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Volumn 399, Issue 2, 1998, Pages 135-147

DNA strand breakage in aquatic organisms and the potential value of the comet assay in environmental monitoring

Author keywords

Aquatic; Biomarkers; Comet assay; DNA strand breaks; Fish; Genotoxicity

Indexed keywords

DNA;

EID: 0032549460     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00252-2     Document Type: Article
Times cited : (438)

References (94)
  • 1
    • 0003078007 scopus 로고
    • Ultimate chemical carcinogens as reactive mutagenic electrophiles
    • H.H. Hiatt, J.D. Watson, J.A. Winsten (Eds.), Cold Spring Harbor Laboratory
    • [1] J.A. Miller, E.C. Miller, Ultimate chemical carcinogens as reactive mutagenic electrophiles. In: H.H. Hiatt, J.D. Watson, J.A. Winsten (Eds.), Origins of Human Cancer, Cold Spring Harbor Laboratory, 1977, pp. 605-628.
    • (1977) Origins of Human Cancer , pp. 605-628
    • Miller, J.A.1    Miller, E.C.2
  • 2
    • 0024399684 scopus 로고
    • Oncogenes, antioncogenes and the molecular bases of multistep carcinogenesis
    • [2] R.A. Weinberg, Oncogenes, antioncogenes and the molecular bases of multistep carcinogenesis, Cancer Res. 49 (1989) 3713-3721.
    • (1989) Cancer Res. , vol.49 , pp. 3713-3721
    • Weinberg, R.A.1
  • 3
    • 0029916455 scopus 로고    scopus 로고
    • Fish models for environmental carcinogenesis in the rainbow trout
    • [3] G.S. Bailey, D.E. Williams, J.D. Hendricks, Fish models for environmental carcinogenesis in the rainbow trout, Environ. Health Perspect. 104 (S1) (1996) 5-21.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.S1 , pp. 5-21
    • Bailey, G.S.1    Williams, D.E.2    Hendricks, J.D.3
  • 4
    • 0027281430 scopus 로고
    • The genotoxic disease syndrome
    • [4] B. Kurelec, The genotoxic disease syndrome, Mar. Environ. Res. 35 (1993) 341-348.
    • (1993) Mar. Environ. Res. , vol.35 , pp. 341-348
    • Kurelec, B.1
  • 5
    • 0842325328 scopus 로고
    • Genotoxic, carcinogenic, and teratogenic hazards in the marine environment, with special reference to the Mediterranean Sea
    • [5] S. De Flora, M. Bagnasco, P. Zanacchi, Genotoxic, carcinogenic, and teratogenic hazards in the marine environment, with special reference to the Mediterranean Sea, Mutat. Res. 258 (1991) 285-320.
    • (1991) Mutat. Res. , vol.258 , pp. 285-320
    • De Flora, S.1    Bagnasco, M.2    Zanacchi, P.3
  • 6
    • 0026657955 scopus 로고
    • Environmental effects of genotoxins (eco-genotoxology)
    • [6] F.E. Wurgler, P.G.N. Kramers, Environmental effects of genotoxins (eco-genotoxology), Mutagenesis 7 (1992) 321-327.
    • (1992) Mutagenesis , vol.7 , pp. 321-327
    • Wurgler, F.E.1    Kramers, P.G.N.2
  • 7
    • 0023811053 scopus 로고
    • Normal oxidative damage to mitochondrial and nuclear DNA is extensive
    • [7] C. Richter, J.-W. Park, B.N. Ames, Normal oxidative damage to mitochondrial and nuclear DNA is extensive, Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 6465-6467.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 6465-6467
    • Richter, C.1    Park, J.-W.2    Ames, B.N.3
  • 8
    • 0030014388 scopus 로고    scopus 로고
    • Normal status of hepatic 7-ethoxyresorufin O-deethylase (EROD) activity, antioxidant enzymes and DNA oxidation in turbot (Scophthalamus maximus) and other flatfish species following exposure to nitroaromatic compounds
    • [8] C.L. Mitchelmore, J.K. Chipman, P. Garcia-Martinez, P. Lemaire, L.D. Peters, D.R. Livingstone, Normal status of hepatic 7-ethoxyresorufin O-deethylase (EROD) activity, antioxidant enzymes and DNA oxidation in turbot (Scophthalamus maximus) and other flatfish species following exposure to nitroaromatic compounds, Mar. Environ. Res. 42 (1-4) (1996) 329-333.
    • (1996) Mar. Environ. Res. , vol.42 , Issue.1-4 , pp. 329-333
    • Mitchelmore, C.L.1    Chipman, J.K.2    Garcia-Martinez, P.3    Lemaire, P.4    Peters, L.D.5    Livingstone, D.R.6
  • 9
    • 0028342951 scopus 로고
    • Repair of oxidative damage to DNA: Enzymology and biology
    • [9] B. Demple, L. Harrison, Repair of oxidative damage to DNA: enzymology and biology, Annu. Rev. Biochem. 63 (1994) 915-948.
    • (1994) Annu. Rev. Biochem. , vol.63 , pp. 915-948
    • Demple, B.1    Harrison, L.2
  • 10
    • 0028814266 scopus 로고
    • DNA damage profiles induced by oxidising agents
    • [10] B. Epe, DNA damage profiles induced by oxidising agents, Rev. Physiol. Biochem. Pharmacol. 27 (1995) 223-249.
    • (1995) Rev. Physiol. Biochem. Pharmacol. , vol.27 , pp. 223-249
    • Epe, B.1
  • 11
    • 0028362863 scopus 로고
    • Stimulation of oxyradical production of hepatic microsomes of flounder (Platichthys flesus) and perch (Perca fluviatilis) by model and pollutant xenobiotics
    • [11] P. Lemaire, A. Matthews, L. Forlin, D.R. Livingstone, Stimulation of oxyradical production of hepatic microsomes of flounder (Platichthys flesus) and perch (Perca fluviatilis) by model and pollutant xenobiotics, Arch. Environ. Contam. Toxicol. 26 (1994) 191-200.
    • (1994) Arch. Environ. Contam. Toxicol. , vol.26 , pp. 191-200
    • Lemaire, P.1    Matthews, A.2    Forlin, L.3    Livingstone, D.R.4
  • 12
    • 0028968351 scopus 로고
    • Benzo(a)pyrene-dione-stimulated oxyradical production by microsomes of digestive gland of the common mussel, Mytilus edulis L.
    • [12] P. Garcia Martinez, D.R. Livingstone, Benzo(a)pyrene-dione-stimulated oxyradical production by microsomes of digestive gland of the common mussel, Mytilus edulis L., Mar. Environ. Res. 39 (1995) 185-189.
    • (1995) Mar. Environ. Res. , vol.39 , pp. 185-189
    • Garcia Martinez, P.1    Livingstone, D.R.2
  • 13
    • 0028967841 scopus 로고
    • Nitrofurantoin-stimulated reactive oxygen species production and genotoxicity in digestive gland microsomes and cytosol of the common mussel (Mytilus edulis L.)
    • [13] P. Garcia Martinez, G.W. Winston, C. Metosh-Dickey, S.C.M. O'Hara, D.R. Livingstone, Nitrofurantoin-stimulated reactive oxygen species production and genotoxicity in digestive gland microsomes and cytosol of the common mussel (Mytilus edulis L.), Toxicol. Appl. Pharmacol. 131 (1995) 332-341.
    • (1995) Toxicol. Appl. Pharmacol. , vol.131 , pp. 332-341
    • Garcia Martinez, P.1    Winston, G.W.2    Metosh-Dickey, C.3    O'Hara, S.C.M.4    Livingstone, D.R.5
  • 14
    • 0001490732 scopus 로고
    • Pro-oxidant/antioxidant processes and organic xenobiotic interactions in marine organisms, in particular the flounder Platichthys flesus and the mussel Mytilus edulis
    • [14] P. Lemaire, D.R. Livingstone, Pro-oxidant/antioxidant processes and organic xenobiotic interactions in marine organisms, in particular the flounder Platichthys flesus and the mussel Mytilus edulis, Trends Comp. Biochem. Physiol. 1 (1993) 1119-1150.
    • (1993) Trends Comp. Biochem. Physiol. , vol.1 , pp. 1119-1150
    • Lemaire, P.1    Livingstone, D.R.2
  • 15
    • 0025905984 scopus 로고
    • Prooxidant and antioxidant mechanisms in aquatic organisms
    • [15] G.W. Winston, R.T. Di Guilio, Prooxidant and antioxidant mechanisms in aquatic organisms, Aquat. Toxicol. 19 (1991) 137-161.
    • (1991) Aquat. Toxicol. , vol.19 , pp. 137-161
    • Winston, G.W.1    Di Guilio, R.T.2
  • 16
    • 0029762815 scopus 로고    scopus 로고
    • DNA repair: Enzymatic mechanisms and relevance to drug response
    • [16] S.S. Chaney, A. Sancar, DNA repair: enzymatic mechanisms and relevance to drug response, J. Natl. Cancer Inst. 88 (19) (1996) 1346-1360.
    • (1996) J. Natl. Cancer Inst. , vol.88 , Issue.19 , pp. 1346-1360
    • Chaney, S.S.1    Sancar, A.2
  • 17
    • 0025040528 scopus 로고
    • Activities of pollutant metabolising and detoxication systems in the liver of plaice, Pleuronectes platessa: Sex and seasonal variations in non-induced fish
    • [17] S.G. George, P. Young, M. Leaver, D. Clarke, Activities of pollutant metabolising and detoxication systems in the liver of plaice, Pleuronectes platessa: sex and seasonal variations in non-induced fish, Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol. 96 (1990) 185-192.
    • (1990) Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol. , vol.96 , pp. 185-192
    • George, S.G.1    Young, P.2    Leaver, M.3    Clarke, D.4
  • 19
    • 85053320304 scopus 로고
    • Enzymology and molecular biology of Phase II xenobiotic-conjugating enzymes in fish
    • D.C. Malins, G.K. Ostrander (Eds.), CRC Press, Boca Raton, FL
    • [19] S.G. George, Enzymology and molecular biology of Phase II xenobiotic-conjugating enzymes in fish, in: D.C. Malins, G.K. Ostrander (Eds.), Aquatic Toxicology, Molecular, Biochemical and Cellular Perspectives, CRC Press, Boca Raton, FL, 1994, pp. 37-86.
    • (1994) Aquatic Toxicology, Molecular, Biochemical and Cellular Perspectives , pp. 37-86
    • George, S.G.1
  • 20
    • 0001848053 scopus 로고    scopus 로고
    • Cytochrome P450 in pollution monitoring. Use of cytochrome P4501A (CYP1A) as a biomarker of organic pollution in aquatic and other organisms
    • M. Richardson (Ed.), Taylor and Francis, London
    • [20] D.R. Livingstone, Cytochrome P450 in pollution monitoring. Use of cytochrome P4501A (CYP1A) as a biomarker of organic pollution in aquatic and other organisms, in: M. Richardson (Ed.), Environmental Xenobiotics, Taylor and Francis, London, 1996, pp. 143-160.
    • (1996) Environmental Xenobiotics , pp. 143-160
    • Livingstone, D.R.1
  • 21
    • 0027233855 scopus 로고
    • Antisera specific for carcinogen DNA adducts and carcinogen modified DNA: Applications for detection of xenobiotics in biological samples
    • [21] M.C. Poirier, Antisera specific for carcinogen DNA adducts and carcinogen modified DNA: applications for detection of xenobiotics in biological samples, Mutat. Res. 288 (1993) 31-38.
    • (1993) Mutat. Res. , vol.288 , pp. 31-38
    • Poirier, M.C.1
  • 22
    • 0028250528 scopus 로고
    • 32P-postlabelling methods for DNA adduct detection: Overview and critical evaluation
    • 32P-postlabelling methods for DNA adduct detection: overview and critical evaluation, Drug Metab. Rev. 26 (1994) 67-85.
    • (1994) Drug Metab. Rev. , vol.26 , pp. 67-85
    • Randerath, K.1    Randerath, E.2
  • 23
    • 85053354469 scopus 로고
    • DNA adduct analysis in fish: Laboratory and field studies
    • D.C. Malins, G.K. Ostrander (Eds.), Lewis Publishers, Boca Raton, FL
    • [23] A.E. Maccubbin, DNA adduct analysis in fish: laboratory and field studies, in: D.C. Malins, G.K. Ostrander (Eds.), Aquatic Toxicology: Molecular, Biochemical and Cellular Perspectives, Lewis Publishers, Boca Raton, FL, 1994, pp. 267-294.
    • (1994) Aquatic Toxicology: Molecular, Biochemical and Cellular Perspectives , pp. 267-294
    • Maccubbin, A.E.1
  • 24
    • 0000074804 scopus 로고
    • Biological monitoring: Testing for genotoxicity
    • J.F. McCarthy, L.R. Shugart (Eds.), Lewis Publishers, Chelsea
    • [24] L. Shugart, Biological monitoring: testing for genotoxicity, in: J.F. McCarthy, L.R. Shugart (Eds.), Biomarkers of Environmental Contamination, Lewis Publishers, Chelsea, 1990, pp. 217-227.
    • (1990) Biomarkers of Environmental Contamination , pp. 217-227
    • Shugart, L.1
  • 25
    • 0020554051 scopus 로고
    • Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential
    • [25] J.F. Sina, C.L. Bean, G.R. Dysart, V.I. Taylor, M.O. Bradley, Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential, Mutat. Res. 113 (1983) 357-391.
    • (1983) Mutat. Res. , vol.113 , pp. 357-391
    • Sina, J.F.1    Bean, C.L.2    Dysart, G.R.3    Taylor, V.I.4    Bradley, M.O.5
  • 26
    • 0026522112 scopus 로고
    • The origins of DNA breaks: A consequence of DNA damage, DNA repair or apoptosis?
    • [26] A. Eastman, M.A. Barry, The origins of DNA breaks: a consequence of DNA damage, DNA repair or apoptosis?, Cancer Invest. 10 (1992) 229-240.
    • (1992) Cancer Invest. , vol.10 , pp. 229-240
    • Eastman, A.1    Barry, M.A.2
  • 27
    • 0016656025 scopus 로고
    • Apurimic and apurimidinic sites in DNA
    • P.C. Hanawalt, R.B. Setlow (Eds.), Plenum, New York
    • [27] T. Lindahl, T. Ljungquist, Apurimic and apurimidinic sites in DNA, in: P.C. Hanawalt, R.B. Setlow (Eds.), Molecular Mechanisms for Repair of DNA, Part A, Plenum, New York, 1975, pp. 31-38.
    • (1975) Molecular Mechanisms for Repair of DNA , Issue.PART A , pp. 31-38
    • Lindahl, T.1    Ljungquist, T.2
  • 28
    • 0026023079 scopus 로고
    • Accumulation of polycyclic aromatic hydrocarbon-induced single-strand breaks is attributed to slower rejoining processes by DNA polymerase inhibitor, cytosine arabinoside in CHO-K1 cells
    • [28] J.K. Park, J.S. Lee, H.H. Lee, I.S. Choi, S.D. Park, Accumulation of polycyclic aromatic hydrocarbon-induced single-strand breaks is attributed to slower rejoining processes by DNA polymerase inhibitor, cytosine arabinoside in CHO-K1 cells, Life Sci. 48 (1991) 1255-1261.
    • (1991) Life Sci. , vol.48 , pp. 1255-1261
    • Park, J.K.1    Lee, J.S.2    Lee, H.H.3    Choi, I.S.4    Park, S.D.5
  • 29
    • 0028865604 scopus 로고
    • The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay)
    • [29] G. Speit, A. Hartmann, The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay), Mutagenesis 10 (6) (1995) 555-559.
    • (1995) Mutagenesis , vol.10 , Issue.6 , pp. 555-559
    • Speit, G.1    Hartmann, A.2
  • 30
    • 0029562550 scopus 로고
    • Alkaline single cell gel (Comet) assay and genotoxicity monitoring using bullheads and carp
    • [30] R. Pandrangi, M. Petras, S. Ralph, M. Vrzoc, Alkaline single cell gel (Comet) assay and genotoxicity monitoring using bullheads and carp, Environ. Mol. Mutag. 26 (1995) 345-356.
    • (1995) Environ. Mol. Mutag. , vol.26 , pp. 345-356
    • Pandrangi, R.1    Petras, M.2    Ralph, S.3    Vrzoc, M.4
  • 31
    • 0030575556 scopus 로고    scopus 로고
    • The alkaline comet test on plant cells: A new genotoxicity test for DNA strand breaks in Vicia faba root cells
    • [31] G. Koppen, L. Verschaeve, The alkaline comet test on plant cells: a new genotoxicity test for DNA strand breaks in Vicia faba root cells, Mutat. Res. 360 (1996) 193-200.
    • (1996) Mutat. Res. , vol.360 , pp. 193-200
    • Koppen, G.1    Verschaeve, L.2
  • 32
    • 0029933579 scopus 로고    scopus 로고
    • Evaluation of three methods for the detection of DNA single-strand breaks in human lymphocytes: Alkaline elution, nick translation, and single cell gel electrophoresis
    • [32] T. Leroy, P. Van Hummelen, D. Anard, P. Castelain, M. Kirsch-Volders, R. Lauwerys, D. Lison, Evaluation of three methods for the detection of DNA single-strand breaks in human lymphocytes: alkaline elution, nick translation, and single cell gel electrophoresis, J. Toxicol. Environ. Health 47 (1996) 409-422.
    • (1996) J. Toxicol. Environ. Health , vol.47 , pp. 409-422
    • Leroy, T.1    Van Hummelen, P.2    Anard, D.3    Castelain, P.4    Kirsch-Volders, M.5    Lauwerys, R.6    Lison, D.7
  • 33
    • 0023718438 scopus 로고
    • Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress
    • [33] D.J. McConkey, P. Hartzell, P. Nicotera, A.H. Wyllie, S. Orrenius, Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress, Toxicol. Lett. 42 (1988) 123-130.
    • (1988) Toxicol. Lett. , vol.42 , pp. 123-130
    • McConkey, D.J.1    Hartzell, P.2    Nicotera, P.3    Wyllie, A.H.4    Orrenius, S.5
  • 34
    • 0023919282 scopus 로고
    • Genotoxicity of active oxygen species in mammalian cells
    • [34] R. Meneghini, Genotoxicity of active oxygen species in mammalian cells, Mutat. Res. 195 (1988) 215-230.
    • (1988) Mutat. Res. , vol.195 , pp. 215-230
    • Meneghini, R.1
  • 35
    • 0031557136 scopus 로고    scopus 로고
    • The contribution of cytotoxicity to DNA - Effects in the single cell gel test (comet assay)
    • [35] A. Hartmann, G. Speit, The contribution of cytotoxicity to DNA - effects in the single cell gel test (comet assay), Toxicol. Lett. 90 (1997) 183-188.
    • (1997) Toxicol. Lett. , vol.90 , pp. 183-188
    • Hartmann, A.1    Speit, G.2
  • 36
    • 0011922591 scopus 로고
    • Measurement of DNA single-strand breaks by sedimentation in alkaline sucrose gradients
    • E.C. Freidberg, Hanawalt, P.C. (Eds.), Marcel Dekker
    • [36] J.T. Lett, Measurement of DNA single-strand breaks by sedimentation in alkaline sucrose gradients, in: E.C. Freidberg, Hanawalt, P.C. (Eds.), DNA Repair: A Laboratory Manual in Research Procedures, Marcel Dekker, 1981, pp. 403-418.
    • (1981) DNA Repair: A Laboratory Manual in Research Procedures , pp. 403-418
    • Lett, J.T.1
  • 37
    • 0023756660 scopus 로고
    • Techniques to measure single strand breaks in cells. A review
    • [37] G. Ahnstrom, Techniques to measure single strand breaks in cells. A review, Int. J. Radiat. Biol. 54 (1988) 695-707.
    • (1988) Int. J. Radiat. Biol. , vol.54 , pp. 695-707
    • Ahnstrom, G.1
  • 38
    • 0017883642 scopus 로고
    • Spectrofluorometric measurements of the binding of ethidium to superhelical DNA from cell nuclei
    • [38] P.R. Cook, I.A. Brazell, Spectrofluorometric measurements of the binding of ethidium to superhelical DNA from cell nuclei, Eur. J. Biochem. 84 (1978) 465-477.
    • (1978) Eur. J. Biochem. , vol.84 , pp. 465-477
    • Cook, P.R.1    Brazell, I.A.2
  • 39
    • 0020436484 scopus 로고
    • A quantitative assay of deoxyguanosine strand breaks and their repair in mammalian cells
    • [39] W.F. Blakely, J.F. Ward, E.I. Joiner, A quantitative assay of deoxyguanosine strand breaks and their repair in mammalian cells, Anal. Biochem. 124 (1982) 125-133.
    • (1982) Anal. Biochem. , vol.124 , pp. 125-133
    • Blakely, W.F.1    Ward, J.F.2    Joiner, E.I.3
  • 40
    • 0019476174 scopus 로고
    • Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation
    • [40] H.C. Birnboim, J.J. Jevcak, Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation, Cancer Res. 41 (1981) 1889-1892.
    • (1981) Cancer Res. , vol.41 , pp. 1889-1892
    • Birnboim, H.C.1    Jevcak, J.J.2
  • 41
    • 0015598569 scopus 로고
    • Radiation induced strand breakage in DNA from mammalian cells. Strand separation in alkaline solution
    • [41] G. Ahnstrom, K. Erixon, Radiation induced strand breakage in DNA from mammalian cells. Strand separation in alkaline solution, Radiat. Biol. 23 (1973) 285-289.
    • (1973) Radiat. Biol. , vol.23 , pp. 285-289
    • Ahnstrom, G.1    Erixon, K.2
  • 43
    • 0000400478 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • [43] N.P. Singh, M.T. McCoy, R.R. Tice, E.L. Scheider, A simple technique for quantitation of low levels of DNA damage in individual cells, Exp. Cell Res. 237 (3-4) (1988) 123-130.
    • (1988) Exp. Cell Res. , vol.237 , Issue.3-4 , pp. 123-130
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Scheider, E.L.4
  • 46
    • 0026672807 scopus 로고
    • Workshop on single-cell gel electrophoresis (the 'comet' assay) held as part of the UKEMS/DNA repair network joint meeting
    • Swansea, March 1992
    • [46] A. Collins, Workshop on single-cell gel electrophoresis (the 'comet' assay) held as part of the UKEMS/DNA repair network joint meeting, Swansea, March 1992, Mutagenesis 7 (5) (1992) 357-358.
    • (1992) Mutagenesis , vol.7 , Issue.5 , pp. 357-358
    • Collins, A.1
  • 47
    • 0028305534 scopus 로고
    • The effects of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay
    • [47] D. Anderson, T.-W. Yu, B.J. Phillips, P. Schmezer, The effects of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay, Mutat. Res. 307 (1994) 261-271.
    • (1994) Mutat. Res. , vol.307 , pp. 261-271
    • Anderson, D.1    Yu, T.-W.2    Phillips, B.J.3    Schmezer, P.4
  • 48
    • 0001361067 scopus 로고    scopus 로고
    • Detection of DNA strand breaks in brown trout (Salmo trutta) hepatocytes and blood cells using the single cell gel electrophoresis (comet) assay
    • in press
    • [48] C.L. Mitchelmore, J.K. Chipman, Detection of DNA strand breaks in brown trout (Salmo trutta) hepatocytes and blood cells using the single cell gel electrophoresis (comet) assay. Aquat. Toxicol (1998) in press.
    • (1998) Aquat. Toxicol
    • Mitchelmore, C.L.1    Chipman, J.K.2
  • 49
    • 0000489348 scopus 로고    scopus 로고
    • Polycyclic and nitro-aromatic compounds produce DNA strand breakage in Brown trout (Salmo trutta) and mussel (Mytilus edulis L.) cells
    • [49] C.L. Mitchelmore, C. Birmelin, D.R. Livingstone, J.K. Chipman, Polycyclic and nitro-aromatic compounds produce DNA strand breakage in Brown trout (Salmo trutta) and mussel (Mytilus edulis L.) cells, Mutagenesis 12 (2) (1997) 101.
    • (1997) Mutagenesis , vol.12 , Issue.2 , pp. 101
    • Mitchelmore, C.L.1    Birmelin, C.2    Livingstone, D.R.3    Chipman, J.K.4
  • 50
    • 0031719969 scopus 로고    scopus 로고
    • The detection of DNA strand breaks in isolated mussel (Mytilus edulis L.) digestive gland cells using the 'comet' assay
    • in press
    • [50] C.L. Mitchelmore, C. Birmelin, D.R. Livingstone, J.K. Chipman, The detection of DNA strand breaks in isolated mussel (Mytilus edulis L.) digestive gland cells using the 'comet' assay, Ecotoxicol. Environ. Safety (1998) in press.
    • (1998) Ecotoxicol. Environ. Safety
    • Mitchelmore, C.L.1    Birmelin, C.2    Livingstone, D.R.3    Chipman, J.K.4
  • 51
    • 0032522756 scopus 로고    scopus 로고
    • Evidence for cytochrome-P450 catalysis and free radical involvement in the production of DNA strand breaks by benzo[a]pyrene and nitroaromatics in mussel (Mytilus edulis L.) digestive gland cells
    • in press
    • [51] C.L. Mitchelmore, C. Birmelin, D.R. Livingstone, J.K. Chipman, Evidence for cytochrome-P450 catalysis and free radical involvement in the production of DNA strand breaks by benzo[a]pyrene and nitroaromatics in mussel (Mytilus edulis L.) digestive gland cells, Aquat. Toxicol. (1998) in press.
    • (1998) Aquat. Toxicol.
    • Mitchelmore, C.L.1    Birmelin, C.2    Livingstone, D.R.3    Chipman, J.K.4
  • 52
    • 0026738581 scopus 로고
    • Single-cell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells
    • [52] C.M. Gedik, S.W.B. Ewen, A.R. Collins, Single-cell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells, Int. J. Radiat. Biol. 62 (1992) 313-320.
    • (1992) Int. J. Radiat. Biol. , vol.62 , pp. 313-320
    • Gedik, C.M.1    Ewen, S.W.B.2    Collins, A.R.3
  • 53
    • 0031851419 scopus 로고    scopus 로고
    • Characterisation of biotransformation enzyme activities and DNA integrity in isolated cells of digestive gland of the common mussel, Mytilus edulis L.
    • in press
    • [53] C. Birmelin, C.L. Mitchelmore, P.S. Goldfarb, D.R. Livingstone. Characterisation of biotransformation enzyme activities and DNA integrity in isolated cells of digestive gland of the common mussel, Mytilus edulis L., Comp. Biochem. Physiol., 1998, in press.
    • (1998) Comp. Biochem. Physiol.
    • Birmelin, C.1    Mitchelmore, C.L.2    Goldfarb, P.S.3    Livingstone, D.R.4
  • 54
    • 0025765751 scopus 로고
    • A microgel electrophoresis technique for the direct quantitation of DNA damage and repair in individual fibroblasts cultured on microscope slides
    • [54] N.P. Singh, R.E. Tice, R.E. Stephens, E.L. Schneider, A microgel electrophoresis technique for the direct quantitation of DNA damage and repair in individual fibroblasts cultured on microscope slides, Mutat. Res. 252 (3) (1993) 289-296.
    • (1993) Mutat. Res. , vol.252 , Issue.3 , pp. 289-296
    • Singh, N.P.1    Tice, R.E.2    Stephens, R.E.3    Schneider, E.L.4
  • 55
    • 0026635166 scopus 로고
    • Fractionation of DNA from marine invertebrate (Maja crispata, Mytilus galloprovincialis) haemolymph by alkaline elution
    • [55] N. Bihari, R. Batel, R.K. Zahn, Fractionation of DNA from marine invertebrate (Maja crispata, Mytilus galloprovincialis) haemolymph by alkaline elution, Comp. Biochem. Physiol. B Biochem. Mol. Biol. 102 (2) (1992) 419-424.
    • (1992) Comp. Biochem. Physiol. B Biochem. Mol. Biol. , vol.102 , Issue.2 , pp. 419-424
    • Bihari, N.1    Batel, R.2    Zahn, R.K.3
  • 56
    • 0026580862 scopus 로고
    • Application of the DNA alkaline unwinding assay to detect DNA strand breaks in marine bivalves
    • [56] D. Nacci, S. Nelson, W. Nelson, E. Jackim, Application of the DNA alkaline unwinding assay to detect DNA strand breaks in marine bivalves, Mar. Environ. Res. 33 (1992) 83-100.
    • (1992) Mar. Environ. Res. , vol.33 , pp. 83-100
    • Nacci, D.1    Nelson, S.2    Nelson, W.3    Jackim, E.4
  • 58
    • 0029113917 scopus 로고
    • Induction of DNA strand breaks in rainbow trout Oncorhynchus mykiss under hypoxic and hyperoxic conditions
    • [58] A. Liepelt, L. Karbe, J. Westendorf, Induction of DNA strand breaks in rainbow trout Oncorhynchus mykiss under hypoxic and hyperoxic conditions, Aquat. Toxicol. 33 (1995) 177-181.
    • (1995) Aquat. Toxicol. , vol.33 , pp. 177-181
    • Liepelt, A.1    Karbe, L.2    Westendorf, J.3
  • 59
    • 0023701536 scopus 로고
    • Quantitation of chemically induced damage to DNA of aquatic organisms by alkaline unwinding assay
    • [59] L. Shugart, Quantitation of chemically induced damage to DNA of aquatic organisms by alkaline unwinding assay, Aquat. Toxicol. 13 (1988) 43-52.
    • (1988) Aquat. Toxicol. , vol.13 , pp. 43-52
    • Shugart, L.1
  • 60
    • 0021319312 scopus 로고
    • DNA repair synthesis following exposure to chemical mutagens in primary liver, stomach and intestinal cells isolated from Rainbow trout
    • [60] D.G. Walton, A.B. Acton, H.F. Stich, DNA repair synthesis following exposure to chemical mutagens in primary liver, stomach and intestinal cells isolated from Rainbow trout, Cancer Res. 44 (3) (1984) 1120-1121.
    • (1984) Cancer Res. , vol.44 , Issue.3 , pp. 1120-1121
    • Walton, D.G.1    Acton, A.B.2    Stich, H.F.3
  • 61
    • 0028957891 scopus 로고
    • DNA-repair in fish from polluted estuaries
    • [61] N.G. Espina, P. Weiss, DNA-repair in fish from polluted estuaries, Mar. Environ. Res. 39 (1-4) (1995) 309-312.
    • (1995) Mar. Environ. Res. , vol.39 , Issue.1-4 , pp. 309-312
    • Espina, N.G.1    Weiss, P.2
  • 62
    • 0029940299 scopus 로고    scopus 로고
    • Contribution of apoptosis to observed DNA damage in mussel cells
    • [62] S.A. Steinert, Contribution of apoptosis to observed DNA damage in mussel cells, Mar. Environ. Res. 42 (1-4) (1996) 253-259.
    • (1996) Mar. Environ. Res. , vol.42 , Issue.1-4 , pp. 253-259
    • Steinert, S.A.1
  • 63
    • 0027423615 scopus 로고
    • Radiation-induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay
    • [63] P.L. Olive, G. Frazer, J.P. Banath, Radiation-induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay, Radiat. Res. 136 (1993) 130-136.
    • (1993) Radiat. Res. , vol.136 , pp. 130-136
    • Olive, P.L.1    Frazer, G.2    Banath, J.P.3
  • 64
    • 0344801351 scopus 로고    scopus 로고
    • An investigation of bone marrow and testicular cells in vivo using the comet assay
    • [64] D. Anderson, A. Dhawan, T.-W. Yu, M.J. Plewa, An investigation of bone marrow and testicular cells in vivo using the comet assay, Mutat. Res. 370 (1996) 159-174.
    • (1996) Mutat. Res. , vol.370 , pp. 159-174
    • Anderson, D.1    Dhawan, A.2    Yu, T.-W.3    Plewa, M.J.4
  • 65
    • 0029096985 scopus 로고
    • Evaluation of the genotoxicity of environmental contaminants in sediments to rainbow trout hepatocytes
    • [65] F. Gagni, C. Blaise, Evaluation of the genotoxicity of environmental contaminants in sediments to rainbow trout hepatocytes, Environ. Toxicol. Water Qual. Int. J. 10 (1995) 217-229.
    • (1995) Environ. Toxicol. Water Qual. Int. J. , vol.10 , pp. 217-229
    • Gagni, F.1    Blaise, C.2
  • 66
    • 0030272592 scopus 로고    scopus 로고
    • Detection of DNA damage in individual cells from marine organisms using the single cell gel assay
    • [66] D.E. Nacci, S. Cayula, E. Jackim, Detection of DNA damage in individual cells from marine organisms using the single cell gel assay, Aquat. Toxicol. 35 (1996) 197-210.
    • (1996) Aquat. Toxicol. , vol.35 , pp. 197-210
    • Nacci, D.E.1    Cayula, S.2    Jackim, E.3
  • 67
    • 0002638643 scopus 로고
    • Monitoring DNA damage in Mytilus galloprovincialis and other aquatic animals
    • [67] A. Herbert, R.K. Zahn, Monitoring DNA damage in Mytilus galloprovincialis and other aquatic animals, Z. Angew. Zool. 77 (1) (1990) 13-33.
    • (1990) Z. Angew. Zool. , vol.77 , Issue.1 , pp. 13-33
    • Herbert, A.1    Zahn, R.K.2
  • 68
    • 0030469053 scopus 로고    scopus 로고
    • The comet assay for the evaluation of the genetic hazard of pollutants in cetaceans - Preliminary results on the genotoxic effects of methyl mercury on the bottle nosed dolphin (Tursiops truncatus) lymphocytes in vitro
    • [68] C. Betti, M. Nigro, The comet assay for the evaluation of the genetic hazard of pollutants in cetaceans - preliminary results on the genotoxic effects of methyl mercury on the bottle nosed dolphin (Tursiops truncatus) lymphocytes in vitro, Mar. Pollut. Bull. 32 (7) (1996) 545-548.
    • (1996) Mar. Pollut. Bull. , vol.32 , Issue.7 , pp. 545-548
    • Betti, C.1    Nigro, M.2
  • 69
    • 0029923268 scopus 로고    scopus 로고
    • DNA strand breakage in freshwater mussels (Anodonta grandis) exposed to lead in the laboratory and field
    • [69] M.C. Black, J.R. Ferrell, R.C. Honning, L.K. Martin, DNA strand breakage in freshwater mussels (Anodonta grandis) exposed to lead in the laboratory and field, Environ. Toxicol. Chem. 15 (5) (1996) 802-808.
    • (1996) Environ. Toxicol. Chem. , vol.15 , Issue.5 , pp. 802-808
    • Black, M.C.1    Ferrell, J.R.2    Honning, R.C.3    Martin, L.K.4
  • 70
    • 0027218169 scopus 로고
    • Nonradiometric detection of DNA crosslinks in mussel hemolymph by alkaline elution
    • [70] R. Batel, M. Vukmirovic, N. Bihari, R.K. Zahn, W.E.G. Muller, Nonradiometric detection of DNA crosslinks in mussel hemolymph by alkaline elution, Anal. Biochem. 212 (1993) 402-406.
    • (1993) Anal. Biochem. , vol.212 , pp. 402-406
    • Batel, R.1    Vukmirovic, M.2    Bihari, N.3    Zahn, R.K.4    Muller, W.E.G.5
  • 71
    • 0029957941 scopus 로고    scopus 로고
    • Alkaline single cell gel (comet) assay and genotoxicity monitoring using two species of tadpoles
    • [71] S. Ralph, M. Petras, R. Pandrangi, M. Vrzoc, Alkaline single cell gel (comet) assay and genotoxicity monitoring using two species of tadpoles, Environ. Mol. Mutag. 28 (2) (1996) 112-120.
    • (1996) Environ. Mol. Mutag. , vol.28 , Issue.2 , pp. 112-120
    • Ralph, S.1    Petras, M.2    Pandrangi, R.3    Vrzoc, M.4
  • 72
    • 0026057031 scopus 로고
    • A rapid method for detecting DNA strand breaks in Mytilus galloprovincialis Lam. induced by genotoxic xenobiotic chemicals
    • [72] R. Accomando, A. Viarengo, R. Bordone, M. Taningher, L. Canesi, M. Orunesu, A rapid method for detecting DNA strand breaks in Mytilus galloprovincialis Lam. induced by genotoxic xenobiotic chemicals, Int. J. Biochem. 23 (2) (1991) 227-229.
    • (1991) Int. J. Biochem. , vol.23 , Issue.2 , pp. 227-229
    • Accomando, R.1    Viarengo, A.2    Bordone, R.3    Taningher, M.4    Canesi, L.5    Orunesu, M.6
  • 74
    • 0029844440 scopus 로고    scopus 로고
    • Cytogenetic studies of PCB77 on brown trout (Salmo trutta fario) using the micronucleus test and the alkaline comet assay
    • [74] K. Belpaeme, K. Delbeke, L. Zhu, M. Kirsch-Volders, Cytogenetic studies of PCB77 on brown trout (Salmo trutta fario) using the micronucleus test and the alkaline comet assay, Mutagenesis 11 (5) (1996) 485-492.
    • (1996) Mutagenesis , vol.11 , Issue.5 , pp. 485-492
    • Belpaeme, K.1    Delbeke, K.2    Zhu, L.3    Kirsch-Volders, M.4
  • 75
    • 0025027321 scopus 로고
    • DNA damage determination by the alkaline elution technique in the haemolymph of mussel Mytilus galloprovincialis treated with benzo[a]pyrene and 4-nitroquinoline-N-oxide
    • [75] N. Bihari, R. Batel, R.K. Zahn, DNA damage determination by the alkaline elution technique in the haemolymph of mussel Mytilus galloprovincialis treated with benzo[a]pyrene and 4-nitroquinoline-N-oxide, Aquat. Toxicol. 18 (1990) 13-22.
    • (1990) Aquat. Toxicol. , vol.18 , pp. 13-22
    • Bihari, N.1    Batel, R.2    Zahn, R.K.3
  • 76
    • 0023912537 scopus 로고
    • An alkaline unwinding assay for the detection of DNA damage in aquatic organisms
    • [76] L. Shugart, An alkaline unwinding assay for the detection of DNA damage in aquatic organisms, Mar. Environ. Res. 24 (1988) 321-325.
    • (1988) Mar. Environ. Res. , vol.24 , pp. 321-325
    • Shugart, L.1
  • 77
    • 0010430983 scopus 로고
    • The use of alkaline elution procedure to measure DNA damage in crab haemolymph treated with benzo[a]pyrene
    • Carcinogenic, Mutagenic, Teratogenic Marine Pollutants: Impact on Human Health and the Environment, Gulf Pub., TX, USA
    • [77] N. Bihari, R. Batel, R.K. Zahn, The use of alkaline elution procedure to measure DNA damage in crab haemolymph treated with benzo[a]pyrene, in: Carcinogenic, Mutagenic, Teratogenic Marine Pollutants: Impact on Human Health and the Environment, Adv. Appl. Biotechnol. Ser., Vol. 5., Gulf Pub., TX, USA, 1990, pp. 121-127.
    • (1990) Adv. Appl. Biotechnol. Ser. , vol.5 , pp. 121-127
    • Bihari, N.1    Batel, R.2    Zahn, R.K.3
  • 79
    • 0028470863 scopus 로고
    • Detection of genotoxic insult as DNA strand breaks in fish blood cells by agarose gel electrophoresis
    • [79] C.W. Theodorakis, S.J. D'Surney, L.R. Shugart, Detection of genotoxic insult as DNA strand breaks in fish blood cells by agarose gel electrophoresis, Environ. Toxicol. Chem. 13 (7) (1994) 1023-1031.
    • (1994) Environ. Toxicol. Chem. , vol.13 , Issue.7 , pp. 1023-1031
    • Theodorakis, C.W.1    D'Surney, S.J.2    Shugart, L.R.3
  • 80
    • 0021924615 scopus 로고
    • DNA damage by benzo[a]pyrene in the liver of mosquito fish gambusia affinis
    • [80] R. Batel, N. Bihari, B. Kurelec, R.K. Zahn, DNA damage by benzo[a]pyrene in the liver of mosquito fish Gambusia affinis, Sci. Total Environ. 41 (1985) 275-283.
    • (1985) Sci. Total Environ. , vol.41 , pp. 275-283
    • Batel, R.1    Bihari, N.2    Kurelec, B.3    Zahn, R.K.4
  • 81
    • 0027279520 scopus 로고
    • Effects of Black Rock harbour sediments on indexes of biotransformation, oxidative stress, and DNA integrity in channel catfish
    • [81] R.T. Di Giulio, C. Habig, E.P. Gallagher, Effects of Black Rock harbour sediments on indexes of biotransformation, oxidative stress, and DNA integrity in channel catfish, Aquat. Toxicol. 26 (1-2) (1993) 1-22.
    • (1993) Aquat. Toxicol. , vol.26 , Issue.1-2 , pp. 1-22
    • Di Giulio, R.T.1    Habig, C.2    Gallagher, E.P.3
  • 82
    • 0028968357 scopus 로고
    • Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanism: Studies with the fresh water clam Corbicula fluminea
    • [82] P. Waldmann, B. Pivcevic, W.E.G. Muller, R.K. Zahn, B. Kurelec, Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanism: studies with the fresh water clam Corbicula fluminea, Mutat. Res. 342 (1995) 113-123.
    • (1995) Mutat. Res. , vol.342 , pp. 113-123
    • Waldmann, P.1    Pivcevic, B.2    Muller, W.E.G.3    Zahn, R.K.4    Kurelec, B.5
  • 83
    • 0030007481 scopus 로고    scopus 로고
    • Influence of DT diaphorase on quinone-mediated genotoxicity in human and fish cell lines
    • [83] B.M. Hasspieler, G.D. Haffner, K. Adeli, Influence of DT diaphorase on quinone-mediated genotoxicity in human and fish cell lines, Mutat. Res. 360 (1996) 43-49.
    • (1996) Mutat. Res. , vol.360 , pp. 43-49
    • Hasspieler, B.M.1    Haffner, G.D.2    Adeli, K.3
  • 84
    • 0025963906 scopus 로고
    • Metabolism of benzo[a]pyrene and (-)-trans-benzo[a]pyrene-7,8-dihydrodiol by freshly isolated hepatocytes from mirror carp
    • [84] J. Zaleski, R.A. Steward, H.C. Sikka, Metabolism of benzo[a]pyrene and (-)-trans-benzo[a]pyrene-7,8-dihydrodiol by freshly isolated hepatocytes from mirror carp, Carcinogenesis 12 (2) (1991) 167-174.
    • (1991) Carcinogenesis , vol.12 , Issue.2 , pp. 167-174
    • Zaleski, J.1    Steward, R.A.2    Sikka, H.C.3
  • 85
    • 0027950848 scopus 로고
    • The effects of temperature on the uptake and metabolism of benzo[a]pyrene in isolated gill cells of the gulf toadfish, Opsanus beta
    • [85] C.J. Kennedy, P.J. Walsh, The effects of temperature on the uptake and metabolism of benzo[a]pyrene in isolated gill cells of the gulf toadfish, Opsanus beta, Fish Physiol. Biochem. 13 (2) (1994) 93-103.
    • (1994) Fish Physiol. Biochem. , vol.13 , Issue.2 , pp. 93-103
    • Kennedy, C.J.1    Walsh, P.J.2
  • 86
    • 0028967111 scopus 로고
    • Growth hormone effect on xenobiotic-metabolizing activities of rainbow trout
    • [86] J.P. Cravedi, E. Perdu-Durand, A. Paris, P. Prunet, Growth hormone effect on xenobiotic-metabolizing activities of rainbow trout, Mar. Environ. Res. 39 (1995) 89-92.
    • (1995) Mar. Environ. Res. , vol.39 , pp. 89-92
    • Cravedi, J.P.1    Perdu-Durand, E.2    Paris, A.3    Prunet, P.4
  • 87
    • 0028904130 scopus 로고
    • Time-course studies of the biotransformation enzymes in control rainbow trout when adjusting to new habitats
    • [87] S. Huuskonen, T. Rasanen, K. Koponen, P. Lindstrom-Seppa, Time-course studies of the biotransformation enzymes in control rainbow trout when adjusting to new habitats, Mar. Environ. Res. 39 (1995) 79-83.
    • (1995) Mar. Environ. Res. , vol.39 , pp. 79-83
    • Huuskonen, S.1    Rasanen, T.2    Koponen, K.3    Lindstrom-Seppa, P.4
  • 88
    • 0025730141 scopus 로고
    • In vitro metabolism of benzo(a)pyrene in the blood of the gulf toadfish, Opsanus beta
    • [88] C.J. Kennedy, K.A. Gill, P.J. Walsh, In vitro metabolism of benzo(a)pyrene in the blood of the gulf toadfish, Opsanus beta, Mar. Environ. Res. 31 (1991) 37-53.
    • (1991) Mar. Environ. Res. , vol.31 , pp. 37-53
    • Kennedy, C.J.1    Gill, K.A.2    Walsh, P.J.3
  • 89
    • 0029170559 scopus 로고
    • Evaluation of the effects of cryopreservation of isolated erythrocytes and leukocytes of largemouth bass by flow cytometry
    • [89] S.K. Fisher, J.T. Lingenfelser, C.H. Jagoe, C.E. Dallas, Evaluation of the effects of cryopreservation of isolated erythrocytes and leukocytes of largemouth bass by flow cytometry, J. Fish Biol. 46 (1995) 432-441.
    • (1995) J. Fish Biol. , vol.46 , pp. 432-441
    • Fisher, S.K.1    Lingenfelser, J.T.2    Jagoe, C.H.3    Dallas, C.E.4
  • 90
    • 0028166360 scopus 로고
    • DNA damage in marine mussel Mytilus galloprovincialis as a biomarker of environmental contamination
    • [90] M. Vukmirovic, N. Bihari, R.K. Zahn, W.E.G. Muller, R. Batel, DNA damage in marine mussel Mytilus galloprovincialis as a biomarker of environmental contamination, Mar. Ecol. Prog. Ser. 109 (1994) 165-171.
    • (1994) Mar. Ecol. Prog. Ser. , vol.109 , pp. 165-171
    • Vukmirovic, M.1    Bihari, N.2    Zahn, R.K.3    Muller, W.E.G.4    Batel, R.5
  • 91
    • 0027439607 scopus 로고
    • Biological markers in fish: DNA integrity, hematological parameters and liver somatic index
    • [91] J.M. Everaarts, L.R. Shugart, M.K. Gustin, W.E. Hawkins, W.W. Walker, Biological markers in fish: DNA integrity, hematological parameters and liver somatic index, Mar. Environ. Res. 35 (1993) 101-107.
    • (1993) Mar. Environ. Res. , vol.35 , pp. 101-107
    • Everaarts, J.M.1    Shugart, L.R.2    Gustin, M.K.3    Hawkins, W.E.4    Walker, W.W.5
  • 92
    • 0028605558 scopus 로고
    • Molecular responses as indicators of marine pollution - DNA damage and enzyme-induction in Limanda limanda and Asterias rubens
    • [92] J.M. Everaarts, H.M. Sleiderink, P.J. Denbesten, R.S. Halbrook, L.R. Shugart, Molecular responses as indicators of marine pollution - DNA damage and enzyme-induction in Limanda limanda and Asterias rubens, Environ. Health Perspect. 94 (102) (1994) 37-43, S12.
    • (1994) Environ. Health Perspect. , vol.94 , Issue.102 , pp. 37-43
    • Everaarts, J.M.1    Sleiderink, H.M.2    Denbesten, P.J.3    Halbrook, R.S.4    Shugart, L.R.5
  • 93
    • 0029416225 scopus 로고
    • DNA integrity as a biomarker of marine pollution: Strand breaks in seastar (Asterias rubens) and dab (Limanda limanda)
    • [93] J.M. Everaarts, DNA integrity as a biomarker of marine pollution: Strand breaks in seastar (Asterias rubens) and dab (Limanda limanda), Mar. Pollut. Bull. 31 (4-12) (1995) 431-438.
    • (1995) Mar. Pollut. Bull. , vol.31 , Issue.4-12 , pp. 431-438
    • Everaarts, J.M.1


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