EGFR kinase possesses a broad specificity for ErbB phosphorylation sites, and ligand increases catalytic-centre activity without affecting substrate binding affinity

Biochemical Journal

Volumn 392, Issue 3, 2005, Pages 417-423

  Fan, Ying Xin ^a   Wong, Lily ^a   Johnson, Gibbes R ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Autophosphorylation; Binding affinity; epidermal growth factor receptor (EGFR); ErbB receptor; Michaelis Menten; Receptor tyrosine kinase (RTK) specificity

Indexed keywords

BIOCHEMISTRY; CATALYSIS; CHEMICAL ACTIVATION; DIMERS; REACTION KINETICS; SUBSTRATES;

AUTOPHOSPHORYLATION; BINDING AFFINITY; EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR); ERBB RECEPTOR; MICHAELIS-MENTEN; RECEPTOR TYROSINE KINASE (RTK) SPECIFICITY;

PROTEINS;

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPARATIVE STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; KINETICS; PRIORITY JOURNAL; PROTEIN BINDING; STEADY STATE;

AMINO ACID SEQUENCE; CATALYSIS; CATALYTIC DOMAIN; EPIDERMAL GROWTH FACTOR; GENES, ERBB; HUMANS; KINETICS; LIGANDS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PHOSPHORYLATION; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 29644431755     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051122     Document Type: Article

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