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Volumn 8, Issue 1, 2008, Pages 29-39

Innovative genomic-based model for personalized treatment of gastric cancer: Integrating current standards and new technologies

Author keywords

Cancer stem cell; Gastric cancer; Gene signature; Individualized treatment; Network biology; Omics; Recurrence; Targeted therapy; Treatment

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; BORTEZOMIB; CAPECITABINE; CISPLATIN; EPIRUBICIN; ERLOTINIB; FLAVOPIRIDOL; GEFITINIB; LAPATINIB; MARIMASTAT; MATUZUMAB; SORAFENIB; SUNITINIB; TRASTUZUMAB;

EID: 38149069029     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.8.1.29     Document Type: Review
Times cited : (90)

References (92)
  • 1
    • 20344398665 scopus 로고    scopus 로고
    • Perspectives in the treatment of gastric cancer
    • Roukos DH, Kappas AM. Perspectives in the treatment of gastric cancer. Nat. Clin. Pract. Oncol. 2, 98-107 (2005).
    • (2005) Nat. Clin. Pract. Oncol , vol.2 , pp. 98-107
    • Roukos, D.H.1    Kappas, A.M.2
  • 3
  • 4
    • 33947214093 scopus 로고    scopus 로고
    • Tailoring treatments for curable gastric cancer
    • Sano T. Tailoring treatments for curable gastric cancer. Br. J. Surg. 94(3), 263-264 (2007).
    • (2007) Br. J. Surg , vol.94 , Issue.3 , pp. 263-264
    • Sano, T.1
  • 5
    • 35748946650 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine
    • Sakuramoto S, Sasako M, Yamaguchi T et al. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N. Engl. J. Med. 357(18), 1810-1820 (2007).
    • (2007) N. Engl. J. Med , vol.357 , Issue.18 , pp. 1810-1820
    • Sakuramoto, S.1    Sasako, M.2    Yamaguchi, T.3
  • 6
    • 33646568784 scopus 로고    scopus 로고
    • Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world
    • Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J. Clin. Oncol. 24(14), 2137-2150 (2006).
    • (2006) J. Clin. Oncol , vol.24 , Issue.14 , pp. 2137-2150
    • Kamangar, F.1    Dores, G.M.2    Anderson, W.F.3
  • 7
    • 34547132141 scopus 로고    scopus 로고
    • American Society of Clinical Oncology. Clinical cancer advances 2006: Major research advances in cancer treatment, prevention, and screening - a report from the American Society of Clinical Oncology
    • Ozols RF, Herbst RS, Colson YL et al.; American Society of Clinical Oncology. Clinical cancer advances 2006: major research advances in cancer treatment, prevention, and screening - a report from the American Society of Clinical Oncology. J. Clin. Oncol. 25(1), 146-162 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.1 , pp. 146-162
    • Ozols, R.F.1    Herbst, R.S.2    Colson, Y.L.3
  • 8
    • 33846943010 scopus 로고    scopus 로고
    • Prevention of gastric cancer: A miss
    • Taylor PR. Prevention of gastric cancer: a miss. J. Natl Cancer Inst. 99(2), 101-103 (2007).
    • (2007) J. Natl Cancer Inst , vol.99 , Issue.2 , pp. 101-103
    • Taylor, P.R.1
  • 10
    • 33846326304 scopus 로고    scopus 로고
    • Genetic screening for signal transduction in the era of network biology
    • Friedman A, Perrimon N. Genetic screening for signal transduction in the era of network biology. Cell 128(2), 225-231 (2007).
    • (2007) Cell , vol.128 , Issue.2 , pp. 225-231
    • Friedman, A.1    Perrimon, N.2
  • 11
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat. Med. 10(8), 789-799 (2004).
    • (2004) Nat. Med , vol.10 , Issue.8 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 12
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjoblom T, Jones S, Wood LD. The consensus coding sequences of human breast and colorectal cancers. Science 314(5797), 268-274 (2006).
    • (2006) Science , vol.314 , Issue.5797 , pp. 268-274
    • Sjoblom, T.1    Jones, S.2    Wood, L.D.3
  • 13
    • 33748093767 scopus 로고    scopus 로고
    • Linking oncogenic pathways with therapeutic opportunities
    • Bild AH, Potti A, Nevins JR. Linking oncogenic pathways with therapeutic opportunities. Nat. Rev. Cancer 6(9), 735-741 (2006).
    • (2006) Nat. Rev. Cancer , vol.6 , Issue.9 , pp. 735-741
    • Bild, A.H.1    Potti, A.2    Nevins, J.R.3
  • 14
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 7(6), 415-428 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.6 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 15
    • 33947583623 scopus 로고    scopus 로고
    • Reprogramming metastatic tumour cells with embryonic microenvironments
    • Hendrix MJ, Seftor EA, Seftor RE et al. Reprogramming metastatic tumour cells with embryonic microenvironments. Nat. Rev. Cancer 7(4), 246-255 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.4 , pp. 246-255
    • Hendrix, M.J.1    Seftor, E.A.2    Seftor, R.E.3
  • 16
    • 33947101019 scopus 로고    scopus 로고
    • Patterns of somatic mutation in human cancer genomes
    • Greenman C, Stephens P, Smith R et al. Patterns of somatic mutation in human cancer genomes. Nature 446(7132), 153-158 (2007).
    • (2007) Nature , vol.446 , Issue.7132 , pp. 153-158
    • Greenman, C.1    Stephens, P.2    Smith, R.3
  • 17
    • 33846588810 scopus 로고    scopus 로고
    • + Helicobacter pylori infection and gastric cancer risk in the EPIC-EURGAST study
    • + Helicobacter pylori infection and gastric cancer risk in the EPIC-EURGAST study. Int. J. Cancer 120(4), 859-867 (2007).
    • (2007) Int. J. Cancer , vol.120 , Issue.4 , pp. 859-867
    • Palli, D.1    Masala, G.2    Del Giudice, G.3
  • 18
    • 33847293670 scopus 로고    scopus 로고
    • High-throughput oncogene mutation profiling in human cancer
    • Thomas RK, Baker AC, Debiasi RM et al. High-throughput oncogene mutation profiling in human cancer. Nat. Genet. 39(3), 347-351 (2007).
    • (2007) Nat. Genet , vol.39 , Issue.3 , pp. 347-351
    • Thomas, R.K.1    Baker, A.C.2    Debiasi, R.M.3
  • 19
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood LD, Parsons DW, Jones S. The genomic landscapes of human breast and colorectal cancers. Science 318(5853), 1108-1113 (2007).
    • (2007) Science , vol.318 , Issue.5853 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3
  • 20
    • 4043057417 scopus 로고    scopus 로고
    • Esophagus
    • Green FL, Page DL, Fleming ID et al, Eds, 6th Edition. Springer-Verlag, NY, USA
    • Green FL, Page DL, Fleming ID et al. (Eds). Esophagus. In: AJCC Cancer Staging Manual. 6th Edition. Springer-Verlag, NY, USA. 91-98 (2002).
    • (2002) AJCC Cancer Staging Manual , pp. 91-98
  • 21
    • 33745126325 scopus 로고    scopus 로고
    • Selecting a specific pre- or postoperative adjuvant therapy for individual patients with operable gastric cancer
    • Briasoulis E, Liakakos T, Dova L et al. Selecting a specific pre- or postoperative adjuvant therapy for individual patients with operable gastric cancer. Expert Rev. Anticancer Ther. 6(6), 931-939 (2006).
    • (2006) Expert Rev. Anticancer Ther , vol.6 , Issue.6 , pp. 931-939
    • Briasoulis, E.1    Liakakos, T.2    Dova, L.3
  • 22
    • 33947712686 scopus 로고    scopus 로고
    • Stratified medicine: Strategic and economic implications of combining drugs and clinical biomarkers
    • Trusheim MR, Berndt ER, Douglas FL. Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers. Nat. Rev. Drug Discov. 6(4), 287-293 (2007).
    • (2007) Nat. Rev. Drug Discov , vol.6 , Issue.4 , pp. 287-293
    • Trusheim, M.R.1    Berndt, E.R.2    Douglas, F.L.3
  • 23
    • 34548275962 scopus 로고    scopus 로고
    • Molecular genetic tools shape a roadmap towards a more accurate prognostic prediction and personalized management of cancer
    • Roukos DH, Murray S, Briasoulis E. Molecular genetic tools shape a roadmap towards a more accurate prognostic prediction and personalized management of cancer. Cancer Biol. Ther. 6(3), 308-312 (2007).
    • (2007) Cancer Biol. Ther , vol.6 , Issue.3 , pp. 308-312
    • Roukos, D.H.1    Murray, S.2    Briasoulis, E.3
  • 24
    • 38149127056 scopus 로고    scopus 로고
    • HER2 and response to paclitaxel in node-positive breast cancer
    • In Press
    • Roukos DH. HER2 and response to paclitaxel in node-positive breast cancer. N. Engl. J. Med. (In Press).
    • N. Engl. J. Med
    • Roukos, D.H.1
  • 25
    • 35348911366 scopus 로고    scopus 로고
    • Roukos DH. Prognosis of breast cancer in carriers of BRCA1 and BRCA2 mutations. N. Engl. J. Med. 357(15), 1555-1556; author reply 1556 (2007).
    • Roukos DH. Prognosis of breast cancer in carriers of BRCA1 and BRCA2 mutations. N. Engl. J. Med. 357(15), 1555-1556; author reply 1556 (2007).
  • 26
    • 13444283596 scopus 로고    scopus 로고
    • Bias as a threat to the validity of cancer molecular-marker research
    • Ransohoff DF. Bias as a threat to the validity of cancer molecular-marker research. Nat. Rev. Cancer 5(2), 142-149 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.2 , pp. 142-149
    • Ransohoff, D.F.1
  • 27
    • 33947576553 scopus 로고    scopus 로고
    • Shaping the future of biomarker research in breast cancer to ensure clinical relevance
    • Hinestrosa MC, Dickersin K, Klein P et al. Shaping the future of biomarker research in breast cancer to ensure clinical relevance. Nat. Rev. Cancer 7(4), 309-315 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.4 , pp. 309-315
    • Hinestrosa, M.C.1    Dickersin, K.2    Klein, P.3
  • 28
    • 33745560074 scopus 로고    scopus 로고
    • The US Food and Drug Administration perspective on cancer biomarker development
    • Gutman S, Kessler LG. The US Food and Drug Administration perspective on cancer biomarker development. Nat. Rev. Cancer 6(7), 565-571 (2006).
    • (2006) Nat. Rev. Cancer , vol.6 , Issue.7 , pp. 565-571
    • Gutman, S.1    Kessler, L.G.2
  • 29
    • 34147164024 scopus 로고    scopus 로고
    • Is molecular profiling ready for use in clinical decision making?
    • Ioannidis JP. Is molecular profiling ready for use in clinical decision making? Oncologist 12(3), 301-311 (2007).
    • (2007) Oncologist , vol.12 , Issue.3 , pp. 301-311
    • Ioannidis, J.P.1
  • 30
    • 34250887474 scopus 로고    scopus 로고
    • Taking gene-expression profiling to the clinic: When will molecular signatures become relevant to patient care?
    • Sotiriou C, Piccart MJ. Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care? Nat. Rev. Cancer 7(7), 545-553 (2007).
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.7 , pp. 545-553
    • Sotiriou, C.1    Piccart, M.J.2
  • 31
    • 33645774635 scopus 로고    scopus 로고
    • Nodal dissection for patients with gastric cancer: A randomised trial
    • Wu CW, Hsiung SA, Lo et al. Nodal dissection for patients with gastric cancer: a randomised trial. Lancet Oncol. 7, 309-315 (2006).
    • (2006) Lancet Oncol , vol.7 , pp. 309-315
    • Wu, C.W.1    Hsiung, S.A.2    Lo3
  • 32
    • 0343415168 scopus 로고    scopus 로고
    • Relevant prognostic factors in gastric cancer: Ten-year results of the German Gastric Cancer Study
    • Siewert JR, Bottcher K, Stein HJ, Roder JD. Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study. Ann Surg. 228(4), 449-461 (1998).
    • (1998) Ann Surg , vol.228 , Issue.4 , pp. 449-461
    • Siewert, J.R.1    Bottcher, K.2    Stein, H.J.3    Roder, J.D.4
  • 33
    • 0642368578 scopus 로고    scopus 로고
    • Principles of surgical treatment of curable gastric cancer
    • Sasako M. Principles of surgical treatment of curable gastric cancer. J. Clin. Oncol. 21, 274S-275S (2003).
    • (2003) J. Clin. Oncol , vol.21
    • Sasako, M.1
  • 34
    • 6944229895 scopus 로고    scopus 로고
    • Is it time to change surgical strategy for gastric cancer in the United States?
    • Kappas AM, Fatouros M, Roukos DH. Is it time to change surgical strategy for gastric cancer in the United States? Ann. Surg. Oncol. 11(8), 727-730 (2004).
    • (2004) Ann. Surg. Oncol , vol.11 , Issue.8 , pp. 727-730
    • Kappas, A.M.1    Fatouros, M.2    Roukos, D.H.3
  • 35
    • 0036787797 scopus 로고    scopus 로고
    • Targeting the optimal extent of lymph node dissection for gastric cancer
    • Roukos DH, Kappas AM. Targeting the optimal extent of lymph node dissection for gastric cancer. J. Surg. Oncol. 81(2), 59-62 (2002).
    • (2002) J. Surg. Oncol , vol.81 , Issue.2 , pp. 59-62
    • Roukos, D.H.1    Kappas, A.M.2
  • 36
    • 0035818048 scopus 로고    scopus 로고
    • Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction
    • Macdonald JS, Smalley SR, Benedetti J et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N. Engl. J. Med . 345, 725-730 (2001).
    • (2001) N. Engl. J. Med , vol.345 , pp. 725-730
    • Macdonald, J.S.1    Smalley, S.R.2    Benedetti, J.3
  • 37
    • 0036217141 scopus 로고    scopus 로고
    • Adjuvant chemoradiotherapy in gastric cancer: Wave goodbye to extensive surgery?
    • Roukos DH. Adjuvant chemoradiotherapy in gastric cancer: wave goodbye to extensive surgery? Ann. Surg. Oncol. 9(3), 220-221 (2002).
    • (2002) Ann. Surg. Oncol , vol.9 , Issue.3 , pp. 220-221
    • Roukos, D.H.1
  • 38
    • 11144242211 scopus 로고    scopus 로고
    • Timeline: Chemotherapy and the war on cancer
    • Chabner BA, Roberts TG Jr. Timeline: chemotherapy and the war on cancer. Nat. Rev. Cancer 5(1), 65-72 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.1 , pp. 65-72
    • Chabner, B.A.1    Roberts Jr, T.G.2
  • 39
    • 0036203559 scopus 로고    scopus 로고
    • Adjuvant chemotherapy in gastric cancer: A meta-analysis of randomized trials and a comparison with previous meta-analyses
    • Panzini I, Gianni L, Fattori PP et al. Adjuvant chemotherapy in gastric cancer: a meta-analysis of randomized trials and a comparison with previous meta-analyses. Tumori 88(1), 21-27 (2002).
    • (2002) Tumori , vol.88 , Issue.1 , pp. 21-27
    • Panzini, I.1    Gianni, L.2    Fattori, P.P.3
  • 40
    • 33745726677 scopus 로고    scopus 로고
    • Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
    • Cunningham D, Allum WH, Stenning SP et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N. Engl. J. Med. 355(1), 11-20 (2006).
    • (2006) N. Engl. J. Med , vol.355 , Issue.1 , pp. 11-20
    • Cunningham, D.1    Allum, W.H.2    Stenning, S.P.3
  • 41
    • 34648837468 scopus 로고    scopus 로고
    • Level I evidence in support of perioperative chemotherapy for operable gastric cancer. Sufficient for wide clinical use?
    • Briasoulis E, Fatouros M, Roukos D. Level I evidence in support of perioperative chemotherapy for operable gastric cancer. Sufficient for wide clinical use? Ann. Surg. Oncol. 14(10), 2691-2695 (2007).
    • (2007) Ann. Surg. Oncol , vol.14 , Issue.10 , pp. 2691-2695
    • Briasoulis, E.1    Fatouros, M.2    Roukos, D.3
  • 42
    • 33847643631 scopus 로고    scopus 로고
    • Drug insight: VEGF as a therapeutic target for breast cancer
    • Schneider BP, Sledge GW Jr. Drug insight: VEGF as a therapeutic target for breast cancer. Nat. Clin. Pract. Oncol. 4(3), 181-189 (2007).
    • (2007) Nat. Clin. Pract. Oncol , vol.4 , Issue.3 , pp. 181-189
    • Schneider, B.P.1    Sledge Jr., G.W.2
  • 43
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • Jain RK, Duda DG, Clark JW, Loeffler JS. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat. Clin. Pract. Oncol. 3(1), 24-40 (2006).
    • (2006) Nat. Clin. Pract. Oncol , vol.3 , Issue.1 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 44
    • 34249883882 scopus 로고    scopus 로고
    • Targeted therapies: The answer to individualized treatment?
    • Hutchinson L. Targeted therapies: the answer to individualized treatment? Nat. Clin. Pract. Oncol. 4(6), 323 (2007).
    • (2007) Nat. Clin. Pract. Oncol , vol.4 , Issue.6 , pp. 323
    • Hutchinson, L.1
  • 45
    • 34648843716 scopus 로고    scopus 로고
    • The UK NCRI MAGIC Trial of Perioperative Chemotherapy in Resectable Gastric Cancer: Implications for clinical practice
    • Chua YJ, Cunningham D. The UK NCRI MAGIC Trial of Perioperative Chemotherapy in Resectable Gastric Cancer: implications for clinical practice. Ann. Surg. Oncol. 14(10), 2687-2690 (2007).
    • (2007) Ann. Surg. Oncol , vol.14 , Issue.10 , pp. 2687-2690
    • Chua, Y.J.1    Cunningham, D.2
  • 46
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver MJ, He YD, van't Veer LG et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347(25), 1999-2009 (2002).
    • (2002) N. Engl. J. Med , vol.347 , Issue.25 , pp. 1999-2009
    • van de Vijver, M.J.1    He, Y.D.2    van't Veer, L.G.3
  • 47
    • 0038826040 scopus 로고    scopus 로고
    • Randomized trial of adjuvant chemotherapy with mitomycin, fluorouracil, and cytosine arabinoside followed by oral fluorouracil in serosanegative gastric cancer: Japan Clinical Oncology Group 9206-1
    • Nashimoto A, Nakajima T, Furukawa H et al. Randomized trial of adjuvant chemotherapy with mitomycin, fluorouracil, and cytosine arabinoside followed by oral fluorouracil in serosanegative gastric cancer: Japan Clinical Oncology Group 9206-1. J. Clin. Oncol. 21(12), 2282-2287 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.12 , pp. 2282-2287
    • Nashimoto, A.1    Nakajima, T.2    Furukawa, H.3
  • 48
    • 2342571632 scopus 로고    scopus 로고
    • Early-stage gastric cancer: A highly treatable disease
    • Roukos DH. Early-stage gastric cancer: a highly treatable disease. Ann. Surg. Oncol. 11(2), 127-129 (2004).
    • (2004) Ann. Surg. Oncol , vol.11 , Issue.2 , pp. 127-129
    • Roukos, D.H.1
  • 49
    • 12644292106 scopus 로고
    • The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma
    • Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol. Microbiol. Scand. 64, 31-49 (1965).
    • (1965) Acta Pathol. Microbiol. Scand , vol.64 , pp. 31-49
    • Lauren, P.1
  • 50
    • 0142008434 scopus 로고    scopus 로고
    • Postoperative nomogram for disease-specific survival after an R0 resection for gastric carcinoma
    • Kattan MW, Karpeh MS, Mazumdar M, Brennan MF. Postoperative nomogram for disease-specific survival after an R0 resection for gastric carcinoma. J. Clin. Oncol. 21(19), 3647-3650 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.19 , pp. 3647-3650
    • Kattan, M.W.1    Karpeh, M.S.2    Mazumdar, M.3    Brennan, M.F.4
  • 51
    • 33847269131 scopus 로고    scopus 로고
    • Early onset gastric cancer: On the road to unraveling gastric carcinogenesis
    • Milne AN, Sitarz R, Carvalho R, Carneiro F, Offerhaus GJ. Early onset gastric cancer: on the road to unraveling gastric carcinogenesis. Curr. Mol. Med. 7(1), 15-28 (2007).
    • (2007) Curr. Mol. Med , vol.7 , Issue.1 , pp. 15-28
    • Milne, A.N.1    Sitarz, R.2    Carvalho, R.3    Carneiro, F.4    Offerhaus, G.J.5
  • 53
    • 41149137046 scopus 로고    scopus 로고
    • Identifying and preventing high-risk gastric cancer individuals with CDH1 mutations
    • In Press
    • Ziogas D, Baltogiannis, Fatouros M, Roukos DH. Identifying and preventing high-risk gastric cancer individuals with CDH1 mutations. Ann. Surg. (In Press).
    • Ann. Surg
    • Ziogas, D.1    Baltogiannis2    Fatouros, M.3    Roukos, D.H.4
  • 54
    • 0036337656 scopus 로고    scopus 로고
    • Role of surgery in the prophylaxis of hereditary cancer syndromes
    • Roukos DH, Kappas AM, Tsianos E. Role of surgery in the prophylaxis of hereditary cancer syndromes. Ann. Surg. Oncol. 9(7), 607-609 (2002).
    • (2002) Ann. Surg. Oncol , vol.9 , Issue.7 , pp. 607-609
    • Roukos, D.H.1    Kappas, A.M.2    Tsianos, E.3
  • 55
    • 35148861546 scopus 로고    scopus 로고
    • Individualized preventive and therapeutic management of hereditary breast ovarian cancer
    • Roukos DH, Briasoulis E. Individualized preventive and therapeutic management of hereditary breast ovarian cancer. Nat. Clin. Pract. Oncol. 4, 578-590 (2007).
    • (2007) Nat. Clin. Pract. Oncol , vol.4 , pp. 578-590
    • Roukos, D.H.1    Briasoulis, E.2
  • 56
    • 0036894814 scopus 로고    scopus 로고
    • Approaching the dilemma between prophylactic bilateral mastectomy or oophorectomy for breast and ovarian cancer prevention in carriers of BRCA1 or BRCA2 mutations
    • Roukos DH, Agnanti NJ, Paraskevaidis E, Kappas AM. Approaching the dilemma between prophylactic bilateral mastectomy or oophorectomy for breast and ovarian cancer prevention in carriers of BRCA1 or BRCA2 mutations. Ann. Surg. Oncol. 9(10), 941-943 (2002).
    • (2002) Ann. Surg. Oncol , vol.9 , Issue.10 , pp. 941-943
    • Roukos, D.H.1    Agnanti, N.J.2    Paraskevaidis, E.3    Kappas, A.M.4
  • 57
    • 38149127270 scopus 로고    scopus 로고
    • The predominant role of surgery in the prevention and new trends in the surgical treatment of hereditary breast ovarian cancer
    • In Press
    • Fatouros M, Baltoyiannis G, Roukos DH. The predominant role of surgery in the prevention and new trends in the surgical treatment of hereditary breast ovarian cancer. Ann. Surg. Oncol. (2007) (In Press).
    • (2007) Ann. Surg. Oncol
    • Fatouros, M.1    Baltoyiannis, G.2    Roukos, D.H.3
  • 58
    • 16644392218 scopus 로고    scopus 로고
    • Preventing breast, ovarian cancer in BRCA carriers: Rational of prophylactic surgery and promises of surveillance
    • Agnantis NJ, Paraskevaidis E, Roukos D. Preventing breast, ovarian cancer in BRCA carriers: rational of prophylactic surgery and promises of surveillance. Ann. Surg. Oncol. 11(12), 1030-1034 (2004).
    • (2004) Ann. Surg. Oncol , vol.11 , Issue.12 , pp. 1030-1034
    • Agnantis, N.J.1    Paraskevaidis, E.2    Roukos, D.3
  • 59
    • 33746851956 scopus 로고    scopus 로고
    • Tumor metastasis: Mechanistic insights and clinical challenges
    • Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat. Med. 12, 695-904 (2006).
    • (2006) Nat. Med , vol.12 , pp. 695-904
    • Steeg, P.S.1
  • 60
    • 34147215394 scopus 로고    scopus 로고
    • Division of labour
    • Christofori G. Division of labour. Nature 446, 735-736 (2007).
    • (2007) Nature , vol.446 , pp. 735-736
    • Christofori, G.1
  • 61
    • 34147220392 scopus 로고    scopus 로고
    • Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
    • Gupta GP, Nguyen DX, Chiang AC et al. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 446(7137), 765-770 (2007).
    • (2007) Nature , vol.446 , Issue.7137 , pp. 765-770
    • Gupta, G.P.1    Nguyen, D.X.2    Chiang, A.C.3
  • 62
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van't Veer LJ, Dai H, van de Vijver MJ et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530-536 (2002).
    • (2002) Nature , vol.415 , pp. 530-536
    • van't Veer, L.J.1    Dai, H.2    van de Vijver, M.J.3
  • 63
    • 33748693297 scopus 로고    scopus 로고
    • Validation and clinical utility of a 70-gene prognostic signature for women with node negative breast cancer
    • Buyse M, Loi S, van't Veer L et al. Validation and clinical utility of a 70-gene prognostic signature for women with node negative breast cancer. J. Natl Cancer Inst. 98, 1183-1192 (2006).
    • (2006) J. Natl Cancer Inst , vol.98 , pp. 1183-1192
    • Buyse, M.1    Loi, S.2    van't Veer, L.3
  • 64
    • 13844310310 scopus 로고    scopus 로고
    • Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    • Wang Y, Klijn JG, Zhang Y et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 365(9460), 671-679 (2005).
    • (2005) Lancet , vol.365 , Issue.9460 , pp. 671-679
    • Wang, Y.1    Klijn, J.G.2    Zhang, Y.3
  • 65
    • 33645825388 scopus 로고    scopus 로고
    • Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer
    • Foekens JA, Atkins D, Zhang Y et al. Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer. J. Clin. Oncol. 24(11), 1665-1671 (2006).
    • (2006) J. Clin. Oncol , vol.24 , Issue.11 , pp. 1665-1671
    • Foekens, J.A.1    Atkins, D.2    Zhang, Y.3
  • 66
    • 33744814477 scopus 로고    scopus 로고
    • Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    • Paik S, Tang G, Shak S et al. Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J. Clin. Oncol. 24, 3726-3734 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 3726-3734
    • Paik, S.1    Tang, G.2    Shak, S.3
  • 67
    • 33751323683 scopus 로고    scopus 로고
    • High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: Is it ready for the clinic?
    • Sims AH, Ong KR, Clarke RB, Howell A. High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic? Breast Cancer Res. 8(5), 214 (2006).
    • (2006) Breast Cancer Res , vol.8 , Issue.5 , pp. 214
    • Sims, A.H.1    Ong, K.R.2    Clarke, R.B.3    Howell, A.4
  • 68
    • 34250652449 scopus 로고    scopus 로고
    • Strong time-dependency of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multi-centre independent validation series
    • Desmedt C, Piette F, Loi S et al. Strong time-dependency of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multi-centre independent validation series. Clin. Cancer Res.13, 3207-3214 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 3207-3214
    • Desmedt, C.1    Piette, F.2    Loi, S.3
  • 69
    • 20444457518 scopus 로고    scopus 로고
    • Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer
    • Glinsky GV, Berezovska O, Glinskii AB. Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J. Clin. Invest. 115(6), 1503-1521 (2005).
    • (2005) J. Clin. Invest , vol.115 , Issue.6 , pp. 1503-1521
    • Glinsky, G.V.1    Berezovska, O.2    Glinskii, A.B.3
  • 70
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breast-cancer cells
    • Liu R, Wang X, Chen GY et al. The prognostic role of a gene signature from tumorigenic breast-cancer cells. N. Engl. J. Med. 356(3), 217-226 (2007).
    • (2007) N. Engl. J. Med , vol.356 , Issue.3 , pp. 217-226
    • Liu, R.1    Wang, X.2    Chen, G.Y.3
  • 71
    • 33846011470 scopus 로고    scopus 로고
    • A five-gene signature and clinical outcome in non-small-cell lung cancer
    • Chen HY, Yu SL, Chen CH et al. A five-gene signature and clinical outcome in non-small-cell lung cancer. N. Engl. J. Med. 356(1), 11-20 (2007).
    • (2007) N. Engl. J. Med , vol.356 , Issue.1 , pp. 11-20
    • Chen, H.Y.1    Yu, S.L.2    Chen, C.H.3
  • 72
    • 33746875641 scopus 로고    scopus 로고
    • A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer
    • Potti A, Mukherjee S, Petersen R et al. A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. N. Engl. J. Med . 355(6), 570-580 (2006).
    • (2006) N. Engl. J. Med , vol.355 , Issue.6 , pp. 570-580
    • Potti, A.1    Mukherjee, S.2    Petersen, R.3
  • 73
    • 33750593381 scopus 로고    scopus 로고
    • Stage II colon cancer prognosis prediction by tumor gene expression profiling
    • Barrier A, Boelle PY, Roser F et al. Stage II colon cancer prognosis prediction by tumor gene expression profiling. J. Clin. Oncol. 24(29), 4685-4691 (2006).
    • (2006) J. Clin. Oncol , vol.24 , Issue.29 , pp. 4685-4691
    • Barrier, A.1    Boelle, P.Y.2    Roser, F.3
  • 74
    • 33947540860 scopus 로고    scopus 로고
    • Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan
    • Del Rio M, Molina F, Bascoul-Mollevi C et al. Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan. J. Clin. Oncol. 25(7), 773-780 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.7 , pp. 773-780
    • Del Rio, M.1    Molina, F.2    Bascoul-Mollevi, C.3
  • 75
    • 0036534202 scopus 로고    scopus 로고
    • DNA microarrays in clinical oncology
    • Ramaswamy S, Golub TR. DNA microarrays in clinical oncology. J. Clin. Oncol. 20(7), 1932-1941 (2002).
    • (2002) J. Clin. Oncol , vol.20 , Issue.7 , pp. 1932-1941
    • Ramaswamy, S.1    Golub, T.R.2
  • 76
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast. 1889
    • Paget S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev. 8(2), 98-101 (1989).
    • (1989) Cancer Metastasis Rev , vol.8 , Issue.2 , pp. 98-101
    • Paget, S.1
  • 77
    • 33645469482 scopus 로고    scopus 로고
    • Stem cells and their niches
    • Moore KA, Lemischka IR. Stem cells and their niches. Science 311(5769), 1880-1885 (2006).
    • (2006) Science , vol.311 , Issue.5769 , pp. 1880-1885
    • Moore, K.A.1    Lemischka, I.R.2
  • 78
    • 33646045010 scopus 로고    scopus 로고
    • Stem cells and cancer: Two faces of eve
    • Clarke MF, Fuller M. Stem cells and cancer: two faces of eve. Cell 124(6), 1111-1115 (2006).
    • (2006) Cell , vol.124 , Issue.6 , pp. 1111-1115
    • Clarke, M.F.1    Fuller, M.2
  • 79
    • 23844512451 scopus 로고    scopus 로고
    • Calculated resistance in cancer
    • Sawyers CL. Calculated resistance in cancer. Nat. Med. 11(8), 824-845 (2005).
    • (2005) Nat. Med , vol.11 , Issue.8 , pp. 824-845
    • Sawyers, C.L.1
  • 80
    • 34547618083 scopus 로고    scopus 로고
    • Drinking from the fire hose - statistical issues in genomewide association studies
    • Hunter DJ, Kraft P. Drinking from the fire hose - statistical issues in genomewide association studies. N. Engl. J. Med . 357(5), 436-439 (2007).
    • (2007) N. Engl. J. Med , vol.357 , Issue.5 , pp. 436-439
    • Hunter, D.J.1    Kraft, P.2
  • 81
    • 34250305146 scopus 로고    scopus 로고
    • ENCODE Project Consortium; Birney E, Stamatoyannopoulos JA, Dutta A et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447(7146), 799-816 (2007).
    • ENCODE Project Consortium; Birney E, Stamatoyannopoulos JA, Dutta A et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447(7146), 799-816 (2007).
  • 82
    • 33747050886 scopus 로고    scopus 로고
    • The role of companion diagnostics in the development and use of mutation-targeted cancer therapies
    • Papadopoulos N, Kinzler KW, Vogelstein B. The role of companion diagnostics in the development and use of mutation-targeted cancer therapies. Nat. Biotechnol. 24(8), 985-995 (2006).
    • (2006) Nat. Biotechnol , vol.24 , Issue.8 , pp. 985-995
    • Papadopoulos, N.1    Kinzler, K.W.2    Vogelstein, B.3
  • 83
    • 33750593818 scopus 로고    scopus 로고
    • Proteomic analysis of cancer tissues: Shedding light on carcinogenesis and possible biomarkers
    • Kuramitsu Y, Nakamura K. Proteomic analysis of cancer tissues: shedding light on carcinogenesis and possible biomarkers. Proteomics 6(20), 5650-5661 (2006).
    • (2006) Proteomics , vol.6 , Issue.20 , pp. 5650-5661
    • Kuramitsu, Y.1    Nakamura, K.2
  • 84
    • 34447564234 scopus 로고    scopus 로고
    • Metabolomics: Available results, current research projects in breast cancer, and future applications
    • Claudino WM, Quattrone A, Biganzoli L, Pestrin M, Bertini I, Di Leo A. Metabolomics: available results, current research projects in breast cancer, and future applications. J. Clin. Oncol. 25(19), 2840-2846 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.19 , pp. 2840-2846
    • Claudino, W.M.1    Quattrone, A.2    Biganzoli, L.3    Pestrin, M.4    Bertini, I.5    Di Leo, A.6
  • 85
    • 1642399172 scopus 로고    scopus 로고
    • Betting odds and genetic associations
    • Thomas DC, Clayton DG. Betting odds and genetic associations. J. Cancer Inst. 96(6), 421-423 (2004).
    • (2004) J. Cancer Inst , vol.96 , Issue.6 , pp. 421-423
    • Thomas, D.C.1    Clayton, D.G.2
  • 86
    • 20044388557 scopus 로고    scopus 로고
    • From signatures to models: Understanding cancer using microarrays
    • Segal E, Friedman N, Kaminski N, Regev A, Koller D. From signatures to models: understanding cancer using microarrays. Nat. Genet. 37(Suppl.) S38-S45 (2005).
    • (2005) Nat. Genet , vol.37 , Issue.SUPPL.
    • Segal, E.1    Friedman, N.2    Kaminski, N.3    Regev, A.4    Koller, D.5
  • 87
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100(1), 57-70 (2000).
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 88
    • 34247843997 scopus 로고    scopus 로고
    • Hedgehog signaling pathway and gastrointestinal stem cell signaling network
    • Katoh Y, Katoh M. Hedgehog signaling pathway and gastrointestinal stem cell signaling network. Int. J. Mol. Med. 18(6), 1019-1023 (2006).
    • (2006) Int. J. Mol. Med , vol.18 , Issue.6 , pp. 1019-1023
    • Katoh, Y.1    Katoh, M.2
  • 89
    • 9444265320 scopus 로고    scopus 로고
    • Gastric cancer originating from bone marrow-derived cells
    • Houghton J, Stoicov C, Nomura S et al. Gastric cancer originating from bone marrow-derived cells. Science 306(5701), 1568-1571 (2004).
    • (2004) Science , vol.306 , Issue.5701 , pp. 1568-1571
    • Houghton, J.1    Stoicov, C.2    Nomura, S.3
  • 90
    • 34147198467 scopus 로고    scopus 로고
    • Synthetic lethal screen identification of chemosensitizer loci in cancer cells
    • Whitehurst AW, Bodemann BO, Cardenas J et al. Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 446(7137), 815-819 (2007).
    • (2007) Nature , vol.446 , Issue.7137 , pp. 815-819
    • Whitehurst, A.W.1    Bodemann, B.O.2    Cardenas, J.3
  • 91
    • 0035875272 scopus 로고    scopus 로고
    • Pathological serosa and node-based classification accurately predicts gastric cancer recurrence risk and outcome, and determines potential and limitation of a Japanese-style extensive surgery for Western patients: A prospective with quality control 10-year follow-up study
    • Roukos DH, Lorenz M, Karakostas K, Paraschou P, Batsis C, Kappas AM. Pathological serosa and node-based classification accurately predicts gastric cancer recurrence risk and outcome, and determines potential and limitation of a Japanese-style extensive surgery for Western patients: a prospective with quality control 10-year follow-up study. Br. J. Cancer 84(12), 1602-1609 (2001).
    • (2001) Br. J. Cancer , vol.84 , Issue.12 , pp. 1602-1609
    • Roukos, D.H.1    Lorenz, M.2    Karakostas, K.3    Paraschou, P.4    Batsis, C.5    Kappas, A.M.6
  • 92
    • 34147211281 scopus 로고    scopus 로고
    • Lung metastasis genes couple breast tumor size and metastatic spread
    • Minn AJ, Gupta GP, Padua D et al. Lung metastasis genes couple breast tumor size and metastatic spread. Proc. Natl Acad. Sci. USA 104(16), 6740-6745 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.16 , pp. 6740-6745
    • Minn, A.J.1    Gupta, G.P.2    Padua, D.3


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