Sex differences in steroid modulation of ethanol withdrawal in male and female rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 1, 2007, Pages 427-436

  Alele, P E ^a   Devaud, Leslie L ^a  

^a IDAHO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CORTICOSTERONE; ESTRADIOL; PENTETRAZOLE; PREGNENOLONE;

ALCOHOL WITHDRAWAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG MECHANISM; FEMALE; MALE; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SEX DIFFERENCE;

ANIMALS; CORTICOSTERONE; ESTRADIOL; ETHANOL; FEMALE; MALE; NEUROPROTECTIVE AGENTS; OVARIECTOMY; PENTYLENETETRAZOLE; PREGNENOLONE; RATS; SEIZURES; SEX CHARACTERISTICS; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 33845898787     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.107896     Document Type: Article

References (37)

1. Alcohol and Health (2000) 10th Special Report to Congress, U.S. Department of Health and Human Services, Bethesda, MD.
2. Alele PE and Devaud LL (2005) Differential adaptations in GABAergic and glutamatergic systems during ethanol withdrawal in male and female rats. Alcohol Clin Exp Res 29:1027-1034.
3. Ashley MJ, Olin JS, LeRiche WH, Kornaczewski A, Schmidt W, and Rankin JG (1977) Morbidity in alcoholics: evidence for accelerated development of physical disease in women. Arch Int Med 137:883-887.
4. Baulieu EE (1997) Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog Horm Res 52:1-32.
5. Blanchard RJ, McKittrick CR, and Blanchard DC (2001) Animal models of social stress: effects on behavior and brain neurochemical systems. Physiol Behav 73:261-271.
6. Brathen G, Brodtkorb E, Helde G, Sand T, and Bovim G (1999) The diversity of seizures related to alcohol use: a study of consecutive patients. Eur J Neurol 6:696-703.
7. Breese GR, Chu K, Dayas CV, Funk D, Knapp DJ, Koob GF, Le DA, O'Dell LE, Overstreet DH, Roberts AJ, et al. (2005) Stress enhancement of craving during sobriety: a risk for relapse. Alcohol Clin Exp Res. 29:185-195.
8. Brown ME, Anton RF, Malcom R, and Ballenger JC (1988) Alcohol detoxification and withdrawal seizures: clinical support for a kindling hypothesis. Biol Psych 23:507-514.
9. Cagetti E, Graziano P, Guidotti A, Baicy K, and Olsen RW (2004) Chronic intermittent ethanol (CIE) administration in rats decreases levels of neurosteroids in hippocampus, accompanied by altered behavioral responses to neurosteroids and memory function. Neuropharmacology 46:570-579.
10. Deshmukh A, Rosenbloom MJ, Sassoon S, O'Reilly A, Pfefferbaum A, and Sullivan EV (2003) Alcoholic men endorse more DSM-IV withdrawal symptoms than alcoholic women matched in drinking history. J Study Alcohol 64:375-379.
11. Devaud LL and Alele PE (2004) Differential effects of chronic ethanol administration and withdrawal on γ-aminobutyric acid type A and NMDA receptor subunit proteins in male and female rat brain. Alcohol Clin Exp Res 28:957-965.
12. Devaud LL, Alele PE, and Chadda R (2003) Sex differences in the central nervous system actions of ethanol. Crit Rev Neurobiol 15:41-59.
13. Devaud LL and Chadda R (2001) Sex differences in rats in the development of and recovery from ethanol dependence assessed by changes in seizure susceptibility. Alcohol Clin Exp Res 25:1689-1696.
14. Devaud LL, Purdy RH, Finn DA, and Morrow AL (1996) Sensitization of gamma-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal. J Pharmacol Exp Ther 278:510-517.
15. Devaud LL, Purdy RH, and Morrow AL (1995) The neurosteroid, 3α-hydroxy-5α-pregnan-20-one, protects against bicuculline-induced seizures during ethanol withdrawal in rats. Alcohol Clin Exp Res 19:350-355.
16. Figueiredo HF, Dolgas CM, and Herman JP (2002) Stress activation of cortex and hippocampus is modulated by sex and stage of estrus. Endocrinology 143:2534-2540.
17. Finn DA, Roberts AJ, and Crabbe JC (1995) Neuroactive steroid sensitivity in withdrawal seizure-prone and -resistant mice. Alcohol Clin Exp Res 19:410-416.
18. Finn DA, Ford MM, Wiren KM, Roselli CE, and Crabbe JC (2004) The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches. Pharmacol Ther 101:91-112.
19. Foldvary-Schaefer N, Harden C, Herzog A, and Falcone T (2004) Hormones and seizures. Cleve Clin J Med 71:S11-18.
20. Frye CA and Rhodes ME (2005) Estrogen-priming can enhance progesterone's antiseizure effects in part by increasing hippocampal levels of allopregnanolone. Pharmacol Biochem Behav 81:907-916.
21. Janis GC, Devaud LL, Mitsuyama H, and Morrow AL (1998) Effects of chronic ethanol consumption and withdrawal on the neuroactive steroid 3α-hydroxy-5α-pregnan-20-one in male and female rats. Alcohol Clin Exp Res 22:2055-2061.
22. Jung ME, Yang SH, Brun-Zinkernagel AM, and Simpkins JW (2002) Estradiol protects against cerebellar damage and motor deficit in ethanol-withdrawn rats. Alcohol 26:83-93.
23. A receptor binding. Pharmacol Biochem Behav 43:441-447.
24. Marsh DJ, Baraban SC, Hollopeter G, and Palmiter RD (1999) Role of the Y5 neuropeptide Y receptor in limbic seizures. Proc Natl Acad Sci USA 96:13518-13523.
25. Paul SM and Purdy RH (1992) Neuroactive steroids. FASEB J 6:2311-2322.
26. Rewal M, Jung ME, Wen Y, Brun-Zinkernagel AM, and Simpkins JW (2003) Role of the GABA-A system in behavioral, motoric and cerebellar protection by estrogen during ethanol withdrawal. Alcohol 31:49-61.
27. Reibel S, Andre V, Chassagnon S, Andre G, Marescaux C, Nehlig A, and Depaulis A (2000) Neuroprotective effects of chronic estradiol benzoate treatment on hippocampal cell loss induced by status epilepticus in the female rat. Neurosci Lett 281:79-82.
28. Romeo E, Brancati A, De Lorenzo A, Fucci P, Furnari C, Pompili E, Sasso GF, Spalletta G, Troisi A, and Pasini A (1996) Marked decrease of plasma neuroactive steroids during alcohol withdrawal. Clin Neuropharmacol 19:366-369.
29. Schenker S (1997) Medical consequences of alcohol abuse: is gender a factor? Alcohol Clin Exp Res 21:179-181.
30. Sinha R, Robinson J, and O'Malley S (1998) Stress response dampening: effects of gender and family history of alcoholism and anxiety disorders. Psychopharmacology 137:311-320.
31. Steckelbroeck S, Watzka M, Riechelt R, Hans VH, Stoffel-Wagner B, Heidrich DD, Schramm J, Bidingmaier F, and Klingmuller D (2001a) Characterization of the 5 alpha-reductase-3-alpha-hydroxysteroid dehydrogenase complex in the human brain. J Clin Endocrin Metab 86:1324-1331.
32. Steckelbroeck S, Watzka M, Stoffel-Wagner B, Hans VH, Redel L, Clussmann H, Elger CE, Bidingmaier F, and Klingmuller D (2001b) Expression of the 17 betahydroxysteroid dehydrogenase type 5 mRNA in the human brain. Mol Cell Endocrinol 171:165-168.
33. VanDoren MJ, Matthews DB, Janis GC, Grobin AC, Devaud LL, and Morrow AL (2000) Neuroactive steroid 3α-hydroxy-5α-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. J Neurosci 20:1982-1989.
34. Webb B, Burnett PW, and Walker DW (2002) Sex differences in ethanol-induced hypnosis and hypothermia in young Long-Evans rats. Alcohol Clin Exp Res 26:695-704.
35. Wise PM (2003) Estrogens: protective or risk factors in brain function? Prog Neurobiol 69:181-191.
36. Wizeman T and Pardue M-L (2001) Exploring the Biological Contributions to Human Health: Does Sex Matter? Board on Health Sciences Policy, National Academy of Sciences, Washington, DC.
37. Woolley CS and Schwartzkroin PA (1998) Hormonal effects on the brain. Epilepsy 39 (Suppl 8):S2-S8.