X, Paul SM. Mapping quantitative trait loci for open-field behavior in mice. Behav Genet 1997; 27: 201-210.
66. 66 Carr LG, Foroud T, Bice P, Gobbett T, Ivashina J, Edenberg H et al. A quantitative trait locus for alcohol consumption in selectively bred rat lines. Alcohol Clin Exp Res 1998; 22: 884-887.
67. 67 Lorentzen JC, Glaser A, Jacobsson L, Galli J, Fakhrai-rad H, Klareskog L et al. Identification of rat susceptibility loci for adjuvant-oil-induced arthritis. Proc Natl Acad Sci 1998; 95: 6383-6387.
68. 68 Calogero AE, Sternberg EM, Bagdy G, Smith G, Bernardini R, Aksentijevich S et al. Neurotransmitter-induced hypothalamic-pituitary-adrenal axis responsiveness is defective in inflammatory disease-susceptible Lewis rats: in vivo and in vitro studies suggesting globally defective hypothalamic secretion of corticotropin-releasing hormone. Neuroendocrinology 1992; 55: 600-608.
69. 69 Glowa JR, Sternberg EM, Gold PW. Differential behavioral response in LEW/N and F344/N rats: effects of corticotropin releasing hormone. Prog Neuro-Psychopharmacol Biol Psychiat 1992; 16: 549-560.
70. 70 Dietl MM, Torrens Y. Substance P et tachykinines. In: Epelbaum J (ed). Neuropeptides et Neuromédiateurs. Editions INSERM: Paris, 1995, pp 281-293.
71. 71 Aguiar MS, Brandāo ML. Effects of microinjections of the neuropeptide substance P in the dorsal periaqueductal gray on the behaviour of rats in the plus-maze test. Physiol Behav 1996; 60: 1183-1186.
72. 72 Pompei P, Angeletti S, Polidori C, Ciccocioppo R, De Caro G, Massi M. Regulation of preprotachykinin-A mRNA in genetic hypertensive and normotensive rats. Mol Brain Res 1997; 47: 78-86.
73. 73 St Lezin EM, Pravenec M, Wong AL, Liu W, Wang N, Lu S et al Effects of renin gene transfer on blood pressure and renin gene espression in a congenic strain of Dahl salt-resistant rats. J Clin Invest 1996; 97: 522-527.
74. 74 Jiang J, Stec DE, Drummond H, Simon JS, Koike G, Jacob HJ et al. Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats. Hypertension 1997; 29: 619-627.
75. 75 Kovács P, Voigt B, Klöting I, Alleles of the spontaneously hypertensive rat decrease blood pressure at loci on chromosomes 4 and 13. Biochem Biophys Res Com 1997; 238: 586-589.
76. 76 Zhang QY, Dene H, Deng AY, Garret MR, Jacob HJ, Rapp JP. Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Mamm Genome 1997; 8: 636-641.
77. 77 Cloninger CR, Van Eerdewegh P, Goate A, Edenberg HJ, Blangero J, Hesselbrock V et al. Anxiety proneness linked to epistatic loci in genome scan of human personality traits. Am J Med Genet 1998; 81: 313-317.