Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism

Journal of Biological Chemistry

Volumn 283, Issue 3, 2008, Pages 1588-1596

  Fan, Ying Xin ^a   Wong, Lily ^a   Ding, Jinhui ^b   Spiridonov, Nikolay A ^a   Johnson, Richard C ^c   Johnson, Gibbes R ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; HYDROPHOBICITY; LIGANDS; MOLECULAR MECHANICS; MUTAGENESIS; PHOSPHORYLATION;

ACTIVATION LOOPS; CATALYTIC REGULATION; EXTRACELLULAR DOMAIN; INTRAMOLECULAR SWITCH;

ENZYME ACTIVITY;

EPIDERMAL GROWTH FACTOR RECEPTOR 2;

ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; GENE MUTATION; HUMAN; HUMAN CELL; KINETICS; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CATALYSIS; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; HSP90 HEAT-SHOCK PROTEINS; HUMANS; KINETICS; MODELS, MOLECULAR; MUTATION; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 38349175328     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708116200     Document Type: Article

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