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Volumn 850, Issue 1-2, 1999, Pages 217-224

Anxiolytic effects of the neuroactive steroid pregnanolone (3α-OH-5β-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum

Author keywords

Anxiolytic; Defensive burying test; Elevated plus maze; Hippocampus; Lateral septum; Neurosteroid

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ELTANOLONE; FLUMAZENIL; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PICROTOXIN;

EID: 0032711337     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)02150-2     Document Type: Article
Times cited : (117)

References (53)
  • 1
    • 0028171876 scopus 로고
    • 1A receptors in the median raphe nucleus and dorsal hippocampus may mediate anxiolytic and anxiogenic behaviors respectively
    • 1A receptors in the median raphe nucleus and dorsal hippocampus may mediate anxiolytic and anxiogenic behaviors respectively. Eur. J. Pharmacol. 264:1994;259-264.
    • (1994) Eur. J. Pharmacol. , vol.264 , pp. 259-264
    • Andrews, N.1    Hogg, S.2    Gonzalez, L.E.3    File, S.E.4
  • 4
    • 0025161662 scopus 로고
    • Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex
    • Belelli D., Lan N.C., Gee K.W. Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex. Neurosci. Biobehav. Rev. 14:1990;315-322.
    • (1990) Neurosci. Biobehav. Rev. , vol.14 , pp. 315-322
    • Belelli, D.1    Lan, N.C.2    Gee, K.W.3
  • 5
    • 0026437608 scopus 로고
    • Hippocampal mossy fibers: Implication in novelty reactions or in anxiety behaviors?
    • Belzung C. Hippocampal mossy fibers: implication in novelty reactions or in anxiety behaviors? Behav. Brain Res. 51:1992;149-155.
    • (1992) Behav. Brain Res. , vol.51 , pp. 149-155
    • Belzung, C.1
  • 8
    • 0031875855 scopus 로고    scopus 로고
    • Corticosterone is permissive to the anxiolytic effect that results from the blockade of hippocampal mineralocorticoid receptors
    • Bitran D., Shiekh M., Dowd J.A., Dugan M.M., Renda P. Corticosterone is permissive to the anxiolytic effect that results from the blockade of hippocampal mineralocorticoid receptors. Pharmacol. Biochem. Behav. 60:1998;879-888.
    • (1998) Pharmacol. Biochem. Behav. , vol.60 , pp. 879-888
    • Bitran, D.1    Shiekh, M.2    Dowd, J.A.3    Dugan, M.M.4    Renda, P.5
  • 10
  • 12
    • 0030018145 scopus 로고    scopus 로고
    • Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety
    • Carbone E., Wieland S., Lan N.C., Gee K.W. Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety. Psychopharmacology. 126:1996;173-178.
    • (1996) Psychopharmacology , vol.126 , pp. 173-178
    • Carbone, E.1    Wieland, S.2    Lan, N.C.3    Gee, K.W.4
  • 14
    • 0028932249 scopus 로고
    • The neurosteroid 3α-hydroxy-5α-pregnan-20-one protects against bicuculline-induced seizures during ethanol withdrawal in rats
    • Devaud L.L., Purdy R.H., Morrow A.L. The neurosteroid 3α-hydroxy-5α-pregnan-20-one protects against bicuculline-induced seizures during ethanol withdrawal in rats. Alcohol.: Clin. Exp. Res. 19:1995;350-355.
    • (1995) Alcohol.: Clin. Exp. Res. , vol.19 , pp. 350-355
    • Devaud, L.L.1    Purdy, R.H.2    Morrow, A.L.3
  • 15
    • 0022654749 scopus 로고
    • Low doses of muscimol produce anticonflict actions in the lateral septum of the rat
    • Drugan R.C., Skolnick P., Paul S.M., Crawley J.N. Low doses of muscimol produce anticonflict actions in the lateral septum of the rat. Neuropharmacology. 25:1986;203-205.
    • (1986) Neuropharmacology , vol.25 , pp. 203-205
    • Drugan, R.C.1    Skolnick, P.2    Paul, S.M.3    Crawley, J.N.4
  • 16
    • 0029122845 scopus 로고
    • Flumazenil blocks the anxiolytic action of allopregnanolone
    • Fernandez-Guasti A., Picazo O. Flumazenil blocks the anxiolytic action of allopregnanolone. Eur. J. Pharmacol. 281:1995;113-115.
    • (1995) Eur. J. Pharmacol. , vol.281 , pp. 113-115
    • Fernandez-Guasti, A.1    Picazo, O.2
  • 17
    • 0026357399 scopus 로고
    • A complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation
    • A complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation. Mol. Pharmacol. 40:1991;995-999.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 995-999
    • Gee, K.1    Lan, N.2
  • 19
    • 0026535610 scopus 로고
    • Regulation of the prefrontal cortical dopamine system by the neuroactive steroid 3α-21-dihydroxy-5α-pregnan-20-one
    • Grobin A.C., Roth R.H., Deutch A.Y. Regulation of the prefrontal cortical dopamine system by the neuroactive steroid 3α-21-dihydroxy-5α-pregnan-20-one. Brain Res. 578:1992;351-356.
    • (1992) Brain Res. , vol.578 , pp. 351-356
    • Grobin, A.C.1    Roth, R.H.2    Deutch, A.Y.3
  • 22
    • 0022539681 scopus 로고
    • Tetrahydro-β-carboline microinjected into the hippocampus induces an anxiety-like state in the rat
    • Huttunen P., Myers R.D. Tetrahydro-β-carboline microinjected into the hippocampus induces an anxiety-like state in the rat. Pharmacol. Biochem. Behav. 24:1986;1733-1738.
    • (1986) Pharmacol. Biochem. Behav. , vol.24 , pp. 1733-1738
    • Huttunen, P.1    Myers, R.D.2
  • 23
    • 0028921193 scopus 로고
    • Anxiolytic-like action of intra-hippocampally administered NMDA antagonists in rats
    • Jessa M., Nazar M., Plaznik A. Anxiolytic-like action of intra-hippocampally administered NMDA antagonists in rats. Pol. J. Pharmacol. 47:1995;81-84.
    • (1995) Pol. J. Pharmacol. , vol.47 , pp. 81-84
    • Jessa, M.1    Nazar, M.2    Plaznik, A.3
  • 26
    • 0024424938 scopus 로고
    • Intra-hippocampal buspirone in animal models of anxiety
    • Kostowski W., Plaznik A., Stefanski R. Intra-hippocampal buspirone in animal models of anxiety. Eur. J. Pharmacol. 168:1989;393-396.
    • (1989) Eur. J. Pharmacol. , vol.168 , pp. 393-396
    • Kostowski, W.1    Plaznik, A.2    Stefanski, R.3
  • 27
    • 0028990270 scopus 로고
    • 1 hippocampus in vitro of guinea-pigs and rats
    • 1 hippocampus in vitro of guinea-pigs and rats. Acta Physiol. Scand. 154:1995;165-176.
    • (1995) Acta Physiol. Scand. , vol.154 , pp. 165-176
    • Landgren, S.1    Selstam, G.2
  • 28
    • 0022483382 scopus 로고
    • Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
    • Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., Paul S.M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 232:1986;1004-1007.
    • (1986) Science , vol.232 , pp. 1004-1007
    • Majewska, M.D.1    Harrison, N.L.2    Schwartz, R.D.3    Barker, J.L.4    Paul, S.M.5
  • 29
    • 0023238727 scopus 로고
    • The anesthetic potency of 3α-hydroxy-5α-pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one determined with an intravenous EEG-threshold in male rats
    • Norberg L., Wahlstrom G., Backstrom T. The anesthetic potency of 3α-hydroxy-5α-pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one determined with an intravenous EEG-threshold in male rats. Pharmacol. Toxicol. 61:1987;42-47.
    • (1987) Pharmacol. Toxicol. , vol.61 , pp. 42-47
    • Norberg, L.1    Wahlstrom, G.2    Backstrom, T.3
  • 31
    • 0022374863 scopus 로고
    • Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
    • Pellow S., Chopin P., File S.E., Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods. 14:1985;149-167.
    • (1985) J. Neurosci. Methods , vol.14 , pp. 149-167
    • Pellow, S.1    Chopin, P.2    File, S.E.3    Briley, M.4
  • 32
    • 0026728888 scopus 로고
    • Excitotoxic lesions of the septum produce anxiolytic effects in the elevated plus-maze and the shock-probe burying tests
    • Pesold C., Treit D. Excitotoxic lesions of the septum produce anxiolytic effects in the elevated plus-maze and the shock-probe burying tests. Physiol. Behav. 52:1992;37-47.
    • (1992) Physiol. Behav. , vol.52 , pp. 37-47
    • Pesold, C.1    Treit, D.2
  • 33
    • 0027955217 scopus 로고
    • The septum and amygdala differentially mediate the anxiolytic effects of benzodiazepines
    • Pesold C., Treit D. The septum and amygdala differentially mediate the anxiolytic effects of benzodiazepines. Brain Res. 638:1994;295-301.
    • (1994) Brain Res. , vol.638 , pp. 295-301
    • Pesold, C.1    Treit, D.2
  • 34
    • 0029998998 scopus 로고    scopus 로고
    • The neuroanatomical specificity of the anxiolytic effects of intra-septal infusions of midazolam
    • Pesold C., Treit D. The neuroanatomical specificity of the anxiolytic effects of intra-septal infusions of midazolam. Brain Res. 710:1996;161-168.
    • (1996) Brain Res. , vol.710 , pp. 161-168
    • Pesold, C.1    Treit, D.2
  • 35
    • 0029056668 scopus 로고
    • Anti-anxiety effects of progesterone and some of its reduced metabolites: An evaluation using the burying behavior test
    • Picazo O., Fernandez-Guasti A. Anti-anxiety effects of progesterone and some of its reduced metabolites: an evaluation using the burying behavior test. Brain Res. 680:1995;135-141.
    • (1995) Brain Res. , vol.680 , pp. 135-141
    • Picazo, O.1    Fernandez-Guasti, A.2
  • 37
    • 0025882098 scopus 로고
    • Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in rat brain
    • Purdy R.H., Morrow A.L., Moore P.H.J., Paul S.M. Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in rat brain. Proc. Natl. Acad. Sci. U.S.A. 88:1991;4553-4557.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 4553-4557
    • Purdy, R.H.1    Morrow, A.L.2    Moore, P.H.J.3    Paul, S.M.4
  • 38
    • 84920362364 scopus 로고
    • Diazepam and allopregnanolone infusions in midbrain central gray facilitate reproductive and open-field behaviors
    • Schwartz-Giblin S., Felzenberg E.R., Robbins A., Pfaff D.W., McCarthy M.M. Diazepam and allopregnanolone infusions in midbrain central gray facilitate reproductive and open-field behaviors. Soc. Neurosci. Abstr. 19:1993;586.
    • (1993) Soc. Neurosci. Abstr. , vol.19 , pp. 586
    • Schwartz-Giblin, S.1    Felzenberg, E.R.2    Robbins, A.3    Pfaff, D.W.4    McCarthy, M.M.5
  • 39
    • 0024368604 scopus 로고
    • A receptor subtype
    • A receptor subtype. Brain Res. Bull. 23:1989;317-322.
    • (1989) Brain Res. Bull. , vol.23 , pp. 317-322
    • Smith, S.S.1
  • 41
    • 0023160197 scopus 로고
    • Locally applied progesterone metabolites alter neuronal responsiveness in the cerebellum
    • Smith S.S., Waterhouse B.D., Woodward D.J. Locally applied progesterone metabolites alter neuronal responsiveness in the cerebellum. Brain Res. Bull. 18:1987;739-747.
    • (1987) Brain Res. Bull. , vol.18 , pp. 739-747
    • Smith, S.S.1    Waterhouse, B.D.2    Woodward, D.J.3
  • 42
    • 0030975631 scopus 로고    scopus 로고
    • Hippocampal mineralocorticoid, but not glucocorticoid, receptors modulate anxiety-like behavior in rats
    • Smythe J.W., Murphy D., Timothy C., Costall B. Hippocampal mineralocorticoid, but not glucocorticoid, receptors modulate anxiety-like behavior in rats. Pharmacol. Biochem. Behav. 56:1997;507-513.
    • (1997) Pharmacol. Biochem. Behav. , vol.56 , pp. 507-513
    • Smythe, J.W.1    Murphy, D.2    Timothy, C.3    Costall, B.4
  • 45
    • 0030915382 scopus 로고    scopus 로고
    • Dissociations among the anxiolytic effects of septal, hippocampal, and amygdaloid lesions
    • Treit D., Menard J. Dissociations among the anxiolytic effects of septal, hippocampal, and amygdaloid lesions. Behav. Neurosci. 111:1997;653-658.
    • (1997) Behav. Neurosci. , vol.111 , pp. 653-658
    • Treit, D.1    Menard, J.2
  • 46
    • 0001290240 scopus 로고    scopus 로고
    • Intra-hippocampal midazolam is anxiolytic in the elevated plus-maze but not in the shock-probe burying test
    • Treit D., Menard J. Intra-hippocampal midazolam is anxiolytic in the elevated plus-maze but not in the shock-probe burying test. Soc. Neurosci. Abstr. 24:1998;690.
    • (1998) Soc. Neurosci. Abstr. , vol.24 , pp. 690
    • Treit, D.1    Menard, J.2
  • 48
    • 0027500968 scopus 로고
    • Dissociating the anti-fear effects of septal and amygdaloid lesions using two pharmacologically validate models of rat anxiety
    • Treit D., Pesold C., Rotzinger S. Dissociating the anti-fear effects of septal and amygdaloid lesions using two pharmacologically validate models of rat anxiety. Behav. Neurosci. 107:1993;770-785.
    • (1993) Behav. Neurosci. , vol.107 , pp. 770-785
    • Treit, D.1    Pesold, C.2    Rotzinger, S.3
  • 49
    • 0029001498 scopus 로고
    • Potency of lipid and protein formulation of 5α-pregnanolone at induction of anaesthesia and the corresponding regional brain distribution
    • Wang M.D., Wahlstrom G., Gee K.W., Backstrom T. Potency of lipid and protein formulation of 5α-pregnanolone at induction of anaesthesia and the corresponding regional brain distribution. Br. J. Anaesth. 74:1995;553-557.
    • (1995) Br. J. Anaesth. , vol.74 , pp. 553-557
    • Wang, M.D.1    Wahlstrom, G.2    Gee, K.W.3    Backstrom, T.4
  • 50
    • 0028986669 scopus 로고
    • Comparative behavioral characterization of the neuroactive steroids 3α-OH, 5α-pregnan-20-one and 3α-OH, 5β-pregnan-20-one in rodents
    • Wieland S., Belluzzi J.D., Stein L., Lan N.C. Comparative behavioral characterization of the neuroactive steroids 3α-OH, 5α-pregnan-20-one and 3α-OH, 5β-pregnan-20-one in rodents. Psychopharmacology. 118:1995;65-71.
    • (1995) Psychopharmacology , vol.118 , pp. 65-71
    • Wieland, S.1    Belluzzi, J.D.2    Stein, L.3    Lan, N.C.4
  • 51
    • 0025987983 scopus 로고
    • Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one
    • Wieland S., Lan N.C., Mirasedeghi S., Gee K.W. Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Brain Res. 565:1991;263-268.
    • (1991) Brain Res. , vol.565 , pp. 263-268
    • Wieland, S.1    Lan, N.C.2    Mirasedeghi, S.3    Gee, K.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.