Verification of a designed intramolecular hydrogen bond in a drug scaffold by nuclear magnetic resonance spectroscopy

Journal of Medicinal Chemistry

Volumn 50, Issue 24, 2007, Pages 5875-5877

  Jansma, Ariane ^a   Zhang, Qiong ^a   Li, Bing ^a   Ding, Qiang ^a   Uno, Tetsuo ^a   Bursulaya, Badry ^a   Liu, Yi ^a   Furet, Pascal ^b   Gray, Nathanael S ^a   Geierstanger, Bernhard H ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFOXIDE; ORGANIC COMPOUND; PHOSPHOTRANSFERASE INHIBITOR; PYRIMIDINONE DERIVATIVE; SOLVENT;

AQUEOUS SOLUTION; ARTICLE; CONFORMATION; HYDROGEN BOND; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR STABILITY; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; TITRIMETRY;

DIMETHYL SULFOXIDE; DRUG DESIGN; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PYRIDINES; PYRIDONES; PYRIMIDINES; SOLUBILITY; WATER;

EID: 37849041348     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm700983a     Document Type: Article

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