Genotoxicological studies in aquatic organisms: An overview

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 552, Issue 1-2, 2004, Pages 1-17

  Jha, Awadhesh N ^a  

^a UNIVERSITY OF PLYMOUTH   (United Kingdom)

Author keywords

Aquatic organisms; Eco genotoxicology; Genetic ecotoxicology

Indexed keywords

CARCINOGEN; TOXIN;

AQUATIC ENVIRONMENT; AQUATIC FAUNA; BIOLOGICAL MONITORING; ECOTOXICOLOGY; ENVIRONMENTAL MANAGEMENT; EVOLUTIONARY ADAPTATION; GENE EXPRESSION PROFILING; GENETIC DAMAGE; GENETIC TOXICOLOGY; GENOME ANALYSIS; GENOMICS; HUMAN; HYPOTHESIS; LARGEMOUTH BASS; MAMMAL; MEDICAL RESEARCH; MUTAGENESIS; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; TUMOR SUPPRESSOR GENE;

ANIMALS; ECOSYSTEM; ENVIRONMENTAL MONITORING; GENETICS, POPULATION; INDUSTRIAL WASTE; MUTAGENS; RISK ASSESSMENT; WATER POLLUTANTS;

MAMMALIA;

EID: 3843148578     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2004.06.034     Document Type: Review

References (149)

1. J.S. Gray Climate change Mar. Pollut. Bull. 22 1991 169 171
2. L.D. Claxton, V.S. Houk and T.J. Hughes Genotoxicity of industrial wastes and effluents Mutat. Res. 410 1998 237 243
3. J.C. Harshbarger and J.B. Clark Epizootiology of neoplasms in bony fish of North America Sci. Total Environ. 94 1990 1 32
4. W.P. Dey, T.H. Peck, C.E. Smith and G.-L. Kreamer Epizoology of hepatic neoplasia in Atlantic tomcod (Microgadus tomcod) from the Hudson River estuary Can. J. Fish. Aquat. Sci. 50 1993 1897 1907
5. W.K. Vogelbein, J.W. Fournie, P.A. van Veld and R.J. Huggett Hepatic neoplasms in the mummichog Fundulus heteroclitus from a creosote-contaminated site Cancer Res. 50 1990 5978 5986
6. D.M. Hesselman, N.J. Blake and E.C. Peters Gonadal neoplasms in hardshelled clams, Mercenaria spp., from the Indian River, Florida: occurrence, prevalence and histopathology J. Invert. Pathol. 52 1988 436 446
7. R.J. Van Beneden Molecular analysis of bivalve tumours; models for environmental/genetic interactions Environ. Health Perspect. 102 Suppl. 12 1994 81 83
8. F.E. Wurgler and P.G.N. Kramers Environmental effects of genotoxins (eco-genotoxicology) Mutagenesis 7 1992 321 327
9. S. Anderson, W. Sadinski, L. Shugart, P. Brussard, M. Depledge, T. Ford, J. Hose, J. Stegeman, W. Suk, I. Wirgin and G. Wogan Genetic and molecular toxicology: a research framework Environ. Health Perspect. 102 Suppl. 12 1994 3 8
10. J.W. Bickham, S. Sandhu, P.D.N. Hebert, L. Chikhi and R. Athwal Effects of chemical contaminants on genetic diversity in natural populations: implications for biomonitoring and ecotoxicology Mutat. Res. 463 2000 33 51
11. M. Lynch, J. Conery and R. Burger Mutation accumulation and the extinction of small populations Am. Nat. 146 1995 489 518
12. R. Lande Risk of population extinction from fixation of deleterious and reverse mutation Genetica 102/103 1998 21 27
13. C. Cislaghi and P.L. Nimis Lichens, air pollution and lung cancer Nature 387 1997 463 464
14. I.D. Adler and J. Ashby The present lack of evidence of unique rodent germ cell mutagens Mutat. Res. 212 1989 56 66
15. D.R. Dixon, A.M. Pruski, L.R.J. Dixon and A.N. Jha Marine invertebrate eco-genotoxicology: a methodological overview Mutagenesis 17 2002 495 507
16. H.S. Rosenkranz Health effects associated with global climate changes: a role for environmental mutagens Environ. Mol. Mutagen. 27 1996 81 83
17. F.W. Whicker and J.S. Bedford Protection of the natural environment from the ionising radiation. Are specific criteria needed? Proceedings of an International Symposium on Environmental Impact of Radioactive Releases International Atomic Energy Agency, IAEA-SM-339/193 1995 561 567
18. T. Boveri Zur Frage der Entstehung maligner Tumoren, Gustav Fischer JENA 1914 1 64
19. A.N. Jha Use of aquatic invertebrates in genotoxicological studies Mutat. Res. 399 1998 1 2
20. R.H. Dashwood and G.S. Bailey Use of fish and fish transgenics in laboratory and field genotoxicological studies Mutat. Res. 399 1998 123 124
21. J.S. Wassom Merging mutation research with genomics Mutat. Res. Forum. 1 1996 2 4
22. J. Delehanty, R.L. White and M.L. Mendelsohn Approaches to determine mutation rates in human DNA Mutat. Res. 167 1986 215 232
23. M.R. Fielden and T.R. Zacharewski Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology Toxicol. Sci. 60 2001 6 10
24. M.N. Moore Biocomplexity: the post-genome challenge in ecotoxicology Aquat. Toxicol. 59 2002 1 15
25. L. Nylund, C. Rosenberg, P. Jappinen and H. Vainio Genotoxicity of kraft pulp spent liquors from different types of chlorinated procedures Mutat. Res. 320 1994 165 174
26. S.S. Rao, B.K. Burnison, S. Efler, E. Wittekindt, P.D. Hansen and D.A. Rokosh Assessment of genotoxic potential of pulp mill effluent and an effluent fraction using Ames mutagenicity and umu-c genotoxicity assays Environ. Toxico. Water Qual. 10 1995 301 305
27. N.D. Denslow, J. Kocerha, M.S. Seulveda, T. Gross and S.E. Holm Gene expression fingerprints of largemouth bass (Micropterus salmoides) exposed to pulp and paper mill effluents Mutat. Res. 552 2004 19 34
28. T.H. Hutchinson and D.B. Pickford Ecological risk assessment and testing for endocrine disruption in the aquatic environment Toxicology 181-182 2002 383 387
29. H.F.P. Joosten, F.A.A. van Acker, D.J. van den Dobbelsteen, G.J.M.J. Horbach and E.I. Krajnc Genotoxicity of hormonal steroids Toxicol. Lett. 151 2004 113 134
30. A.N. Jha, J.A. Hagger and S.J. Hill Tributyltin induces cytogenetic damage in the early life stages of marine mussel, Mytilus edulis Environ. Mol. Mutagen. 35 2000 343 350
31. F. Cimma and L. Ballarin Tributyltin induces cytoskeletal alterations in the colonial ascidian Botryllus schlosseri phagocytes via interaction with calmodulin Aquat. Toxicol. 48 2000 419 429
32. J.A. Hagger, A.S. Fisher, S.J. Hill, M.H. Depledge and A.N. Jha Genotoxic, cytotoxic and ontogenic effects of tri-n-butyltin on the marine worm, Platynereis dumerilii (Polychaete: Nereidae) Aquat. Toxicol. 57 2002 243 255
33. M. Brown, C. Robinson, I.M. Davies, C.F. Moffat, J. Redshaw and J.A. Craft Temporal changes in gene expression in the liver of male plaice (Pleuronectes platessa) in response to exposure to ethynyl oestradiol analysed by macroarray and Real-Time PCR Mutat. Res. 552 2004 35 49
34. F. Anders, M. Schartl, A. Barkenow and A. Anders Xiphophorus as an in vivo model for studies on normal and defective control of oncogenes Adv. Cancer Res. 42 1984 191 275
35. M. Schartl, C.R. Schmidt, A. Anders and A. Barkenow Elevated expression of the cellular src gene in tumours of different etiology in Xiphophorus Int. J. Cancer 36 1985 199 207
36. R.J. Van Beneden, K.W. Henderson, D.G. Blair, T.S. Papas and H.S. Gardner Oncogenes in hematopoietic and hepatic fish neoplasms Cancer Res. 50 1990 5671 5674
37. J. Wittbrodt, D. Adam, B. Malitschek, W. Maueler, F. Raulf, A. Telling, S.M. Robertson and M. Schartl Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus Nature 341 1989 415 421
38. R.J. Van Beneden, D.R. Watson, T.T. Chen, J.A. Lautenberger and T.S. Papas Cellular myc (c-myc) in fish (rainbow trout): its relationship to other vertebrate myc genes and to the transforming genes of the MC29 family of viruses Proc. Natl. Acad. Sci. U.S.A. 83 1986 3698 3702
39. M. Schartl Homology of melanoma-inducing loci in Xiphophorus Genetics 126 1990 1083 1091
40. J.M. Rotchell, J.S. Lee, J.K. Chipman and G.K. Ostrander Structure, expression and activation of fish ras genes Aquat. Toxicol. 55 2001 1 21
41. M. Hollstein, D. Sidransky, B. Vogelstein and C.C. Harris p53 mutations in human cancers Science 253 1991 49 53
42. J.C. Harshbarger, C.J. Dawe, Hematopoietic neoplasms in invertebrate and poikilothermic vertebrate animals, in: R.M. Dutcher, L. Chieco-Bianchi (Eds.), Comparative Studies on Animal Species, Unifying Concepts of Leukemia, Karger, Basel, Bibl. Haemat. 39 (1973) pp. 227-239.
43. A. Bhaskaran, D. May, M. Rand-Weaver and C.R. Tyler Fish p53 as a possible biomarker for genotoxins in the aquatic environment Environ. Mol. Mutagen. 33 1999 177 184
44. J. Cachot, J. Couteau, T. Frebourg, F. Leboulenger and J.-M. Flaman Functional analysis of chemically-induced mutations at the flounder TP53 locus, the FACISM assay Mutat. Res. 552 2004 51 60
45. G.R. Gardner, P.P. Yevich, J. Hurst, P. Thayer, S. Benyi, J.C. Harshbarger and R.J. Pruell Germinomas and teratoid siphon anomalies in softshell clams, Mya arenaria, environmentally exposed to herbicides Environ. Health Perspect. 90 1991 43 51
46. R.A. Butler, M.L. Kelley, W. Powell, M.E. Hahn and R.J. Van Beneden An aryl hydrocarbon receptor homologue from the soft-shell clam, Mya arenaria: evience that invertebrate AHR homologue lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-naphthoflavin binding Gene 278 2001 223 234
47. 3H]-TCDD exposure in soft-shell clams Mya arenaria Environ. Toxicol. Chem. 16 1997 1888 1894
48. K.E. Olberding, M.L. Kelley, R.A. Butler and R.J. Van Beneden A HECT E3 ubiquitin-protein ligase with sequence similarity to E6AP does not target p53 for degradation in the softshell clam (Mya arenaria) Mutat. Res. 552 2004 61 71
49. R. Bijlsma, J. Bundgaard, A.C. Boerema and W.F. Van Putten Genetic and environmental stress and the persistence of population R. Bijlsma V. Loeschcke Environmental Stress, Adaptation and Evolution 1997 Birkhauser Verlag, Basel Switzerland 193 207
50. D. Charlesworth and B. Charlesworth Inbreeding depression and its evolutionary consequences Ann. Rev. Ecol. Syst. 18 1987 237 268
51. P.A. Parsons Fluctuating asymmetry: a biological monitor of environmental and genomic stress Heredity 68 1992 361 364
52. G.M. Clark The genetic basis of developmental stability. I. Relationship between stability, heterozygosity and genomic coadaptation Genetica 89 1993 15 23
53. P.L. Klerks, P.L. Leberg, R.F. Lance, D.J. McMillin and J.C. Means Lack of development of pollutant-resistance or genetic differentiation of darter gobies (Gobionellus boleosoma) inhabiting a produced-water discharge site Mar. Environ. Res. 44 1997 377 395
54. I. Wirgin and J.R. Waldman Resistance to contaminants in north American fish populations Mutat. Res. 552 2004 73 100
55. B. Kurelec The multixenobiotic resistance mechanism in aquatic organisms Crit. Rev. Toxicol. 22 1992 23 43
56. T. Smital and B. Kurelec The chemosenitizers of multixenobiotic resistance mechanism in aquatic invertebrates: a new class of pollutants Mutat. Res. 399 1998 43 53
57. T. Smital, T. Luckenbach, R. Sauerborn, A.M. Hamdoun, R.L. Vega and D. Epel Emerging contaminants-pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defence in aquatic organisms Mutat. Res. 552 2004 101 117
58. K.S. Bentley, A.M. Sarrif, M.C. Cimino and A.E. Auletta Assessing the risk of heritable gene mutation in mammals: Drosophila sex-linked recessive lethal test and tests measuring DNA damage and repair in mammalian germ cells Environ. Molec. Mutagen. 23 1994 3 11
59. W.F. Morgan Non-targeted and delayed effects of exposure to ionising radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects Radiat. Res. 159 2003 581 596
60. A. Shimada and A. Shima Transgenerational genomic instability as revealed by a somatic mutation assay using the medaka fish Mutat. Res. 552 2004 119 129
61. O. Niwa and R. Kominami Untargeted mutation of the maternally derived mouse hypervariable minisatellite allele in F1 mice born to irradiated spermatozoa Proc. Natl. Acad. Sci. U.S.A. 98 2001 1705 1710
62. P. De Voogt, B. van Hattum, P. Leonards, J.C. Klamer and H. Govers Bioconcentration of polycyclic heteroaromatic hydrocarbons in the guppy (Poecilia reticula) Aquat. Toxicol. 20 1991 101 104
63. S.R. Wild and K.C. Jones Polynuclear aromatic hydrocarbons in the United Kingdom environment: a preliminary source inventory and budget Environ. Pollut. 88 1995 91 108
64. R.J. Law, V.J. Dawes, R.J. Woodhead and P. Matthiessen Polycyclic aromatic hydrocarbons (PAH) in seawater around England and Wales Mar. Pollu. Bull. 34 1997 306 322
65. D.R. Livingstone Biotechnology and pollution monitoring: use of molecular biomarkers in the aquatic environment J Chem. Tech. Biotech. 57 1993 195 211
66. A.D. Vethak and T. ap Rheinalt Fish disease as a monitor for marine pollution: the case of the North Sea Rev. Fish Biol. Fisher 2 1992 1 32
67. J.B. Bishop, R.W. Morris, J.C. Seely, L.A. Hughes, K.T. Cain and W.M. Generoso Alterations in the reproductive patterns of female mice exposed to xenobiotics Fund. Appl. Toxicol. 40 1997 191 204
68. C.L. Yauk and J.S. Quinn Multilocus DNA fingerprinting reveals high rate of heritable genetic mutation in herring gulls nesting in an industrialized urban site Proc. Natl. Acad. Sci. U.S.A. 93 1996 12137 12141
69. C.M. Somers, C.L. Yauk, P.A. White, C.L.J. Parfett and J.S. Quinn Air pollution induces heritable DNA mutations Proc. Natl. Acad. Sci. U.S.A. 99 2002 15904 15907
70. C.M. Somers, B.E. McCarry, F. Malek and J.S. Quinn Reduction of particulate air pollution lowers the risk of heritable mutations in mice Science 304 2004 1008 1010
71. F.A. Atienzar and A.N. Jha The random amplified polymorphic DNA (RAPD) assay to determine DNA alterations, repair and transgenerational effects in B(a)P exposed Daphnia magna Mutat. Res. 552 2004 125 140
72. D.K. Khandka, M. Tuna, M. Tal, A. Nejidat and A. Golan Goldhirsh Variability in the pattern of random amplified polymorphic DNA Electrophoresis 18 1997 2852 2856
73. M.P. Bagley, S.L. Anderson and B.P. May Choice of methodology for assessing genetic impacts of environmental stressors: polymorphism and reproducibility of RAPD and AFLP fingerprints Ecotoxicology 10 2001 239 244
74. T. Perez, J. Albornoz and A. Dominguez An evaluation of RAPD fragment reproducibility and nature Mol. Ecol. 7 1998 1347 1357
75. C.W. Theodorakis and L.R. Shugart Genetic ecotoxicology. Part II. Population genetic structure in radionuclide-contaminated mosquitofish (Gambusia affinis) Ecotoxicology 6 1997 335 354
76. S.G. Nadig, K.L. Lee and S.M. Adams Evaluation of alterations of genetic diversity in sunfish populations exposed to contaminants using RAPD assay Aquat. Toxicol. 43 1998 163 178
77. D.E. Krane, D.C. Sternberg and G. Allen Burton Randomly amplified polymorphic DNA profile-based measures of genetic diversity in crayfish correlated with environmental impacts Environ. Chem. Toxicol. 18 1998 504 508
78. X.L. Ma, D.L. Cowles and R.L. Carter Effect of pollution on genetic diversity in the bay mussel Mytilus galloprovincialis and the acorn barnacle Balanus glandula Mar. Environ. Res. 50 2000 559 563
79. C. Jones and A. Kortenkamp RAPD library fingerprinting of bacterial and human DNA: applications in mutation detection Terato. Carcino. Mutagen. 20 2000 49 63
80. N.M. Belfiore and S.L. Anderson Effects of contaminants on genetic patterns in aquatic organisms: a review Mutat. Res. 489 2001 97 122
81. A. Castano, N. Bols, T. Braunbeck, P. Dierickx, M. Halder, B. Isomaa, K. Kawahara, L.E. Lee, C. Mothersill, P. Part, G. Repetto, J.R. Sintes, H. Rufli, R. Smith, C. Wood and H. Segner The use of fish cells in ecotoxicology Alter. Lab. Anim. 31 2003 317 351
82. S.M. Baksi and J.M. Frazier Isolated fish heapatocytes-model systems for toxicology research Aquat. Toxicol. 16 1990 229 256
83. M. Kohlpoth, B. Rusche and M. Nusse Flow cytometric measurement of micronuclei induced in a permanent fish cell line as a possible screening test for the genotoxicity of industrial waste waters Mutagenesis 14 1999 397 402
84. S. Nehls and H. Senger Detection of DNA damage in two cell lines from rainbow trout, RTG-2 and RTL-W1, using the comet assay Environ. Toxicol. 16 2001 321 329
85. U. Kammann, M. Bunke, H. Steinhart and N. Theobald A permanent fish cell line (EPC) for genotoxicity testing of marine sediments with the comet assay Mutat. Res. 498 2001 67 77
86. S. Raisuddin and A.N. Jha Relative sensitivity of fish and mammalian cells to sodium arsenate and arsenite as determined by alkaline single-cell gel electrophoresis and cytokinesis-block micronucleus assay Environ. Mol. Mutagen. 44 2004 83 89
87. A. Castano and C. Becerril In vitro assessment of DNA damage after short and long term exposure to benzo(a) pyrene using RAPD and the RTG-2 fish cell line Mutat. Res. 552 2004 141 151
88. A.N. Jha, V.V. Cheung, M.E. Foulkes, S.J. Hill and M.H. Depledge Detection of genotoxins in the marine environment: adoption and evaluation of an integrated approach using the embryo-larval stages of the marine mussel, Mytilus edulis Mutat. Res. 464 2000 213 228
89. S. De Flora, M. Bagnasco and P. Zanacchi Genotoxic, carcinogenic, and teratogenic hazards in the marine environment, with special reference to the Mediterranean Sea Mutat. Res. 258 1991 285 320
90. E. Cardis, S. Jones and P. Kleihues The future of population monitoring in cancer research Environ. Health Perspect. 104 Suppl. 3 1996 527 528
91. C. Bolognesi, G. Frenzilli, C. Lasagna, E. Perrone and P. Roggieri Genotoxicity biomarkers in Mytilus galloprovincialis: wild versus caged mussels Mutat. Res. 552 2004 153 162
92. M.J. Winter, N. Day, R.A. Hayes, E.W. Taylor, P.J. Butler and J.K. Chipman DNA strand breaks and adducts in feral and caged chub (Leuciscus cephalus) exposed to rivers exhibiting variable water quality around Birmingham, UK Mutat. Res. 552 2004 163 175
93. B.P. Lyons, G.D. Stentiford, M. Green, J. Bignell, K. bateman, S.W. Feist, F. Goodsir, W.J. Reynolds and J.E. Thain DNA adduct analysis and histopathological biomarkers in European flounder (Platichthys flesus) sampled from UK estuaries Mutat. Res. 552 2004 177 186
94. B.P. Lyons, C. Stewart and M.K. Kirby The detection of biomarkers of genotoxin exposure in the European flounder (Platichthys flesus) collected from the River Tyne Estuary Mutat. Res. 446 1999 111 119
95. W.L. Reichert, M.S. Myers, K. Peck-Miller, B. French, B.F. Anulacion, T.K. Collier, J.E. Stein and U. Varanasi Molecular epizootiology of genotoxic events in marine fish: linking contaminant exposure, DNA damage, and tissue-level alterations Mutat. Res. 411 1998 215 225
96. P.C. Baumann Epizootics of cancer in fish associated with genotoxins in sediment and water Mutat. Res. 411 1998 227 233
97. G. Frenzilli, V. Scarcelli, I.D. Barga, M. Nigro, L. Forlin, C. Bolognesi and J. Sturve DNA damage in Eelpout (Zoarces viviparous) from Goteborg harbour Mutat. Res. 552 2004 187 195
98. J.S. Harvey, B.P. Lyons, T.S. Page, C. Stewart and J.M. Parry An assessment of the genotoxic impact of the Sea Empress oil spill by the measurement of DNA adduct levels in selected invertebrate and vertebrate species Mutat. Res. 441 1999 103 114
99. Royal Society, Carcinogenesis in the marine environment, Pollutant Control Priorities in the Aquatic Environment: Scientific Guidelines for Management, Report of a Royal Society Study Group, The Royal Society, London, UK, 1994, pp. 55-80.
100. M.H. Bother, P.W. Gill, W.S. Boothman, B.B. Taylor and H.A. Karl Chemical gradients in sediment cores from an EPA reference site off the Farallon islands-assessing chemical indicators of dredged material disposal in the deep sea Mar. Pollut. Bull. 36 1998 443 457
101. P. van Den Hurk, R.H.M. Ertman and J. Stronkhorst Toxicity of harbour canal sediments before dredging and after off-shore disposal Mar. Pollut. Bull. 34 1997 244 249
102. F. Akcha, G. Leday and A. Pfohl-Leszkowicz Measurement of DNA adducts and strand breaks in dab (Limanda limanda) collected in the field: Effects of biotic (age, sex) and abiotic (sampling site and period) factors on the extent of DNA damage Mutat. Res. 552 2004 197 207
103. N. Bihari and M. Fafandel Interspecies differences in DNA single starnd breaks caused by benzo(a)pyrene and marine environment Mutat. Res. 552 2004 209 217
104. T. Hamers, E.J.J. Kalis, J.H.J. van den Berg, L.M. Maas, F.-J. van Schooten and A.J. Murk Applicability of the black slug Arion ater for monitoring exposure to poly aromatic hydrocarbons and their subsequent bioactivation into DNA binding metabolites Mutat. Res. 552 2004 219 233
105. A.M. Pruski and D.R. Dixon Toxic vents and DNA damage: first evidence from a naturally contaminated deep-sea environment Aquat. Toxicol. 64 2003 1 13
106. D.R. Dixon, A.M. Pruski and L.R.J. Dixon The effects of hydrostatic pressure change on DNA integrity in the hydrothermal-vent mussel Bathymodiolus zoricus; implications for future deep-sea mutagenicity studies Mutat. Res. 552 2004 235 246
107. D.J. Schaeffer Diagnosing ecosystem health Ecotox. Environ. Safety 34 1996 18 34
108. M. Power and L.S. McCarty Fallacies in ecological risk assessment practices Environ. Sci. Technol. 31 1997 370 375
109. M. Borras and J. Nadal Biomarkers of genotoxicity and other end-points in an integrated approach to environmental risk assessment Mutagenesis 19 2004 165 168
110. M.N. Moore, M.H. Depledge, J.W. Readman and D.R.P. Leonard An integrated biomarker-based strategy for ecotoxicological evaluation of risk in environmental management Mutat Res. 552 2004 247 268
111. R.N. Hooftman The induction of chromosome aberrations in Notobranchius rachowi (Pisces: Cyprinodontidae) after treatment with ethyl methanesulphonate or benzo(a)pyrene Mutat. Res. 91 1981 347 352
112. A.P. Krishnaja and M.S. Rege Induction of chromosomal aberrations in fish Boleophthalmus dussumieri after exposure in vivo to mitomycin C and heavy metals mercury, selenium and chromium Mutat. Res. 102 1982 71 82
113. G.M. Alink, E.M.H. Frederix-Wolters, M.A. van der Gaag, J.F.J. van de Kerkhoff and C.L.M. Poles Induction of sister-chromatid exchanges in fish exposed to Rhine water Mutat. Res. 78 1980 369 374
114. M.B. Maddock, H. Northrup and T.J. Ellingham Induction of sister-chromatid exchanges and chromosomal aberrations in haematopoietic tissue of a marine fish following in vivo exposure to genotoxic carcinogens Mutat. Res. 172 1986 165 175
115. D.R. Dixon and K.R. Clarke Sister chromatid exchange-a sensitive method for detecting damage caused by exposure to environmental mutagens in the chromosomes of adult Mytilus edulis Mar. Biol. Lett. 3 1982 163 172
116. A.N. Jha, T.H. Hutchinson, J.M. Mackay, B.M. Elliott and D.R. Dixon Development of an in vivo genotoxicity assay using the marine worm Platynereis dumerilii (Polychaete: Neridae) Mutat. Res. 359 1996 141 150
117. A.N. Jha, T.H. Hutchinson, J.M. Mackay, B.M. Elliott and D.R. Dixon Evaluation of genotoxicity of municipal sewage effluent using the marine worm Platynereis dumerilii (Polychaete: Neridae) Mutat. Res. 391 1997 179 188
118. G.G. Pesch, C.E. Pesch and A.R. Malcolm Neanthes arenaceodentata, a cytogenetic model for marine genetic toxicology Aquat. Toxicol. 1 1981 301 311
119. G. Pagano, A. Esposito, P. Bove, M. de Angelis, A. Rota, E. Vamvakinos and G.G. Giordano Arsenic-induced developmental defects and mitotic abnormalities in sea-urchin development Mutat. Res. 104 1982 351 354
120. J.E. Hose, H.W. Puffer, P.S. Oshida and S.M. Bay Developmental and cytogenetic abnormalities induced in the purple sea urchin by environmental levels of benzo(a)pyrene Arch. Environ. Contam. Toxicol. 12 1983 319 325
121. S.L. Anderson, J.E. Hose and J.P. Knezovich Genotoxic and developmental effects in sea urchins are sensitive indicators of effects of genotoxic chemicals Environ. Toxicol. Chem. 13 1994 1033 1041
122. J.E. Hose and E.D. Brown Field applications of the piscine anaphase aberration test: lessons from the Exxon Valdez oil spill Mutat. Res. 1998 167 178
123. M.N. Wrisberg and M.A. van Der Gaag In vivo detection of genotoxicity of waste water from a wheat and rye straw paper factory Sci. Total Environ. 121 1992 95 108
124. T. Burgeot, F. Galgani and E. His The micronucleus assay in Crassostyrea gigas for the detection of seawater genotoxicity Mutat. Res. 342 1995 125 140
125. P. Venier, S. Maron and S. Canova Detection of micronuclei in gill cells and haemocytes of mussels exposed to benzo(a)pyrene Mutat. Res. 390 1997 33 44
126. C. Bolognesi, E. Landini, P. Roggieri, R. Fabbri and A. Viarengo Genotoxicity biomarkers in the assessment of heavy metal effects in mussels: experimental studies Environ. Mol. Mutagen. 33 1999 287 292
127. K. Saotome, T. Sofuni and M. Hayashi A micronucleus assay in sea urchin embryos Mutat. Res. 446 1999 121 127
128. R.N. Hooftman and W.K. de Raat Induction of nuclear anomalies (micronuclei) in the peripheral blood erythrocytes of eastern mudminnow Umbra pygmaea by ethyl methanesulphonate Mutat. Res. 104 1982 147 152
129. K. Al-Sabti and C.D. Metcalfe Fish micronuclei for assessing genotoxicity in water Mutat. Res. 343 1995 121 135
130. A. Jaylet, P. Deparis, V. Ferrier, S. Grinfeld and R. Siboulet A new micronucleus test using peripheral blood erythrocytes of the newt Pleurodels walt to detect mutagens in fresh-water Mutat. Res. 164 1986 245 257
131. L. Gauthier The amphibian micronucleus test, a model for in vivo monitoring of genotoxic aquatic pollution Alytes 14 1996 53 84
132. F. Ayllon and E. Garcia-Vazquez Induction of micronuclei and other nuclear abnormalities in European minnow Phoxinus phoxinus and mollie Poecilia latipinna: an assessment of the fish micronucleus test Mutat. Res. 467 2000 177 186
133. A.T. Natarajan Chromosome aberrations: past, present and future Mutat. Res. 504 2002 3 16
134. A.N. Jha, I. Dominquez, A.S. Balajee, T.H. Hutchinson, D.R. Dixon and A.T. Natarajan Localisation of a vertebrate telomeric sequence in the chromosomes of two marine worms (phylum Annelida: class Polychaeta) Chromosome Res. 3 1995 507 508
135. P.L. Pascoe, S.J. Patton, R. Critcher and D.R. Dixon Robertsonian polymorphism in the marine gastropod Nucella lapillus: advances in karyology using rDNA loci and NORs Chromosoma 104 1995 455 460
136. C.L. Mitchelmore and J.K. Chipman DNA strand breakage in aquatic organisms and the potential value of the comet assay in environmental monitoring Mutat. Res. 399 1998 135 147
137. S. Cotelle and J.F. Ferard Comet assay in genetic ecotoxicology: a review Environ. Mol. Mutagen. 34 1999 246 255
138. R.F. Lee and S. Steinert Use of the single cell gel electrophoresis/comet assay for detecting DNA damage in aquatic (marine and freshwater) animals Mutat. Res. 544 2003 43 64
139. S.J. Santos, N.P. Singh and A.T. Natarajan Fluorescence in situ hybridisation with comets Exp. Cell Res. 232 1997 407 411
140. J.L. Fernandez, F. Vazquez-Gundin, M.T. Rivero, A. Genesca, J. Gosalvez and V. Goyanes DBD-FISH on neutral comets: simultaneous analysis of DNA single-and double-strand breaks in individual cells Exp. Cell Res. 270 2001 102 109
141. D.J. McKenna, N.F. Rajab, S.R. McKeown, G. McKerr and V.J. McKelvey-Martin Use of the comet-fish assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell line Radiat. Res. 159 2003 49 56
142. P. Slijepcevic and A.T. Natarajan Distribution of radiation induced G1 exchange and terminal deletion break points in Chinese hamster chromosomes as detected by G banding Int. J. Radiat. Biol. 66 1994 747 755
143. Y. Xiao and A.T. Natarajan The heterogeneity of Chinese hamster X chromosomes in X-ray-induced chromosomal aberrations Int. J. Radiat. Biol. 75 1999 419 427
144. J. Surralles, S. Sebastian and A.T. Natarajan Chromosomes with high gene density are preferentially repaired in human cells Mutagenesis 12 1997 437 442
145. P.C. Hanawalt Genomic instability: environmental invasion and the enemies within Mutat. Res. 400 1998 117 125
146. W.L. de Laat, N.G.J. Jaspers and J.H.J. Hoeijmakers Molecular mechanism of nucleotide excision repair Genes Dev. 13 1999 768 785
147. J. Vijg and H. van Steeg Transgenic assays for mutations and cancer: current status and future perspectives Mutat. Res. 400 1998 337 354
148. J. Surralles, M.J. Ramirez, R. Marcos, A.T. Natarajan and L.H.F. Mullenders Clusters of transcription-coupled repair in the human genome Proc. Natl. Acad. Sci. U.S.A. 99 2002 10571 10574
149. A. van Hoffen, A.S. Balajee, A.A. van Zeeland and L.H.F. Mullenders Nucleotide excision repair and its interplay with transcription Toxicology 193 2003 79 90