Integration of high speed microwave chemistry and a statistical 'design of experiment' approach for the synthesis of the mitotic kinesin Eg5 inhibitor monastrol

Tetrahedron

Volumn 64, Issue 9, 2008, Pages 2035-2041

  Glasnov, Toma N ^a   Tye, Heather ^b   Kappe, C Oliver ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b EVOTEC UK LTD   (United Kingdom)

Author keywords

Design of experiments; Dihydropyrimidines; Heterocycles; Microwave irradiation; Multicomponent reaction

Indexed keywords

HETEROCYCLIC COMPOUND; MONASTROL;

ARTICLE; CATALYST; CHEMICAL REACTION; DRUG DESIGN; DRUG SYNTHESIS; MICROWAVE RADIATION; PRIORITY JOURNAL; REACTION TIME; TEMPERATURE SENSITIVITY;

EID: 38349155790     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2007.12.056     Document Type: Article

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