Differential kinetochore requirements for establishment and maintenance of the spindle checkpoint are dependent on the mechanism of checkpoint activation in Saccharomyces cerevisiae

Cell Cycle

Volumn 3, Issue 2, 2004, Pages 192-199

  Poddar, Atasi ^a   Daniel, Jewel A ^a   Daum, John R ^a   Burke, Daniel J ^a  

^a UNIVERSITY OF VIRGINIA MEDICAL CENTER   (United States)

Author keywords

Kinetochore; Mitosis; MPS1; ndc10 1; Spindle checkpoint

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; BUB1 RELATED PROTEIN; NOCODAZOLE; PROTEIN BUB2; PROTEIN MAD2; UNCLASSIFIED DRUG; BUB2 PROTEIN, S CEREVISIAE; CARRIER PROTEIN; CBF2 PROTEIN, S CEREVISIAE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; MAD2 PROTEIN, S CEREVISIAE; MPS1 PROTEIN, S CEREVISIAE; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CELL MUTANT; CENTROMERE; CONTROLLED STUDY; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TEMPERATURE SENSITIVITY; CELL CYCLE; DRUG EFFECT; GENETICS; METABOLISM; MICROTUBULE; PHYSIOLOGY;

SACCHAROMYCES CEREVISIAE;

CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; KINETOCHORES; MICROTUBULES; MITOTIC SPINDLE APPARATUS; NOCODAZOLE; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

EID: 3843069030     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.3.2.635     Document Type: Article

References (32)

1. Burke DJ. Complexity in the spindle checkpoint. Curr Opin Genet Dev 2000; 10:26-31.
2. Cleveland DW, Mao Y, Sullivan KF. Centromeres and kinetochores: From epigenetics to mitotic checkpoint signaling. Cell 2003; 112:407-21.
3. Li SJ, Hochstrasser M. The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Mol Cell Biol 2000; 20:2367-77.
4. Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J Cell Biol 1998; 141:1393-406.
5. McCleland ML, Gardner RD, Kallio MJ, Daum JR, Gorbsky GJ, Burke DJ, et al. The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev 2003; 17:101-14.
6. Chen RH, Shevchenko A, Mann M, Murray AW. Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores. J Cell Biol 1998; 143:283-95.
7. Chen RH. BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1. J Cell Biol 2002; 158:487-96.
8. Taylor SS, Ha E, McKeon F. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. J Cell Biol 1998; 142:1-11.
9. Winey M, Huneycutt BJ. Centrosomes and checkpoints: The MPS1 family of kinases. Oncogene 2002; 21:6161-9.
10. Weiss E, Winey M. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J Cell Biol 1996; 132:111-23.
11. Hardwick KG, Weiss E, Luca FC, Winey M, Murray AW. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science 1996; 273:953-6.
12. Hardwick KG, Murray AW. Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J Cell Biol 1995; 131:709-20.
13. Winey M, Goersch L, Baum P, Byers B. MPS1 and MPS2: Novel yeast genes defining distinct steps of spindle pole body duplication. J Cell Biol 1991; 114:745-54.
14. Schutz AR, Winey M. New alleles of the yeast MPS1 gene reveal multiple requirements in spindle pole body duplication. Mol Biol Cell 1998; 9:759-74.
15. Hwang LH, Lau LF, Smith DL, Mistrot CA, Hardwick KG, Hwang ES, et al. Budding yeast Cdc20: A target of the spindle checkpoint. Science 1998; 279:1041-4.
16. Yu H. Regulation of APC-Cdc20 by the spindle checkpoint. Curr Opin Cell Biol 2002; 14:706-14.
17. Musacchio A, Hardwick KG. The spindle checkpoint: Structural insights into dynamic signalling. Nat Rev Mol Cell Biol 2002; 3:731-41.
18. Abrieu A, Kahana JA, Wood KW, Cleveland DW. CENP-E as an essential component of the mitotic checkpoint in vitro. Cell 2000; 102:817-26.
19. Abrieu A, Magnaghi-Jaulin L, Kahana JA, Peter M, Castro A, Vigneron S, et al. Mps1 is a kinetochore associated kinase essential for the vertebrate mitotic checkpoint. Cell 2001; 106:83-93.
20. Gardner RD, Poddar A, Yellman C, Tavormina PA, Monteagudo MC, Burke DJ. The spindle checkpoint of the yeast Saccharomyces cerevisiae requires kinetochore function and maps to the CBF3 domain. Genetics 2001; 157:1493-502.
21. Fraschini R, Beretta A, Lucchini G, Piatti S. Role of the kinetochore protein Ndc10 in mitotic checkpoint activation in Saccharomyces cerevisiae. Mol Genet Genomics 2001; 266:115-25.
22. Burke D, Dawson D, Stearns T. Methods in yeast genetics. A Cold Spring Harbor Laboratory Course Manual 2000; 103-81.
23. Tavormina PA, Burke DJ. Cell cycle arrest in cdc20 mutants of Saccharomyces cerevisiae is independent of Ndc10p and kinetochore function but requires a subset of spindle checkpoint genes. Genetics 1998; 148:1701-13.
24. Goh PY, Kilmartin JV. NDC10: A gene involved in chromosome segregation in Saccharomyces cerevisiae. J Cell Biol 1993; 121:503-12.
25. Li R. Bifurcation of the mitotic checkpoint pathway in budding yeast. Proc Natl Acad Sci USA 1999; 96:4989-94.
26. Nicklas RB. How cells get the right chromosomes. Science 1997; 275:632-7.
27. Li X, Nicklas RB. Mitotic forces control a cell-cycle checkpoint. Nature 1995; 373:630-2.
28. Taylor SS, McKeon F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 1997; 89:727-35.
29. Rieder CL, Cole RW, Khodjakov A, Sluder G. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J Cell Biol 1995; 130:941-8.
30. Howell BJ, Hoffman DB, Fang G, Murray AW, Salmon ED. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells. J Cell Biol 2000; 150:1233-50.
31. Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ. Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. J Cell Biol 2002; 158:841-7.
32. Habu T, Kim SH, Weinstein J, Matsumoto T. Identification of a MAD2-binding protein, CMT2, and its role in mitosis. EMBO J 2002; 21:6419-28.