Progesterone enhances ethanol-induced modulation of mesocortical dopamine neurons: Antagonism by finasteride

Journal of Neurochemistry

Volumn 83, Issue 5, 2002, Pages 1103-1109

  Dazzi, Laura ^a   Serra, Mariangela ^a   Seu, Emanuele ^a   Cherchi, Giulia ^a   Pisu, M Giuseppina ^a   Purdy, Robert H ^a   Biggio, Giovanni ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Dopamine; Ethanol; Microdialysis; Neurosteroids; Prefrontal cortex

Indexed keywords

ALCOHOL; DOPAMINE; FINASTERIDE; NEUROSTEROID; PROGESTERONE; STEROID 5ALPHA REDUCTASE INHIBITOR; TRITIUM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG ABUSE; EMOTION; ISOTOPE LABELING; MALE; MICRODIALYSIS; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT;

ANIMALS; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ANTAGONISM; DRUG SYNERGISM; ENZYME INHIBITORS; ETHANOL; EXTRACELLULAR SPACE; FINASTERIDE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; MALE; MICRODIALYSIS; NEURONS; PREFRONTAL CORTEX; PREGNANOLONE; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; TRITIUM;

EID: 0036893188     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01218.x     Document Type: Article

References (62)

1. Abercrombie E. D., Keefe K. A., DiFrischia D. S. and Zigmond M. J. (1989) Differential effect of stress on in vivo dopamine release in the striatum, nucleus accumbens, and medial prefrontal cortex. J. Neurochem. 52, 1655-1658.
2. Allen D. (1996) Are alcoholic women more likely to drink premenstrually? Alcohol Alcohol. 31, 145-147.
3. Barbaccia M. L., Affricano D., Trabucchi M., Purdy R. H., Colombo G., Agabio R. and Gessa G. L. (1999) Ethanol markedly increases 'GABAergic' neurosteroids in alcohol-preferring rats. Eur. J. Pharmacol. 384, R1-R2.
4. A receptor function, and anxiety: A study in menopausal women. Psychoneuroendocrinology 25, 659-675.
5. Bassareo V. and DiChiara G. (1997) Differential influence of associative and nonassociative learning mechanisms on the responsiveness of prefrontal and accumbal dopamine transmission to food stimuli in rats fed ad libitum. J. Neurosci. 17, 851-861.
6. Belelli D., Bolger M. B. and Gee K. W. (1989) Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Eur. J. Pharmacol. 166, 325-329.
7. Biggio G. and Purdy R. H., eds. (2001) International Review of Neurobiology, Vol. 46: Neurosteroids and Brain Function. Academic Press, New York.
8. Bowen C. A., Purdy R. H. and Grant K. A. (1999) An investigation of endogenous neuroactive steroid-induced modulation of ethanol's discriminative stimulus effects. Behav. Pharmacol. 10, 297-311.
9. Chuong C. J. and Burgos D. M. (1995) Medical history in women with premenstrual syndrome. J. Psychosom. Obstetr. Gynecol. 16, 21-27.
10. Concas A., Mostallino M. C., Porcu P., Follesa P., Barbaccia M. L., Trabucchi M., Purdy R. H., Grisenti P. and Biggio G. (1998) Role of brain allopregnanolone in the plasticity of γ-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery. Proc. Natl. Acad. Sci. USA 95, 13284-13289.
11. Crawley J. N., Glowa J. R., Majewska M. D. and Paul S. M. (1986) Anxiolytic activity of an endogenous adrenal steroid. Brain Res. 398, 382-385.
12. A receptor modulators. J. Pharmacol. Exp. Ther. 273, 241-247.
13. Dazzi L., Serra M., Porceddu M. L., Sanna A., Chessa M. F. and Biggio G. (1997) Enhancement of basal and pentylenetetrazol (PTZ)-stimulated dopamine release in the brain of freely moving rats by PTZ-induced kindling. Synapse 26, 351-358.
14. Dazzi L., Serra M., Vacca G., Ladu S., Latrofa A., Trapani G. and Biggio G. (2002) Depletion of cortical allopregnanolone potentiates stress-induced increase in cortical dopamine output. Brain Res. 932, 135-139.
15. Deutch A. Y. and Roth R. H. (1990) The determinants of stress-induced activation of the prefrontal cortical dopamine system. Prog. Brain Res. 85, 367-403.
16. Devaud L. L., Purdy R. H. and Morrow A. L. (1995) The neurosteroid, 3α-hydroxy-5α-pregnane-20-one, protects against bicuculline-induced seizures during ethanol withdrawal in rats. Alcohol. Clin. Exp. Res. 19, 350-355.
17. A receptors to neuroactive steroids in rats during ethanol withdrawal. J. Pharmacol. Exp. Ther. 278, 510-517.
18. DiChiara G. and Imperato A. (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc. Natl. Acad. Sci. USA 85, 5274-5278.
19. Engel S. R. and Grant K. A. (2001) Neurosteroids and behavior, in International Review of Neurobiology, Vol. 46: Neurosteroids and Brain Function (Biggio G. and Purdy R. H., eds), pp. 321-342. Academic Press, New York.
20. Finn D. A., Roberts A. J. and Crabbe J. C. (1995) Neuroactive steroid sensitivity in withdrawal seizure-prone and -resistant mice. Alcohol. Clin. Exp. Res. 19, 410-415.
21. Florio R, Quirici B., Casarosa E., Lombardi I., Luisi M., Genazzani A. D., Petraglia F. and Genazzani A. R. (2001) Neuroendocrine effects of raloxifene hydrochloride in postmenopausal women. Gynecol. Endocrinol. 15, 359-366.
22. A receptor expression and function during progesterone treatment and withdrawal. Mol. Pharmacol. 57, 1262-1270.
23. A receptor plasticity during long-term exposure to and withdrawal from progesterone. Brain Res. Rev. 37, 81-90.
24. - ionophore by steroids in rat brain. Eur. J. Pharmacol. 136, 419-423.
25. Genazzani A. R., Petraglia F., Bernardi F., Casarosa E., Salvestroni C., Tonetti A., Nappi R. E., Luisi S., Palumbo M., Purdy R. H. and Luisi M. (1998) Circulating levels of allopregnanolone in humans: Gender, age, and endocrine influences. J. Clin. Endocrinol. Metab. 83, 2099-2103.
26. Gessa G. L., Muntoni F., Collu M., Vargiu L. and Mereu G. (1985) Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res. 348, 201-203.
27. Girdler S. S., Straneva P. A., Light K. C., Pedersen C. A. and Morrow A. L. (2001) Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder. Biol. Psychiatry 49, 788-797.
28. Goldman-Rakic P. S. (1987) Circuitry of the primate prefrontal cortex and the regulation of behavior by representational memory, in Handbook of Physiology: The Nervous System. Higher Functions of the Brain (Plum F., ed.), pp. 373-417. American Physiological Society, Bethesda, MD.
29. Grace A. A. (2000) The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving. Addiction 95, 119-128.
30. Grobin A. C., Roth R. H. and Deutch A. Y. (1992) Regulation of the prefrontal cortical dopamine system by the neuroactive steroid 3α,21-dihydroxy-5α-pregnane-20-one. Brain Res. 578, 351-356.
31. A receptors in the acute and chronic effects of ethanol. Psychopharmacology 139, 2-19.
32. Hutson P. H. and Barton C. L. (1997) L-701,324, a glycine/NMDA receptor antagonist, blocks the increase of cortical dopamine metabolism by stress and DMCM. Eur. J. Pharmacol. 326, 127-132.
33. Imperato A., Dazzi L., Serra M., Gessa G. L. and Biggio G. (1994) Differential effects of abecarnil on basal release of acetylcholine and dopamine in the rat brain. Eur. J. Pharmacol. 261, 205-208.
34. Inglis F. M. and Moghaddam B. (1999) Dopaminergic innervation of amygdala is highly responsive to stress. J. Neurochem. 72, 1088-1094.
35. Jentsch J. D., Redmond D. E. Jr, Elsworth J. D., Taylor J. R., Youngren K. D. and Roth R. H. (1997) Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine. Science 277, 953-955.
36. Kokate T. G., Cohen A. L., Karp E. and Rogawski M. A. (1996) Neuroactive steroids protect against piloxcarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. Neuropharmacology 35, 1049-1056.
37. A receptor function. Trends Pharmacol. Sci. 16, 295-303.
38. MacDonald A. B., Stewart S. H., Hutson R., Rhyno E. and Loughlin H. L. (2001) The roles of alcohol and alcohol expectancy in the dampening of responses to hyperventilation among high anxiety sensitive young adults. Addict. Behav. 26, 841-867.
39. A receptor. Mechanism of action and physiological significance. Prog. Neurobiol. 38, 379-395.
40. Majewska M. D., Harrison N. L., Rochelle D. S., Barker J. L. and Paul S. M. (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232, 1004-1007.
41. A receptors. Brain Res. 805, 88-94.
42. Miczek K. A., DeBold J. F. and van Erp A. M. M. (1994) Neuropharmacological characteristics of individual differences in alcohol effects on aggression in rodents and primates. Behav. Pharmacol. 5, 407-421.
43. Mihic S. J., Ye Q., Wick M. J., Koltchine V. V., Krasowski M. D., Finn S. E., Mascia M. P., Valenzuela C. F., Hanson K. K., Greenblatt E. P., Harris R. A. and Harrison N. L. (1997) Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors. Nature 398, 385-389.
44. Morrow A. L., VanDoren M. J., Penland S. N. and Matthews D. B. (2001) The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brain Res. Rev. 37, 98-109.
45. Motzo C., Porceddu M. L., Maira G., Flore G., Concas A., Dazzi L. and Biggio G. (1996) Inhibition of basal and stress-induced dopamine release in the cerebral cortex and nucleus accumbens of freely moving rats by the neurosteroid allopregnanolone. J. Psychopharmacol. 10, 266-272.
46. Paxinos G. and Watson C. (1982) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
47. Pick C. G., Peter Y., Terkel J., Gavish M. and Weizman R. (1996) Effect of the neuroactive steroid α-THDOC on staircase test behavior in mice. Psychopharmacology 128, 61-66.
48. Purdy R. H., Morrow A. L., Moore P. H. Jr and Paul S. M. (1991) Stress-induced elevations of gamma-aminobutyric acid type A receptoractive steroids in the rat brain. Proc. Natl. Acad. Sci. USA 88, 4553-4557.
49. Rapkin A. J., Morgan M., Goldman L., Brann D. W., Simone D. and Mahesh V. B. (1997) Progesterone metabolite allopregnanolone in women with premenstrual syndrome. Obstetr. Gynecol. 90, 709-714.
50. Rasgon N., Serra M., Biggio G., Pisu M. G., Fairbanks L., Tanavoli S. and Rapkin A. (2001) Neuroactive steroid-serotonergic interaction: Responses to an intravenous 1-tryptophan challenge in women with premenstrual syndrome. Eur. J. Endocrinol. 145, 25-33.
51. Rasmusson G. H., Reynolds G. F., Steinberg N. G., Walton E., Patel G. F., Liang T., Cascieri M. A., Cheung A. H., Brooks J. R. and Berman C. (1986) Azasteroids; structure-activity relationships for inhibition of 5α-reductase and androgen receptor binding. J. Med. Chem. 29, 2298-2315.
52. Romeo E., Ströhle A., Spalletta G., di Michele F., Hermann B., Holsboer F., Pasini A. and Rupprecht R. (1998) Effects of antidepressant treatment on neuroactive steroids in major depression. Am. J. Psychiatry 155, 910-913.
53. A receptor function in rat brain. J. Neurochem. 75, 732-740.
54. Sutton S. K. and Davidson R. J. (1997) Prefrontal brain asymmetry: A biological substrate of the behavioral approach and inhibition systems. Am. Psychol. Soc. 8, 204-210.
55. Tam S. Y. and Roth R. H. (1990) Modulation of mesoprefrontal dopamine neurons by central benzodiazepine receptors. I. Pharmacological characterization. J. Pharmacol. Exp. Ther. 252, 989-996.
56. Thyer B. A., Parrish R. T., Himle J., Cameron O. G., Curtis G. C. and Nesse R. M. (1986) Alcohol abuse among clinically anxious patients. Behav. Res. Ther. 24, 357-359.
57. Tobin M. B., Schmidt P. J. and Rubinow D. R. (1994) Reported alcohol use in women with premenstrual syndrome. Am. J. Psychiatry 151, 1503-1504.
58. Trapani G., Dazzi L., Pisu M. G., Seu E. and Biggio G. (2002) A rapid method for obtaining finasteride, a 5α-reductase inhibitor, from commercial tablets. Brain Res. Prot. 9, 130-134.
59. Tzschentke T. M. (2001) Pharmacology and behavioral pharmacology of the mesocortical dopamine system. Prog. Neurobiol. 63, 241-320.
60. Uzunova V., Sheline Y., Davis J. M., Rasmusson A., Uzunov D. P., Costa E. and Guidotti A. (1998) Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc. Natl. Acad. Sci. USA 95, 3239-3244.
61. VanDoren M. J., Matthews D. B., Janis G. C., Grobin A. C., Devaud L. L. and Morrow A. L. (2000) Neuroactive steroid 3alphahydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. J. Neurosci. 20, 1982-1989.
62. Weiss F. and Porrino L. J. (2002) Behavioral neurobiology of alcohol addiction: Recent advances and challenges. J. Neurosci. 22, 3332-3337.