Chromosomes with high gene density are preferentially repaired in human cells

Mutagenesis

Volumn 12, Issue 6, 1997, Pages 437-442

  Surralles J ^a,c   Sebastian, S ^a,d   Natarajan, A T ^a,b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b JA Cohen Institute Interuniversity Research Institute for Radiopathology and Radiation Protection   (Netherlands)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLASTOGEN; CYTARABINE; MESYLIC ACID ETHYL ESTER;

ARTICLE; BIOLOGICAL MONITORING; CHROMOSOME; CHROMOSOME 1; CHROMOSOME 18; CHROMOSOME 19; CHROMOSOME 20; CHROMOSOME 4; CHROMOSOME BREAKAGE; CONTROLLED STUDY; CPG ISLAND; DNA REPAIR; EXCISION REPAIR; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CLUSTER; GENE NUMBER; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ARA;

EID: 0030844072     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/12.6.437     Document Type: Article

References (40)

1. Bird,A-P. (1986) CpG rich islands and the function of DNA methylation. Nature, 321, 209-213.
2. Blount,B.C., Mack,M.M. Wehr,C-M., MacGregor,J.T., Hiatt,R.A., Wang,G., Wickramasinghe,S.N., Everson,R.B. and Ames,B.N. (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl Acad. Sci. USA, 94, 3290-3295.
3. Boei,J.J.W.A, Vermeulen,S. and Natarajan,A.T. (1996) Detection of chromosomal aberrations by fluorescence in situ hybridization in the first three postirradiation divisions of human lymphocytes. Mutat. Res., 349, 127-135.
4. Craig,J.M. and Bickmore,W.A. (1994) The distribution of CpG islands in mammalian chromosomes. Nature Genet., 7, 376-382.
5. Domínguez,I., Boei,J.J.W.A., Balajee,A.S. and Natarajan,A.T. (1996) Analysis of radiation induced chromosome aberrations in Chinese hamster cells by FISH using chromosome specific DNA libraries. Int. J. Radiat. Biol. 70, 199-208.
6. Drapkin,R., Sancar,A. and Reinberg,D. (1994) Where transcription meets repair. Cell, 77, 9-12.
7. Durante,M., Geri.C., Bonnati.,S, and Parenti,R. (1989) Non-random alkylation of DNA sequences induced in vivo by chemical mutagen. Carcinogenesis, 10, 1357-1361.
8. Fenech,M. and Neville,S. (1992) Conversion of excision repairable DNA lesions to micronuclei within one cell cycle in human lymphocytes. Environ. Mol. Mutagen., 19, 27-36.
9. Fenech,M., Rinaldi,J. and Surrallés J. (1994) The origin of micronuclei induced by cytosine arabinoside and its synergistic interaction with hydroxyurea in human lymphocytes. Mutagenesis, 9, 273-277.
10. Friedberg,E.C. (1996) Relationships between DNA repair and transcription. Annu. Rev. Biochem., 65, 15-42.
11. Friedberg,E.C., Walker,G.C. and Siede,W. (1995) DNA Repair and Mutagenesis. ASM Press Washington. DC
12. Grigorova,M. Xiao,Y. and Natarajan,A.T. (1997) Analysis of radiation induced chromosome aberrations in Chinese hamster splenocytes by FISH using chromosome specific DNA libraries. In preparation.
13. Hagmar,L. et al. (1994) Cancer risk in humans predicted by increased levels of chromosomal aberrations in lymphocytes: Nordic study group on the health risk of chromosome damage. Cancer Res., 54, 2919-2922.
14. Jeppesen,P. and Turner,B.M. (1993) The inactive X chromosome in female mammals is distinguished by a lack of hisione H4 acetylation, a cytogenetic marker for gene expression. Cell, 74, 281-289.
15. Knehr,S., Zitzelsberger,H., Brasselmann,H., Nahrstedt,U. and Bauchinger,M. (1996) Chromosome analysis by fluorescence in situ hybridization: further indications of a non-DNA proportional involvement of single chromosomes in radiation induced structural aberrations. Int. J. Radiat. Biol., 70, 385-392.
16. Lucas,J.N., Awa,A., Straume,T., Poggensee,M., Kodama,Y., Nakano,M., Ohtaki,K., Weier,H.U., Pinkel,D., Gray,J. and Littlefield,G. (1992) Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation. Int. J. Radiat. Biol., 62, 53-63.
17. Mirzayans,R., Cubitt,S., Enns,L., Karimian,K., Radatus,B., Hirani-Hojatti,S., Murthy,K. and Paterson,M.C. (1994) Comparative genotoxicity of 2,3′-o-cyclocytidine, β-xylocytidine and 1-β-o-arabinofuranosylcytosine in human tumor cell line. Carcinogenesis. 15, 2319-2324.
18. Mullenders,L.H.F., Vrieling,H., Venema,J. and van Zeeland,A.A. (1991) Hierarchies of DNA repair in mammalian cells: biological consequence. Mutat. Res., 250, 223-228.
19. Natarajan,A.T., Vyas,R.C., Wiegant,J. and Jurado,M.P. (1991) A cytogenetic follow-up study of the victims of a radiation in Goiania (Brazil). Mutat. Res., 247, 103-111.
20. Natarajan,A.T., Darroudi,F., Vermeulen,S. and Wiegant,J. (1992a) Frequency of X-ray and neutron induced chromosomal trans locations in human peripheral blood lymphocytes as detected by in situ hybridization using chromosome specific DNA libraries. In Sugahara,T., Sagan,L.A. and Aoyama,T. (eds). Low Dose Irradiation and Biological Defence Mechanisms. Elsevier Science. Amsterdam. The Netherlands, pp. 343-346
21. Natarajan,A.T., Vyas,R.C., Darroudi,F. and Vermeulen,S. (1992b) Frequencies of X-ray induced chromosome translocations in human peripheral lymphocytes as detected by in situ hybridization using chromosome specific DNA libraries. Int. J. Radiat. Biol. 61, 199-203.
22. Natarajan,A.T, Boei,J.J.W.A., Darroudi,F., Van Diemen,P.C.M., Dulout,F., Hande,M.P. and Ramalho,A.T. (1996a) Current cytogenetic methods for detecting exposure and effects of mutagens and carcinogens. Environ. Hlth Perspect., 104, 445-448.
23. Natarajan,A.T. et al. (1996b) Mechanisms of induction of chromosomal aberrations and their detection by fluorescence in situ hybridization. Mutat. Res., 372, 247-258.
24. Pinkel,D., Straume,T. and Gray,J.W. (1988) Cytogenetic analysis using qualitative, high sensitivity, fluorescence hybridization. Proc. Natl Acad. Sci. USA, 83, 2934-2938.
25. Ramanathan,B. and Smerdon,M.J. (1989) Enhanced DNA repair synthesis in hyperacetylated nucleosomes. J. Biol. Chem., 264, 11026-11034.
26. Sachs,R.K.,Awa, A., Kodama,Y., Nakano,M., Ohtaki,K. and Lucas, J.N. (1993) Ratios of radiation-produced chromosome aberrations as indicators of large-scale DNA geometry during interphase. Radiat. Res., 133, 345-350.
27. Scicchitano,D.A. and Hanawalt,P.C. (1995) Repair of N-methylpurines in specific DNA sequences in Chinese hamster ovary cells: absence of strand specificity in the dihydrofolate reductase gene. Proc. Natl Acad. Sci. USA, 86, 3050-3054.
28. Slijeocevic,P. and Natarajan,A.T. (1994a) Distribution of X-ray induced G2 chromatid damage among Chinese hamster chromosomes: influence of chromatid configuration. Mutat. Res., 323, 113-119.
29. Slijeocevic,P. and Natarajan,A.T. (1994b) Distribution of radiation-induced G1 exchange and terminal deletion break points in Chinese hamster chromosomes as detected by G-banding. Int. J. Radiat. Biol., 66, 747-755.
30. Smerdon,M.J. (1991) DNA repair and the role of chromatin structure. Curr. Opin. Cell Biol., 3, 422-428.
31. Surrallés,J. and Natarajan,A.T. (1997) Analysis of XIST function and position effect of translocations involving the inactive X-chromosorne. Proc. Natl Acad. Sci. USA, submitted for publication.
32. Surrallés,J., Xamena,N., Creus,A. and Marcos,R. (1995) The suitability of the micronucleus assay in human lymphocytes as a new biomarker of excision repair. Mutat. Res., 342, 43-59.
33. Surrallés,J., Jeppesen,P., Morrison,H. and Natarajan,A.T. (1996) Analysis of loss of inactive X chromosome in interphase cells. Am. J. Hum. Genet., 59. 1091-1096.
34. Surrallés,J., Darroudi,F. and Natarajan,A.T. (1997) Low level of DNA repair in human chromosome 1 heterochromatin. Genes Chromosomes Cancer, in press.
35. Tucker,J.D. and Senft,J.R. (1994) Analysis of naturally occurring and radiation-induced break points locations in human chromosomes 1, 2 and 4. Radiat. Res., 140, 31-36.
36. Tucker,J.D., Lee,D.A. and Moore,D.H. (1995a) Validation of chromosome staining. II. A detailed analysis of aberrations following high doses of ionizing radiation in vitro. Int. J. Radiat. Biol., 67, 19-28.
37. Tucker,J.D., Morgan,W.F., Awa,A.A., Bauchinger,M., Blakey,D., Cornforth,M.N., Littlefield,L.G., Natarajan,A.T. and Shasserre,C. (1995b) A proposed system for scoring structural aberrations detected by chromosome staining. Cytogenet. Cell Genet., 68, 211-221.
38. Turner,B.M. (1993) Decoding the nucleosome. Cell, 75, 5-8.
39. Verma,R.S. and Babu,A. (1995) Human Chromosomes. Principles and Techniques. McGraw-Hill. New York, NY.
40. Wang,W., Sitaram,A. and Scicchitano,D.A. (1995) 3-Methyladenine and 7-methylguanine exhibit no preferential removal from the transcribed strand of the dihydrofolate reductase gene in Chinese hamster ovary B11 cells. Biochemistry, 34, 1798-1804.